3546-03-0,MFCD00868180
Catalog No.:AA007BRR

3546-03-0 | Cyamemazine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
99%
1 week  
$177.00   $124.00
- +
10mg
99%
1 week  
$257.00   $180.00
- +
25mg
99%
1 week  
$479.00   $335.00
- +
50mg
99%
1 week  
$781.00   $547.00
- +
100mg
99%
1 week  
$1,289.00   $902.00
- +
250mg
98%
1 week  
$2,451.00   $1,716.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA007BRR
Chemical Name:
Cyamemazine
CAS Number:
3546-03-0
Molecular Formula:
C19H21N3S
Molecular Weight:
323.4551
MDL Number:
MFCD00868180
SMILES:
N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1
Properties
Computed Properties
 
Complexity:
443  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.4  

Literature

Title: Potential role of cortical 5-HT(2A) receptors in the anxiolytic action of cyamemazine in benzodiazepine withdrawal.

Journal: Psychiatry research 20120730

Title: N-demethylation of cyamemazine via non-classical Polonovski reaction and its conjugation to bovine serum albumin.

Journal: Bioorganic & medicinal chemistry letters 20120315

Title: Segmental hair analysis can demonstrate external contamination in postmortem cases.

Journal: Forensic science international 20120210

Title: Laryngeal teflonoma identified by Fourier-transform infrared microspectroscopy after forensic autopsy: an interesting tool for foreign material identification in forensic cases.

Journal: Forensic science international 20120110

Title: Active cyamemazine metabolites in patients treated with cyamemazine (Tercian®): influence on cerebral dopamine D2 and serotonin 5-HT (2A) receptor occupancy as measured by positron emission tomography (PET).

Journal: Psychopharmacology 20111001

Title: [A fatal laryngeal lesion].

Journal: Annales de pathologie 20110601

Title: [Pharmacological management of anxiety in patients suffering from schizophrenia].

Journal: L'Encephale 20110501

Title: Detection of amitriptyline, nortriptyline and bromazepam in liver, CSF and hair in the homicidal poisoning of a one-month-old girl autopsied 8 months after death.

Journal: Forensic science international 20110415

Title: Effect of cyamemazine on the steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: a preliminary retrospective study.

Journal: Therapeutic drug monitoring 20101201

Title: Buprenorphine-related deaths: unusual forensic situations.

Journal: International journal of legal medicine 20101101

Title: A tendency for re-offending in drug-facilitated crime.

Journal: Forensic science international 20100320

Title: Antipsychotics-induced ischaemic colitis and gastrointestinal necrosis: a review of the French pharmacovigilance database.

Journal: Pharmacoepidemiology and drug safety 20091001

Title: [Prescribing patterns of antipsychotics in 13 French psychiatric hospitals].

Journal: L'Encephale 20090401

Title: [Treatment of a serious autistic disorder in a child with Naltrexone in an oral suspension form].

Journal: L'Encephale 20090401

Title: Cyamemazine metabolites: effects on human cardiac ion channels in-vitro and on the QTc interval in guinea pigs.

Journal: The Journal of pharmacy and pharmacology 20081101

Title: Fatal intoxication with milnacipran.

Journal: Journal of forensic and legal medicine 20080801

Title: Affinity of cyamemazine metabolites for serotonin, histamine and dopamine receptor subtypes.

Journal: European journal of pharmacology 20080114

Title: The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).

Journal: BMC psychiatry 20080101

Title: Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071201

Title: [Acute Datura stramonium poisoning in an emergency department].

Journal: Presse medicale (Paris, France : 1983) 20071001

Title: Simultaneous prescribing of atypical antipsychotics, conventional antipsychotics and anticholinergics-a European study.

Journal: Pharmacy world & science : PWS 20070601

Title: Primary steps of the photochemical reactions of 2-cyano-10-(3-[dimethylamino, N-oxide]-2-methylpropyl)-5-oxide-phenothiazine, the photoproduct of cyamemazine, a phototoxic neuroleptic: comparison with the sulfoxide.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20060301

Title: Effects of cyamemazine on hERG, INa, ICa, Ito, Isus and IK1 channel currents, and on the QTc interval in guinea pigs.

Journal: European journal of pharmacology 20060227

Title: Double-blind, comparative study of cyamemazine vs. bromazepam in the benzodiazepine withdrawal syndrome.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060101

Title: False-positive results in the detection of methadone in urines of patients treated with psychotropic substances.

Journal: Clinical chemistry 20051101

Title: Double-blind study of cyamemazine and diazepam in the alcohol withdrawal syndrome.

Journal: Human psychopharmacology 20051001

Title: [Alcohol dependence and depressive disorders in the course of opiate dependence].

Journal: L'Encephale 20051001

Title: A positron emission tomography (PET) study of cerebral dopamine D2 and serotonine 5-HT2A receptor occupancy in patients treated with cyamemazine (Tercian).

Journal: Psychopharmacology 20050701

Title: Contrasting action of flavonoids on phototoxic effects induced in human skin fibroblasts by UVA alone or UVA plus cyamemazine, a phototoxic neuroleptic.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20050501

Title: An insight into the mechanisms of the phototoxic response induced by cyamemazine in cultured fibroblasts and keratinocytes.

Journal: Photochemistry and photobiology 20040201

Title: Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome.

Journal: CNS drug reviews 20040101

Title: Primary photochemical processes of the phototoxic neuroleptic cyamemazine: a study by laser flash photolysis and steady-state irradiation.

Journal: Photochemistry and photobiology 20040101

Title: Acute fatal poisoning with cyamemazine.

Journal: Forensic science international 20031014

Title: Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes.

Journal: Biochemical pharmacology 20030201

Title: Reduction of extracellular dopamine and metabolite concentrations in rat striatum by low doses of acute cyamemazine.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030201

Title: [Catatonia de novo, report on a case: immediate vital prognosis and psychiatric prognosis in longer term].

Journal: L'Encephale 20030101

Title: Interspecies variability and drug interactions of loxapine metabolism in liver microsomes.

Journal: European journal of drug metabolism and pharmacokinetics 20030101

Title: 5-HT2A receptor antagonist properties of cyamemazine in rat and guinea pig smooth muscle.

Journal: European journal of pharmacology 20021115

Title: A randomised, double-blind comparison of milnacipran and imipramine in the treatment of depression.

Journal: Journal of affective disorders 20021001

Title: [Pharmaco-epidemiological study on antipsychotic drug prescription in French Psychiatry: Patient characteristics, antipsychotic treatment, and care management for schizophrenia].

Journal: L'Encephale 20020101

Title: Cyamemazine as an anxiolytic drug on the elevated plus maze and light/dark paradigm in mice.

Journal: Behavioural brain research 20010928

Title: Transient ST segment elevation in right precordial leads induced by psychotropic drugs: relationship to the Brugada syndrome.

Journal: Journal of cardiovascular electrophysiology 20010101

Title: Concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol in a lethal case involving zuclopenthixol, diazepam, and cyamemazine.

Journal: Journal of analytical toxicology 20010101

Title: Hypertonia and malignant hyperthermia due to morphine and neuroleptic.

Journal: Lancet (London, England) 19810214

Title: Bourin M, et al. Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome. CNS Drug Rev. 2004 Fall;10(3):219-29.

Title: Vendrell-Criado V, et al. Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment. J Photochem Photobiol B. 2020 Jan;202:111686.

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Related Products of 3546-03-0
Tags:3546-03-0 Molecular Formula|3546-03-0 MDL|3546-03-0 SMILES|3546-03-0 Cyamemazine
Catalog No.: AA007BRR
3546-03-0,MFCD00868180
3546-03-0 | Cyamemazine
Pack Size: 5mg
Purity: 99%
1 week
$177.00 $124.00
Pack Size: 10mg
Purity: 99%
1 week
$257.00 $180.00
Pack Size: 25mg
Purity: 99%
1 week
$479.00 $335.00
Pack Size: 50mg
Purity: 99%
1 week
$781.00 $547.00
Pack Size: 100mg
Purity: 99%
1 week
$1,289.00 $902.00
Pack Size: 250mg
Purity: 98%
1 week
$2,451.00 $1,716.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA007BRR
Chemical Name: Cyamemazine
CAS Number: 3546-03-0
Molecular Formula: C19H21N3S
Molecular Weight: 323.4551
MDL Number: MFCD00868180
SMILES: N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1
Properties
Complexity: 443  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 23  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.4  
Literature fold

Title: Potential role of cortical 5-HT(2A) receptors in the anxiolytic action of cyamemazine in benzodiazepine withdrawal.

Journal: Psychiatry research20120730

Title: N-demethylation of cyamemazine via non-classical Polonovski reaction and its conjugation to bovine serum albumin.

Journal: Bioorganic & medicinal chemistry letters20120315

Title: Segmental hair analysis can demonstrate external contamination in postmortem cases.

Journal: Forensic science international20120210

Title: Laryngeal teflonoma identified by Fourier-transform infrared microspectroscopy after forensic autopsy: an interesting tool for foreign material identification in forensic cases.

Journal: Forensic science international20120110

Title: Active cyamemazine metabolites in patients treated with cyamemazine (Tercian®): influence on cerebral dopamine D2 and serotonin 5-HT (2A) receptor occupancy as measured by positron emission tomography (PET).

Journal: Psychopharmacology20111001

Title: [A fatal laryngeal lesion].

Journal: Annales de pathologie20110601

Title: [Pharmacological management of anxiety in patients suffering from schizophrenia].

Journal: L'Encephale20110501

Title: Detection of amitriptyline, nortriptyline and bromazepam in liver, CSF and hair in the homicidal poisoning of a one-month-old girl autopsied 8 months after death.

Journal: Forensic science international20110415

Title: Effect of cyamemazine on the steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: a preliminary retrospective study.

Journal: Therapeutic drug monitoring20101201

Title: Buprenorphine-related deaths: unusual forensic situations.

Journal: International journal of legal medicine20101101

Title: A tendency for re-offending in drug-facilitated crime.

Journal: Forensic science international20100320

Title: Antipsychotics-induced ischaemic colitis and gastrointestinal necrosis: a review of the French pharmacovigilance database.

Journal: Pharmacoepidemiology and drug safety20091001

Title: [Prescribing patterns of antipsychotics in 13 French psychiatric hospitals].

Journal: L'Encephale20090401

Title: [Treatment of a serious autistic disorder in a child with Naltrexone in an oral suspension form].

Journal: L'Encephale20090401

Title: Cyamemazine metabolites: effects on human cardiac ion channels in-vitro and on the QTc interval in guinea pigs.

Journal: The Journal of pharmacy and pharmacology20081101

Title: Fatal intoxication with milnacipran.

Journal: Journal of forensic and legal medicine20080801

Title: Affinity of cyamemazine metabolites for serotonin, histamine and dopamine receptor subtypes.

Journal: European journal of pharmacology20080114

Title: The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).

Journal: BMC psychiatry20080101

Title: Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20071201

Title: [Acute Datura stramonium poisoning in an emergency department].

Journal: Presse medicale (Paris, France : 1983)20071001

Title: Simultaneous prescribing of atypical antipsychotics, conventional antipsychotics and anticholinergics-a European study.

Journal: Pharmacy world & science : PWS20070601

Title: Primary steps of the photochemical reactions of 2-cyano-10-(3-[dimethylamino, N-oxide]-2-methylpropyl)-5-oxide-phenothiazine, the photoproduct of cyamemazine, a phototoxic neuroleptic: comparison with the sulfoxide.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology20060301

Title: Effects of cyamemazine on hERG, INa, ICa, Ito, Isus and IK1 channel currents, and on the QTc interval in guinea pigs.

Journal: European journal of pharmacology20060227

Title: Double-blind, comparative study of cyamemazine vs. bromazepam in the benzodiazepine withdrawal syndrome.

Journal: Progress in neuro-psychopharmacology & biological psychiatry20060101

Title: False-positive results in the detection of methadone in urines of patients treated with psychotropic substances.

Journal: Clinical chemistry20051101

Title: Double-blind study of cyamemazine and diazepam in the alcohol withdrawal syndrome.

Journal: Human psychopharmacology20051001

Title: [Alcohol dependence and depressive disorders in the course of opiate dependence].

Journal: L'Encephale20051001

Title: A positron emission tomography (PET) study of cerebral dopamine D2 and serotonine 5-HT2A receptor occupancy in patients treated with cyamemazine (Tercian).

Journal: Psychopharmacology20050701

Title: Contrasting action of flavonoids on phototoxic effects induced in human skin fibroblasts by UVA alone or UVA plus cyamemazine, a phototoxic neuroleptic.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology20050501

Title: An insight into the mechanisms of the phototoxic response induced by cyamemazine in cultured fibroblasts and keratinocytes.

Journal: Photochemistry and photobiology20040201

Title: Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome.

Journal: CNS drug reviews20040101

Title: Primary photochemical processes of the phototoxic neuroleptic cyamemazine: a study by laser flash photolysis and steady-state irradiation.

Journal: Photochemistry and photobiology20040101

Title: Acute fatal poisoning with cyamemazine.

Journal: Forensic science international20031014

Title: Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes.

Journal: Biochemical pharmacology20030201

Title: Reduction of extracellular dopamine and metabolite concentrations in rat striatum by low doses of acute cyamemazine.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20030201

Title: [Catatonia de novo, report on a case: immediate vital prognosis and psychiatric prognosis in longer term].

Journal: L'Encephale20030101

Title: Interspecies variability and drug interactions of loxapine metabolism in liver microsomes.

Journal: European journal of drug metabolism and pharmacokinetics20030101

Title: 5-HT2A receptor antagonist properties of cyamemazine in rat and guinea pig smooth muscle.

Journal: European journal of pharmacology20021115

Title: A randomised, double-blind comparison of milnacipran and imipramine in the treatment of depression.

Journal: Journal of affective disorders20021001

Title: [Pharmaco-epidemiological study on antipsychotic drug prescription in French Psychiatry: Patient characteristics, antipsychotic treatment, and care management for schizophrenia].

Journal: L'Encephale20020101

Title: Cyamemazine as an anxiolytic drug on the elevated plus maze and light/dark paradigm in mice.

Journal: Behavioural brain research20010928

Title: Transient ST segment elevation in right precordial leads induced by psychotropic drugs: relationship to the Brugada syndrome.

Journal: Journal of cardiovascular electrophysiology20010101

Title: Concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol in a lethal case involving zuclopenthixol, diazepam, and cyamemazine.

Journal: Journal of analytical toxicology20010101

Title: Hypertonia and malignant hyperthermia due to morphine and neuroleptic.

Journal: Lancet (London, England)19810214

Title: Bourin M, et al. Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome. CNS Drug Rev. 2004 Fall;10(3):219-29.

Title: Vendrell-Criado V, et al. Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment. J Photochem Photobiol B. 2020 Jan;202:111686.

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