Name: Name:2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid
Brand: AABLOCKS
SKU: AA007JIP
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA007JIP

Chemical Name: 2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid

CAS Number: 300657-03-8

Molecular Formula: C31H26N2O3

Molecular Weight: 474.5497

MDL Number: MFCD09991687

SMILES: CCc1c(c2ccccc2)c(nn1c1ccccc1c1cccc(c1)OCC(=O)O)c1ccccc1

Properties

Complexity: 689

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 36

Hydrogen Bond Acceptor Count: 4

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 8

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 7.2

Literature fold

Title: Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes.

Journal: European journal of medicinal chemistry20120601

Title: Synthesis of BMS-309403-related compounds, including [¹⁴C]BMS-309403, a radioligand for adipocyte fatty acid binding protein.

Journal: Chemical & pharmaceutical bulletin20120101

Title: BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase.

Journal: PloS one20120101

Title: BMS309403 directly suppresses cardiac contractile function.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20110901

Title: Fatty acid binding protein 4 regulates intracellular lipid accumulation in human trophoblasts.

Journal: The Journal of clinical endocrinology and metabolism20110701

Title: Expression and function of fatty acid-binding protein 4 during mouse decidualization.

Journal: Fertility and sterility20110630

Title: Identification of a potential biomarker for FABP4 inhibition: the power of lipidomics in preclinical drug testing.

Journal: Journal of biomolecular screening20110601

Title: New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein.

Journal: Bioorganic & medicinal chemistry letters20110515

Title: Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells.

Journal: British journal of pharmacology20110401

Title: Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

Journal: Nature20070621

Title: Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).

Journal: Bioorganic & medicinal chemistry letters20070615

Title: Urea metabolism in the llama.

Journal: Comparative biochemistry and physiology. A, Comparative physiology19751201

Title: Sulsky R, et al. Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg Med Chem Lett. 2007 Jun 15;17(12):3511-5.

Title: Lin W, et al. BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase. PLoS One. 2012;7(8):e44570.

Title: Lee MY, et al. Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells. Br J Pharmacol. 2011 Apr;162(7):1564-76.

300657-03-8 | 2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid