289656-45-7,MFCD09027349
Catalog No.:AA002UXW

289656-45-7 | 2,2-Bis(4-fluorophenyl)-2-phenylacetamide

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5mg
98%
in stock  
$43.00   $30.00
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50mg
≥98%
in stock  
$46.00   $32.00
- +
100mg
≥98%
in stock  
$82.00   $57.00
- +
500mg
≥98%
in stock  
$348.00   $243.00
- +
1g
≥98%
in stock  
$609.00   $426.00
- +
10g
98%
in stock  
$3,527.00   $2,469.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA002UXW
Chemical Name:
2,2-Bis(4-fluorophenyl)-2-phenylacetamide
CAS Number:
289656-45-7
Molecular Formula:
C20H15F2NO
Molecular Weight:
323.3360
MDL Number:
MFCD09027349
SMILES:
Fc1ccc(cc1)C(c1ccc(cc1)F)(c1ccccc1)C(=O)N
Properties
Computed Properties
 
Complexity:
397  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.1  

Literature

Title: Drugs for preventing red blood cell dehydration in people with sickle cell disease.

Journal: The Cochrane database of systematic reviews 20120711

Title: Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma.

Journal: Journal of signal transduction 20120101

Title: Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's Disease.

Journal: International journal of Alzheimer's disease 20120101

Title: Anti-haemolytic effect of senicapoc and decrease in NT-proBNP in adults with sickle cell anaemia.

Journal: British journal of haematology 20111201

Title: Senicapoc trial results support the existence of different sub-phenotypes of sickle cell disease with possible drug-induced phenotypic shifts.

Journal: British journal of haematology 20111201

Title: Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the Gardos channel blocker senicapoc (ICA-17043).

Journal: British journal of haematology 20110401

Title: Drugs for preventing red blood cell dehydration in people with sickle cell disease.

Journal: The Cochrane database of systematic reviews 20100120

Title: Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes.

Journal: PloS one 20100101

Title: Promising therapies in sickle cell disease.

Journal: Cardiovascular & hematological disorders drug targets 20090301

Title: Senicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia.

Journal: Expert opinion on investigational drugs 20090201

Title: Pathophisiology of sickle cell disease and new drugs for the treatment.

Journal: Mediterranean journal of hematology and infectious diseases 20090101

Title: Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia.

Journal: Blood 20080415

Title: Gardos pathway to sickle cell therapies?

Journal: Blood 20080415

Title: Novel inhibitors of the Gardos channel for the treatment of sickle cell disease.

Journal: Journal of medicinal chemistry 20080227

Title: Dose-escalation study of ICA-17043 in patients with sickle cell disease.

Journal: Pharmacotherapy 20061101

Title: Investigational agents for sickle cell disease.

Journal: Expert opinion on investigational drugs 20060801

Title: Current therapy of sickle cell disease.

Journal: Haematologica 20060101

Title: [Clinical trials of new therapeutic pharmacology for sickle cell disease].

Journal: Sante (Montrouge, France) 20060101

Title: New therapies for sickle cell disease.

Journal: Hematology/oncology clinics of North America 20051001

Title: ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice.

Journal: Blood 20030315

Title: Stocker JW, et al. ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood. 2003 Mar 15;101(6):2412-8.

Title: Van Der Velden J, et al. K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma. PLoS One. 2013 Jun 24;8(6):e66886.

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Additional Info:
SDS
Tags:289656-45-7 Molecular Formula|289656-45-7 MDL|289656-45-7 SMILES|289656-45-7 2,2-Bis(4-fluorophenyl)-2-phenylacetamide
Catalog No.: AA002UXW
289656-45-7,MFCD09027349
289656-45-7 | 2,2-Bis(4-fluorophenyl)-2-phenylacetamide
Pack Size: 5mg
Purity: 98%
in stock
$43.00 $30.00
Pack Size: 50mg
Purity: ≥98%
in stock
$46.00 $32.00
Pack Size: 100mg
Purity: ≥98%
in stock
$82.00 $57.00
Pack Size: 500mg
Purity: ≥98%
in stock
$348.00 $243.00
Pack Size: 1g
Purity: ≥98%
in stock
$609.00 $426.00
Pack Size: 10g
Purity: 98%
in stock
$3,527.00 $2,469.00
Quantity
- +
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Technical Information
Catalog Number: AA002UXW
Chemical Name: 2,2-Bis(4-fluorophenyl)-2-phenylacetamide
CAS Number: 289656-45-7
Molecular Formula: C20H15F2NO
Molecular Weight: 323.3360
MDL Number: MFCD09027349
SMILES: Fc1ccc(cc1)C(c1ccc(cc1)F)(c1ccccc1)C(=O)N
Properties
Complexity: 397  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 24  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.1  
Literature fold

Title: Drugs for preventing red blood cell dehydration in people with sickle cell disease.

Journal: The Cochrane database of systematic reviews20120711

Title: Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma.

Journal: Journal of signal transduction20120101

Title: Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's Disease.

Journal: International journal of Alzheimer's disease20120101

Title: Anti-haemolytic effect of senicapoc and decrease in NT-proBNP in adults with sickle cell anaemia.

Journal: British journal of haematology20111201

Title: Senicapoc trial results support the existence of different sub-phenotypes of sickle cell disease with possible drug-induced phenotypic shifts.

Journal: British journal of haematology20111201

Title: Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the Gardos channel blocker senicapoc (ICA-17043).

Journal: British journal of haematology20110401

Title: Drugs for preventing red blood cell dehydration in people with sickle cell disease.

Journal: The Cochrane database of systematic reviews20100120

Title: Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes.

Journal: PloS one20100101

Title: Promising therapies in sickle cell disease.

Journal: Cardiovascular & hematological disorders drug targets20090301

Title: Senicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia.

Journal: Expert opinion on investigational drugs20090201

Title: Pathophisiology of sickle cell disease and new drugs for the treatment.

Journal: Mediterranean journal of hematology and infectious diseases20090101

Title: Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia.

Journal: Blood20080415

Title: Gardos pathway to sickle cell therapies?

Journal: Blood20080415

Title: Novel inhibitors of the Gardos channel for the treatment of sickle cell disease.

Journal: Journal of medicinal chemistry20080227

Title: Dose-escalation study of ICA-17043 in patients with sickle cell disease.

Journal: Pharmacotherapy20061101

Title: Investigational agents for sickle cell disease.

Journal: Expert opinion on investigational drugs20060801

Title: Current therapy of sickle cell disease.

Journal: Haematologica20060101

Title: [Clinical trials of new therapeutic pharmacology for sickle cell disease].

Journal: Sante (Montrouge, France)20060101

Title: New therapies for sickle cell disease.

Journal: Hematology/oncology clinics of North America20051001

Title: ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice.

Journal: Blood20030315

Title: Stocker JW, et al. ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood. 2003 Mar 15;101(6):2412-8.

Title: Van Der Velden J, et al. K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma. PLoS One. 2013 Jun 24;8(6):e66886.

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