Name: Name:4'-HYDROXY ATOMOXETINE
Brand: AABLOCKS
SKU: AA00DF8V
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00DF8V

Chemical Name: 4'-HYDROXY ATOMOXETINE

CAS Number: 435293-66-6

Molecular Formula: C17H21NO2

Molecular Weight: 271.3541

MDL Number: MFCD09840695

SMILES: CNCC[C@H](c1ccccc1)Oc1ccc(cc1C)O

Properties

Complexity: 266

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 1

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 20

Hydrogen Bond Acceptor Count: 3

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 6

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.4

Literature fold

Title: Development and validation of a liquid chromatography-tandem mass spectrometry assay for hair analysis of atomoxetine and its metabolites: Application in clinical practice.

Journal: Forensic science international20120510

Title: Determination of atomoxetine metabolites in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20120215

Title: Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial kappa-opioid agonist effect.

Journal: Bioorganic & medicinal chemistry letters20040802

Title: Effect of potent CYP2D6 inhibition by paroxetine on atomoxetine pharmacokinetics.

Journal: Journal of clinical pharmacology20021101

Title: Identification of the human cytochromes P450 responsible for atomoxetine metabolism.

Journal: Drug metabolism and disposition: the biological fate of chemicals20020301

Title: JT Brown, Single Dose Pharmacokinetics of Atomoxetine in Children.

Title: Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711.

435293-66-6 | 4'-HYDROXY ATOMOXETINE