Name: Name:AVE-3085
Brand: AABLOCKS
SKU: AA01EOH7
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA01EOH7

Chemical Name: AVE-3085

CAS Number: 450348-85-3

Molecular Formula: C17H13F2NO3

Molecular Weight: 317.2868

MDL Number: MFCD30532601

SMILES: O=C(c1ccc2c(c1)OC(O2)(F)F)NC1Cc2c(C1)cccc2

Properties

Complexity: 459

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 23

Hydrogen Bond Acceptor Count: 5

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 2

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.8

Literature fold

Title: AVE3085 protects coronary endothelium from the impairment of asymmetric dimethylarginine by activation and recoupling of eNOS.

Journal: Cardiovascular drugs and therapy20121001

Title: Endothelial nitric oxide synthase enhancer for protection of endothelial function from asymmetric dimethylarginine-induced injury in human internal thoracic artery.

Journal: The Journal of thoracic and cardiovascular surgery20120901

Title: Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice.

Journal: Cardiovascular research20111101

Title: AVE3085, an enhancer of endothelial nitric oxide synthase, restores endothelial function and reduces blood pressure in spontaneously hypertensive rats.

Journal: British journal of pharmacology20110701

Title: Blockade of NADPH oxidase restores vasoreparative function in diabetic CD34+ cells.

Journal: Investigative ophthalmology & visual science20110701

Title: New strategy of endothelial protection in cardiac surgery: use of enhancer of endothelial nitric oxide synthase.

Journal: World journal of surgery20100701

Title: Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure.

Journal: Basic research in cardiology20090901

Title: Diastolic heart failure: a misNOmer.

Journal: Basic research in cardiology20090901

Title: Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling.

Journal: The Journal of pharmacology and experimental therapeutics20080501

Title: Chen Y, et al. AVE 3085, a novel endothelial nitric oxide synthase enhancer, attenuates cardiac remodeling in mice through the Smad signaling pathway. Arch Biochem Biophys. 2015 Mar 15;570:8-13.

Title: Xue HM, et al. AVE3085 protects coronary endothelium from the impairment of asymmetric dimethylarginine by activation and recoupling of eNOS. Cardiovasc Drugs Ther. 2012 Oct;26(5):383-92.

Title: Yang Q, et al. AVE3085, an enhancer of endothelial nitric oxide synthase, restores endothelial function and reduces blood pressure in spontaneously hypertensive rats. Br J Pharmacol. 2011 Jul;163(5):1078-85

450348-85-3 | AVE-3085