4774-24-7,MFCD00242605
Catalog No.:AA00D7YV

4774-24-7 | 2-Piperazin-1-yl-quinoline

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
95%
in stock  
$84.00   $59.00
- +
1g
98%
in stock  
$86.00   $60.00
- +
5g
98%
in stock  
$197.00   $138.00
- +
25g
98%
in stock  
$824.00 $577.00
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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Technical Information
Catalog Number:
AA00D7YV
Chemical Name:
2-Piperazin-1-yl-quinoline
CAS Number:
4774-24-7
Molecular Formula:
C13H15N3
Molecular Weight:
213.2783
MDL Number:
MFCD00242605
SMILES:
N1CCN(CC1)c1ccc2c(n1)cccc2
Properties
Computed Properties
 
Complexity:
225  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.5  

Literature

Title: Daily passive cycling attenuates the hyperexcitability and restores the responsiveness of the extensor monosynaptic reflex to quipazine in the chronic spinally transected rat.

Journal: Journal of neurotrauma 20140615

Title: Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.

Journal: Journal of medicinal chemistry 20140327

Title: Sensory feedback modulates quipazine-induced stepping behavior in the newborn rat.

Journal: Behavioural brain research 20120401

Title: The upright posture improves plantar stepping and alters responses to serotonergic drugs in spinal rats.

Journal: The Journal of physiology 20120401

Title: Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.

Journal: European journal of medicinal chemistry 20120301

Title: Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120101

Title: Mass-spectrometric studies of new 6-nitroquipazines-serotonin transporter inhibitors.

Journal: Analytical and bioanalytical chemistry 20120101

Title: Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines.

Journal: Pain research and treatment 20120101

Title: Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress.

Journal: Biological psychiatry 20111201

Title: Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.

Journal: Bioorganic & medicinal chemistry letters 20110915

Title: Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome.

Journal: Brain : a journal of neurology 20110801

Title: Neurochemical excitation of propriospinal neurons facilitates locomotor command signal transmission in the lesioned spinal cord.

Journal: Journal of neurophysiology 20110601

Title: Further evidence of olfactory ensheathing glia facilitating axonal regeneration after a complete spinal cord transection.

Journal: Experimental neurology 20110501

Title: Effects of direct- and indirect-acting serotonin receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in rhesus monkeys.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110401

Title: Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site.

Journal: Neuropharmacology 20110201

Title: Methods to quantify pharmacologically induced alterations in motor function in human incomplete SCI.

Journal: Journal of visualized experiments : JoVE 20110101

Title: Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spinal Cord Injury.

Journal: Neurology research international 20110101

Title: Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers.

Journal: The Journal of biological chemistry 20101231

Title: Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.

Journal: Journal of medicinal chemistry 20101111

Title: Why variability facilitates spinal learning.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100811

Title: Afferent inputs to mid- and lower-lumbar spinal segments are necessary for stepping in spinal cats.

Journal: Annals of the New York Academy of Sciences 20100601

Title: Facilitation of postural limb reflexes with epidural stimulation in spinal rabbits.

Journal: Journal of neurophysiology 20100201

Title: A novel 5-HT(2A) receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: approaching early-onset antidepressants.

Journal: Pharmacology, biochemistry, and behavior 20100101

Title: Psychedelics and the human receptorome.

Journal: PloS one 20100101

Title: The interactions of the 5-HT3 receptor with quipazine-like arylpiperazine ligands: the journey track at the end of the first decade of the third millennium.

Journal: Current topics in medicinal chemistry 20100101

Title: The emerging modern face of mood disorders: a didactic editorial with a detailed presentation of data and definitions.

Journal: Annals of general psychiatry 20100101

Title: Neuroanatomical study of the A11 diencephalospinal pathway in the non-human primate.

Journal: PloS one 20100101

Title: Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.

Journal: Journal of medicinal chemistry 20091112

Title: Effects of serotonergic agents on survival and hemolymph composition of the larval mosquito Aedes aegypti (Diptera: Culicidae, L.) in vivo: does serotonin regulate hemolymph acid-base homeostasis?

Journal: The Journal of experimental biology 20091101

Title: Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands.

Journal: The Biochemical journal 20091023

Title: Physical binding pocket induction for affinity prediction.

Journal: Journal of medicinal chemistry 20091008

Title: Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.

Journal: Nature neuroscience 20091001

Title: Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.

Journal: Journal of medicinal chemistry 20090813

Title: Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

Journal: Journal of medicinal chemistry 20090611

Title: Synthesis and preliminary screening of novel N-{2-[4-(substituted)piperazin-1-yl]-2-oxoethyl}acetamides as potential atypical antipsychotic agents.

Journal: Journal of enzyme inhibition and medicinal chemistry 20090601

Title: Serotonin receptor agonist quipazine promotes proliferation and apoptosis of human hepatocyte strain of L-02 strain.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20090601

Title: Morphofunctional study of injured spinal cord of rats after activation of serotonergic receptors and motor load.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20090101

Title: Synthesis and biological evaluation of one novel technetium-99m-labeled nitroquipazine derivative as an imaging agent for serotonin transporter.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20081201

Title: Synthesis and preliminary pharmacological evaluation of N-2-(4-(4-(2-substitutedthiazol-4-yl) piperazin-1-yl)-2-oxoethyl)acetamides as novel atypical antipsychotic agents.

Journal: Bioorganic & medicinal chemistry letters 20081201

Title: Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection.

Journal: The European journal of neuroscience 20081201

Title: Effect of intrathecal administration of serotoninergic and noradrenergic drugs on postural performance in rabbits with spinal cord lesions.

Journal: Journal of neurophysiology 20080801

Title: Anxiolytics may promote locomotor function recovery in spinal cord injury patients.

Journal: Neuropsychiatric disease and treatment 20080801

Title: Facilitation of stepping with epidural stimulation in spinal rats: role of sensory input.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080730

Title: Step training reinforces specific spinal locomotor circuitry in adult spinal rats.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080716

Title: Dose dependence of the 5-HT agonist quipazine in facilitating spinal stepping in the rat with epidural stimulation.

Journal: Neuroscience letters 20080627

Title: A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor.

Journal: Biochemistry 20080617

Title: Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes.

Journal: The Journal of biological chemistry 20080321

Title: 5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function.

Journal: European journal of pharmacology 20080212

Title: Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 20080201

Title: 5-HT-receptive structures are localized in the interblastomere cleft of Paracentrotus lividus early embryos.

Journal: Zygote (Cambridge, England) 20080201

Title: Conservation of structure, signaling and pharmacology between two serotonin receptor subtypes from decapod crustaceans, Panulirus interruptus and Procambarus clarkii.

Journal: The Journal of experimental biology 20080101

Title: Quantification of deficits in lateral paw positioning after spinal cord injury in dogs.

Journal: BMC veterinary research 20080101

Title: Acute and constitutive increases in central serotonin levels reduce social play behaviour in peri-adolescent rats.

Journal: Psychopharmacology 20071201

Title: Epidural spinal cord stimulation plus quipazine administration enable stepping in complete spinal adult rats.

Journal: Journal of neurophysiology 20071101

Title: Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.

Journal: Journal of medicinal chemistry 20070920

Title: Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2'-Substituted 6-nitroquipazines.

Journal: Bioorganic & medicinal chemistry 20070515

Title: Presynaptic modulation of 5-HT release in the rat septal region.

Journal: Neuroscience 20070511

Title: 5-HT3 receptor-mediated photic-like responses of the circadian clock in the rat.

Journal: Neuropharmacology 20070201

Title: Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves).

Journal: Brazilian journal of biology = Revista brasleira de biologia 20070201

Title: [Effect of local microapplication of serotoninergic drugs on membrane currents of Paracentrotus lividus early embryos].

Journal: Ontogenez 20070101

Title: Implications of assist-as-needed robotic step training after a complete spinal cord injury on intrinsic strategies of motor learning.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20061011

Title: Effect of robotic-assisted treadmill training and chronic quipazine treatment on hindlimb stepping in spinally transected rats.

Journal: Journal of neurotrauma 20060701

Title: Increased serotonergic functions following adminstration of 1-(1-naphthyl) piperazine in propranolol injected rats.

Journal: Pakistan journal of pharmaceutical sciences 20060701

Title: Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice.

Journal: Brain research bulletin 20060615

Title: Effects of 5-HT2A receptor stimulation on the discrimination of durations by rats.

Journal: Behavioural pharmacology 20060201

Title: Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20051214

Title: Preclinical pharmacology of FMPD [6-fluoro-10-[3-(2-methoxyethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene]: a potential novel antipsychotic with lower histamine H1 receptor affinity than olanzapine.

Journal: The Journal of pharmacology and experimental therapeutics 20051201

Title: Is the platelet serotonin transporter different in venous vs. arterial blood?

Journal: Neurochemical research 20051101

Title: Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT(1A) receptor.

Journal: The Journal of pharmacy and pharmacology 20051001

Title: Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on temporal differentiation: evidence for the involvement of 5-HT2A but not 5-HT3 receptors in interval timing behaviour.

Journal: Psychopharmacology 20050901

Title: Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 4: 3-Alkyl-4-halo-6-nitroquipazines.

Journal: Bioorganic & medicinal chemistry 20050815

Title: Long-lasting recovery of locomotor function in chronic spinal rat following chronic combined pharmacological stimulation of serotonergic receptors with 8-OHDPAT and quipazine.

Journal: Neuroscience letters 20050801

Title: Hyperglycemia induced by pharmacological activation of central serotonergic pathways depends on the functional integrity of brain CRH system and 5-HT3 receptors.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050801

Title: N1/P2 component of auditory evoked potential reflect changes of the brain serotonin biosynthesis in rats.

Journal: Nutritional neuroscience 20050801

Title: Serotonin receptor mechanisms mediate the discriminative stimulus properties of the atypical antipsychotic clozapine in C57BL/6 mice.

Journal: Psychopharmacology 20050601

Title: Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2.

Journal: Journal of neurochemistry 20050601

Title: The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus.

Journal: Behavioral neuroscience 20050601

Title: Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome.

Journal: Dialogues in clinical neuroscience 20050601

Title: Structure-affinity relationship studies on arylpiperazine derivatives related to quipazine as serotonin transporter ligands. Molecular basis of the selectivity SERT/5HT3 receptor.

Journal: Bioorganic & medicinal chemistry 20050516

Title: Serotonin-related enhancement of recovery of hind limb motor functions in spinal rats after grafting of embryonic raphe nuclei.

Journal: Journal of neurotrauma 20050501

Title: Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on the discrimination of durations: evidence for the involvement of 5-HT2A but not 5-HT3 receptors.

Journal: Behavioural pharmacology 20050201

Title: Involvement of the retinohypothalamic tract in the photic-like effects of the serotonin agonist quipazine in the rat.

Journal: Neuroscience 20050101

Title: Puerarin acts through brain serotonergic mechanisms to induce thermal effects.

Journal: Journal of pharmacological sciences 20041201

Title: Developmental alterations in serotoninergic neurotransmission in Borna disease virus (BDV)-infected rats: a multidisciplinary analysis.

Journal: Journal of neurovirology 20041001

Title: Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation.

Journal: The Journal of pharmacy and pharmacology 20041001

Title: Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists.

Journal: Journal of computer-aided molecular design 20041001

Title: Effect of valproic acid on serotonin-2A receptor signaling in C6 glioma cells.

Journal: Journal of neurochemistry 20040901

Title: Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20040901

Title: Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040801

Title: Synergistic activation of the central pattern generator for locomotion by l-beta-3,4-dihydroxyphenylalanine and quipazine in adult paraplegic mice.

Journal: Neuroscience letters 20040325

Title: Role of NMDA receptor activation in serotonin agonist-induced air-stepping in paraplegic mice.

Journal: Spinal cord 20040301

Title: Turning behaviour induced by stimulation of the 5-HT receptors in the subthalamic nucleus.

Journal: The European journal of neuroscience 20040101

Title: LSD, 5-HT (serotonin), and the evolution of a behavioral assay.

Journal: Neuroscience and biobehavioral reviews 20040101

Title: Serotonin patterns locomotor network activity in the developing zebrafish by modulating quiescent periods.

Journal: Journal of neurobiology 20031201

Title: Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter: Part 3. A potential 5-HT transporter imaging agent, 3-(3-[18F]fluoropropyl)-6-nitroquipazine.

Journal: Bioorganic & medicinal chemistry 20031117

Title: 5-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat.

Journal: The European journal of neuroscience 20031001

Title: Identification of two serine residues essential for agonist-induced 5-HT2A receptor desensitization.

Journal: Biochemistry 20030916

Title: Biochemical evidence for the presence of serotonin transporters in the rat cochlea.

Journal: Hearing research 20030801

Title: Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

Journal: Journal of medicinal chemistry 20030703

Title: Role of 5-HT3 receptors in the mechanisms of central pain syndrome.

Journal: Bulletin of experimental biology and medicine 20030601

Title: Response of the mouse circadian system to serotonin 1A/2/7 agonists in vivo: surprisingly little.

Journal: Journal of biological rhythms 20030401

Title: Thyrotropin-releasing hormone mediates serotonin-induced secretion of GH in cattle.

Journal: Domestic animal endocrinology 20030301

Title: Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter.

Journal: Bioorganic & medicinal chemistry letters 20021216

Title: Novel (bisarylmethoxy)butylpiperidine analogues as neurotransmitter transporter inhibitors with activity at dopamine receptor sites.

Journal: Bioorganic & medicinal chemistry 20021201

Title: Neurogenetics of emotional reactivity to stress in animals.

Journal: Dialogues in clinical neuroscience 20021201

Title: Electrostatic potential surfaces of 5-HT(3)R agonists suggest accessory cation-pi site adjacent to agonist binding domain.

Journal: Bioorganic & medicinal chemistry letters 20021007

Title: Effects of serotonin 1A agonist on acute spinal cord injury.

Journal: Spinal cord 20021001

Title: Synthesis of a fluorine-18-labelled derivative of 6-nitroquipazine, as a radioligand for the in vivo serotonin transporter imaging with PET.

Journal: Bioorganic & medicinal chemistry 20020801

Title: Metachlorophenylpiperazine (m-CPP) induced intracavernous pressure responses in anaesthetized rats.

Journal: International journal of impotence research 20020801

Title: Locomotor recovery in the chronic spinal rat: effects of long-term treatment with a 5-HT2 agonist.

Journal: The European journal of neuroscience 20020801

Title: PET examination of [(11)C]5-methyl-6-nitroquipazine, a radioligand for visualization of the serotonin transporter.

Journal: Nuclear medicine and biology 20020801

Title: Evidence for serotonergic modulation of progesterone-induced hyperphagia, depression and algesia in female mice.

Journal: Brain research 20020712

Title: Electroencephalographic activation by tacrine, deprenyl, and quipazine: cholinergic vs. non-cholinergic contributions.

Journal: European journal of pharmacology 20020628

Title: The Interactions of the 5-HT(3) receptor with arylpiperazine, tropane, and quinuclidine ligands.

Journal: Current topics in medicinal chemistry 20020601

Title: 5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens.

Journal: Pharmacology, biochemistry, and behavior 20020501

Title: Stimulus generalization by fenfluramine in a quipazine-ketanserin drug discrimination is not dependent on indirect serotonin release.

Journal: Pharmacology, biochemistry, and behavior 20020501

Title: Serotonin sets the day state in the neurons that control coupling between the optic lobe circadian pacemakers in the cricket Gryllus bimaculatus.

Journal: The Journal of experimental biology 20020501

Title: Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines.

Journal: Bioorganic & medicinal chemistry letters 20020311

Title: Serotonergic attenuation of the reinforcing and neurochemical effects of cocaine in squirrel monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 20020301

Title: Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis.

Journal: Neuropharmacology 20020201

Title: Mechanisms of ligand-induced desensitization of the 5-hydroxytryptamine(2A) receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20020201

Title: In vitro evidence that 5-hydroxytryptamine increases efflux of glial glutamate via 5-HT(2A) receptor activation.

Journal: Journal of neuroscience research 20020201

Title: Studies on modulation of feeding behavior by atypical antipsychotics in female mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20020201

Title: RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity.

Journal: British journal of pharmacology 20010901

Title: Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors.

Journal: Neuropharmacology 20010801

Title: Acute trazodone and quipazine treatment attenuates apomorphine-induced aggressive behaviour in male rats without major impact on emotional behaviour or monoamine content post mortem.

Journal: Pharmacological research 20010401

Title: In vitro and in vivo ligand binding to the 5HT(3) serotonin receptor characterised by time-resolved fluorescence spectroscopy.

Journal: Chembiochem : a European journal of chemical biology 20010302

Title: Addition of a 5-HT receptor agonist to methylphenidate potentiates the reduction of [123I]FP-CIT binding to dopamine transporters in rat frontal cortex and hippocampus.

Journal: Synapse (New York, N.Y.) 20010301

Title: Neural circuits regulating pulsatile luteinizing hormone release in the female guinea-pig: opioid, adrenergic and serotonergic interactions.

Journal: Journal of neuroendocrinology 20010301

Title: Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors.

Journal: Synapse (New York, N.Y.) 20000201

Title: High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.

Journal: Journal of neurochemistry 19990501

Title: Chronic haloperidol produces a time- and dose-related slowing of lick rhythm in rats: implications for rodent models of tardive dyskinesia and neuroleptic-induced parkinsonism.

Journal: Psychopharmacology 19980501

Title: Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.

Journal: Journal of medicinal chemistry 19980226

Title: Similarities and differences between the subchronic and withdrawal effects of clozapine and olanzapine on forelimb force steadiness.

Journal: Psychopharmacology 19970801

Title: Neurochemical and behavioral evidence that quipazine-ketanserin discrimination is mediated by serotonin2A receptor.

Journal: The Journal of pharmacology and experimental therapeutics 19951101

Title: Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity.

Journal: The Journal of pharmacology and experimental therapeutics 19951001

Title: The interaction of trichloroethanol with murine recombinant 5-HT3 receptors.

Journal: British journal of pharmacology 19950401

Title: Pharmacological comparison of antipsychotic drugs and sigma-antagonists in rodents.

Journal: Pharmacology & toxicology 19940101

Title: Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.

Journal: Molecular pharmacology 19930301

Title: The role of the central serotonergic system in pilocarpine-induced seizures: receptor mechanisms.

Journal: Neuroscience research 19891101

Title: Central antiserotonergic and antidopaminergic action of pirenperone, a putative 5-HT2 receptor antagonist.

Journal: Polish journal of pharmacology and pharmacy 19850101

Title: Possible involvement of serotonergic neurons in the reduction of locomotor hyperactivity caused by amphetamine in neonatal rats depleted of brain dopamine.

Journal: Brain research 19820722

Title: REM sleep deprivation changes behavioral response to catecholaminergic and serotonergic receptor activation in rats.

Journal: Pharmacology, biochemistry, and behavior 19810701

Title: Effect of drugs influencing central 5-hydroxytryptaminergic mechanisms on morphine-induced catalepsy in the rat.

Journal: The Journal of pharmacy and pharmacology 19790401

Title: Effect of drugs influencing central serotonergic mechanisms on haloperidol-induced catalepsy.

Journal: Psychopharmacology 19790329

Title: A combination therapy of neural and glial restricted precursor cells and chronic quipazine treatment paired with passive cycling promotes quipazine-induced stepping in adult spinalized rats.

Journal: The journal of spinal cord medicine

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SDS
Tags:4774-24-7 Molecular Formula|4774-24-7 MDL|4774-24-7 SMILES|4774-24-7 2-Piperazin-1-yl-quinoline
Catalog No.: AA00D7YV
4774-24-7,MFCD00242605
4774-24-7 | 2-Piperazin-1-yl-quinoline
Pack Size: 250mg
Purity: 95%
in stock
$84.00 $59.00
Pack Size: 1g
Purity: 98%
in stock
$86.00 $60.00
Pack Size: 5g
Purity: 98%
in stock
$197.00 $138.00
Pack Size: 25g
Purity: 98%
in stock
$824.00 $577.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA00D7YV
Chemical Name: 2-Piperazin-1-yl-quinoline
CAS Number: 4774-24-7
Molecular Formula: C13H15N3
Molecular Weight: 213.2783
MDL Number: MFCD00242605
SMILES: N1CCN(CC1)c1ccc2c(n1)cccc2
Properties
Complexity: 225  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 16  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.5  
Literature fold

Title: Daily passive cycling attenuates the hyperexcitability and restores the responsiveness of the extensor monosynaptic reflex to quipazine in the chronic spinally transected rat.

Journal: Journal of neurotrauma20140615

Title: Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.

Journal: Journal of medicinal chemistry20140327

Title: Sensory feedback modulates quipazine-induced stepping behavior in the newborn rat.

Journal: Behavioural brain research20120401

Title: The upright posture improves plantar stepping and alters responses to serotonergic drugs in spinal rats.

Journal: The Journal of physiology20120401

Title: Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.

Journal: European journal of medicinal chemistry20120301

Title: Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20120101

Title: Mass-spectrometric studies of new 6-nitroquipazines-serotonin transporter inhibitors.

Journal: Analytical and bioanalytical chemistry20120101

Title: Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines.

Journal: Pain research and treatment20120101

Title: Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress.

Journal: Biological psychiatry20111201

Title: Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.

Journal: Bioorganic & medicinal chemistry letters20110915

Title: Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome.

Journal: Brain : a journal of neurology20110801

Title: Neurochemical excitation of propriospinal neurons facilitates locomotor command signal transmission in the lesioned spinal cord.

Journal: Journal of neurophysiology20110601

Title: Further evidence of olfactory ensheathing glia facilitating axonal regeneration after a complete spinal cord transection.

Journal: Experimental neurology20110501

Title: Effects of direct- and indirect-acting serotonin receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in rhesus monkeys.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20110401

Title: Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site.

Journal: Neuropharmacology20110201

Title: Methods to quantify pharmacologically induced alterations in motor function in human incomplete SCI.

Journal: Journal of visualized experiments : JoVE20110101

Title: Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

Journal: Journal of pharmacy & bioallied sciences20110101

Title: Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spinal Cord Injury.

Journal: Neurology research international20110101

Title: Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers.

Journal: The Journal of biological chemistry20101231

Title: Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.

Journal: Journal of medicinal chemistry20101111

Title: Why variability facilitates spinal learning.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20100811

Title: Afferent inputs to mid- and lower-lumbar spinal segments are necessary for stepping in spinal cats.

Journal: Annals of the New York Academy of Sciences20100601

Title: Facilitation of postural limb reflexes with epidural stimulation in spinal rabbits.

Journal: Journal of neurophysiology20100201

Title: A novel 5-HT(2A) receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: approaching early-onset antidepressants.

Journal: Pharmacology, biochemistry, and behavior20100101

Title: Psychedelics and the human receptorome.

Journal: PloS one20100101

Title: The interactions of the 5-HT3 receptor with quipazine-like arylpiperazine ligands: the journey track at the end of the first decade of the third millennium.

Journal: Current topics in medicinal chemistry20100101

Title: The emerging modern face of mood disorders: a didactic editorial with a detailed presentation of data and definitions.

Journal: Annals of general psychiatry20100101

Title: Neuroanatomical study of the A11 diencephalospinal pathway in the non-human primate.

Journal: PloS one20100101

Title: Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.

Journal: Journal of medicinal chemistry20091112

Title: Effects of serotonergic agents on survival and hemolymph composition of the larval mosquito Aedes aegypti (Diptera: Culicidae, L.) in vivo: does serotonin regulate hemolymph acid-base homeostasis?

Journal: The Journal of experimental biology20091101

Title: Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands.

Journal: The Biochemical journal20091023

Title: Physical binding pocket induction for affinity prediction.

Journal: Journal of medicinal chemistry20091008

Title: Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.

Journal: Nature neuroscience20091001

Title: Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.

Journal: Journal of medicinal chemistry20090813

Title: Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

Journal: Journal of medicinal chemistry20090611

Title: Synthesis and preliminary screening of novel N-{2-[4-(substituted)piperazin-1-yl]-2-oxoethyl}acetamides as potential atypical antipsychotic agents.

Journal: Journal of enzyme inhibition and medicinal chemistry20090601

Title: Serotonin receptor agonist quipazine promotes proliferation and apoptosis of human hepatocyte strain of L-02 strain.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT20090601

Title: Morphofunctional study of injured spinal cord of rats after activation of serotonergic receptors and motor load.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections20090101

Title: Synthesis and biological evaluation of one novel technetium-99m-labeled nitroquipazine derivative as an imaging agent for serotonin transporter.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine20081201

Title: Synthesis and preliminary pharmacological evaluation of N-2-(4-(4-(2-substitutedthiazol-4-yl) piperazin-1-yl)-2-oxoethyl)acetamides as novel atypical antipsychotic agents.

Journal: Bioorganic & medicinal chemistry letters20081201

Title: Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection.

Journal: The European journal of neuroscience20081201

Title: Effect of intrathecal administration of serotoninergic and noradrenergic drugs on postural performance in rabbits with spinal cord lesions.

Journal: Journal of neurophysiology20080801

Title: Anxiolytics may promote locomotor function recovery in spinal cord injury patients.

Journal: Neuropsychiatric disease and treatment20080801

Title: Facilitation of stepping with epidural stimulation in spinal rats: role of sensory input.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20080730

Title: Step training reinforces specific spinal locomotor circuitry in adult spinal rats.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20080716

Title: Dose dependence of the 5-HT agonist quipazine in facilitating spinal stepping in the rat with epidural stimulation.

Journal: Neuroscience letters20080627

Title: A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor.

Journal: Biochemistry20080617

Title: Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes.

Journal: The Journal of biological chemistry20080321

Title: 5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function.

Journal: European journal of pharmacology20080212

Title: Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys.

Journal: The Journal of pharmacology and experimental therapeutics20080201

Title: 5-HT-receptive structures are localized in the interblastomere cleft of Paracentrotus lividus early embryos.

Journal: Zygote (Cambridge, England)20080201

Title: Conservation of structure, signaling and pharmacology between two serotonin receptor subtypes from decapod crustaceans, Panulirus interruptus and Procambarus clarkii.

Journal: The Journal of experimental biology20080101

Title: Quantification of deficits in lateral paw positioning after spinal cord injury in dogs.

Journal: BMC veterinary research20080101

Title: Acute and constitutive increases in central serotonin levels reduce social play behaviour in peri-adolescent rats.

Journal: Psychopharmacology20071201

Title: Epidural spinal cord stimulation plus quipazine administration enable stepping in complete spinal adult rats.

Journal: Journal of neurophysiology20071101

Title: Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.

Journal: Journal of medicinal chemistry20070920

Title: Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2'-Substituted 6-nitroquipazines.

Journal: Bioorganic & medicinal chemistry20070515

Title: Presynaptic modulation of 5-HT release in the rat septal region.

Journal: Neuroscience20070511

Title: 5-HT3 receptor-mediated photic-like responses of the circadian clock in the rat.

Journal: Neuropharmacology20070201

Title: Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves).

Journal: Brazilian journal of biology = Revista brasleira de biologia20070201

Title: [Effect of local microapplication of serotoninergic drugs on membrane currents of Paracentrotus lividus early embryos].

Journal: Ontogenez20070101

Title: Implications of assist-as-needed robotic step training after a complete spinal cord injury on intrinsic strategies of motor learning.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20061011

Title: Effect of robotic-assisted treadmill training and chronic quipazine treatment on hindlimb stepping in spinally transected rats.

Journal: Journal of neurotrauma20060701

Title: Increased serotonergic functions following adminstration of 1-(1-naphthyl) piperazine in propranolol injected rats.

Journal: Pakistan journal of pharmaceutical sciences20060701

Title: Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice.

Journal: Brain research bulletin20060615

Title: Effects of 5-HT2A receptor stimulation on the discrimination of durations by rats.

Journal: Behavioural pharmacology20060201

Title: Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20051214

Title: Preclinical pharmacology of FMPD [6-fluoro-10-[3-(2-methoxyethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene]: a potential novel antipsychotic with lower histamine H1 receptor affinity than olanzapine.

Journal: The Journal of pharmacology and experimental therapeutics20051201

Title: Is the platelet serotonin transporter different in venous vs. arterial blood?

Journal: Neurochemical research20051101

Title: Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT(1A) receptor.

Journal: The Journal of pharmacy and pharmacology20051001

Title: Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on temporal differentiation: evidence for the involvement of 5-HT2A but not 5-HT3 receptors in interval timing behaviour.

Journal: Psychopharmacology20050901

Title: Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 4: 3-Alkyl-4-halo-6-nitroquipazines.

Journal: Bioorganic & medicinal chemistry20050815

Title: Long-lasting recovery of locomotor function in chronic spinal rat following chronic combined pharmacological stimulation of serotonergic receptors with 8-OHDPAT and quipazine.

Journal: Neuroscience letters20050801

Title: Hyperglycemia induced by pharmacological activation of central serotonergic pathways depends on the functional integrity of brain CRH system and 5-HT3 receptors.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme20050801

Title: N1/P2 component of auditory evoked potential reflect changes of the brain serotonin biosynthesis in rats.

Journal: Nutritional neuroscience20050801

Title: Serotonin receptor mechanisms mediate the discriminative stimulus properties of the atypical antipsychotic clozapine in C57BL/6 mice.

Journal: Psychopharmacology20050601

Title: Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2.

Journal: Journal of neurochemistry20050601

Title: The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus.

Journal: Behavioral neuroscience20050601

Title: Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome.

Journal: Dialogues in clinical neuroscience20050601

Title: Structure-affinity relationship studies on arylpiperazine derivatives related to quipazine as serotonin transporter ligands. Molecular basis of the selectivity SERT/5HT3 receptor.

Journal: Bioorganic & medicinal chemistry20050516

Title: Serotonin-related enhancement of recovery of hind limb motor functions in spinal rats after grafting of embryonic raphe nuclei.

Journal: Journal of neurotrauma20050501

Title: Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on the discrimination of durations: evidence for the involvement of 5-HT2A but not 5-HT3 receptors.

Journal: Behavioural pharmacology20050201

Title: Involvement of the retinohypothalamic tract in the photic-like effects of the serotonin agonist quipazine in the rat.

Journal: Neuroscience20050101

Title: Puerarin acts through brain serotonergic mechanisms to induce thermal effects.

Journal: Journal of pharmacological sciences20041201

Title: Developmental alterations in serotoninergic neurotransmission in Borna disease virus (BDV)-infected rats: a multidisciplinary analysis.

Journal: Journal of neurovirology20041001

Title: Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation.

Journal: The Journal of pharmacy and pharmacology20041001

Title: Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists.

Journal: Journal of computer-aided molecular design20041001

Title: Effect of valproic acid on serotonin-2A receptor signaling in C6 glioma cells.

Journal: Journal of neurochemistry20040901

Title: Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry20040901

Title: Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20040801

Title: Synergistic activation of the central pattern generator for locomotion by l-beta-3,4-dihydroxyphenylalanine and quipazine in adult paraplegic mice.

Journal: Neuroscience letters20040325

Title: Role of NMDA receptor activation in serotonin agonist-induced air-stepping in paraplegic mice.

Journal: Spinal cord20040301

Title: Turning behaviour induced by stimulation of the 5-HT receptors in the subthalamic nucleus.

Journal: The European journal of neuroscience20040101

Title: LSD, 5-HT (serotonin), and the evolution of a behavioral assay.

Journal: Neuroscience and biobehavioral reviews20040101

Title: Serotonin patterns locomotor network activity in the developing zebrafish by modulating quiescent periods.

Journal: Journal of neurobiology20031201

Title: Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter: Part 3. A potential 5-HT transporter imaging agent, 3-(3-[18F]fluoropropyl)-6-nitroquipazine.

Journal: Bioorganic & medicinal chemistry20031117

Title: 5-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat.

Journal: The European journal of neuroscience20031001

Title: Identification of two serine residues essential for agonist-induced 5-HT2A receptor desensitization.

Journal: Biochemistry20030916

Title: Biochemical evidence for the presence of serotonin transporters in the rat cochlea.

Journal: Hearing research20030801

Title: Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

Journal: Journal of medicinal chemistry20030703

Title: Role of 5-HT3 receptors in the mechanisms of central pain syndrome.

Journal: Bulletin of experimental biology and medicine20030601

Title: Response of the mouse circadian system to serotonin 1A/2/7 agonists in vivo: surprisingly little.

Journal: Journal of biological rhythms20030401

Title: Thyrotropin-releasing hormone mediates serotonin-induced secretion of GH in cattle.

Journal: Domestic animal endocrinology20030301

Title: Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter.

Journal: Bioorganic & medicinal chemistry letters20021216

Title: Novel (bisarylmethoxy)butylpiperidine analogues as neurotransmitter transporter inhibitors with activity at dopamine receptor sites.

Journal: Bioorganic & medicinal chemistry20021201

Title: Neurogenetics of emotional reactivity to stress in animals.

Journal: Dialogues in clinical neuroscience20021201

Title: Electrostatic potential surfaces of 5-HT(3)R agonists suggest accessory cation-pi site adjacent to agonist binding domain.

Journal: Bioorganic & medicinal chemistry letters20021007

Title: Effects of serotonin 1A agonist on acute spinal cord injury.

Journal: Spinal cord20021001

Title: Synthesis of a fluorine-18-labelled derivative of 6-nitroquipazine, as a radioligand for the in vivo serotonin transporter imaging with PET.

Journal: Bioorganic & medicinal chemistry20020801

Title: Metachlorophenylpiperazine (m-CPP) induced intracavernous pressure responses in anaesthetized rats.

Journal: International journal of impotence research20020801

Title: Locomotor recovery in the chronic spinal rat: effects of long-term treatment with a 5-HT2 agonist.

Journal: The European journal of neuroscience20020801

Title: PET examination of [(11)C]5-methyl-6-nitroquipazine, a radioligand for visualization of the serotonin transporter.

Journal: Nuclear medicine and biology20020801

Title: Evidence for serotonergic modulation of progesterone-induced hyperphagia, depression and algesia in female mice.

Journal: Brain research20020712

Title: Electroencephalographic activation by tacrine, deprenyl, and quipazine: cholinergic vs. non-cholinergic contributions.

Journal: European journal of pharmacology20020628

Title: The Interactions of the 5-HT(3) receptor with arylpiperazine, tropane, and quinuclidine ligands.

Journal: Current topics in medicinal chemistry20020601

Title: 5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens.

Journal: Pharmacology, biochemistry, and behavior20020501

Title: Stimulus generalization by fenfluramine in a quipazine-ketanserin drug discrimination is not dependent on indirect serotonin release.

Journal: Pharmacology, biochemistry, and behavior20020501

Title: Serotonin sets the day state in the neurons that control coupling between the optic lobe circadian pacemakers in the cricket Gryllus bimaculatus.

Journal: The Journal of experimental biology20020501

Title: Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines.

Journal: Bioorganic & medicinal chemistry letters20020311

Title: Serotonergic attenuation of the reinforcing and neurochemical effects of cocaine in squirrel monkeys.

Journal: The Journal of pharmacology and experimental therapeutics20020301

Title: Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis.

Journal: Neuropharmacology20020201

Title: Mechanisms of ligand-induced desensitization of the 5-hydroxytryptamine(2A) receptor.

Journal: The Journal of pharmacology and experimental therapeutics20020201

Title: In vitro evidence that 5-hydroxytryptamine increases efflux of glial glutamate via 5-HT(2A) receptor activation.

Journal: Journal of neuroscience research20020201

Title: Studies on modulation of feeding behavior by atypical antipsychotics in female mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry20020201

Title: RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity.

Journal: British journal of pharmacology20010901

Title: Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors.

Journal: Neuropharmacology20010801

Title: Acute trazodone and quipazine treatment attenuates apomorphine-induced aggressive behaviour in male rats without major impact on emotional behaviour or monoamine content post mortem.

Journal: Pharmacological research20010401

Title: In vitro and in vivo ligand binding to the 5HT(3) serotonin receptor characterised by time-resolved fluorescence spectroscopy.

Journal: Chembiochem : a European journal of chemical biology20010302

Title: Addition of a 5-HT receptor agonist to methylphenidate potentiates the reduction of [123I]FP-CIT binding to dopamine transporters in rat frontal cortex and hippocampus.

Journal: Synapse (New York, N.Y.)20010301

Title: Neural circuits regulating pulsatile luteinizing hormone release in the female guinea-pig: opioid, adrenergic and serotonergic interactions.

Journal: Journal of neuroendocrinology20010301

Title: Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors.

Journal: Synapse (New York, N.Y.)20000201

Title: High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.

Journal: Journal of neurochemistry19990501

Title: Chronic haloperidol produces a time- and dose-related slowing of lick rhythm in rats: implications for rodent models of tardive dyskinesia and neuroleptic-induced parkinsonism.

Journal: Psychopharmacology19980501

Title: Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.

Journal: Journal of medicinal chemistry19980226

Title: Similarities and differences between the subchronic and withdrawal effects of clozapine and olanzapine on forelimb force steadiness.

Journal: Psychopharmacology19970801

Title: Neurochemical and behavioral evidence that quipazine-ketanserin discrimination is mediated by serotonin2A receptor.

Journal: The Journal of pharmacology and experimental therapeutics19951101

Title: Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity.

Journal: The Journal of pharmacology and experimental therapeutics19951001

Title: The interaction of trichloroethanol with murine recombinant 5-HT3 receptors.

Journal: British journal of pharmacology19950401

Title: Pharmacological comparison of antipsychotic drugs and sigma-antagonists in rodents.

Journal: Pharmacology & toxicology19940101

Title: Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.

Journal: Molecular pharmacology19930301

Title: The role of the central serotonergic system in pilocarpine-induced seizures: receptor mechanisms.

Journal: Neuroscience research19891101

Title: Central antiserotonergic and antidopaminergic action of pirenperone, a putative 5-HT2 receptor antagonist.

Journal: Polish journal of pharmacology and pharmacy19850101

Title: Possible involvement of serotonergic neurons in the reduction of locomotor hyperactivity caused by amphetamine in neonatal rats depleted of brain dopamine.

Journal: Brain research19820722

Title: REM sleep deprivation changes behavioral response to catecholaminergic and serotonergic receptor activation in rats.

Journal: Pharmacology, biochemistry, and behavior19810701

Title: Effect of drugs influencing central 5-hydroxytryptaminergic mechanisms on morphine-induced catalepsy in the rat.

Journal: The Journal of pharmacy and pharmacology19790401

Title: Effect of drugs influencing central serotonergic mechanisms on haloperidol-induced catalepsy.

Journal: Psychopharmacology19790329

Title: A combination therapy of neural and glial restricted precursor cells and chronic quipazine treatment paired with passive cycling promotes quipazine-induced stepping in adult spinalized rats.

Journal: The journal of spinal cord medicine

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