Name: Name:methyl 12-methoxy-13-(17-methoxy-17-oxovobasan-3alpha-yl)ibogamine-18-carboxylate
Brand: AABLOCKS
SKU: AA00CIFM
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00CIFM

Chemical Name: methyl 12-methoxy-13-(17-methoxy-17-oxovobasan-3alpha-yl)ibogamine-18-carboxylate

CAS Number: 3371-85-5

Molecular Formula: C43H52N4O5

Molecular Weight: 704.8968

MDL Number: MFCD30723103

SMILES: COC(=O)[C@H]1[C@H]2C[C@H](c3cc4[nH]c5c(c4cc3OC)CCN3[C@@H]4[C@]5(C[C@@H](C[C@@H]4CC)C3)C(=O)OC)c3c(C[C@@H]1N(C/C/2=C\C)C)c1ccccc1[nH]3

Properties

Complexity: 1410

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 7

Defined Bond Stereocenter Count: 1

Formal Charge: 0

Heavy Atom Count: 52

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 7

Undefined Atom Stereocenter Count: 1

Undefined Bond Stereocenter Count: 0

XLogP3: 6.1

Literature fold

Title: The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells.

Journal: Autophagy20081101

Title: Autophagy-mediated chemosensitizing effect of the plant alkaloid voacamine on multidrug resistant cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20070301

Title: Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells.

Journal: International journal of oncology20051201

Title: Voacamine, a bisindolic alkaloid from Peschiera fuchsiaefolia, enhances the cytotoxic effect of doxorubicin on multidrug-resistant tumor cells.

Journal: International journal of oncology20031201

Title: Doubts cast on antimalarial drug.

Journal: The Lancet. Infectious diseases20030201

Title: Treatment of allergic rhinitis: H1-antihistamines and intranasal steroids.

Journal: Current drug targets. Inflammation and allergy20020901

Title: Liquid chromatographic/mass spectrometric determination of biologically active alkaloids in extracts of Peschiera fuschiaefolia.

Journal: Journal of mass spectrometry : JMS20020201

Title: Biological activities of the plant-derived bisindole voacamine with reference to malaria.

Journal: Phytotherapy research : PTR20010201

Title: Kitajima M, et al. Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1962-4.

Title: Meschini S, et al. Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. Int J Oncol. 2005 Dec;27(6):1597-603.

3371-85-5 | methyl 12-methoxy-13-(17-methoxy-17-oxovobasan-3alpha-yl)ibogamine-18-carboxylate