409345-29-5,MFCD08690525
Catalog No.:AA0037EI

409345-29-5 | (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$48.00   $33.00
- +
5mg
≥95%
in stock  
$160.00   $112.00
- +
10mg
≥95%
in stock  
$298.00   $208.00
- +
25mg
≥95%
in stock  
$679.00   $475.00
- +
50mg
96%
in stock  
$1,129.00   $790.00
- +
100mg
96%
in stock  
$1,988.00   $1,392.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0037EI
Chemical Name:
(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
CAS Number:
409345-29-5
Molecular Formula:
C20H23NO3
Molecular Weight:
325.4015
MDL Number:
MFCD08690525
SMILES:
COC1CCC(CC1)C(=O)c1ccc2c(c1)cc1c(n2)OCCC1
Properties
Properties
 
Form:
Solid  
MP:
102-104°C  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
446  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.7  

Literature

Title: Antagonism of metabotropic glutamate 1 receptors attenuates behavioral effects of cocaine and methamphetamine in squirrel monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 20121001

Title: Subregion-specific role of glutamate receptors in the nucleus accumbens on drug context-induced reinstatement of cocaine-seeking behavior in rats.

Journal: Addiction biology 20120301

Title: Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome.

Journal: Psychopharmacology 20120101

Title: Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against β-amyloid toxicity.

Journal: Molecular pharmacology 20120101

Title: Metabotropic glutamate antagonists alone and in combination with morphine: comparison across two models of acute pain and a model of persistent, inflammatory pain.

Journal: Behavioural pharmacology 20111201

Title: Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.

Journal: Neuropharmacology 20110601

Title: Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination.

Journal: Pharmacology, biochemistry, and behavior 20110401

Title: Synthesis and evaluation of 6-[1-(2-[(18)F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain.

Journal: Bioorganic & medicinal chemistry 20110101

Title: Evaluation of cannabinoid receptor 2 and metabotropic glutamate receptor 1 functional responses using a cell impedance-based technology.

Journal: Journal of biomolecular screening 20101201

Title: Pharmacological effects of metabotropic glutamate receptor ligands on prepulse inhibition in DBA/2J mice.

Journal: European journal of pharmacology 20100810

Title: Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats.

Journal: Psychopharmacology 20100101

Title: Role of the metabotropic glutamate receptor subtype 1 in the harmaline-induced tremor in rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20090901

Title: Inhibition of mGluR1 and IP3Rs impairs long-term memory formation in young chicks.

Journal: Neurobiology of learning and memory 20080701

Title: JNJ16259685, a selective mGlu1 antagonist, suppresses isolation-induced aggression in male mice.

Journal: European journal of pharmacology 20080531

Title: Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats.

Journal: Pharmacological research 20080301

Title: Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats.

Journal: Alcoholism, clinical and experimental research 20080201

Title: Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats.

Journal: Alcohol (Fayetteville, N.Y.) 20080201

Title: Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task.

Journal: Behavioural brain research 20051014

Title: Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.

Journal: Journal of medicinal chemistry 20050324

Title: JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist.

Journal: Neuropharmacology 20041201

Title: Navarro JF,et al. JNJ16259685, a selective mGlu1 antagonist, suppresses isolation-induced aggression in male mice. Eur J Pharmacol. 2008 May 31;586(1-3):217-20.

Title: Hodgson RA, et al. Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination. Pharmacol Biochem Behav. 2011 Apr;98(2):181-7.

Title: Lavreysen H,et al. JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Neuropharmacology. 2004 Dec;47(7):961-72.

Title: I Fukunaga , et al. Potent and Specific Action of the mGlu1 Antagonists YM-298198 and JNJ16259685 on Synaptic Transmission in Rat Cerebellar Slices. Br J Pharmacol. 2007 Jul;151(6):870-6.

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Tags:409345-29-5 Molecular Formula|409345-29-5 MDL|409345-29-5 SMILES|409345-29-5 (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
Catalog No.: AA0037EI
409345-29-5,MFCD08690525
409345-29-5 | (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
Pack Size: 1mg
Purity: ≥95%
in stock
$48.00 $33.00
Pack Size: 5mg
Purity: ≥95%
in stock
$160.00 $112.00
Pack Size: 10mg
Purity: ≥95%
in stock
$298.00 $208.00
Pack Size: 25mg
Purity: ≥95%
in stock
$679.00 $475.00
Pack Size: 50mg
Purity: 96%
in stock
$1,129.00 $790.00
Pack Size: 100mg
Purity: 96%
in stock
$1,988.00 $1,392.00
Quantity
- +
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bulk Quotation Request
Technical Information
Catalog Number: AA0037EI
Chemical Name: (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
CAS Number: 409345-29-5
Molecular Formula: C20H23NO3
Molecular Weight: 325.4015
MDL Number: MFCD08690525
SMILES: COC1CCC(CC1)C(=O)c1ccc2c(c1)cc1c(n2)OCCC1
Properties
Form: Solid  
MP: 102-104°C  
Storage: 2-8℃;  
Complexity: 446  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 24  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.7  
Literature fold

Title: Antagonism of metabotropic glutamate 1 receptors attenuates behavioral effects of cocaine and methamphetamine in squirrel monkeys.

Journal: The Journal of pharmacology and experimental therapeutics20121001

Title: Subregion-specific role of glutamate receptors in the nucleus accumbens on drug context-induced reinstatement of cocaine-seeking behavior in rats.

Journal: Addiction biology20120301

Title: Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome.

Journal: Psychopharmacology20120101

Title: Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against β-amyloid toxicity.

Journal: Molecular pharmacology20120101

Title: Metabotropic glutamate antagonists alone and in combination with morphine: comparison across two models of acute pain and a model of persistent, inflammatory pain.

Journal: Behavioural pharmacology20111201

Title: Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.

Journal: Neuropharmacology20110601

Title: Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination.

Journal: Pharmacology, biochemistry, and behavior20110401

Title: Synthesis and evaluation of 6-[1-(2-[(18)F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain.

Journal: Bioorganic & medicinal chemistry20110101

Title: Evaluation of cannabinoid receptor 2 and metabotropic glutamate receptor 1 functional responses using a cell impedance-based technology.

Journal: Journal of biomolecular screening20101201

Title: Pharmacological effects of metabotropic glutamate receptor ligands on prepulse inhibition in DBA/2J mice.

Journal: European journal of pharmacology20100810

Title: Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats.

Journal: Psychopharmacology20100101

Title: Role of the metabotropic glutamate receptor subtype 1 in the harmaline-induced tremor in rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20090901

Title: Inhibition of mGluR1 and IP3Rs impairs long-term memory formation in young chicks.

Journal: Neurobiology of learning and memory20080701

Title: JNJ16259685, a selective mGlu1 antagonist, suppresses isolation-induced aggression in male mice.

Journal: European journal of pharmacology20080531

Title: Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats.

Journal: Pharmacological research20080301

Title: Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats.

Journal: Alcoholism, clinical and experimental research20080201

Title: Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats.

Journal: Alcohol (Fayetteville, N.Y.)20080201

Title: Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task.

Journal: Behavioural brain research20051014

Title: Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.

Journal: Journal of medicinal chemistry20050324

Title: JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist.

Journal: Neuropharmacology20041201

Title: Navarro JF,et al. JNJ16259685, a selective mGlu1 antagonist, suppresses isolation-induced aggression in male mice. Eur J Pharmacol. 2008 May 31;586(1-3):217-20.

Title: Hodgson RA, et al. Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination. Pharmacol Biochem Behav. 2011 Apr;98(2):181-7.

Title: Lavreysen H,et al. JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Neuropharmacology. 2004 Dec;47(7):961-72.

Title: I Fukunaga , et al. Potent and Specific Action of the mGlu1 Antagonists YM-298198 and JNJ16259685 on Synaptic Transmission in Rat Cerebellar Slices. Br J Pharmacol. 2007 Jul;151(6):870-6.

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