33237-74-0,MFCD01698392
Catalog No.:AA00C9LV

33237-74-0 | APRINDINE HCL

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
3 weeks  
$475.00   $332.00
- +
250mg
3 weeks  
$2,646.00   $1,852.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00C9LV
Chemical Name:
APRINDINE HCL
CAS Number:
33237-74-0
Molecular Formula:
C22H31ClN2
Molecular Weight:
358.9479
MDL Number:
MFCD01698392
SMILES:
CCN(CCCN(C1Cc2c(C1)cccc2)c1ccccc1)CC.Cl
Properties
Properties
 
Form:
Solid  
MP:
119 - 120°C  
Storage:
2-8℃;Keep in dry area;  

Computed Properties
 
Complexity:
332  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Relationship between serum aprindine concentration and neurologic side effects in Japanese.

Journal: Biological & pharmaceutical bulletin 20090401

Title: Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation.

Journal: Journal of cardiovascular pharmacology 20070901

Title: Pharmacological cardioversion of persistent atrial fibrillation with and without a history of drug-resistant paroxysmal atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20060901

Title: [Strategy for cardiac arrhythmias in acute coronary syndrome].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060401

Title: Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias.

Journal: Biological & pharmaceutical bulletin 20060301

Title: Effect of antiarrhythmic agents on heart rate variability indices after myocardial infarction: comparative experimental study of aprindine and procainamide.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20051001

Title: Proteasomal degradation of Kir6.2 channel protein and its inhibition by a Na+ channel blocker aprindine.

Journal: Biochemical and biophysical research communications 20050617

Title: Drug-induced changes in fibrillation cycle length and organization index can predict chemical cardioversion of long-lasting atrial fibrillation with bepridil alone or in combination with aprindine.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20041201

Title: Maintenance of sinus rhythm and recovery of atrial mechanical function after cardioversion with bepridil or in combination with aprindine in long-lasting persistent atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20040901

Title: Usefulness and safety of bepridil in converting persistent atrial fibrillation to sinus rhythm.

Journal: The American journal of cardiology 20030815

Title: [Comparison of the efficacies of disopyramide, cibenzoline and aprindine for the termination of paroxysmal and persistent atrial fibrillation in elderly and non-elderly patients].

Journal: Journal of cardiology 20030401

Title: Atrial fibrillation threshold predicted long-term efficacy of pharmacological treatment of patients without structural heart disease.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20021001

Title: Inhibitory effect of aprindine on Na+/Ca2+ exchange current in guinea-pig cardiac ventricular myocytes.

Journal: British journal of pharmacology 20020601

Title: Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20020601

Title: Inhibitory effects of aprindine on the delayed rectifier K+ current and the muscarinic acetylcholine receptor-operated K+ current in guinea-pig atrial cells.

Journal: British journal of pharmacology 19990201

Title: Prediction of catalepsies induced by amiodarone, aprindine and procaine: similarity in conformation of diethylaminoethyl side chain.

Journal: The Journal of pharmacology and experimental therapeutics 19981101

Title: Effects of aprindine on ischemia/reperfusion-induced cardiac contractile dysfunction of perfused rat heart.

Journal: Japanese journal of pharmacology 19960301

Title: Complex frequency-dependent interaction of class-I antiarrhythmic drugs as they affect intraventricular conduction.

Journal: European heart journal 19950601

Title: Combined application of class I antiarrhythmic drugs causes 'additive', 'reductive', or 'synergistic' sodium channel block in cardiac muscles.

Journal: Cardiovascular research 19901101

Title: Effect of sotalol, aprindine and their combination on maximum upstroke velocity of action potential in guinea-pig papillary muscle.

Journal: European journal of pharmacology 19861119

Title: Drug-induced torsade de pointes.

Journal: Clinical pharmacy 19850101

Title: Effective plasma concentrations of aprindine in canine ventricular arrhythmias.

Journal: Journal of cardiovascular pharmacology 19840101

Title: Quantitative analysis of the antiarrhythmic effect of drugs on canine ventricular arrhythmias by the determination of minimum effective plasma concentrations.

Journal: Japanese circulation journal 19830101

Title: New drugs for treating cardiac arrhythmias.

Journal: Postgraduate medicine 19810101

Title: Antiarrhythmic and antifibrillatory properties of aprindine.

Journal: The Journal of pharmacology and experimental therapeutics 19750801

Title: [Accident during local anesthesia in a patient with antiarrhythmic therapy].

Journal: Zeitschrift fur Kardiologie 19750701

Title: M L De Bruin, et al . Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death. Eur Heart J. 2005 Mar;26(6):590-7.

Title: Y Ohmoto-Sekine, et al. Inhibitory effects of aprindine on the delayed rectifier K+ current and the muscarinic acetylcholine receptor-operated K+ current in guinea-pig atrial cells. Br J Pharmacol. 1999 Feb;126(3):751-61.

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Tags:33237-74-0 Molecular Formula|33237-74-0 MDL|33237-74-0 SMILES|33237-74-0 APRINDINE HCL
Catalog No.: AA00C9LV
33237-74-0,MFCD01698392
33237-74-0 | APRINDINE HCL
Pack Size: 25mg
Purity:
3 weeks
$475.00 $332.00
Pack Size: 250mg
Purity:
3 weeks
$2,646.00 $1,852.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00C9LV
Chemical Name: APRINDINE HCL
CAS Number: 33237-74-0
Molecular Formula: C22H31ClN2
Molecular Weight: 358.9479
MDL Number: MFCD01698392
SMILES: CCN(CCCN(C1Cc2c(C1)cccc2)c1ccccc1)CC.Cl
Properties
Form: Solid  
MP: 119 - 120°C  
Storage: 2-8℃;Keep in dry area;  
Complexity: 332  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 25  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 8  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Relationship between serum aprindine concentration and neurologic side effects in Japanese.

Journal: Biological & pharmaceutical bulletin20090401

Title: Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation.

Journal: Journal of cardiovascular pharmacology20070901

Title: Pharmacological cardioversion of persistent atrial fibrillation with and without a history of drug-resistant paroxysmal atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society20060901

Title: [Strategy for cardiac arrhythmias in acute coronary syndrome].

Journal: Nihon rinsho. Japanese journal of clinical medicine20060401

Title: Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias.

Journal: Biological & pharmaceutical bulletin20060301

Title: Effect of antiarrhythmic agents on heart rate variability indices after myocardial infarction: comparative experimental study of aprindine and procainamide.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie20051001

Title: Proteasomal degradation of Kir6.2 channel protein and its inhibition by a Na+ channel blocker aprindine.

Journal: Biochemical and biophysical research communications20050617

Title: Drug-induced changes in fibrillation cycle length and organization index can predict chemical cardioversion of long-lasting atrial fibrillation with bepridil alone or in combination with aprindine.

Journal: Circulation journal : official journal of the Japanese Circulation Society20041201

Title: Maintenance of sinus rhythm and recovery of atrial mechanical function after cardioversion with bepridil or in combination with aprindine in long-lasting persistent atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society20040901

Title: Usefulness and safety of bepridil in converting persistent atrial fibrillation to sinus rhythm.

Journal: The American journal of cardiology20030815

Title: [Comparison of the efficacies of disopyramide, cibenzoline and aprindine for the termination of paroxysmal and persistent atrial fibrillation in elderly and non-elderly patients].

Journal: Journal of cardiology20030401

Title: Atrial fibrillation threshold predicted long-term efficacy of pharmacological treatment of patients without structural heart disease.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology20021001

Title: Inhibitory effect of aprindine on Na+/Ca2+ exchange current in guinea-pig cardiac ventricular myocytes.

Journal: British journal of pharmacology20020601

Title: Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society20020601

Title: Inhibitory effects of aprindine on the delayed rectifier K+ current and the muscarinic acetylcholine receptor-operated K+ current in guinea-pig atrial cells.

Journal: British journal of pharmacology19990201

Title: Prediction of catalepsies induced by amiodarone, aprindine and procaine: similarity in conformation of diethylaminoethyl side chain.

Journal: The Journal of pharmacology and experimental therapeutics19981101

Title: Effects of aprindine on ischemia/reperfusion-induced cardiac contractile dysfunction of perfused rat heart.

Journal: Japanese journal of pharmacology19960301

Title: Complex frequency-dependent interaction of class-I antiarrhythmic drugs as they affect intraventricular conduction.

Journal: European heart journal19950601

Title: Combined application of class I antiarrhythmic drugs causes 'additive', 'reductive', or 'synergistic' sodium channel block in cardiac muscles.

Journal: Cardiovascular research19901101

Title: Effect of sotalol, aprindine and their combination on maximum upstroke velocity of action potential in guinea-pig papillary muscle.

Journal: European journal of pharmacology19861119

Title: Drug-induced torsade de pointes.

Journal: Clinical pharmacy19850101

Title: Effective plasma concentrations of aprindine in canine ventricular arrhythmias.

Journal: Journal of cardiovascular pharmacology19840101

Title: Quantitative analysis of the antiarrhythmic effect of drugs on canine ventricular arrhythmias by the determination of minimum effective plasma concentrations.

Journal: Japanese circulation journal19830101

Title: New drugs for treating cardiac arrhythmias.

Journal: Postgraduate medicine19810101

Title: Antiarrhythmic and antifibrillatory properties of aprindine.

Journal: The Journal of pharmacology and experimental therapeutics19750801

Title: [Accident during local anesthesia in a patient with antiarrhythmic therapy].

Journal: Zeitschrift fur Kardiologie19750701

Title: M L De Bruin, et al . Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death. Eur Heart J. 2005 Mar;26(6):590-7.

Title: Y Ohmoto-Sekine, et al. Inhibitory effects of aprindine on the delayed rectifier K+ current and the muscarinic acetylcholine receptor-operated K+ current in guinea-pig atrial cells. Br J Pharmacol. 1999 Feb;126(3):751-61.

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