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449808-64-4,MFCD18711690
Catalog No.:AA00DB8E

449808-64-4 | R1487

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$53.00   $37.00
- +
5mg
98%
in stock  
$75.00   $53.00
- +
10mg
98%
in stock  
$121.00   $85.00
- +
50mg
97%
in stock  
$171.00   $120.00
- +
100mg
97%
in stock  
$289.00   $203.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00DB8E
Chemical Name:
R1487
CAS Number:
449808-64-4
Molecular Formula:
C19H19ClF2N4O3
Molecular Weight:
424.8290
MDL Number:
MFCD18711690
SMILES:
Fc1ccc(c(c1)F)Oc1cc2cnc(nc2n(c1=O)C)NC1CCOCC1.Cl
Properties
Computed Properties
 
Complexity:
602  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase.

Journal: Journal of medicinal chemistry 20110414

Title: Some aspects of the reproductive endocrinology of the stallion and cryptorchid.

Journal: Journal of reproduction and fertility. Supplement 19751001

Title: Goldstein DM et al. Discovery of 6-(2,4-difluorophenoxy)-2--hydroxy-1-(2-hydroxyethyl)propylamino-8-methyl-8H-pyrido,3-dpyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido,3-dpyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54(7):2255-65.

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SDS
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Tags:449808-64-4 Molecular Formula|449808-64-4 MDL|449808-64-4 SMILES|449808-64-4 R1487
Catalog No.: AA00DB8E
449808-64-4,MFCD18711690
449808-64-4 | R1487
Pack Size： 1mg
Purity： ≥98%
in stock
$53.00 $37.00
Pack Size： 5mg
Purity： 98%
in stock
$75.00 $53.00
Pack Size： 10mg
Purity： 98%
in stock
$121.00 $85.00
Pack Size： 50mg
Purity： 97%
in stock
$171.00 $120.00
Pack Size： 100mg
Purity： 97%
in stock
$289.00 $203.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00DB8E
Chemical Name: R1487
CAS Number: 449808-64-4
Molecular Formula: C19H19ClF2N4O3
Molecular Weight: 424.8290
MDL Number: MFCD18711690
SMILES: Fc1ccc(c(c1)F)Oc1cc2cnc(nc2n(c1=O)C)NC1CCOCC1.Cl
Properties
Complexity: 602  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase.

Journal: Journal of medicinal chemistry20110414

Title: Some aspects of the reproductive endocrinology of the stallion and cryptorchid.

Journal: Journal of reproduction and fertility. Supplement19751001

Title: Goldstein DM et al. Discovery of 6-(2,4-difluorophenoxy)-2--hydroxy-1-(2-hydroxyethyl)propylamino-8-methyl-8H-pyrido,3-dpyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido,3-dpyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54(7):2255-65.

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