Name: Name:6-(1-METHANESULFONYL-1-METHYL-ETHYL)-8-(3-[(E)-2-(4-METHANESULFONYL-PHENYL)-2-(3-METHYL-[1,2,4]OXADIAZOL-5-YL)-VINYL]-PHENYL)-QUINOLINE
Brand: AABLOCKS
SKU: AA00CNGI
Rating: 90 (10 reviews)

Catalog No.: AA00CNGI

346629-30-9 | 6-(1-METHANESULFONYL-1-METHYL-ETHYL)-8-(3-[(E)-2-(4-METHANESULFONYL-PHENYL)-2-(3-METHYL-[1,2,4]OXADIAZOL-5-YL)-VINYL]-PHENYL)-QUINOLINE

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Technical Information

Catalog Number: AA00CNGI

Chemical Name: 6-(1-METHANESULFONYL-1-METHYL-ETHYL)-8-(3-[(E)-2-(4-METHANESULFONYL-PHENYL)-2-(3-METHYL-[1,2,4]OXADIAZOL-5-YL)-VINYL]-PHENYL)-QUINOLINE

CAS Number: 346629-30-9

Molecular Formula: C31H29N3O5S2

Molecular Weight: 587.7091

MDL Number: MFCD27978898

SMILES: Cc1noc(n1)C(=Cc1cccc(c1)c1cc(cc2c1nccc2)C(S(=O)(=O)C)(C)C)c1ccc(cc1)S(=O)(=O)C

Properties

Complexity: 1150

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 1

Formal Charge: 0

Heavy Atom Count: 41

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 0

Isotope Atom Count: 0

Rotatable Bond Count: 7

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 5.6

Literature fold

Title: Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness.

Journal: Journal of medicinal chemistry20111208

Title: Randomized, placebo-controlled study of a selective PDE4 inhibitor in the treatment of asthma.

Journal: Respiratory medicine20090301

Title: Optimization and structure-activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: identification of MK-0873, a potent and effective PDE4 inhibitor.

Journal: Bioorganic & medicinal chemistry letters20081015

Title: Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.

Journal: Journal of medicinal chemistry20080925

Title: Design, synthesis, and biological evaluation of 8-biarylquinolines: a novel class of PDE4 inhibitors.

Journal: Bioorganic & medicinal chemistry letters20080215

Title: L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition.

Journal: Biochemical pharmacology20070615

Title: Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560.

Journal: Journal of mass spectrometry : JMS20060601

Title: Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis.

Journal: The Journal of clinical investigation20021001

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