Name: Name:N-(6-Chloropyridin-3-yl)-3,4-difluorobenzamide
Brand: AABLOCKS
SKU: AA00I633
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00I633

Chemical Name: N-(6-Chloropyridin-3-yl)-3,4-difluorobenzamide

CAS Number: 325457-89-4

Molecular Formula: C12H7ClF2N2O

Molecular Weight: 268.6466

MDL Number: MFCD17166959

SMILES: Clc1ccc(cn1)NC(=O)c1ccc(c(c1)F)F

Properties

Complexity: 306

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 18

Hydrogen Bond Acceptor Count: 4

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 2

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 2.8

Literature fold

Title: K(v) 7 (KCNQ) channel openers normalize central 2-deoxyglucose uptake in a mouse model of mania and increase prefrontal cortical and hippocampal serine-9 phosphorylation levels of GSK3β.

Journal: Journal of neurochemistry20120501

Title: The pharmacological effect of positive KCNQ (Kv7) modulators on dopamine release from striatal slices.

Journal: Basic & clinical pharmacology & toxicology20111101

Title: Kv7 (KCNQ) channel openers induce hypothermia in the mouse.

Journal: Neuroscience letters20110120

Title: Differential effects of ICA-27243 on cloned K(V)7 channels.

Journal: Pharmacology20100101

Title: The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site.

Journal: Neuroscience letters20091113

Title: Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania.

Journal: Behavioural brain research20090317

Title: In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models.

Journal: The Journal of pharmacology and experimental therapeutics20080901

Title: N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator.

Journal: Molecular pharmacology20080301

Title: Wickenden AD, et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86.

Title: Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.

325457-89-4 | N-(6-Chloropyridin-3-yl)-3,4-difluorobenzamide