396-01-0,MFCD00006708
Catalog No.:AA003FLT

396-01-0 | 2,4,7-Triamino-6-Phenylpteridine

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5g
≥98%
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10g
98%(HPLC)
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA003FLT
Chemical Name:
2,4,7-Triamino-6-Phenylpteridine
CAS Number:
396-01-0
Molecular Formula:
C12H11N7
Molecular Weight:
253.2626
MDL Number:
MFCD00006708
SMILES:
Nc1nc(N)c2c(n1)nc(c(n2)c1ccccc1)N
Properties
Properties
 
BP:
386.46°C (rough estimate)  
Form:
Solid  
MP:
316°C  
Refractive Index:
1.8260 (estimate)  
Solubility:
formic acid: soluble200 mg + 4 mL warm Formic Acid, clear, yellow-green  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
307  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1  

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Title: Incidence of cardiac arrhythmias associated with mild hypokalemia induced by low-dose diuretic therapy for hypertension.

Journal: Southern medical journal 19890801

Title: Triamterene nephrolithiasis.

Journal: Military medicine 19890301

Title: Maintenance of potassium balance during long-term diuretic therapy in chronic heart failure patients with thiazide-induced hypokalemia: comparison of potassium supplementation with potassium chloride and potassium-sparing agents, amiloride and triamterene.

Journal: International journal of clinical pharmacology, therapy, and toxicology 19880501

Title: [13 cases of drug-induced calculi].

Journal: Annales d'urologie 19880101

Title: Angiotensin converting enzyme inhibitors and diuretics.

Journal: British medical journal (Clinical research ed.) 19871121

Title: Triamterene bladder calculus.

Journal: Urology 19870801

Title: Indomethacin and ibuprofen-induced reversible acute renal failure in a patient with systemic lupus erythematosus.

Journal: The Netherlands journal of medicine 19870401

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Journal: Presse medicale (Paris, France : 1983) 19861108

Title: Acute renal failure and hyperkalemia associated with triamterene and indomethacin.

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Title: Triamterene stones and computerized axial tomography.

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Title: Effects of triamterene and amiloride on urinary sediment in hypertensive patients taking hydrochlorothiazide.

Journal: Lancet (London, England) 19850713

Title: Triamterene calculus.

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SDS
Tags:396-01-0 Molecular Formula|396-01-0 MDL|396-01-0 SMILES|396-01-0 2,4,7-Triamino-6-Phenylpteridine
Catalog No.: AA003FLT
396-01-0,MFCD00006708
396-01-0 | 2,4,7-Triamino-6-Phenylpteridine
Pack Size: 1g
Purity: ≥98%
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$29.00 $20.00
Pack Size: 5g
Purity: ≥98%
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$62.00 $43.00
Pack Size: 10g
Purity: 98%(HPLC)
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$121.00 $85.00
Pack Size: 25g
Purity: 98%(HPLC)
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$267.00 $187.00
Pack Size: 100g
Purity: 98%(HPLC)
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Technical Information
Catalog Number: AA003FLT
Chemical Name: 2,4,7-Triamino-6-Phenylpteridine
CAS Number: 396-01-0
Molecular Formula: C12H11N7
Molecular Weight: 253.2626
MDL Number: MFCD00006708
SMILES: Nc1nc(N)c2c(n1)nc(c(n2)c1ccccc1)N
Properties
BP: 386.46°C (rough estimate)  
Form: Solid  
MP: 316°C  
Refractive Index: 1.8260 (estimate)  
Solubility: formic acid: soluble200 mg + 4 mL warm Formic Acid, clear, yellow-green  
Storage: 2-8℃;  
Complexity: 307  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 19  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1  
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Title: Photostability studies on the furosemide-triamterene drug association.

Journal: Farmaco (Societa chimica italiana : 1989)20030901

Title: Pharmacological characterization of unique prazosin-binding sites in human kidney.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20030701

Title: Kinetic modeling of triamterene intestinal absorption and its inhibition by folic acid and methotrexate.

Journal: Journal of drug targeting20030501

Title: Drug-induced myopia.

Journal: Prescrire international20030201

Title: Restoration of arterial baroreflex function contributes to organ protection in spontaneously hypertensive rats treated with long-term hydrochlorothiazide mixture.

Journal: Clinical and experimental pharmacology & physiology20030101

Title: Potentially significant drug interactions of class III antiarrhythmic drugs.

Journal: Drug safety20030101

Title: Drug-induced urinary calculi.

Journal: Reviews in urology20030101

Title: Liddle's syndrome associated with a point mutation in the extracellular domain of the epithelial sodium channel gamma subunit.

Journal: Journal of hypertension20021201

Title: Screening for 18 diuretics and probenecid in doping analysis by liquid chromatography-tandem mass spectrometry.

Journal: Biomedical chromatography : BMC20021201

Title: Thiazide-induced lichenoid photosensitivity.

Journal: Clinical and experimental dermatology20021101

Title: Acetazolamide-induced muscle weakness in hypokalemic periodic paralysis.

Journal: Internal medicine (Tokyo, Japan)20020901

Title: Use of the trispan device to assist coil embolization of high-flow arteriovenous fistulas.

Journal: AJNR. American journal of neuroradiology20020801

Title: Non-traumatic neurological emergencies: emergency neuroradiological interventions.

Journal: European radiology20020701

Title: Micellar electrokinetic capillary chromatography analysis of diuretics in pharmaceutical formulations.

Journal: Talanta20020516

Title: Determination of triamterene by transitory retention in a continuous flow solid phase system with fluorimetric transduction.

Journal: Journal of pharmaceutical and biomedical analysis20020515

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Effects of anion and cation inhibitors and carbonic anhydrase inhibitors upon the activity of the gypsy moth (Lepidoptera: Lymantriidae) nucleo-polyhedrovirus.

Journal: Journal of economic entomology20020401

Title: [Simultaneous analysis of four diuretic drugs by HPLC and its application to health food supplements advertising weight reduction].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan20020401

Title: Determination of triamterene and its main metabolite hydroxytriamterene sulfate in human urine by capillary electrophoresis using ultraviolet absorbance and laser-induced fluorescence detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20020325

Title: Determination of triamterene and leucovorin in biological fluids by UV derivative-spectrophotometry and partial least-squares (PLS-1) calibration.

Journal: Journal of pharmaceutical and biomedical analysis20020101

Title: [Liddle's syndrome: late diagnosis of a rare cause of arterial hypertension].

Journal: Jornal de pediatria20020101

Title: Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design.

Journal: Journal of medicinal chemistry20011220

Title: Neck-bridge device for endovascular treatment of wide-neck bifurcation aneurysms: initial experience.

Journal: Radiology20011101

Title: Are certain diuretics also anticonvulsants?

Journal: Annals of neurology20011001

Title: Spectrophotometric simultaneous determination of triamterene and hydrochlorothiazide in triamterene-H tablets by multivariate calibration methods.

Journal: Journal of pharmaceutical and biomedical analysis20010901

Title: Prolonged exercise following diuretic-induced hypohydration effects on fluid and electrolyte hormones.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme20010901

Title: A family with liddle's syndrome caused by a mutation in the beta subunit of the epithelial sodium channel.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993)20010801

Title: ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.

Journal: Journal of medicinal chemistry20010719

Title: The influence of age on the pharmacokinetics and pharmacodynamics of bemetizide and triamterene: a single and multiple dose study.

Journal: Archives of gerontology and geriatrics20010601

Title: Disappearance of spironolactone-induced gynecomastia with triamteren.

Journal: Internal medicine (Tokyo, Japan)20010601

Title: Neural tube defects in relation to use of folic acid antagonists during pregnancy.

Journal: American journal of epidemiology20010515

Title: Simultaneous direct determination of amiloride and triamterene in urine using isopotential fluorometry.

Journal: Analytical biochemistry20010501

Title: Antihypertensive drug prescription trends at the primary health care centres in Bahrain.

Journal: Pharmacoepidemiology and drug safety20010501

Title: Folic acid antagonists during pregnancy and risk of birth defects.

Journal: The New England journal of medicine20010322

Title: Evaluation of the TriSpan neck bridge device for the treatment of wide-necked aneurysms: an experimental study in canines.

Journal: Stroke20010201

Title: Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology20010101

Title: [Periodic paralysis secondary to urinary or gastrointestinal potassium loss].

Journal: Ryoikibetsu shokogun shirizu20010101

Title: Rational therapy of chronic venous insufficiency--chances and limits of the therapeutic use of horse-chestnut seeds extract.

Journal: BMC cardiovascular disorders20010101

Title: In vitro antioxidant and photo-oxidant properties of dipyridamole.

Journal: International journal of toxicology20010101

Title: Determination of hydrochlorothiazide, triamterene and propranolol hydrochloride by the spectrophotometric method and high-performance liquid chromatography (HPLC).

Journal: Acta poloniae pharmaceutica20010101

Title: [Urinary lithiasis of medical origin].

Journal: Therapie20010101

Title: Nephrogenic diabetes insipidus persisting 57 months after cessation of lithium carbonate therapy: report of a case and review of the literature.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists20000101

Title: Exercise-induced acute renal failure associated with ibuprofen, hydrochlorothiazide, and triamterene.

Journal: Journal of the American Society of Nephrology : JASN19950601

Title: Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits.

Journal: Nature19940203

Title: Identification of highly potent and selective inhibitors of Toxoplasma gondii dihydrofolate reductase.

Journal: Antimicrobial agents and chemotherapy19930901

Title: Megaloblastic anaemia in an elderly patient treated with triamterene.

Journal: The Netherlands journal of medicine19910601

Title: Irreversible renal failure associated with triamterene.

Journal: American journal of nephrology19910101

Title: Triamterene nephrolithiasis: renewed attention is warranted.

Journal: The Journal of urology19901201

Title: Hypokalemic and ECG sequelae of combined beta-agonist/diuretic therapy. Protection by conventional doses of spironolactone but not triamterene.

Journal: Chest19901001

Title: [Urinary lithiasis due to triamterene].

Journal: Annales d'urologie19900101

Title: Potassium restoration in hypertensive patients made hypokalemic by hydrochlorothiazide.

Journal: Archives of internal medicine19891201

Title: Incidence of cardiac arrhythmias associated with mild hypokalemia induced by low-dose diuretic therapy for hypertension.

Journal: Southern medical journal19890801

Title: Triamterene nephrolithiasis.

Journal: Military medicine19890301

Title: Maintenance of potassium balance during long-term diuretic therapy in chronic heart failure patients with thiazide-induced hypokalemia: comparison of potassium supplementation with potassium chloride and potassium-sparing agents, amiloride and triamterene.

Journal: International journal of clinical pharmacology, therapy, and toxicology19880501

Title: [13 cases of drug-induced calculi].

Journal: Annales d'urologie19880101

Title: Angiotensin converting enzyme inhibitors and diuretics.

Journal: British medical journal (Clinical research ed.)19871121

Title: Triamterene bladder calculus.

Journal: Urology19870801

Title: Indomethacin and ibuprofen-induced reversible acute renal failure in a patient with systemic lupus erythematosus.

Journal: The Netherlands journal of medicine19870401

Title: Dyazide-induced reversible acute renal failure associated with intracellular crystal deposition.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation19861201

Title: [Nephrogenic diabetes insipidus associated with triamterene-cyclothiazide].

Journal: Presse medicale (Paris, France : 1983)19861108

Title: Acute renal failure and hyperkalemia associated with triamterene and indomethacin.

Journal: Veterinary and human toxicology19860601

Title: Triamterene stones and computerized axial tomography.

Journal: Urology19860201

Title: Metabolic fate and solubility of triamterene--not an explanation for triamterene nephrolithiasis.

Journal: Journal of pharmaceutical sciences19860201

Title: [Effect of diuretics on the course of experimental arrhythmias].

Journal: Farmakologiia i toksikologiia19860101

Title: [Nephrolithiasis caused by triamterene. Presentation of 2 cases].

Journal: Actas urologicas espanolas19860101

Title: The true composition of kidney stones passed during triamterene therapy.

Journal: The Journal of urology19851101

Title: Renal failure with potassium-sparing diuretics.

Journal: The New Zealand medical journal19850814

Title: Effects of triamterene and amiloride on urinary sediment in hypertensive patients taking hydrochlorothiazide.

Journal: Lancet (London, England)19850713

Title: Triamterene calculus.

Journal: The Journal of urology19850601

Title: Anuric renal failure precipitated by indomethacin and triamterene.

Journal: Nephron19850101

Title: Early changes in plasma and urinary potassium in diuretic-treated patients with systemic hypertension.

Journal: The American journal of cardiology19841101

Title: Propranolol in the treatment of cirrhotic ascites.

Journal: Archives of internal medicine19840901

Title: [Nephrolithiasis caused by triamterene].

Journal: Revista clinica espanola19840801

Title: Relationship of renal prostaglandins to three diuretics.

Journal: Prostaglandins, leukotrienes, and medicine19840601

Title: The short-term effects of reducing elevated blood pressure in elderly patients with propranolol and dyazide.

Journal: Age and ageing19840301

Title: Diuretic-induced hypokalemia in uncomplicated systemic hypertension: effect of plasma potassium correction on cardiac arrhythmias.

Journal: The American journal of cardiology19831101

Title: Thiazide-induced hyponatremia.

Journal: Southern medical journal19831101

Title: Amantadine-dyazide interaction.

Journal: Canadian Medical Association journal19831101

Title: [Detection and diagnosis of drug induced lithiasis].

Journal: Annales de biologie clinique19830101

Title: Drug-induced acute interstitial nephritis with granulomas.

Journal: Human pathology19830101

Title: Pharmacokinetics of triamterene after i.v. administration to man: determination of bioavailability.

Journal: European journal of clinical pharmacology19830101

Title: Risk of kidney stones.

Journal: JAMA19821022

Title: Lithium intoxication and its clinical management.

Journal: Southern medical journal19820601

Title: [Acute kidney failure caused by triamterene and hydrochlorothiazide].

Journal: Deutsche medizinische Wochenschrift (1946)19820528

Title: Diuretic induced hypokalemia in the elderly.

Journal: The Journal of family practice19820401

Title: Reversible acute renal failure from combined triamterene and indomethacin: a study in healthy subjects.

Journal: Annals of internal medicine19820301

Title: Triamterene-induced acute interstitial nephritis.

Journal: Lancet (London, England)19820123

Title: [Triamterene induced nephrolithiasis (author's transl)].

Journal: Journal d'urologie19820101

Title: [Triamterene and renal calculi].

Journal: Nephrologie19820101

Title: Hypokalemic periodic paralysis exacerbated by acetazolamide.

Journal: Neurology19811101

Title: Nephrogenic diabetes insipidus associated with Dyazide (triamterene-hydrochlorothiazide).

Journal: British medical journal (Clinical research ed.)19811031

Title: Triamterene nephrolithiasis complicating dyazide therapy.

Journal: The Journal of urology19810801

Title: Triamterene-induced nephrolithiasis.

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Title: Triamterene urolithiasis.

Journal: Canadian Medical Association journal19810615

Title: Acute interstitial nephritis associated with thiazide diuretics. Clinical and pathologic observations in three cases.

Journal: The American journal of medicine19801201

Title: Triamterene nephrolithiasis.

Journal: JAMA19801128

Title: Triamterene-induced nephrolithiasis.

Journal: Annals of internal medicine19800301

Title: [Drug induced nephrolithiasis: observation of an oxalate and hydroxylated triamterene stone (author's transl)].

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Title: Triamterene-induced nephrolithiasis.

Journal: Annals of internal medicine19791101

Title: Triamterene-induced immune haemolytic anaemia with acute intravascular haemolysis and acute renal failure.

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Title: [Triamterene-induced immune hemolytic anemia with acute intravascular hemolysis and acute renal failure (author's transl)].

Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology19790801

Title: [Severe megaloblastic anaemia by triamterene in a patient with alcoholic liver cirrhosis (author's transl)].

Journal: Deutsche medizinische Wochenschrift (1946)19790601

Title: Maintenance of potassium balance during diuretic therapy.

Journal: Acta medica Scandinavica19790101

Title: Antiarrhythmic activity of four pteridine compounds in ouabain intoxication.

Journal: Clinical pharmacology and therapeutics19750201

Title: Diuretic-induced renal colic.

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Title: Mechanism of triamterene-induced megaloblastosis.

Journal: Annals of internal medicine19700901

Title: Digitoxin induced cardiac necrosis and its inhibition.

Journal: Cardiologia19690101

Title: Busch, A.E., et al., Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis. Pflugers Arch, 1996. 432(5): p. 760-6.

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