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278603-08-0,Molecular Weight
Catalog No.:AA007JR1

278603-08-0 | Nh125

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99+%
in stock  
$10.00   $7.00
- +
10mg
99+%
in stock  
$34.00   $24.00
- +
50mg
99+%
in stock  
$96.00   $68.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA007JR1
Chemical Name:
Nh125
CAS Number:
278603-08-0
Molecular Formula:
C27H45IN2
Molecular Weight:
524.5641
MDL Number:
Molecular Weight
SMILES:
CCCCCCCCCCCCCCCCn1cc[n+](c1C)Cc1ccccc1.[I-]
NSC Number:
717205
Properties
Computed Properties
 
Complexity:
364  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
17  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.

Journal: EMBO molecular medicine 20141201

Title: Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact.

Journal: Biochemistry 20120313

Title: 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor.

Journal: The Journal of biological chemistry 20111223

Title: Antibacterial activities of imidazolium, pyrrolidinium and piperidinium salts.

Journal: Bioorganic & medicinal chemistry letters 20110315

Title: P-glycoprotein mediates resistance to histidine kinase inhibitors.

Journal: Molecular pharmacology 20040901

Title: Arora S, et al. Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res. 2003 Oct 15;63(20):6894-9.

Title: Chen Z, et al. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem. 2011 Dec 23;286(51):43951-8.

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SDS
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904830-08-6
Tags:278603-08-0 Molecular Formula|278603-08-0 MDL|278603-08-0 SMILES|278603-08-0 Nh125
Catalog No.: AA007JR1
278603-08-0,Molecular Weight
278603-08-0 | Nh125
Pack Size： 1mg
Purity： 99+%
in stock
$10.00 $7.00
Pack Size： 10mg
Purity： 99+%
in stock
$34.00 $24.00
Pack Size： 50mg
Purity： 99+%
in stock
$96.00 $68.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA007JR1
Chemical Name: Nh125
CAS Number: 278603-08-0
Molecular Formula: C27H45IN2
Molecular Weight: 524.5641
MDL Number: Molecular Weight
SMILES: CCCCCCCCCCCCCCCCn1cc[n+](c1C)Cc1ccccc1.[I-]
NSC Number: 717205
Properties
Complexity: 364  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 30  
Hydrogen Bond Acceptor Count: 1  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 17  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.

Journal: EMBO molecular medicine20141201

Title: Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact.

Journal: Biochemistry20120313

Title: 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor.

Journal: The Journal of biological chemistry20111223

Title: Antibacterial activities of imidazolium, pyrrolidinium and piperidinium salts.

Journal: Bioorganic & medicinal chemistry letters20110315

Title: P-glycoprotein mediates resistance to histidine kinase inhibitors.

Journal: Molecular pharmacology20040901

Title: Arora S, et al. Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res. 2003 Oct 15;63(20):6894-9.

Title: Chen Z, et al. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem. 2011 Dec 23;286(51):43951-8.

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