370-86-5,MFCD00009699
Catalog No.:AA00IMCJ

370-86-5 | Fccp

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1mg
98%
in stock  
$7.00   $5.00
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10mg
98%
in stock  
$17.00   $12.00
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50mg
>98%(GC)
in stock  
$66.00   $46.00
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250mg
98%
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1g
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  • Technical Information
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  • Literature
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Technical Information
Catalog Number:
AA00IMCJ
Chemical Name:
Fccp
CAS Number:
370-86-5
Molecular Formula:
C10H5F3N4O
Molecular Weight:
254.1681
MDL Number:
MFCD00009699
SMILES:
N#CC(=NNc1ccc(cc1)OC(F)(F)F)C#N
Properties
Computed Properties
 
Complexity:
388  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.7  

Literature

Title: Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.

Journal: Molecular medicine (Cambridge, Mass.) 20160101

Title: BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria.

Journal: Autophagy 20140601

Title: Role of yessotoxin in calcium and cAMP-crosstalks in primary and K-562 human lymphocytes: the effect is mediated by anchor kinase A mitochondrial proteins.

Journal: Journal of cellular biochemistry 20121201

Title: Effect of chronic sleep restriction and aging on calcium signaling and apoptosis in the hippocampus of young and aged animals.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20121001

Title: Neuroprotection by lowering cholesterol: a decrease in membrane cholesterol content reduces transporter-mediated glutamate release from brain nerve terminals.

Journal: Biochimica et biophysica acta 20121001

Title: Structures and mechanisms of antitumor agents: xestoquinones uncouple cellular respiration and disrupt HIF signaling in human breast tumor cells.

Journal: Journal of natural products 20120928

Title: Induction of the mitochondrial permeability transition (MPT) by micromolar iron: liberation of calcium is more important than NAD(P)H oxidation.

Journal: Biochimica et biophysica acta 20120901

Title: Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation.

Journal: Journal of neurochemistry 20120901

Title: Mitochondrial free [Ca(2+)] dynamics measured with a novel low-Ca(2+) affinity aequorin probe.

Journal: The Biochemical journal 20120801

Title: The P2X7 receptor is a key modulator of aerobic glycolysis.

Journal: Cell death & disease 20120801

Title: Interventricular heterogeneity as a substrate for arrhythmogenesis of decoupled mitochondria during ischemia in the whole heart.

Journal: American journal of physiology. Heart and circulatory physiology 20120715

Title: Cytotoxicity of a mitochondriotropic quercetin derivative: mechanisms.

Journal: Biochimica et biophysica acta 20120701

Title: The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis.

Journal: The Journal of pharmacology and experimental therapeutics 20120701

Title: Simplified bicyclic pyridinol analogues protect mitochondrial function.

Journal: Bioorganic & medicinal chemistry 20120601

Title: Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: role for triglyceride content reduction.

Journal: American journal of physiology. Endocrinology and metabolism 20120515

Title: Electrochemical impedance spectroscopic measurements of FCCP-induced change in membrane permeability of MDCK cells.

Journal: The Analyst 20120507

Title: 'Mild mitochondrial uncoupling' induced protection against neuronal excitotoxicity requires AMPK activity.

Journal: Biochimica et biophysica acta 20120501

Title: PK11195 inhibits mitophagy targeting the F1Fo-ATPsynthase in Bcl-2 knock-down cells.

Journal: Current molecular medicine 20120501

Title: Acute feedback control of astrocytic glycolysis by lactate.

Journal: Glia 20120401

Title: A simplified hydroethidine method for fast and accurate detection of superoxide production in isolated mitochondria.

Journal: Analytical biochemistry 20120401

Title: PKCδ and ε regulate the morphological integrity of the ER-Golgi intermediate compartment (ERGIC) but not the anterograde and retrograde transports via the Golgi apparatus.

Journal: Biochimica et biophysica acta 20120401

Title: Mitochondrial Ca(2+) mobilization is a key element in olfactory signaling.

Journal: Nature neuroscience 20120325

Title: Measuring mitochondrial respiration in intact single muscle fibers.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20120315

Title: Mitochondrial calpain 10 is degraded by Lon protease after oxidant injury.

Journal: Archives of biochemistry and biophysics 20120115

Title: Redox state-dependent aggregation of mitochondria induced by cytochrome c.

Journal: Molecular and cellular biochemistry 20120101

Title: A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets.

Journal: PloS one 20120101

Title: Mitochondrial uncouplers inhibit hepatic stellate cell activation.

Journal: BMC gastroenterology 20120101

Title: Mitochondrial involvement in carbachol-induced intracellular Ca2+ mobilization and contraction in rat gastric smooth muscle.

Journal: Life sciences 20111121

Title: Comparative bioenergetic assessment of transformed cells using a cell energy budget platform.

Journal: Integrative biology : quantitative biosciences from nano to macro 20111101

Title: Cytoskeleton proteins F-actin and tubulin distribution and interaction with mitochondria in the granulosa cells surrounding stage III zebrafish (Danio rerio) oocytes.

Journal: Theriogenology 20111001

Title: Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.

Journal: Nature cell biology 20111001

Title: Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and H₂O₂.

Journal: Journal of neurochemistry 20110701

Title: Control of hydrogen photoproduction by the proton gradient generated by cyclic electron flow in Chlamydomonas reinhardtii.

Journal: The Plant cell 20110701

Title: Linking energy metabolism to dysfunctions in mitochondrial respiration--a metabolomics in vitro approach.

Journal: Toxicology letters 20110624

Title: High-mobility group box 1 is essential for mitochondrial quality control.

Journal: Cell metabolism 20110608

Title: Changes in mitochondrial redox state, membrane potential and calcium precede mitochondrial dysfunction in doxorubicin-induced cell death.

Journal: Biochimica et biophysica acta 20110601

Title: Hydrogen sulphide inhibits carbachol-induced contractile responses in β-escin permeabilized guinea-pig taenia caecum.

Journal: European journal of pharmacology 20110511

Title: Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice.

Journal: Free radical biology & medicine 20110401

Title: Intracellular glutathione levels are involved in carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone-induced apoptosis in As4.1 juxtaglomerular cells.

Journal: International journal of molecular medicine 20110401

Title: Apoptotic microtubule network organization and maintenance depend on high cellular ATP levels and energized mitochondria.

Journal: Apoptosis : an international journal on programmed cell death 20110401

Title: Accumulation of dodecyltriphenylphosphonium in mitochondria induces their swelling and ROS-dependent growth inhibition in yeast.

Journal: Journal of bioenergetics and biomembranes 20110401

Title: Membrane potential is involved in regulation of photosynthetic reactions in the marine diatom Thalassiosira weissflogii.

Journal: Journal of photochemistry and photobiology. B, Biology 20110207

Title: Visualization and quantification of endoplasmic reticulum Ca2+ in renal cells using confocal microscopy and Fluo5F.

Journal: Biochemical and biophysical research communications 20110107

Title: Effect of mitochondrial dysfunction and oxidative stress on endogenous levels of coenzyme Q(10) in human cells.

Journal: Journal of biochemical and molecular toxicology 20110101

Title: Subcellular localization of hexokinases I and II directs the metabolic fate of glucose.

Journal: PloS one 20110101

Title: Newly developed Mg2+-selective fluorescent probe enables visualization of Mg2+ dynamics in mitochondria.

Journal: PloS one 20110101

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Mitochondrial uncoupling downregulates calsequestrin expression and reduces SR Ca2+ stores in cardiomyocytes.

Journal: Cardiovascular research 20101001

Title: Permissive role of sphingosine on calcium-dependent endocytosis in chromaffin cells.

Journal: Pflugers Archiv : European journal of physiology 20101001

Title: Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange.

Journal: Biochimica et biophysica acta 20100901

Title: Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity.

Journal: Mechanisms of ageing and development 20100901

Title: Attenuation of the hypoxia-induced protein kinase Cdelta interaction with the 'd' subunit of F1Fo-ATP synthase in neonatal cardiac myocytes: implications for energy preservation and survival.

Journal: The Biochemical journal 20100715

Title: Oxidation of intramyocellular lipids is dependent on mitochondrial function and the availability of extracellular fatty acids.

Journal: American journal of physiology. Endocrinology and metabolism 20100701

Title: Glutamate-induced alterations in Ca2+ signaling are modulated by mitochondrial Ca2+ handling capacity in brain slices of R6/1 transgenic mice.

Journal: The European journal of neuroscience 20100701

Title: Monitoring mitochondrial [Ca(2+)] dynamics with rhod-2, ratiometric pericam and aequorin.

Journal: Cell calcium 20100701

Title: Carbonyl cyanide p-(trifluoromethoxy) phenylhydroazone induces caspase-independent apoptosis in As4.1 juxtaglomerular cells.

Journal: Anticancer research 20100701

Title: Greater cytosolic and mitochondrial calcium transients in adrenal medullary slices of hypertensive, compared with normotensive rats.

Journal: European journal of pharmacology 20100625

Title: Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity.

Journal: The Journal of physiology 20100615

Title: Oxygen-dependence of metabolic rate in the muscles of craniates.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20100601

Title: Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca(2+) current in liver cells.

Journal: Archives of biochemistry and biophysics 20100315

Title: Altered myoplasmic Ca(2+) handling in rat fast-twitch skeletal muscle fibres during disuse atrophy.

Journal: Pflugers Archiv : European journal of physiology 20100301

Title: Mitochondrial Ca2+ activates a cation current in Aplysia bag cell neurons.

Journal: Journal of neurophysiology 20100301

Title: Assessment of mitochondrial potential: implications for the correct monitoring of human sperm function.

Journal: International journal of andrology 20100201

Title: Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis.

Journal: The Journal of biological chemistry 20100101

Title: Extracellular ATP and P2Y2 receptors mediate intercellular Ca(2+) waves induced by mechanical stimulation in submandibular gland cells: Role of mitochondrial regulation of store operated Ca(2+) entry.

Journal: Cell calcium 20100101

Title: Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro.

Journal: PloS one 20100101

Title: Uncoupling protein-1 is not leaky.

Journal: Biochimica et biophysica acta 20100101

Title: On the mechanism of chloroquine resistance in Plasmodium falciparum.

Journal: PloS one 20100101

Title: Trichoderma viride cellulase induces resistance to the antibiotic pore-forming peptide alamethicin associated with changes in the plasma membrane lipid composition of tobacco BY-2 cells.

Journal: BMC plant biology 20100101

Title: Examining the neglected side of calcium regulation in taste cells.

Journal: The Journal of physiology 20091201

Title: Effects of carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone on the growth inhibition in human pulmonary adenocarcinoma Calu-6 cells.

Journal: Toxicology 20091130

Title: The optimal dosage and window of opportunity to maintain mitochondrial homeostasis following traumatic brain injury using the uncoupler FCCP.

Journal: Experimental neurology 20090801

Title: Modulation of Trypanosoma rangeli ecto-phosphatase activity by hydrogen peroxide.

Journal: Free radical biology & medicine 20090715

Title: Modulation of mitochondrial K(+) permeability and reactive oxygen species production by the p13 protein of human T-cell leukemia virus type 1.

Journal: Biochimica et biophysica acta 20090701

Title: Stimulation of glutamate receptors in cultured hippocampal neurons causes Ca2+-dependent mitochondrial contraction.

Journal: Cell calcium 20090701

Title: Factors affecting SOCE activation in mammalian skeletal muscle fibers.

Journal: The journal of physiological sciences : JPS 20090701

Title: Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila.

Journal: PLoS pathogens 20090701

Title: Metabolic inhibition strongly inhibits Na+-dependent Mg2+ efflux in rat ventricular myocytes.

Journal: Biophysical journal 20090617

Title: Regulation of glycolytic oscillations by mitochondrial and plasma membrane H+-ATPases.

Journal: Biophysical journal 20090506

Title: Kir 2.2 inward rectifier potassium channels are inhibited by an endogenous factor in Xenopus oocytes independently from the action of a mitochondrial uncoupler.

Journal: Journal of cellular physiology 20090401

Title: Role of the endoplasmic reticulum and mitochondria on quantal catecholamine release from chromaffin cells of control and hypertensive rats.

Journal: The Journal of pharmacology and experimental therapeutics 20090401

Title: Uncouple my heart: the benefits of inefficiency.

Journal: Journal of bioenergetics and biomembranes 20090401

Title: Features of mitochondrial energetics in living unicellular eukaryote Tetrahymena pyriformis. A model for study of mammalian intracellular adaptation.

Journal: Biochemistry. Biokhimiia 20090401

Title: In vitro-matured rat oocytes have low mitochondrial deoxyribonucleic acid and adenosine triphosphate contents and have abnormal mitochondrial redistribution.

Journal: Fertility and sterility 20090301

Title: Mitochondrial free [Ca2+] levels and the permeability transition.

Journal: Cell calcium 20090301

Title: Carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP) as an O2(*-) generator induces apoptosis via the depletion of intracellular GSH contents in Calu-6 cells.

Journal: Lung cancer (Amsterdam, Netherlands) 20090201

Title: Biosensor plates detect mitochondrial physiological regulators and mutations in vivo.

Journal: Analytical biochemistry 20090201

Title: Knockdown of JNK rescues 3T3-L1 adipocytes from insulin resistance induced by mitochondrial dysfunction.

Journal: Biochemical and biophysical research communications 20090123

Title: Redox-active dinitrodiphenylthioethers against Leishmania: synthesis, structure-activity relationships and mechanism of action studies.

Journal: Bioorganic & medicinal chemistry 20090115

Title: Calcium homeostasis is dysregulated in parkinsonian patients with L-DOPA-induced dyskinesias.

Journal: Clinical neuropharmacology 20090101

Title: Mild mitochondrial uncoupling induces 3T3-L1 adipocyte de-differentiation by a PPARgamma-independent mechanism, whereas TNFalpha-induced de-differentiation is PPARgamma dependent.

Journal: Journal of cell science 20090101

Title: Distribution characteristics of telithromycin, a novel ketolide antimicrobial agent applied for treatment of respiratory infection, in lung epithelial lining fluid and alveolar macrophages.

Journal: Drug metabolism and pharmacokinetics 20090101

Title: Acute inhibition of selected membrane-proximal mouse T cell receptor signaling by mitochondrial antagonists.

Journal: PloS one 20090101

Title: Regulation of 5-aminolevulinic acid-mediated protoporphyrin IX accumulation in human urothelial carcinomas.

Journal: Pathobiology : journal of immunopathology, molecular and cellular biology 20090101

Title: Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction.

Journal: Toxicology and applied pharmacology 20081201

Title: Detailing the role of Bax translocation, cytochrome c release, and perinuclear clustering of the mitochondria in the killing of HeLa cells by TNF.

Journal: Journal of cellular physiology 20081101

Title: Mitochondria-derived reactive oxygen species mediate sympathoexcitation induced by angiotensin II in the rostral ventrolateral medulla.

Journal: Journal of hypertension 20081101

Title: Mitochondrial uncouplers act synergistically with the fumigant phosphine to disrupt mitochondrial membrane potential and cause cell death.

Journal: Toxicology 20081030

Title: Metabolic pathways in Anopheles stephensi mitochondria.

Journal: The Biochemical journal 20081015

Title: Mitochondrial calcium buffering contributes to the maintenance of Basal calcium levels in mouse taste cells.

Journal: Journal of neurophysiology 20081001

Title: Role of mitochondria in modulation of spontaneous Ca2+ waves in freshly dispersed interstitial cells of Cajal from the rabbit urethra.

Journal: The Journal of physiology 20081001

Title: Mitochondria modulate Ca2+-dependent glutamate release from rat cortical astrocytes.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080924

Title: Real-time imaging of mitochondria in transgenic zebrafish expressing mitochondrially targeted GFP.

Journal: BioTechniques 20080901

Title: Functional live cell imaging of the pulmonary neuroepithelial body microenvironment.

Journal: American journal of respiratory cell and molecular biology 20080801

Title: Acetyl-L-Carnitine selectively prevents post-ischemic LTP via a possible action on mitochondrial energy metabolism.

Journal: Neuropharmacology 20080801

Title: Glucose and glucose transporters regulate lymphatic pump activity through activation of the mitochondrial ATP-sensitive K+ channel.

Journal: The journal of physiological sciences : JPS 20080801

Title: Essential role for Nix in autophagic maturation of erythroid cells.

Journal: Nature 20080710

Title: Effects of anoxia and aglycemia on cytosolic calcium regulation in rat sensory neurons.

Journal: Journal of neurophysiology 20080701

Title: Ca2+-induced Ca2+ release in Aplysia bag cell neurons requires interaction between mitochondrial and endoplasmic reticulum stores.

Journal: Journal of neurophysiology 20080701

Title: Plant inner membrane anion channel (PIMAC) function in plant mitochondria.

Journal: Plant & cell physiology 20080701

Title: Amiodarone increases the accumulation of DEA in a human alveolar epithelium-derived cell line.

Journal: Biological & pharmaceutical bulletin 20080701

Title: Oxidative stress as regulatory factor for fatty-acid-induced uncoupling involving liver mitochondrial ADP/ATP and aspartate/glutamate antiporters of old rats.

Journal: Biochemistry. Biokhimiia 20080701

Title: Detection of de- and hyperpolarization of mitochondria of cultured astrocytes and neurons by the cationic fluorescent dye rhodamine 123.

Journal: Journal of neuroscience methods 20080615

Title: Dual effect of nitric oxide on ATP-sensitive K+ channels in rat pancreatic beta cells.

Journal: Pflugers Archiv : European journal of physiology 20080601

Title: Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production.

Journal: European journal of immunology 20080601

Title: Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line.

Journal: Cancer chemotherapy and pharmacology 20080501

Title: Nitric oxide degradation by potato tuber mitochondria: evidence for the involvement of external NAD(P)H dehydrogenases.

Journal: Biochimica et biophysica acta 20080501

Title: Inhibition of carrier-mediated uptake of epirubicin reduces cytotoxicity in primary culture of rat hepatocytes.

Journal: Journal of applied toxicology : JAT 20080401

Title: Roles of mitochondria and temperature in the control of intracellular calcium in adult rat sensory neurons.

Journal: Cell calcium 20080401

Title: Effect of metabolic inhibition on couplon behavior in rabbit ventricular myocytes.

Journal: Biophysical journal 20080301

Title: Mitochondrial behavior during oogenesis in zebrafish: a confocal microscopy analysis.

Journal: Development, growth & differentiation 20080301

Title: Shear fluid-induced Ca2+ release and the role of mitochondria in rat cardiac myocytes.

Journal: Annals of the New York Academy of Sciences 20080301

Title: Potential contribution of a voltage-activated proton conductance to acid extrusion from rat hippocampal neurons.

Journal: Neuroscience 20080219

Title: The highly toxic oxyanion tellurite (TeO (3) (2-) ) enters the phototrophic bacterium Rhodobacter capsulatus via an as yet uncharacterized monocarboxylate transport system.

Journal: Archives of microbiology 20080201

Title: Effect of mitochondria poisoning by FCCP on Ca2+ signaling in mouse skeletal muscle fibers.

Journal: Pflugers Archiv : European journal of physiology 20080101

Title: The use of CalciumOrange-5N as a specific marker of mitochondrial Ca2+ in mouse skeletal muscle fibers.

Journal: Pflugers Archiv : European journal of physiology 20080101

Title: Effects of anoxia, aglycemia, and acidosis on cytosolic Mg2+, ATP, and pH in rat sensory neurons.

Journal: American journal of physiology. Cell physiology 20080101

Title: [Release of glutamate from cytosol of synaptosomes under conditions of experimental hypergravity].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20080101

Title: Mechanisms and methods in glucose metabolism and cell death.

Journal: Methods in enzymology 20080101

Title: The role of UCP2 and ADP/ATP antiporter in superoxide radical-induced uncoupling in kidney mitochondria.

Journal: Doklady. Biochemistry and biophysics 20080101

Title: Acute administration of 3,5-diiodo-L-thyronine to hypothyroid rats affects bioenergetic parameters in rat skeletal muscle mitochondria.

Journal: FEBS letters 20071222

Title: Flux control analysis of mitochondrial oxidative phosphorylation in rat skeletal muscle: pyruvate and palmitoyl-carnitine as substrates give different control patterns.

Journal: European journal of applied physiology 20071201

Title: Uncoupling is without an effect on the production of reactive oxygen species by in situ synaptic mitochondria.

Journal: Journal of neurochemistry 20071201

Title: Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta.

Journal: Basic & clinical pharmacology & toxicology 20071201

Title: Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions.

Journal: The Journal of pharmacology and experimental therapeutics 20071101

Title: Effects of metabolic inhibition on conduction, Ca transients, and arrhythmia vulnerability in embryonic mouse hearts.

Journal: American journal of physiology. Heart and circulatory physiology 20071001

Title: Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cells.

Journal: Free radical biology & medicine 20070915

Title: On-line measurements of oscillating mitochondrial membrane potential in glucose-fermenting Saccharomyces cerevisiae.

Journal: Yeast (Chichester, England) 20070901

Title: Modulation of CCK-8-evoked intracellular Ca2+ waves by hydrogen peroxide in mouse pancreatic acinar cells.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070901

Title: Membrane potential and H2O2 production in duodenal mitochondria from broiler chickens (Gallus gallus domesticus) with low and high feed efficiency.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20070801

Title: Saturable uptake of lipophilic amine drugs into isolated hepatocytes: mechanisms and consequences for quantitative clearance prediction.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070801

Title: Glitazones induce astroglioma cell death by releasing reactive oxygen species from mitochondria: modulation of cytotoxicity by nitric oxide.

Journal: Molecular pharmacology 20070801

Title: Metabolic inhibition-induced transient Ca2+ increase depends on mitochondria in a human proximal renal cell line.

Journal: American journal of physiology. Renal physiology 20070801

Title: Superoxide (*O2- ) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen.

Journal: Journal of neurophysiology 20070801

Title: The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria.

Journal: Cell calcium 20070701

Title: Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20070701

Title: Regulation of transient receptor potential melastatin 7 (TRPM7) currents by mitochondria.

Journal: Molecules and cells 20070630

Title: 'Mild Uncoupling' does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress.

Journal: Journal of neurochemistry 20070601

Title: Low mitochondrial DNA and ATP contents contribute to the absence of birefringent spindle imaged with PolScope in in vitro matured human oocytes.

Journal: Human reproduction (Oxford, England) 20070601

Title: Role of Ca2+-independent phospholipase A2gamma in Ca2+-induced mitochondrial permeability transition.

Journal: The Journal of pharmacology and experimental therapeutics 20070501

Title: Post-Injury Administration of Mitochondrial Uncouplers Increases Tissue Sparing and Improves Behavioral Outcome following Traumatic Brain Injury in Rodents.

Journal: Journal of neurotrauma 20070501

Title: Effect of the inhibitory neurotransmitter glycine on slow destructive processes in brain cortex slices under anoxic conditions.

Journal: Biochemistry. Biokhimiia 20070501

Title: ROS generation in endothelial hypoxia and reoxygenation stimulates MAP kinase signaling and kinase-dependent neutrophil recruitment.

Journal: Free radical biology & medicine 20070415

Title: Topography of the active site of the Saccharomyces cerevisiae plasmalemmal dicarboxylate transporter studied using lipophilic derivatives of its substrates.

Journal: Biochemistry. Biokhimiia 20070301

Title: Targeting the hypoxia inducible factor pathway with mitochondrial uncouplers.

Journal: Molecular and cellular biochemistry 20070201

Title: Bidirectional Ca2+ coupling of mitochondria with the endoplasmic reticulum and regulation of multimodal Ca2+ entries in rat brown adipocytes.

Journal: American journal of physiology. Cell physiology 20070201

Title: Cell surface oxygen consumption: a major contributor to cellular oxygen consumption in glycolytic cancer cell lines.

Journal: Biochimica et biophysica acta 20070201

Title: Downmodulation of mitochondrial F0F1 ATP synthase by diazoxide in cardiac myoblasts: a dual effect of the drug.

Journal: American journal of physiology. Heart and circulatory physiology 20070201

Title: Moderate dependence of ROS formation on DeltaPsim in isolated brain mitochondria supported by NADH-linked substrates.

Journal: Neurochemical research 20070101

Title: Anoxia-induced changes in pyridine nucleotide redox state in cortical neurons and astrocytes.

Journal: Neurochemical research 20070101

Title: Inhibitory effect of t-butyl hydroperoxide on mitochondrial oxidative phosphorylation in isolated rat hepatocytes.

Journal: Physiological research 20070101

Title: The KATP channel is critical for calcium sequestration into non-ER compartments in mouse pancreatic beta cells.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

Title: Local influence of mitochondrial calcium transport in retinal amacrine cells.

Journal: Visual neuroscience 20070101

Title: Effect of oxidative phosphorylation uncoupler FCCP and F1F0-ATPase inhibitor oligomycin on the electromechanical activity of human myocardium.

Journal: Advances in medical sciences 20070101

Title: Homocysteine-mediated activation and mitochondrial translocation of calpain regulates MMP-9 in MVEC.

Journal: American journal of physiology. Heart and circulatory physiology 20061201

Title: Irgarol inhibits the synthesis of ATP in mitochondria from rat liver.

Journal: Chemosphere 20061201

Title: Hydrogen peroxide: a feed-forward dilator that couples myocardial metabolism to coronary blood flow.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20061201

Title: Preliminary evidence on existence of transplasma membrane electron transport in Entamoeba histolytica trophozoites: a key mechanism for maintaining optimal redox balance.

Journal: Journal of bioenergetics and biomembranes 20061201

Title: The role of monocarboxylate transporters in uptake of lactic acid in HeLa cells.

Journal: International journal of pharmaceutics 20061115

Title: Accumulation of lipophilic dications by mitochondria and cells.

Journal: The Biochemical journal 20061115

Title: Integration of rapid cytosolic Ca2+ signals by mitochondria in cat ventricular myocytes.

Journal: American journal of physiology. Cell physiology 20061101

Title: Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively.

Journal: The Biochemical journal 20061101

Title: Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation.

Journal: Cardiovascular research 20061101

Title: FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation.

Journal: Cardiovascular research 20061101

Title: Properties of yeast Saccharomyces cerevisiae plasma membrane dicarboxylate transporter.

Journal: Biochemistry. Biokhimiia 20061001

Title: Differential role of Presenilin-1 and -2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts.

Journal: Journal of neuroscience research 20060901

Title: The spirostenol (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate blocks mitochondrial uptake of Abeta in neuronal cells and prevents Abeta-induced impairment of mitochondrial function.

Journal: Steroids 20060801

Title: Arachidonic acid enhances intracellular [Ca2+]i increase and mitochondrial depolarization induced by glutamate in cerebellar granule cells.

Journal: Biochemistry. Biokhimiia 20060801

Title: Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial function.

Journal: Journal of neurochemistry 20060701

Title: Characterization of ryanodine receptor-mediated calcium release in human B cells: relevance to diagnostic testing for malignant hyperthermia.

Journal: Anesthesiology 20060601

Title: Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure.

Journal: The Journal of biological chemistry 20060414

Title: Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis.

Journal: Cell death and differentiation 20060401

Title: Cross-talk between the sarcoplasmic reticulum and the mitochondrial calcium handling systems may play an important role in the regulation of contraction in anococcygeus smooth muscle.

Journal: Mitochondrion 20060401

Title: Spatially organised mitochondrial calcium uptake through a novel pathway in chick neurones.

Journal: Cell calcium 20060301

Title: Mitochondrial Ca2+ flux is a critical determinant of the Ca2+ dependence of mast cell degranulation.

Journal: Journal of leukocyte biology 20060301

Title: Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060301

Title: Histamine-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells.

Journal: American journal of physiology. Cell physiology 20060201

Title: Calcium mobilization by nicotinic acid adenine dinucleotide phosphate (NAADP) in rat astrocytes.

Journal: Cell calcium 20060201

Title: V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.

Journal: Nature cell biology 20060201

Title: Apoptotic effect of ethanol is potentiated by caffeine-induced calcium release in rat astrocytes.

Journal: Neuroscience letters 20060130

Title: Aging-related changes of intracellular Ca2+ stores and contractile response of intestinal smooth muscle.

Journal: Experimental gerontology 20060101

Title: Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-delta-dependent mechanism.

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Tags:370-86-5 Molecular Formula|370-86-5 MDL|370-86-5 SMILES|370-86-5 Fccp
Catalog No.: AA00IMCJ
370-86-5,MFCD00009699
370-86-5 | Fccp
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Purity: 98%
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Technical Information
Catalog Number: AA00IMCJ
Chemical Name: Fccp
CAS Number: 370-86-5
Molecular Formula: C10H5F3N4O
Molecular Weight: 254.1681
MDL Number: MFCD00009699
SMILES: N#CC(=NNc1ccc(cc1)OC(F)(F)F)C#N
Properties
Complexity: 388  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 18  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.7  
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Title: Apoptotic microtubule network organization and maintenance depend on high cellular ATP levels and energized mitochondria.

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Title: Membrane potential is involved in regulation of photosynthetic reactions in the marine diatom Thalassiosira weissflogii.

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Title: Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange.

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Title: Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity.

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Title: Effects of carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone on the growth inhibition in human pulmonary adenocarcinoma Calu-6 cells.

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Title: Modulation of Trypanosoma rangeli ecto-phosphatase activity by hydrogen peroxide.

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Title: Stimulation of glutamate receptors in cultured hippocampal neurons causes Ca2+-dependent mitochondrial contraction.

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Title: Factors affecting SOCE activation in mammalian skeletal muscle fibers.

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Title: Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila.

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Title: Kir 2.2 inward rectifier potassium channels are inhibited by an endogenous factor in Xenopus oocytes independently from the action of a mitochondrial uncoupler.

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Title: Role of the endoplasmic reticulum and mitochondria on quantal catecholamine release from chromaffin cells of control and hypertensive rats.

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Title: Uncouple my heart: the benefits of inefficiency.

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Title: Features of mitochondrial energetics in living unicellular eukaryote Tetrahymena pyriformis. A model for study of mammalian intracellular adaptation.

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Title: In vitro-matured rat oocytes have low mitochondrial deoxyribonucleic acid and adenosine triphosphate contents and have abnormal mitochondrial redistribution.

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Title: Carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP) as an O2(*-) generator induces apoptosis via the depletion of intracellular GSH contents in Calu-6 cells.

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Title: Biosensor plates detect mitochondrial physiological regulators and mutations in vivo.

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Title: Knockdown of JNK rescues 3T3-L1 adipocytes from insulin resistance induced by mitochondrial dysfunction.

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Title: Redox-active dinitrodiphenylthioethers against Leishmania: synthesis, structure-activity relationships and mechanism of action studies.

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Title: Calcium homeostasis is dysregulated in parkinsonian patients with L-DOPA-induced dyskinesias.

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Title: Mild mitochondrial uncoupling induces 3T3-L1 adipocyte de-differentiation by a PPARgamma-independent mechanism, whereas TNFalpha-induced de-differentiation is PPARgamma dependent.

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Title: Distribution characteristics of telithromycin, a novel ketolide antimicrobial agent applied for treatment of respiratory infection, in lung epithelial lining fluid and alveolar macrophages.

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Title: Functional live cell imaging of the pulmonary neuroepithelial body microenvironment.

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Title: Acetyl-L-Carnitine selectively prevents post-ischemic LTP via a possible action on mitochondrial energy metabolism.

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Title: Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line.

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Title: Nitric oxide degradation by potato tuber mitochondria: evidence for the involvement of external NAD(P)H dehydrogenases.

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Title: Flux control analysis of mitochondrial oxidative phosphorylation in rat skeletal muscle: pyruvate and palmitoyl-carnitine as substrates give different control patterns.

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Title: Uncoupling is without an effect on the production of reactive oxygen species by in situ synaptic mitochondria.

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Title: Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta.

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Title: Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions.

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Title: Metabolic inhibition-induced transient Ca2+ increase depends on mitochondria in a human proximal renal cell line.

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Title: Superoxide (*O2- ) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen.

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Title: Local influence of mitochondrial calcium transport in retinal amacrine cells.

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Title: Irgarol inhibits the synthesis of ATP in mitochondria from rat liver.

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Title: Hydrogen peroxide: a feed-forward dilator that couples myocardial metabolism to coronary blood flow.

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Title: Preliminary evidence on existence of transplasma membrane electron transport in Entamoeba histolytica trophozoites: a key mechanism for maintaining optimal redox balance.

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Title: The role of monocarboxylate transporters in uptake of lactic acid in HeLa cells.

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Title: Integration of rapid cytosolic Ca2+ signals by mitochondria in cat ventricular myocytes.

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Title: Properties of yeast Saccharomyces cerevisiae plasma membrane dicarboxylate transporter.

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Title: Differential role of Presenilin-1 and -2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts.

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Title: The spirostenol (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate blocks mitochondrial uptake of Abeta in neuronal cells and prevents Abeta-induced impairment of mitochondrial function.

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Title: Cross-talk between the sarcoplasmic reticulum and the mitochondrial calcium handling systems may play an important role in the regulation of contraction in anococcygeus smooth muscle.

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Title: Mitochondrial Ca2+ flux is a critical determinant of the Ca2+ dependence of mast cell degranulation.

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Title: Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex.

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Title: Histamine-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells.

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Title: Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

Journal: The Journal of biological chemistry20050513

Title: Differential sensitivity of Kir2 inward-rectifier potassium channels to a mitochondrial uncoupler: identification of a regulatory site.

Journal: Molecular pharmacology20050401

Title: Metabolic inhibition alters subcellular calcium release patterns in rat ventricular myocytes: implications for defective excitation-contraction coupling during cardiac ischemia and failure.

Journal: Circulation research20050318

Title: Cellular and subcellular calcium accumulation during glutamate-induced injury in cerebellar granule neurons.

Journal: Journal of neurochemistry20050301

Title: Formation of insoluble magnesium phosphates during growth of the archaea Halorubrum distributum and Halobacterium salinarium and the bacterium Brevibacterium antiquum.

Journal: FEMS microbiology ecology20050301

Title: Proton transfer through the membrane-water interfaces in uncoupled mitochondria.

Journal: Biochemistry. Biokhimiia20050201

Title: Regulation of inward rectifier K+ channels by shift of intracellular pH dependence.

Journal: Journal of cellular physiology20050101

Title: Hypoxic regulation of Ca2+ signaling in cultured rat astrocytes.

Journal: Glia20050101

Title: Glutamate-mediated influx of extracellular Ca2+ is coupled with reactive oxygen species generation in cultured hippocampal neurons but not in astrocytes.

Journal: Journal of neuroscience research20050101

Title: [A correlation between respiration and synthesis of ATP in mitochondria at different degree of uncoupling of oxidative phosphorylation].

Journal: Biofizika20050101

Title: Mitochondrial activation and the pyruvate paradox in a human cell line.

Journal: FEBS letters20041217

Title: Efficacy of MitoTracker Green and CMXrosamine to measure changes in mitochondrial membrane potentials in living cells and tissues.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20041001

Title: Intracellular pH and KATP channel activity in dorsal vagal neurons of juvenile rats in situ during metabolic disturbances.

Journal: Brain research20040813

Title: A novel mechanism of regulation of cardiac contractility by mitochondrial functional state.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20040801

Title: Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant.

Journal: FEBS letters20040730

Title: Induction of the mitochondrial permeability transition by the DNA alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine. Sorting cause and consequence of mitochondrial dysfunction.

Journal: Biochimica et biophysica acta20040723

Title: 'Wages of fear': transient threefold decrease in intracellular ATP level imposes apoptosis.

Journal: Biochimica et biophysica acta20040723

Title: Transmembrane reorientation of the substrate-binding site in vesicular acetylcholine transporter.

Journal: Biochemistry20040713

Title: Maternally-inherited Leigh syndrome-related mutations bolster mitochondrial-mediated apoptosis.

Journal: Journal of neurochemistry20040701

Title: Developmental up-regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury.

Journal: The European journal of neuroscience20040701

Title: Oxygen consumption in unfertilized salmonid eggs: an indicator of egg quality?

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology20040701

Title: Rotenone-sensitive mitochondrial potential in Phytomonas serpens: electrophoretic Ca(2+) accumulation.

Journal: Biochimica et biophysica acta20040607

Title: Partial reconstruction of in vitro gluconeogenesis arising from mitochondrial l-lactate uptake/metabolism and oxaloacetate export via novel L-lactate translocators.

Journal: The Biochemical journal20040515

Title: Functional transitions of F0F1-ATPase mediated by the inhibitory peptide IF1 in yeast coupled submitochondrial particles.

Journal: European journal of biochemistry20040501

Title: Characteristics of intermittent mitochondrial transport in guinea pig enteric nerve fibers.

Journal: American journal of physiology. Gastrointestinal and liver physiology20040401

Title: Involvement of membrane GABA transporter in alpha-latrotoxin-stimulated [3H]GABA release.

Journal: Neurochemistry international20040401

Title: The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells.

Journal: The Journal of physiology20040401

Title: Differences in toxicity of the catechol-O-methyl transferase inhibitors, tolcapone and entacapone to cultured human neuroblastoma cells.

Journal: Neuropharmacology20040301

Title: Assay of mitochondrial functions by resazurin in vitro.

Journal: Acta pharmacologica Sinica20040301

Title: Mitochondrial polarisation status and [Ca2+]i signalling in rat cerebellar granule neurones aged in vitro.

Journal: Neurobiology of aging20040301

Title: Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cells.

Journal: American journal of physiology. Cell physiology20040201

Title: Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ.

Journal: The Journal of biological chemistry20040102

Title: NMDA-evoked consumption and recovery of mitochondrially targeted aequorin suggests increased Ca2+ uptake by a subset of mitochondria in hippocampal neurons.

Journal: Brain research20031212

Title: Mechanism of superoxide anion generation in intact mitochondria in the presence of lucigenin and cyanide.

Journal: Biochemistry. Biokhimiia20031201

Title: Tellurite uptake by cells of the facultative phototroph Rhodobacter capsulatus is a Delta pH-dependent process.

Journal: FEBS letters20031120

Title: Inner mitochondrial membrane potential (DeltaPsim), cytoplasmic ATP content and free Ca2+ levels in metaphase II mouse oocytes.

Journal: Human reproduction (Oxford, England)20031101

Title: Arsenate transport and reduction in the hyper-tolerant fungus Aspergillus sp. P37.

Journal: Environmental microbiology20031101

Title: Preconditioning of cortical neurons by oxygen-glucose deprivation: tolerance induction through abbreviated neurotoxic signaling.

Journal: American journal of physiology. Cell physiology20031001

Title: Both calcium and ROS as common signals mediate Na(2)SeO(3)-induced apoptosis in SW480 human colonic carcinoma cells.

Journal: Journal of inorganic biochemistry20031001

Title: Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state.

Journal: Journal of neurochemistry20030901

Title: Decrease of intracellular ATP content downregulated UCP2 expression in mouse hepatocytes.

Journal: Biochemical and biophysical research communications20030829

Title: Glutamate decreases mitochondrial size and movement in primary forebrain neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20030827

Title: Mitochondrial and myoplasmic [Ca2+] in single fibres from mouse limb muscles during repeated tetanic contractions.

Journal: The Journal of physiology20030815

Title: Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo.

Journal: The Biochemical journal20030701

Title: Effects of fatty acids in isolated mitochondria: implications for ischemic injury and cardioprotection.

Journal: American journal of physiology. Heart and circulatory physiology20030701

Title: Hyperforin inhibits vesicular uptake of monoamines by dissipating pH gradient across synaptic vesicle membrane.

Journal: Life sciences20030613

Title: Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria.

Journal: Brain research20030613

Title: Effects of minimally toxic levels of carbonyl cyanide P-(trifluoromethoxy) phenylhydrazone (FCCP), elucidated through differential gene expression with biochemical and morphological correlations.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20030601

Title: A cuvette-based fluorometric analysis of mitochondrial membrane potential measured in cultured astrocyte monolayers.

Journal: Journal of neuroscience methods20030530

Title: Effect of transforming growth factor-beta on calcium homeostasis in prostate carcinoma cells.

Journal: Biochemical and biophysical research communications20030516

Title: Propagation of slow waves requires IP3 receptors and mitochondrial Ca2+ uptake in canine colonic muscles.

Journal: The Journal of physiology20030515

Title: Age-related changes in neuronal glucose uptake in response to glutamate and beta-amyloid.

Journal: Journal of neuroscience research20030515

Title: Regulation of the cardiac mitochondrial membrane potential by retinoids.

Journal: The Journal of pharmacology and experimental therapeutics20030501

Title: Identification of oligomerization and drug-binding domains of the membrane fusion protein EmrA.

Journal: The Journal of biological chemistry20030411

Title: A novel signalling pathway originating in mitochondria modulates rat skeletal muscle membrane excitability.

Journal: The Journal of physiology20030401

Title: Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20030401

Title: Effects of mitochondrial uncoupling on adipocyte intracellular Ca(2+) and lipid metabolism.

Journal: The Journal of nutritional biochemistry20030401

Title: Na+/Mg2+ transporter acts as a Mg2+ buffering mechanism in PC12 cells.

Journal: Biochemical and biophysical research communications20030328

Title: Mitochondria efficiently buffer subplasmalemmal Ca2+ elevation during agonist stimulation.

Journal: The Journal of biological chemistry20030321

Title: Metabolic regulation of Ca2+ release in permeabilized mammalian skeletal muscle fibres.

Journal: The Journal of physiology20030301

Title: Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries.

Journal: The Journal of clinical investigation20030301

Title: Potentiation of Fas-mediated apoptosis by attenuated production of mitochondria-derived reactive oxygen species.

Journal: Cell death and differentiation20030301

Title: The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis.

Journal: Journal of immunology (Baltimore, Md. : 1950)20030215

Title: Effects of hypoxia and mitochondrial inhibition on the capacitative calcium entry in rabbit pulmonary arterial smooth muscle cells.

Journal: Life sciences20030214

Title: Mitochondrial respiration and Ca2+ waves are linked during fertilization and meiosis completion.

Journal: Development (Cambridge, England)20030201

Title: Outer mitochondrial membrane permeabilization during apoptosis triggers caspase-independent mitochondrial and caspase-dependent plasma membrane potential depolarization: a single-cell analysis.

Journal: Journal of cell science20030201

Title: Platelet-activating factor and solute transport processes in the kidney.

Journal: American journal of physiology. Renal physiology20030201

Title: Delta 9-tetrahydrocannabinol disrupts mitochondrial function and cell energetics.

Journal: American journal of physiology. Lung cellular and molecular physiology20030201

Title: The production of nitric oxide in EL4 lymphoma cells overexpressing growth hormone.

Journal: Journal of neuroimmunology20030101

Title: Agonist-induced mitochondrial Ca2+ transients in smooth muscle.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20030101

Title: Inhibitory effects of Bcl-2 on mitochondrial respiration.

Journal: Physiological research20030101

Title: Non-invasive glucose monitoring by NAD(P)H autofluorescence spectroscopy in fibroblasts and adipocytes: a model for skin glucose sensing.

Journal: Diabetes technology & therapeutics20030101

Title: [Role of the ADP/ATP and aspartate/glutamate antiporters in the uncoupling effect of fatty acids in the liver mitochondria of the frog Rana temporaria].

Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii20030101

Title: Mitochondrial Ca2+ in mouse soleus single muscle fibres in response to repeated tetanic contractions.

Journal: Advances in experimental medicine and biology20030101

Title: NMDA receptor activation contributes to a portion of the decreased mitochondrial membrane potential and elevated intracellular free calcium in strain-injured neurons.

Journal: Journal of neurotrauma20021201

Title: High-throughput measurement of mitochondrial membrane potential in a neural cell line using a fluorescence plate reader.

Journal: Biochemical and biophysical research communications20021115

Title: Simultaneous determination of cyanide and carbonyls in cyanogenic plants by gas chromatography-electron capture/photoionization detection.

Journal: The Analyst20021101

Title: Lucigenin-derived chemiluminescence in intact isolated mitochondria.

Journal: Biochemistry. Biokhimiia20021101

Title: Adenoviral-induced islet cell cytotoxicity is not counteracted by Bcl-2 overexpression.

Journal: Molecular medicine (Cambridge, Mass.)20021101

Title: Facilitated diffusion of urate in avian brush-border membrane vesicles.

Journal: American journal of physiology. Cell physiology20021001

Title: Time course of action of antagonists of mitochondrial Ca uptake in intact ventricular myocytes.

Journal: Pflugers Archiv : European journal of physiology20021001

Title: Differential sensitivity of inward rectifier K+ channels to metabolic inhibitors.

Journal: The Journal of biological chemistry20020927

Title: Role of Hsp70 (DnaK-DnaJ-GrpE) and Hsp100 (ClpA and ClpB) chaperones in refolding and increased thermal stability of bacterial luciferases in Escherichia coli cells.

Journal: Biochemistry. Biokhimiia20020901

Title: Mitochondrial Ca2+ uptake regulates the excitability of myenteric neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20020815

Title: Carotid body chemosensory excitation induced by nitric oxide: involvement of oxidative metabolism.

Journal: Respiratory physiology & neurobiology20020801

Title: Ouabain suppresses glucose-induced mitochondrial ATP production and insulin release by generating reactive oxygen species in pancreatic islets.

Journal: Diabetes20020801

Title: Coupling of calcium homeostasis to axonal sodium in axons of mouse optic nerve.

Journal: Journal of neurophysiology20020801

Title: Membrane depolarization of isolated rat liver mitochondria attenuates permeability transition pore opening and oxidant production.

Journal: Antioxidants & redox signaling20020801

Title: Development of a high throughput screening assay for mitochondrial membrane potential in living cells.

Journal: Journal of biomolecular screening20020801

Title: Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: implications for assays of cardiolipin and mitochondrial mass.

Journal: Journal of neurochemistry20020701

Title: Mitochondrial sequestration and Ca(2+)-dependent release of cytosolic Zn(2+) loads in cortical neurons.

Journal: Neurobiology of disease20020701

Title: Contribution of glycolytic and mitochondrial pathways in glucose-induced changes in islet respiration and insulin secretion.

Journal: Pflugers Archiv : European journal of physiology20020701

Title: Evaluation of beta-amyloid peptide 25-35 on calcium homeostasis in cultured rat dorsal root ganglion neurons.

Journal: Brain research20020607

Title: Contribution of Ca(2+) transporters to relaxation in intact ventricular myocytes from developing rats.

Journal: American journal of physiology. Heart and circulatory physiology20020601

Title: Regulation of intracellular calcium in N1E-115 neuroblastoma cells: the role of Na(+)/Ca(2+) exchange.

Journal: American journal of physiology. Cell physiology20020501

Title: Acetylcholine and potassium elicit different patterns of exocytosis in chromaffin cells when the intracellular calcium handling is disturbed.

Journal: Pflugers Archiv : European journal of physiology20020501

Title: Inhibition of mitochondrial function affects cellular Ca2+ handling in pancreatic B-cells.

Journal: Pflugers Archiv : European journal of physiology20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Impairment of mitochondrial metabolism differentially affects striatal neuronal subtypes.

Journal: Neuroreport20020416

Title: Glucose release from GLUT2-null hepatocytes: characterization of a major and a minor pathway.

Journal: American journal of physiology. Endocrinology and metabolism20020401

Title: Thyroxine reversibly inhibits the uncoupling action of protonophores on energy production in rat thymus lymphocytes.

Journal: Biochemistry. Biokhimiia20020401

Title: Distinct effects of different calcium-mobilizing agents on cell death in NG108-15 neuroblastoma X glioma cells.

Journal: Molecular pharmacology20020301

Title: Mitochondrial Ca(2+) buffering regulates synaptic transmission between retinal amacrine cells.

Journal: Journal of neurophysiology20020301

Title: NMDA-induced calcium loads recycle across the mitochondrial inner membrane of hippocampal neurons in culture.

Journal: Journal of neurophysiology20020201

Title: Modulation of apoptosis by mitochondrial uncouplers: apoptosis-delaying features despite intrinsic cytotoxicity.

Journal: Biochemical pharmacology20020201

Title: Mitochondria regulate Ca2+ wave initiation and inositol trisphosphate signal transduction in oligodendrocyte progenitors.

Journal: Journal of neurochemistry20020201

Title: Anacardic acid-mediated changes in membrane potential and pH gradient across liposomal membranes.

Journal: Biochimica et biophysica acta20020102

Title: FCCP depolarizes plasma membrane potential by activating proton and Na+ currents in bovine aortic endothelial cells.

Journal: Pflugers Archiv : European journal of physiology20020101

Title: Elevated intracellular zinc and altered proton homeostasis in forebrain neurons.

Journal: Neuroscience20020101

Title: Active transport of L-proline in Trypanosoma cruzi.

Journal: The Journal of eukaryotic microbiology20020101

Title: A conserved inhibitory and differential stimulatory action of nucleotides on K(IR)6.0/SUR complexes is essential for excitation-metabolism coupling by K(ATP) channels.

Journal: The Journal of biological chemistry20011228

Title: The contributions of plasma membrane Na+-Ca2+-exchange and the Ca2+-ATPase to the regulation of cytosolic calcium ([Ca2+]i) in a clonal pituitary cell line (AtT-20) of mouse corticotropes.

Journal: Life sciences20011228

Title: Suramin inhibits respiration and induces membrane permeability transition in isolated rat liver mitochondria.

Journal: Toxicology20011201

Title: Mitochondrial modulation of calcium signaling at the initiation of development.

Journal: Cell calcium20011201

Title: Amyloid beta-peptide promotes permeability transition pore in brain mitochondria.

Journal: Bioscience reports20011201

Title: Mitochondria are the main ATP source for a cytosolic pool controlling the activity of ATP-sensitive K(+) channels in mouse cardiac myocytes.

Journal: Cardiovascular research20011101

Title: Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice.

Journal: Biochemical Society transactions20011101

Title: Mechanisms of the deleterious effects of tamoxifen on mitochondrial respiration rate and phosphorylation efficiency.

Journal: Toxicology and applied pharmacology20011101

Title: Confocal microscopy analysis of the activity of mitochondria contained within the 'mitochondrial cloud' during oogenesis in Xenopus laevis.

Journal: Zygote (Cambridge, England)20011101

Title: Amiloride derivatives are potent blockers of KATP channels.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20011001

Title: Ethylazinphos interaction with membrane lipid organization induces increase of proton permeability and impairment of mitochondrial bioenergetic functions.

Journal: Toxicology and applied pharmacology20010915

Title: Ca(2+) and H+ homeostasis in fission yeast: a role of Ca(2+)/H+ exchange and distinct V-H+-ATPases of the secretory pathway organelles.

Journal: FEBS letters20010914

Title: Potentiation by propofol of the response of rat submandibular acinar cells to purinergic agonists.

Journal: Cell calcium20010901

Title: Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential.

Journal: Cell death and differentiation20010901

Title: Mechanisms of pH regulation in the regulated secretory pathway.

Journal: The Journal of biological chemistry20010831

Title: Ethanolamine transport in human placental brush-border membrane vesicles.

Journal: The Journal of pharmacology and experimental therapeutics20010801

Title: Development and application of a self-referencing glucose microsensor for the measurement of glucose consumption by pancreatic beta-cells.

Journal: Analytical chemistry20010801

Title: Effect of cyclosporin A and its vehicle on cardiac and skeletal muscle mitochondria: relationship to efficacy of the respiratory chain.

Journal: British journal of pharmacology20010701

Title: Carvedilol in heart mitochondria: protonophore or opener of the mitochondrial K(ATP) channels?

Journal: Life sciences20010601

Title: ATP synthesis is coupled to rat liver mitochondrial RNA synthesis.

Journal: Molecular and cellular biochemistry20010501

Title: Induction of cyclosporin A-sensitive pore in mitochondria of intact neurons during uncoupling of oxidative phosphorylation.

Journal: Bulletin of experimental biology and medicine20010501

Title: The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ.

Journal: The Journal of biological chemistry20010413

Title: Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo).

Journal: European journal of pharmacology20010413

Title: Photoreducible high spin iron electron paramagnetic resonance signals in dark-adapted Photosystem II: are they oxidised non-haem iron formed from interaction of oxygen with PSII electron acceptors?

Journal: Biochimica et biophysica acta20010402

Title: Activation of K+ channels induces apoptosis in vascular smooth muscle cells.

Journal: American journal of physiology. Cell physiology20010401

Title: A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons.

Journal: Journal of neurochemistry20010401

Title: Carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP) induces initiation factor 2 alpha phosphorylation and translation inhibition in PC12 cells.

Journal: FEBS letters20010309

Title: N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx.

Journal: Journal of neuroscience research20010301

Title: Calcium-magnesium interactions in pancreatic acinar cells.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20010301

Title: The effects of singlet oxygen produced by photodynamic action on the mitochondrial permeability transition differ in accordance with the localization of the sensitizer.

Journal: Archives of biochemistry and biophysics20010215

Title: Nucleotide effects on liver and muscle mitochondrial non-phosphorylating respiration and membrane potential.

Journal: Biochimica et biophysica acta20010119

Title: MitoTracker labeling in primary neuronal and astrocytic cultures: influence of mitochondrial membrane potential and oxidants.

Journal: Journal of neuroscience methods20010115

Title: Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin.

Journal: Cancer research20010115

Title: Increased sensitivity of mitochondrial respiration to inhibition by nitric oxide in cardiac hypertrophy.

Journal: Journal of molecular and cellular cardiology20010101

Title: Release of calcium from mitochondrial and nonmitochondrial intracellular stores in mouse pancreatic acinar cells by hydrogen peroxide.

Journal: The Journal of membrane biology20010101

Title: Regulation of cyclosporin A sensitive mitochondrial permeability transition by the redox state of pyridine nucleotides.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology20010101

Title: Targeting of reporter molecules to mitochondria to measure calcium, ATP, and pH.

Journal: Methods in cell biology20010101

Title: Gene therapy with sodium/iodide symporter in hepatocarcinoma.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association20010101

Title: The excitatory effect of nitric oxide on carotid body chemoreception is blocked by oligomycin.

Journal: Advances in experimental medicine and biology20010101

Title: The synthesis and antibacterial activity of totarol derivatives. Part 3: Modification of ring-B.

Journal: Bioorganic & medicinal chemistry20000701

Title: Atorvastatin transport in the Caco-2 cell model: contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporter.

Journal: Pharmaceutical research20000201

Title: Expression cloning of a reserpine-sensitive vesicular monoamine transporter.

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Title: Connop BP et al.Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone on amyloid precursor protein processing. J Neurochem. 1999 Apr;72(4):1457-65.

Title: Tanpradit N, et al. Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) pre-exposure ensures follicle integrity during in vitro culture of ovarian tissue but not during cryopreservation in the domestic cat model. J Assist Reprod Genet. 2016 Dec;33(12):1621-1631. Epub 2016 Sep 17.

Title: Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2(5):120080.

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