4376-18-5,MFCD00002466
Catalog No.:AA003S2Z

4376-18-5 | Methyl hydrogen phthalate

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5g
95%
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$11.00   $8.00
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10g
95%
in stock  
$20.00   $14.00
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25g
95%
in stock  
$40.00   $28.00
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100g
95%
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$133.00   $93.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003S2Z
Chemical Name:
Methyl hydrogen phthalate
CAS Number:
4376-18-5
Molecular Formula:
C9H8O4
Molecular Weight:
180.1574
MDL Number:
MFCD00002466
SMILES:
COC(=O)c1ccccc1C(=O)O
NSC Number:
8281
Properties
Properties
 
BP:
328.9°C at 760 mmHg  
Form:
Solid  
MP:
82-84 °C(lit.)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
212  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.1  

Literature

Title: Placental lncRNA Expression Is Associated With Prenatal Phthalate Exposure.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20180501

Title: Lethal and sublethal effects of phthalate diesters in Silurana tropicalis larvae.

Journal: Environmental toxicology and chemistry 20161001

Title: Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor α, β, γ subtypes: an in silico approach.

Journal: Journal of applied toxicology : JAT 20140701

Title: Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example.

Journal: Journal of exposure science & environmental epidemiology 20121101

Title: Dose-response analysis of phthalate effects on gene expression in rat whole embryo culture.

Journal: Toxicology and applied pharmacology 20121001

Title: Consumer product exposures associated with urinary phthalate levels in pregnant women.

Journal: Journal of exposure science & environmental epidemiology 20120901

Title: Simultaneous determination of multiple phthalate metabolites and bisphenol-A in human urine by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

Title: Phthalates exposure of Chinese reproductive age couples and its effect on male semen quality, a primary study.

Journal: Environment international 20120701

Title: Circulating levels of phthalate metabolites are associated with prevalent diabetes in the elderly.

Journal: Diabetes care 20120701

Title: Associations between circulating levels of bisphenol A and phthalate metabolites and coronary risk in the elderly.

Journal: Ecotoxicology and environmental safety 20120601

Title: Circulating levels of bisphenol A (BPA) and phthalates in an elderly population in Sweden, based on the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS).

Journal: Ecotoxicology and environmental safety 20120101

Title: Degradation of Phthalate Esters by Fusarium sp. DMT-5-3 and Trichosporon sp. DMI-5-1 Isolated from Mangrove Sediments.

Journal: Progress in molecular and subcellular biology 20120101

Title: Serum concentrations of phthalate metabolites are related to abdominal fat distribution two years later in elderly women.

Journal: Environmental health : a global access science source 20120101

Title: Comparison of initial hydrolysis of the three dimethyl phthalate esters (DMPEs) by a basidiomycetous yeast, Trichosporon DMI-5-1, from coastal sediment.

Journal: Environmental science and pollution research international 20111101

Title: 2-Methyl-propan-2-aminium 2-(meth-oxy-carbon-yl)benzoate.

Journal: Acta crystallographica. Section E, Structure reports online 20111001

Title: Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention.

Journal: Environmental health perspectives 20110701

Title: Occurrence of phthalate metabolites in human urine from several Asian countries.

Journal: Environmental science & technology 20110401

Title: Butane-1,4-diaminium 2-(meth-oxy-carbon-yl)benzoate dihydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20110301

Title: Exposure to phthalates among premenstrual girls from rural and urban Gharbiah, Egypt: a pilot exposure assessment study.

Journal: Environmental health : a global access science source 20110101

Title: Chemical exposure as etiology in developmental origin of adult onset human cancer.

Journal: Frontiers in pharmacology 20110101

Title: Natural products-based insecticidal agents 6. Design, semisynthesis, and insecticidal activity of novel monomethyl phthalate derivatives of podophyllotoxin against Mythimna separata Walker in vivo.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: Association of exposure to phthalates with endometriosis and uterine leiomyomata: findings from NHANES, 1999-2004.

Journal: Environmental health perspectives 20100601

Title: Prenatal phthalate exposure is associated with childhood behavior and executive functioning.

Journal: Environmental health perspectives 20100401

Title: [Aerobic granulation for dimethyl phthalate biodegradation in a sequencing batch reactor].

Journal: Huan jing ke xue= Huanjing kexue 20090915

Title: Medications as a potential source of exposure to phthalates in the U.S. population.

Journal: Environmental health perspectives 20090201

Title: Concentrations of phthalate metabolites in milk, urine, saliva, and Serum of lactating North Carolina women.

Journal: Environmental health perspectives 20090101

Title: Phthalate exposure in girls during early puberty.

Journal: Journal of pediatric endocrinology & metabolism : JPEM 20090101

Title: Comparative toxicological evaluation of phthalate diesters and metabolites in Sprague-Dawley male rats for risk assessment.

Journal: Journal of toxicology and environmental health. Part A 20090101

Title: Degradation of dimethyl carboxylic phthalate ester by Burkholderia cepacia DA2 isolated from marine sediment of South China Sea.

Journal: Ecotoxicology (London, England) 20081101

Title: Baby products and phthalates.

Journal: Pediatrics 20080901

Title: Prenatal phenol and phthalate exposures and birth outcomes.

Journal: Environmental health perspectives 20080801

Title: Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations.

Journal: Environmental health perspectives 20080301

Title: Baby care products: possible sources of infant phthalate exposure.

Journal: Pediatrics 20080201

Title: The internal exposure of Taiwanese to phthalate--an evidence of intensive use of plastic materials.

Journal: Environment international 20080101

Title: A pilot study associating urinary concentrations of phthalate metabolites and semen quality.

Journal: Systems biology in reproductive medicine 20080101

Title: Activated sludge-mediated biodegradation of dimethyl phthalate under fermentative conditions.

Journal: Journal of environmental sciences (China) 20080101

Title: Associations between urinary phthalate monoesters and thyroid hormones in pregnant women.

Journal: Human reproduction (Oxford, England) 20071001

Title: Environmental fate of endocrine-disrupting dimethyl phthalate esters (DMPE) under sulfate-reducing condition.

Journal: The Science of the total environment 20070801

Title: Anaerobic degradation of dimethyl phthalate in wastewater in a UASB reactor.

Journal: Water research 20070701

Title: Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males.

Journal: Environmental health perspectives 20070601

Title: Denitrifying degradation of dimethyl phthalate.

Journal: Applied microbiology and biotechnology 20070201

Title: In silico prediction of pregnane X receptor activators by machine learning approaches.

Journal: Molecular pharmacology 20070101

Title: Phthalate monoesters in perfusate from a dual placenta perfusion system, the placenta tissue and umbilical cord blood.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20070101

Title: Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls.

Journal: Environmental health perspectives 20070101

Title: Transplacental transfer of monomethyl phthalate and mono(2-ethylhexyl) phthalate in a human placenta perfusion system.

Journal: International journal of toxicology 20070101

Title: Participation in environmental health research by placenta donation - a perception study.

Journal: Environmental health : a global access science source 20070101

Title: Anoxic biodegradation of dimethyl phthalate (DMP) by activated sludge cultures under nitrate-reducing conditions.

Journal: Journal of environmental sciences (China) 20070101

Title: Synthesis characterization and biological study of diorganotin(IV) complexes of monomethyl phthalate.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20061101

Title: Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites.

Journal: Epidemiology (Cambridge, Mass.) 20061101

Title: Mono-(2-ethylhexyl) phthalate rapidly increases celsr2 protein phosphorylation in HeLa cells via protein kinase C and casein kinase 1.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060501

Title: Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age.

Journal: Environmental health perspectives 20060201

Title: Detection of phthalate metabolites in human saliva.

Journal: Archives of toxicology 20051101

Title: Personal care product use predicts urinary concentrations of some phthalate monoesters.

Journal: Environmental health perspectives 20051101

Title: Decrease in anogenital distance among male infants with prenatal phthalate exposure.

Journal: Environmental health perspectives 20050801

Title: Determination of phthalate monoesters in human milk, consumer milk, and infant formula by tandem mass spectrometry (LC-MS-MS).

Journal: Analytical and bioanalytical chemistry 20050601

Title: Biochemical pathway and degradation of phthalate ester isomers by bacteria.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20050101

Title: Temporal variability of urinary phthalate metabolite levels in men of reproductive age.

Journal: Environmental health perspectives 20041201

Title: Environmental phthalate monoesters activate pregnane X receptor-mediated transcription.

Journal: Toxicology and applied pharmacology 20040915

Title: Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030615

Title: Dimethylphthalate hydrolysis by specific microbial esterase.

Journal: Chemosphere 20030601

Title: Phthalate exposure and human semen parameters.

Journal: Epidemiology (Cambridge, Mass.) 20030501

Title: Phthalate esters detected in various water samples and biodegradation of the phthalates by microbes isolated from river water.

Journal: Biological & pharmaceutical bulletin 20020201

Title: Chong Liu, et al. Urinary biomarkers of phthalates exposure and risks of thyroid cancer and benign nodule. J Hazard Mater. 2020 Feb 5;383:121189.

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SDS
Tags:4376-18-5 Molecular Formula|4376-18-5 MDL|4376-18-5 SMILES|4376-18-5 Methyl hydrogen phthalate
Catalog No.: AA003S2Z
4376-18-5,MFCD00002466
4376-18-5 | Methyl hydrogen phthalate
Pack Size: 5g
Purity: 95%
in stock
$11.00 $8.00
Pack Size: 10g
Purity: 95%
in stock
$20.00 $14.00
Pack Size: 25g
Purity: 95%
in stock
$40.00 $28.00
Pack Size: 100g
Purity: 95%
in stock
$133.00 $93.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA003S2Z
Chemical Name: Methyl hydrogen phthalate
CAS Number: 4376-18-5
Molecular Formula: C9H8O4
Molecular Weight: 180.1574
MDL Number: MFCD00002466
SMILES: COC(=O)c1ccccc1C(=O)O
NSC Number: 8281
Properties
BP: 328.9°C at 760 mmHg  
Form: Solid  
MP: 82-84 °C(lit.)  
Storage: Keep in dry area;Room Temperature;  
Complexity: 212  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 13  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.1  
Literature fold

Title: Placental lncRNA Expression Is Associated With Prenatal Phthalate Exposure.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20180501

Title: Lethal and sublethal effects of phthalate diesters in Silurana tropicalis larvae.

Journal: Environmental toxicology and chemistry20161001

Title: Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor α, β, γ subtypes: an in silico approach.

Journal: Journal of applied toxicology : JAT20140701

Title: Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example.

Journal: Journal of exposure science & environmental epidemiology20121101

Title: Dose-response analysis of phthalate effects on gene expression in rat whole embryo culture.

Journal: Toxicology and applied pharmacology20121001

Title: Consumer product exposures associated with urinary phthalate levels in pregnant women.

Journal: Journal of exposure science & environmental epidemiology20120901

Title: Simultaneous determination of multiple phthalate metabolites and bisphenol-A in human urine by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20120901

Title: Phthalates exposure of Chinese reproductive age couples and its effect on male semen quality, a primary study.

Journal: Environment international20120701

Title: Circulating levels of phthalate metabolites are associated with prevalent diabetes in the elderly.

Journal: Diabetes care20120701

Title: Associations between circulating levels of bisphenol A and phthalate metabolites and coronary risk in the elderly.

Journal: Ecotoxicology and environmental safety20120601

Title: Circulating levels of bisphenol A (BPA) and phthalates in an elderly population in Sweden, based on the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS).

Journal: Ecotoxicology and environmental safety20120101

Title: Degradation of Phthalate Esters by Fusarium sp. DMT-5-3 and Trichosporon sp. DMI-5-1 Isolated from Mangrove Sediments.

Journal: Progress in molecular and subcellular biology20120101

Title: Serum concentrations of phthalate metabolites are related to abdominal fat distribution two years later in elderly women.

Journal: Environmental health : a global access science source20120101

Title: Comparison of initial hydrolysis of the three dimethyl phthalate esters (DMPEs) by a basidiomycetous yeast, Trichosporon DMI-5-1, from coastal sediment.

Journal: Environmental science and pollution research international20111101

Title: 2-Methyl-propan-2-aminium 2-(meth-oxy-carbon-yl)benzoate.

Journal: Acta crystallographica. Section E, Structure reports online20111001

Title: Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention.

Journal: Environmental health perspectives20110701

Title: Occurrence of phthalate metabolites in human urine from several Asian countries.

Journal: Environmental science & technology20110401

Title: Butane-1,4-diaminium 2-(meth-oxy-carbon-yl)benzoate dihydrate.

Journal: Acta crystallographica. Section E, Structure reports online20110301

Title: Exposure to phthalates among premenstrual girls from rural and urban Gharbiah, Egypt: a pilot exposure assessment study.

Journal: Environmental health : a global access science source20110101

Title: Chemical exposure as etiology in developmental origin of adult onset human cancer.

Journal: Frontiers in pharmacology20110101

Title: Natural products-based insecticidal agents 6. Design, semisynthesis, and insecticidal activity of novel monomethyl phthalate derivatives of podophyllotoxin against Mythimna separata Walker in vivo.

Journal: Bioorganic & medicinal chemistry letters20100801

Title: Association of exposure to phthalates with endometriosis and uterine leiomyomata: findings from NHANES, 1999-2004.

Journal: Environmental health perspectives20100601

Title: Prenatal phthalate exposure is associated with childhood behavior and executive functioning.

Journal: Environmental health perspectives20100401

Title: [Aerobic granulation for dimethyl phthalate biodegradation in a sequencing batch reactor].

Journal: Huan jing ke xue= Huanjing kexue20090915

Title: Medications as a potential source of exposure to phthalates in the U.S. population.

Journal: Environmental health perspectives20090201

Title: Concentrations of phthalate metabolites in milk, urine, saliva, and Serum of lactating North Carolina women.

Journal: Environmental health perspectives20090101

Title: Phthalate exposure in girls during early puberty.

Journal: Journal of pediatric endocrinology & metabolism : JPEM20090101

Title: Comparative toxicological evaluation of phthalate diesters and metabolites in Sprague-Dawley male rats for risk assessment.

Journal: Journal of toxicology and environmental health. Part A20090101

Title: Degradation of dimethyl carboxylic phthalate ester by Burkholderia cepacia DA2 isolated from marine sediment of South China Sea.

Journal: Ecotoxicology (London, England)20081101

Title: Baby products and phthalates.

Journal: Pediatrics20080901

Title: Prenatal phenol and phthalate exposures and birth outcomes.

Journal: Environmental health perspectives20080801

Title: Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations.

Journal: Environmental health perspectives20080301

Title: Baby care products: possible sources of infant phthalate exposure.

Journal: Pediatrics20080201

Title: The internal exposure of Taiwanese to phthalate--an evidence of intensive use of plastic materials.

Journal: Environment international20080101

Title: A pilot study associating urinary concentrations of phthalate metabolites and semen quality.

Journal: Systems biology in reproductive medicine20080101

Title: Activated sludge-mediated biodegradation of dimethyl phthalate under fermentative conditions.

Journal: Journal of environmental sciences (China)20080101

Title: Associations between urinary phthalate monoesters and thyroid hormones in pregnant women.

Journal: Human reproduction (Oxford, England)20071001

Title: Environmental fate of endocrine-disrupting dimethyl phthalate esters (DMPE) under sulfate-reducing condition.

Journal: The Science of the total environment20070801

Title: Anaerobic degradation of dimethyl phthalate in wastewater in a UASB reactor.

Journal: Water research20070701

Title: Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males.

Journal: Environmental health perspectives20070601

Title: Denitrifying degradation of dimethyl phthalate.

Journal: Applied microbiology and biotechnology20070201

Title: In silico prediction of pregnane X receptor activators by machine learning approaches.

Journal: Molecular pharmacology20070101

Title: Phthalate monoesters in perfusate from a dual placenta perfusion system, the placenta tissue and umbilical cord blood.

Journal: Reproductive toxicology (Elmsford, N.Y.)20070101

Title: Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls.

Journal: Environmental health perspectives20070101

Title: Transplacental transfer of monomethyl phthalate and mono(2-ethylhexyl) phthalate in a human placenta perfusion system.

Journal: International journal of toxicology20070101

Title: Participation in environmental health research by placenta donation - a perception study.

Journal: Environmental health : a global access science source20070101

Title: Anoxic biodegradation of dimethyl phthalate (DMP) by activated sludge cultures under nitrate-reducing conditions.

Journal: Journal of environmental sciences (China)20070101

Title: Synthesis characterization and biological study of diorganotin(IV) complexes of monomethyl phthalate.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20061101

Title: Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites.

Journal: Epidemiology (Cambridge, Mass.)20061101

Title: Mono-(2-ethylhexyl) phthalate rapidly increases celsr2 protein phosphorylation in HeLa cells via protein kinase C and casein kinase 1.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20060501

Title: Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age.

Journal: Environmental health perspectives20060201

Title: Detection of phthalate metabolites in human saliva.

Journal: Archives of toxicology20051101

Title: Personal care product use predicts urinary concentrations of some phthalate monoesters.

Journal: Environmental health perspectives20051101

Title: Decrease in anogenital distance among male infants with prenatal phthalate exposure.

Journal: Environmental health perspectives20050801

Title: Determination of phthalate monoesters in human milk, consumer milk, and infant formula by tandem mass spectrometry (LC-MS-MS).

Journal: Analytical and bioanalytical chemistry20050601

Title: Biochemical pathway and degradation of phthalate ester isomers by bacteria.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research20050101

Title: Temporal variability of urinary phthalate metabolite levels in men of reproductive age.

Journal: Environmental health perspectives20041201

Title: Environmental phthalate monoesters activate pregnane X receptor-mediated transcription.

Journal: Toxicology and applied pharmacology20040915

Title: Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20030615

Title: Dimethylphthalate hydrolysis by specific microbial esterase.

Journal: Chemosphere20030601

Title: Phthalate exposure and human semen parameters.

Journal: Epidemiology (Cambridge, Mass.)20030501

Title: Phthalate esters detected in various water samples and biodegradation of the phthalates by microbes isolated from river water.

Journal: Biological & pharmaceutical bulletin20020201

Title: Chong Liu, et al. Urinary biomarkers of phthalates exposure and risks of thyroid cancer and benign nodule. J Hazard Mater. 2020 Feb 5;383:121189.

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