Name: Name:N-(5-Methyl-1H-pyrazol-3-yl)-2-phenyl-5,6,7,8-tetrahydroquinazolin-4-amine
Brand: AABLOCKS
SKU: AA00C5NQ
Rating: 90 (10 reviews)

Catalog No.: AA00C5NQ

404828-08-6 | N-(5-Methyl-1H-pyrazol-3-yl)-2-phenyl-5,6,7,8-tetrahydroquinazolin-4-amine

Pack Size： 1mg

Purity： 98% by HPLC

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Technical Information

Catalog Number: AA00C5NQ

Chemical Name: N-(5-Methyl-1H-pyrazol-3-yl)-2-phenyl-5,6,7,8-tetrahydroquinazolin-4-amine

CAS Number: 404828-08-6

Molecular Formula: C18H19N5

Molecular Weight: 305.3770

MDL Number: MFCD09037536

SMILES: Cc1[nH]nc(c1)Nc1nc(nc2c1CCCC2)c1ccccc1

Properties

Complexity: 384

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 23

Hydrogen Bond Acceptor Count: 4

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 3

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 4.4

Literature fold

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology20111101

Title: Identification of new inhibitors of protein kinase R guided by statistical modeling.

Journal: Bioorganic & medicinal chemistry letters20110701

Title: The discovery of the potent aurora inhibitor MK-0457 (VX-680).

Journal: Bioorganic & medicinal chemistry letters20090701

Title: Discovery and development of aurora kinase inhibitors as anticancer agents.

Journal: Journal of medicinal chemistry20090514

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America20071218

Title: CH...O and CH...N hydrogen bonds in ligand design: a novel quinazolin-4-ylthiazol-2-ylamine protein kinase inhibitor.

Journal: Journal of medicinal chemistry20050224

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