Name: Name:SPLA2 INHIBITOR
Brand: AABLOCKS
SKU: AA00D5S0
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00D5S0

Chemical Name: SPLA2 INHIBITOR

CAS Number: 393569-31-8

Molecular Formula: C31H37NO4

Molecular Weight: 487.6298

MDL Number: MFCD06411576

SMILES: OC(=O)CC[C@@H](Cc1ccc(cc1)OCc1ccccc1)NC(=O)CCCCCCc1ccccc1

Properties

Complexity: 604

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 1

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 36

Hydrogen Bond Acceptor Count: 4

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 16

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 6.8

Literature fold

Title: An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats.

Journal: Diabetes20120901

Title: Secretory phospholipase A2 inhibition attenuates intercellular adhesion molecule-1 expression in human esophageal adenocarcinoma cells.

Journal: The Annals of thoracic surgery20110501

Title: Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis.

Journal: Arthritis research & therapy20110101

Title: 1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity.

Journal: Journal of medicinal chemistry20100722

Title: Modulation of growth in human esophageal adenocarcinoma cells by group IIa secretory phospholipase A(2).

Journal: The Journal of thoracic and cardiovascular surgery20100301

Title: The use of live-animal micro-computed tomography to determine the effect of a novel phospholipase A2 inhibitor on alveolar bone loss in an in vivo mouse model of periodontitis.

Journal: Journal of periodontal research20090601

Title: Inhibitors of cyclo-oxygenase-2 and secretory phospholipase A2 preserve bone architecture following ovariectomy in adult rats.

Journal: Bone20060701

Title: Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats.

Journal: Journal of immunology (Baltimore, Md. : 1950)20060601

Title: A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis.

Journal: International immunopharmacology20050501

Title: Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist.

Journal: British journal of pharmacology20030901

Title: D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity.

Journal: Chembiochem : a European journal of chemical biology20030303

393569-31-8 | SPLA2 INHIBITOR