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321688-88-4,MFCD00534351
Catalog No.:AA00C6EL

321688-88-4 | 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime]

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$65.00   $45.00
- +
10mg
≥98%
in stock  
$105.00   $73.00
- +
25mg
≥98%
in stock  
$242.00   $169.00
- +
50mg
≥98%
in stock  
$386.00   $270.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00C6EL
Chemical Name:
2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime]
CAS Number:
321688-88-4
Molecular Formula:
C18H19NO3
Molecular Weight:
297.3484
MDL Number:
MFCD00534351
SMILES:
CC1=CC(=O)C(=C/C/1=N/OC(=O)c1ccccc1C)C(C)C
Properties
Computed Properties
 
Complexity:
555  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.9  

Literature

Title: Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.

Journal: The American journal of pathology 20111001

Title: Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions.

Journal: Chemistry & biology 20080501

Title: Yuan J, et al. Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo. Am J Pathol. 2011 Oct;179(4):2091-9.

Title: Sanhaji M, et al. p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors. Cell Cycle. 2012 Feb 1;11(3):543-53.

Title: Lee KS, et al. Pinning down the polo-box domain. Chem Biol. 2008 May;15(5):415-6.

Title: Reindl W, et al. Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions. Chem Biol. 2008 May;15(5):459-66.

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SDS
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Tags:321688-88-4 Molecular Formula|321688-88-4 MDL|321688-88-4 SMILES|321688-88-4 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime]
Catalog No.: AA00C6EL
321688-88-4,MFCD00534351
321688-88-4 | 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime]
Pack Size： 5mg
Purity： ≥98%
in stock
$65.00 $45.00
Pack Size： 10mg
Purity： ≥98%
in stock
$105.00 $73.00
Pack Size： 25mg
Purity： ≥98%
in stock
$242.00 $169.00
Pack Size： 50mg
Purity： ≥98%
in stock
$386.00 $270.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00C6EL
Chemical Name: 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime]
CAS Number: 321688-88-4
Molecular Formula: C18H19NO3
Molecular Weight: 297.3484
MDL Number: MFCD00534351
SMILES: CC1=CC(=O)C(=C/C/1=N/OC(=O)c1ccccc1C)C(C)C
Properties
Complexity: 555  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 22  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.9  
Literature fold

Title: Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.

Journal: The American journal of pathology20111001

Title: Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions.

Journal: Chemistry & biology20080501

Title: Yuan J, et al. Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo. Am J Pathol. 2011 Oct;179(4):2091-9.

Title: Sanhaji M, et al. p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors. Cell Cycle. 2012 Feb 1;11(3):543-53.

Title: Lee KS, et al. Pinning down the polo-box domain. Chem Biol. 2008 May;15(5):415-6.

Title: Reindl W, et al. Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions. Chem Biol. 2008 May;15(5):459-66.

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