481-74-3,MFCD00001208
Catalog No.:AA006WW1

481-74-3 | Chrysophanol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$7.00   $5.00
- +
100mg
98%
in stock  
$34.00   $24.00
- +
250mg
98%
in stock  
$76.00   $53.00
- +
1g
98%
in stock  
$293.00   $205.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA006WW1
Chemical Name:
Chrysophanol
CAS Number:
481-74-3
Molecular Formula:
C15H10O4
Molecular Weight:
254.2375
MDL Number:
MFCD00001208
SMILES:
Cc1cc(O)c2c(c1)C(=O)c1c(C2=O)c(O)ccc1
Properties
Properties
 
BP:
357.45°C (rough estimate)  
Form:
Solid  
MP:
194-198 °C  
Refractive Index:
1.4872 (estimate)  
Solubility:
chloroform: soluble1%  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
405  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.5  

Literature

Title: Cytochrome P450 mediated metabolic activation of chrysophanol.

Journal: Chemico-biological interactions 20180601

Title: From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20180201

Title: Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20170401

Title: The natural anthraquinones from Rheum palmatum induced the metabolic disorder of melatonin by inhibiting human CYP and SULT enzymes.

Journal: Toxicology letters 20161116

Title: In vitro glucuronidation of five rhubarb anthraquinones by intestinal and liver microsomes from humans and rats.

Journal: Chemico-biological interactions 20140805

Title: Anthraquinone profile, antioxidant and antimicrobial activity of bark extracts of Rhamnus alaternus, R. fallax, R. intermedia and R. pumila.

Journal: Food chemistry 20130115

Title: Isolation and identification of Flavobacterium columnare and Streptococcus iniae antibacterial compounds from the terrestrial plant Atraphaxis laetevirens.

Journal: Journal of agricultural and food chemistry 20121024

Title: Tautomers of anthrahydroquinones: enzymatic reduction and implications for chrysophanol, monodictyphenone, and related xanthone biosyntheses.

Journal: Journal of the American Chemical Society 20120912

Title: A strategy for detecting absorbed bioactive compounds for quality control in the water extract of rhubarb by ultra performance liquid chromatography with photodiode array detector.

Journal: Chinese journal of integrative medicine 20120901

Title: Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats.

Journal: Chinese journal of integrative medicine 20120901

Title: Juglanthraquinone C, a novel natural compound derived from Juglans mandshurica Maxim, induces S phase arrest and apoptosis in HepG2 cells.

Journal: Apoptosis : an international journal on programmed cell death 20120801

Title: Antiviral activity of Aloe hijazensis against some haemagglutinating viruses infection and its phytoconstituents.

Journal: Archives of pharmacal research 20120801

Title: Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans.

Journal: Journal of biotechnology 20120731

Title: Potential feeding deterrents found in hemlock woolly adelgid, Adelges tsugae.

Journal: Die Naturwissenschaften 20120701

Title: A note on the relevance of chrysophanol to food and anticancer research.

Journal: Molecular nutrition & food research 20120601

Title: Chrysophanol-induced necrotic-like cell death through an impaired mitochondrial ATP synthesis in Hep3B human liver cancer cells.

Journal: Archives of pharmacal research 20120501

Title: Rapid and efficient purification of chrysophanol in Rheum Palmatum LINN by supercritical fluid extraction coupled with preparative liquid chromatography in tandem.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120415

Title: [A comparative study on the absorption kinetics parameters of rhubarb free anthraquinones between normal dogs and dogs with severe acute pancreatitis].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120401

Title: Toxicology study of senna (CAS No. 8013-11-4) in C57BL/6NTAC Mice and toxicology and carcinogenesis study of senna in genetically modified C3B6.129F1/Tac-Trp53tm1Brd haploinsufficient mice (Feed Studies).

Journal: National Toxicology Program genetically modified model report 20120401

Title: Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition.

Journal: BMB reports 20120301

Title: Chemical compositions extracted from Wikstroemia indica and their multiple activities.

Journal: Pharmaceutical biology 20120201

Title: [Chemical constituents of Berchemia lineate].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20120201

Title: Two novel naphthalene glucosides and an anthraquinone isolated from Rumex dentatus and their antiproliferation activities in four cell lines.

Journal: Molecules (Basel, Switzerland) 20120117

Title: Simultaneous determination of eight anthraquinones in Semen Cassiae by HPLC-DAD.

Journal: Phytochemical analysis : PCA 20120101

Title: The tibetan uterotonic zhi byed 11: mechanisms of action, efficacy, and historical use for postpartum hemorrhage.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Rhein induces apoptosis in human breast cancer cells.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Chemical-based species classification of rhubarb using simultaneous determination of five bioactive substances by HPLC and LDA analysis.

Journal: Phytochemical analysis : PCA 20120101

Title: Comparison of dispersive liquid-liquid microextraction based on organic solvent and ionic liquid combined with high-performance liquid chromatography for the analysis of emodin and its metabolites in urine samples.

Journal: Journal of separation science 20120101

Title: Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in Caco-2 cells.

Journal: PloS one 20120101

Title: Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice.

Journal: PloS one 20120101

Title: Three new phenolic glucosides from the roots of Rheum palmatum.

Journal: Chemical & pharmaceutical bulletin 20120101

Title: Chrysophanol-8-O-glucoside, an anthraquinone derivative in rhubarb, has antiplatelet and anticoagulant activities.

Journal: Journal of pharmacological sciences 20120101

Title: Astragalin from Cassia alata induces DNA adducts in vitro and repairable DNA damage in the yeast Saccharomyces cerevisiae.

Journal: International journal of molecular sciences 20120101

Title: Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Antinociceptive activity of ethanol extract from Duguetia chrysocarpa Maas (Annonaceae).

Journal: TheScientificWorldJournal 20120101

Title: The effects of jiang-zhi-ning and its main components on cholesterol metabolism.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: [Determination of four anthraquinones in Sanhuang tablets by QAMS].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101

Title: Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.

Journal: Journal of medical microbiology 20111201

Title: Anthraquinones from the bark of Senna macranthera.

Journal: Anais da Academia Brasileira de Ciencias 20111201

Title: Potent in vivo antifungal activity against powdery mildews of pregnane glycosides from the roots of Cynanchum wilfordii.

Journal: Journal of agricultural and food chemistry 20111123

Title: Development of a liquid chromatography tandem mass spectrometry method for simultaneous determination of eight adulterants in slimming functional foods.

Journal: Journal of chromatography. A 20111021

Title: Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats.

Journal: Journal of ethnopharmacology 20111011

Title: A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract.

Journal: Journal of ethnopharmacology 20111011

Title: Simultaneous quantification of twelve active components in Yiqing granule by ultra-performance liquid chromatography: application to quality control study.

Journal: Biomedical chromatography : BMC 20110901

Title: Anthraquinone profile, antioxidant and antimicrobial properties of bark extracts of Rhamnus catharticus and R. orbiculatus.

Journal: Natural product communications 20110901

Title: [Study on chemical constituents from the root of Hemerocallis citrina].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110901

Title: The use of response surface methodology to optimize the ultrasound-assisted extraction of five anthraquinones from Rheum palmatum L.

Journal: Molecules (Basel, Switzerland) 20110715

Title: [Chemical constituents of Carya cathayensis and their antitumor bioactivity].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110701

Title: Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway.

Journal: Phytotherapy research : PTR 20110601

Title: Inhibitory effect of a bioactivity-guided fraction from Rheum undulatum on the acid production of Streptococcus mutans biofilms at sub-MIC levels.

Journal: Fitoterapia 20110401

Title: Novel methodology for the extraction and identification of natural dyestuffs in historical textiles by HPLC-UV-Vis-ESI MS. Case study: chasubles from the Wawel Cathedral collection.

Journal: Analytical and bioanalytical chemistry 20110301

Title: [Studies on identification and secondary metabolites of endophytic fungi strain E8 from Curcuma wenyujin].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110301

Title: The Apoptotic Effect of the Hexane Extract of Rheum undulatum L. in Oral Cancer Cells through the Down-regulation of Specificity Protein 1 and Survivin.

Journal: Laboratory animal research 20110301

Title: Preparative isolation of three anthraquinones from Rumex japonicus by high-speed counter-current chromatography.

Journal: Molecules (Basel, Switzerland) 20110127

Title: Metabolism and pharmacokinetics of san-huang-xie-xin-tang, a polyphenol-rich chinese medicine formula, in rats and ex-vivo antioxidant activity.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones.

Journal: Bioorganic & medicinal chemistry 20110101

Title: Emodin Induces Apoptotic Death in Murine Myelomonocytic Leukemia WEHI-3 Cells In Vitro and Enhances Phagocytosis in Leukemia Mice In Vivo.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol-Induced Toxicity in HepG2/CYP2E1 Cells.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury.

Journal: PloS one 20110101

Title: Is propolis safe as an alternative medicine?

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: Anthraquinones of Cissus populnea Guill & Perr (Amplidaceae).

Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM 20110101

Title: [The secondary metabolites of the HS-3 Alternaria sp. fungus associated with holothurians].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20101201

Title: Anti-Inflammatory activity of chrysophanol through the suppression of NF-kappaB/caspase-1 activation in vitro and in vivo.

Journal: Molecules (Basel, Switzerland) 20100916

Title: [Antimicrobial activity and chemical differences between the two chemotypes of rhubarbs].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100901

Title: Temperature-assisted ionic liquid dispersive liquid-liquid microextraction combined with high performance liquid chromatography for the determination of anthraquinones in Radix et Rhizoma Rhei samples.

Journal: Talanta 20100815

Title: Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers.

Journal: Journal of pharmaceutical and biomedical analysis 20100801

Title: [Determination of aurantio-obtusin and chrysophanol in cassiae semen by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100801

Title: Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells.

Journal: Molecular nutrition & food research 20100701

Title: Qualitative and quantitative analysis of anthraquinone derivatives in rhizomes of tissue culture-raised Rheum emodi Wall. plants.

Journal: Journal of plant physiology 20100615

Title: Cassia occidentalis L.: a review on its ethnobotany, phytochemical and pharmacological profile.

Journal: Fitoterapia 20100601

Title: Ultrasonic cell grinder extraction of anthraquinones from radix et rhizoma Rhei and determination by ultra-performance liquid chromatography.

Journal: Journal of separation science 20100601

Title: [Chemical constituents of Discocleidion rufescens].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100601

Title: A new bianthracene C-arabinopyranoside from Senna septemtrionalis.

Journal: Natural product communications 20100501

Title: [Studies on the chemical constituents of Kalimeris indica].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100401

Title: [Liposomal encapsulation of free anthraquinones in rhizoma et radix rhei and its quality control].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100401

Title: Qualitative and quantitative analysis of traditional Chinese medicine Niu Huang Jie Du Pill using ultra performance liquid chromatography coupled with tunable UV detector and rapid resolution liquid chromatography coupled with time-of-flight tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20100205

Title: [Rationality of commercial specification of rhubarb based on chemical analysis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100201

Title: Comparison of three different extraction methods and HPLC determination of the anthraquinones aloe-emodine, emodine, rheine, chrysophanol and physcione in the bark of Rhamnus alpinus L. (Rhamnaceae).

Journal: Phytochemical analysis : PCA 20100101

Title: [Chemical constituents from petroleum ether fraction of ethanol extract of Acorus tatarinowii].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

Title: Comparison of raw and processed Radix Polygoni Multiflori (Heshouwu) by high performance liquid chromatography and mass spectrometry.

Journal: Chinese medicine 20100101

Title: Pharmacological properties of the ethanol extract of Muehlenbeckia platyclada (F. Muell.) meisn. leaves.

Journal: International journal of molecular sciences 20100101

Title: Protective effect of the daming capsule on impaired baroreflexes in STZ-induced diabetic rats with hyperlipoidemia.

Journal: BMC complementary and alternative medicine 20100101

Title: Evaluation of extracts from Coccoloba mollis using the Salmonella/microsome system and in vivo tests.

Journal: Genetics and molecular biology 20100101

Title: Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components.

Journal: World journal of gastroenterology 20091221

Title: Multiple convergence in polyketide biosynthesis: a third folding mode to the anthraquinone chrysophanol.

Journal: Chemical communications (Cambridge, England) 20091128

Title: Metabolism and pharmacokinetics of anthraquinones in Rheum palmatum in rats and ex vivo antioxidant activity.

Journal: Planta medica 20091001

Title: Induction of defence mechanisms in grapevine leaves by emodin- and anthraquinone-rich plant extracts and their conferred resistance to downy mildew.

Journal: Plant physiology and biochemistry : PPB 20090901

Title: Study on the anthraquinones separated from the cultivation of Trichoderma harzianum strain Th-R16 and their biological activity.

Journal: Journal of agricultural and food chemistry 20090826

Title: Effective constituents in Xiexin Decoction for anti-inflammation.

Journal: Journal of ethnopharmacology 20090817

Title: [Anthraquinone contents in five processed products from Rheum palamatum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801

Title: [Effect of processing on the chemical contents and hepatic and renal toxicity of rhubarb studied by canonical correlation analysis].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090801

Title: Simultaneous determination of the 10 major components of Da-Cheng-Qi decoction in dog plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090715

Title: A TD-DFT study on the photo-physicochemical properties of chrysophanol from rheum.

Journal: International journal of molecular sciences 20090701

Title: [Identification and determination of major constituents in Polygonum cuspidatum Sieb. et Zucc. by high performance liquid chromatography/electrospray ionization-ion trap-time-of-flight mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20090701

Title: High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.

Journal: Journal of medicinal chemistry 20090625

Title: Investigations of free anthraquinones from rhubarb against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats.

Journal: Basic & clinical pharmacology & toxicology 20090601

Title: Factors affecting the production of Trichoderma harzianum secondary metabolites during the interaction with different plant pathogens.

Journal: Letters in applied microbiology 20090601

Title: [Simultaneous determination of anthraquinones in Liuwei'anxiao capsules by HPLC].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090601

Title: Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Journal: Journal of bioscience and bioengineering 20090301

Title: Quantitative HPLC determination and extraction of anthraquinones in Senna alata leaves.

Journal: Journal of chromatographic science 20090301

Title: [Study on the optimal extracion craft of Xiaochuang gel by central composite design-response surface methodology].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090301

Title: Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.

Journal: Analytica chimica acta 20090202

Title: Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro.

Journal: Journal of enzyme inhibition and medicinal chemistry 20090201

Title: Profiling the metabolic differences of anthraquinone derivatives using liquid chromatography/tandem mass spectrometry with data-dependent acquisition.

Journal: Rapid communications in mass spectrometry : RCM 20090201

Title: Natural products as promising drug candidates for the treatment of hepatitis B and C.

Journal: Acta pharmacologica Sinica 20090101

Title: [Studies on chemical constituents of roasted seeds of Cassia obtusifolia].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090101

Title: Ultrasonic extraction and HPLC determination of anthraquinones, aloe-emodine, emodine, rheine, chrysophanol and physcione, in roots of Polygoni multiflori.

Journal: Phytochemical analysis : PCA 20090101

Title: New bioactive compounds from Aloe hijazensis.

Journal: Natural product research 20090101

Title: Convergence in the biosynthesis of acetogenic natural products from plants, fungi, and bacteria.

Journal: Phytochemistry 20090101

Title: Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats.

Journal: Diabetology & metabolic syndrome 20090101

Title: Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models.

Journal: Nutrition research and practice 20090101

Title: Is senna laxative use associated to cathartic colon, genotoxicity, or carcinogenicity?

Journal: Journal of toxicology 20090101

Title: Antitumor and antimetastatic actions of anthrone-C-glucoside, cassialoin isolated from Cassia garrettiana heartwood in colon 26-bearing mice.

Journal: Cancer science 20081101

Title: Anti-diabetic properties of chrysophanol and its glucoside from rhubarb rhizome.

Journal: Biological & pharmaceutical bulletin 20081101

Title: Anthraquinone-benzisochromanquinone dimers from the roots of Berchemia floribunda.

Journal: Chemical & pharmaceutical bulletin 20080901

Title: Development and validation of a UPLC method for quality control of rhubarb-based medicine: fast simultaneous determination of five anthraquinone derivatives.

Journal: Journal of pharmaceutical and biomedical analysis 20080805

Title: Uredinorubellins and caeruleoramularin, photodynamically active anthraquinone derivatives produced by two species of the genus ramularia.

Journal: Journal of natural products 20080801

Title: Phenols from the roots of Rheum palmatum attenuate chemotaxis in rat hepatic stellate cells.

Journal: Planta medica 20080801

Title: [Studies on chemical constituents from rattan of Polygonum multiflorum].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080801

Title: Simultaneous determination of anthraquinones in radix Polygoni multiflori by capillary gas chromatography coupled with flame ionization and mass spectrometric detection.

Journal: Journal of chromatography. A 20080718

Title: Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives.

Journal: Bioorganic & medicinal chemistry letters 20080715

Title: Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671.

Journal: The Journal of antibiotics 20080701

Title: Study of interactions of anthraquinones with DNA using ethidium bromide as a fluorescence probe.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080601

Title: Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones.

Journal: European journal of medicinal chemistry 20080601

Title: Anti-proliferative effects of estrogen receptor-modulating compounds isolated from Rheum palmatum.

Journal: Archives of pharmacal research 20080601

Title: Novel bioactive metabolites from a marine derived bacterium Nocardia sp. ALAA 2000.

Journal: The Journal of antibiotics 20080601

Title: Lipoxygenase inhibitory constituents from rhubarb.

Journal: Archives of pharmacal research 20080501

Title: [Studies on chemical constituents and volatile oil of Xiaochengqi decoction].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501

Title: Preparation of 1,8-di-O-alkylaloe-emodins and 15-amino-, 15-thiocyano-, and 15-selenocyanochrysophanol derivatives from aloe-emodin and studying their cytotoxic effects.

Journal: Chemical & pharmaceutical bulletin 20080401

Title: Purification of hydroxyanthraquinones and cinnamic acid from the roots of Rheum officinale Baill.

Journal: Journal of separation science 20080201

Title: [Novel exploration of cathartic pharmacology induced by rhubarb].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201

Title: [The studies on the Ku Huang granula technology].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080201

Title: Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography.

Journal: Talanta 20080115

Title: Optimization and validation of a chromatographic method for the simultaneous quantification of six bioactive compounds in Rhizoma et Radix Polygoni Cuspidati.

Journal: The Journal of pharmacy and pharmacology 20080101

Title: Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants.

Journal: Journal of natural products 20080101

Title: Paeciloxanthone, a new cytotoxic xanthone from the marine mangrove fungus Paecilomyces sp. (Tree1-7).

Journal: Journal of Asian natural products research 20080101

Title: Simultaneous determination of eight major bioactive compounds in Dachengqi Tang (DT) by high-performance liquid chromatography.

Journal: Chinese medicine 20080101

Title: Anthraquinone pharmacokinetics in Xiexin decoction and the different combinations of its constituent herbs.

Journal: European journal of drug metabolism and pharmacokinetics 20080101

Title: Effect of butanol fraction from Cassia tora L. seeds on glycemic control and insulin secretion in diabetic rats.

Journal: Nutrition research and practice 20080101

Title: Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin.

Journal: Nutrition research and practice 20080101

Title: Large-scale separation of hydroxyanthraquinones from Rheum palmatum L. by pH-zone-refining counter-current chromatography.

Journal: Journal of chromatography. A 20071228

Title: Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase.

Journal: Biological & pharmaceutical bulletin 20071101

Title: In situ synthesis of molecularly imprinted polymers on glass microspheres in a column.

Journal: Analytical and bioanalytical chemistry 20071001

Title: [Study on correlation of soil nutrients and content of active constituents in root of Rumex gmelini].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071001

Title: Simultaneous determination and pharmacokinetic studies of aloe emodin and chrysophanol in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography.

Journal: Biomedical chromatography : BMC 20070701

Title: Monodictyquinone A: a new antimicrobial anthraquinone from a sea urchin-derived fungus Monodictys sp.

Journal: Chemical & pharmaceutical bulletin 20070701

Title: Cellular absorption of anthraquinones emodin and chrysophanol in human intestinal Caco-2 cells.

Journal: Bioscience, biotechnology, and biochemistry 20070701

Title: Antiprotozoal activity of Senna racemosa.

Journal: Journal of ethnopharmacology 20070613

Title: Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis.

Journal: Journal of natural products 20070601

Title: Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb.

Journal: Natural product research 20070520

Title: Simultaneous quantification of five anthraquinones in rat plasma by high-performance liquid chromatography with fluorescence detection.

Journal: Biomedical chromatography : BMC 20070501

Title: Synergistic interaction of physcion and chrysophanol on plant powdery mildew.

Journal: Pest management science 20070501

Title: Application of 1-alkyl-3-methylimidazolium-based ionic liquids as background electrolyte in capillary zone electrophoresis for the simultaneous determination of five anthraquinones in Rhubarb.

Journal: Talanta 20070430

Title: Polyketide folding in higher plants: biosynthesis of the phenylanthraquinone knipholone.

Journal: The Journal of organic chemistry 20070427

Title: Efficient isolation of anthraquinone-derivatives from Trichoderma harzianum ETS 323.

Journal: Journal of biochemical and biophysical methods 20070410

Title: [Comparative study on in vitro drug-release between Tuizhang ophthalmic gel and Tuizhang oculentum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401

Title: Simultaneous determination of anthraquinones in rhubarb by high-performance liquid chromatography and capillary electrophoresis.

Journal: Journal of chromatography. A 20070323

Title: Chemical constituents from the roots of Homonoia riparia.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070301

Title: Simultaneous analysis of eight bioactive compounds in Danning tablet by HPLC-ESI-MS and HPLC-UV.

Journal: Journal of pharmaceutical and biomedical analysis 20070219

Title: Simultaneous determination of eight active components in Chinese medicine 'YIQING' capsule using high-performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20070104

Title: Rapid separation and determination of structurally related anthraquinones in Rhubarb by pressurized capillary electrochromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20070104

Title: Ferulic acid esters from Euphorbia hylonoma.

Journal: Fitoterapia 20070101

Title: Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine.

Journal: Journal of ethnobiology and ethnomedicine 20070101

Title: Preparative isolation and purification of hydroxyanthraquinones from Rheum tanguticum Maxim. on normal phase silica gel: using a Flash Master Personal system.

Journal: Preparative biochemistry & biotechnology 20070101

Title: Identification of natural compounds with anti-hepatitis B virus activity from Rheum palmatum L. ethanol extract.

Journal: Chemotherapy 20070101

Title: [Comparative studies on purgative potency among three spieces of certified rhubarb].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

Title: Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L.

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Journal: Electrophoresis 20050501

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Journal: Chemical & pharmaceutical bulletin 20050501

Title: PTP1B inhibitors from Ardisia japonica.

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Title: Analysis of the anthraquinones aloe-emodin and aloin by gas chromatography/mass spectrometry.

Journal: International immunopharmacology 20041220

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Title: Chrysophanol glycosides from callus cultures of monocotyledonous Kniphofia spp. (Asphodelaceae).

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SDS
Tags:481-74-3 Molecular Formula|481-74-3 MDL|481-74-3 SMILES|481-74-3 Chrysophanol
Catalog No.: AA006WW1
481-74-3,MFCD00001208
481-74-3 | Chrysophanol
Pack Size: 1mg
Purity: 98%
in stock
$7.00 $5.00
Pack Size: 100mg
Purity: 98%
in stock
$34.00 $24.00
Pack Size: 250mg
Purity: 98%
in stock
$76.00 $53.00
Pack Size: 1g
Purity: 98%
in stock
$293.00 $205.00
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Technical Information
Catalog Number: AA006WW1
Chemical Name: Chrysophanol
CAS Number: 481-74-3
Molecular Formula: C15H10O4
Molecular Weight: 254.2375
MDL Number: MFCD00001208
SMILES: Cc1cc(O)c2c(c1)C(=O)c1c(C2=O)c(O)ccc1
Properties
BP: 357.45°C (rough estimate)  
Form: Solid  
MP: 194-198 °C  
Refractive Index: 1.4872 (estimate)  
Solubility: chloroform: soluble1%  
Storage: Inert atmosphere;Room Temperature;  
Complexity: 405  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 19  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.5  
Literature fold

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Title: From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity.

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Title: Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes.

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Title: The natural anthraquinones from Rheum palmatum induced the metabolic disorder of melatonin by inhibiting human CYP and SULT enzymes.

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Title: In vitro glucuronidation of five rhubarb anthraquinones by intestinal and liver microsomes from humans and rats.

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Title: Isolation and identification of Flavobacterium columnare and Streptococcus iniae antibacterial compounds from the terrestrial plant Atraphaxis laetevirens.

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Title: Tautomers of anthrahydroquinones: enzymatic reduction and implications for chrysophanol, monodictyphenone, and related xanthone biosyntheses.

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Title: A strategy for detecting absorbed bioactive compounds for quality control in the water extract of rhubarb by ultra performance liquid chromatography with photodiode array detector.

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Title: Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats.

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Title: Juglanthraquinone C, a novel natural compound derived from Juglans mandshurica Maxim, induces S phase arrest and apoptosis in HepG2 cells.

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Title: Antiviral activity of Aloe hijazensis against some haemagglutinating viruses infection and its phytoconstituents.

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Title: Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans.

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Title: Potential feeding deterrents found in hemlock woolly adelgid, Adelges tsugae.

Journal: Die Naturwissenschaften20120701

Title: A note on the relevance of chrysophanol to food and anticancer research.

Journal: Molecular nutrition & food research20120601

Title: Chrysophanol-induced necrotic-like cell death through an impaired mitochondrial ATP synthesis in Hep3B human liver cancer cells.

Journal: Archives of pharmacal research20120501

Title: Rapid and efficient purification of chrysophanol in Rheum Palmatum LINN by supercritical fluid extraction coupled with preparative liquid chromatography in tandem.

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Title: [A comparative study on the absorption kinetics parameters of rhubarb free anthraquinones between normal dogs and dogs with severe acute pancreatitis].

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Title: Toxicology study of senna (CAS No. 8013-11-4) in C57BL/6NTAC Mice and toxicology and carcinogenesis study of senna in genetically modified C3B6.129F1/Tac-Trp53tm1Brd haploinsufficient mice (Feed Studies).

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Title: Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition.

Journal: BMB reports20120301

Title: Chemical compositions extracted from Wikstroemia indica and their multiple activities.

Journal: Pharmaceutical biology20120201

Title: [Chemical constituents of Berchemia lineate].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20120201

Title: Two novel naphthalene glucosides and an anthraquinone isolated from Rumex dentatus and their antiproliferation activities in four cell lines.

Journal: Molecules (Basel, Switzerland)20120117

Title: Simultaneous determination of eight anthraquinones in Semen Cassiae by HPLC-DAD.

Journal: Phytochemical analysis : PCA20120101

Title: The tibetan uterotonic zhi byed 11: mechanisms of action, efficacy, and historical use for postpartum hemorrhage.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Rhein induces apoptosis in human breast cancer cells.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Chemical-based species classification of rhubarb using simultaneous determination of five bioactive substances by HPLC and LDA analysis.

Journal: Phytochemical analysis : PCA20120101

Title: Comparison of dispersive liquid-liquid microextraction based on organic solvent and ionic liquid combined with high-performance liquid chromatography for the analysis of emodin and its metabolites in urine samples.

Journal: Journal of separation science20120101

Title: Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in Caco-2 cells.

Journal: PloS one20120101

Title: Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice.

Journal: PloS one20120101

Title: Three new phenolic glucosides from the roots of Rheum palmatum.

Journal: Chemical & pharmaceutical bulletin20120101

Title: Chrysophanol-8-O-glucoside, an anthraquinone derivative in rhubarb, has antiplatelet and anticoagulant activities.

Journal: Journal of pharmacological sciences20120101

Title: Astragalin from Cassia alata induces DNA adducts in vitro and repairable DNA damage in the yeast Saccharomyces cerevisiae.

Journal: International journal of molecular sciences20120101

Title: Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Antinociceptive activity of ethanol extract from Duguetia chrysocarpa Maas (Annonaceae).

Journal: TheScientificWorldJournal20120101

Title: The effects of jiang-zhi-ning and its main components on cholesterol metabolism.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: [Determination of four anthraquinones in Sanhuang tablets by QAMS].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20120101

Title: Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.

Journal: Journal of medical microbiology20111201

Title: Anthraquinones from the bark of Senna macranthera.

Journal: Anais da Academia Brasileira de Ciencias20111201

Title: Potent in vivo antifungal activity against powdery mildews of pregnane glycosides from the roots of Cynanchum wilfordii.

Journal: Journal of agricultural and food chemistry20111123

Title: Development of a liquid chromatography tandem mass spectrometry method for simultaneous determination of eight adulterants in slimming functional foods.

Journal: Journal of chromatography. A20111021

Title: Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats.

Journal: Journal of ethnopharmacology20111011

Title: A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract.

Journal: Journal of ethnopharmacology20111011

Title: Simultaneous quantification of twelve active components in Yiqing granule by ultra-performance liquid chromatography: application to quality control study.

Journal: Biomedical chromatography : BMC20110901

Title: Anthraquinone profile, antioxidant and antimicrobial properties of bark extracts of Rhamnus catharticus and R. orbiculatus.

Journal: Natural product communications20110901

Title: [Study on chemical constituents from the root of Hemerocallis citrina].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20110901

Title: The use of response surface methodology to optimize the ultrasound-assisted extraction of five anthraquinones from Rheum palmatum L.

Journal: Molecules (Basel, Switzerland)20110715

Title: [Chemical constituents of Carya cathayensis and their antitumor bioactivity].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20110701

Title: Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway.

Journal: Phytotherapy research : PTR20110601

Title: Inhibitory effect of a bioactivity-guided fraction from Rheum undulatum on the acid production of Streptococcus mutans biofilms at sub-MIC levels.

Journal: Fitoterapia20110401

Title: Novel methodology for the extraction and identification of natural dyestuffs in historical textiles by HPLC-UV-Vis-ESI MS. Case study: chasubles from the Wawel Cathedral collection.

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Title: [Studies on identification and secondary metabolites of endophytic fungi strain E8 from Curcuma wenyujin].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20110301

Title: The Apoptotic Effect of the Hexane Extract of Rheum undulatum L. in Oral Cancer Cells through the Down-regulation of Specificity Protein 1 and Survivin.

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Title: Preparative isolation of three anthraquinones from Rumex japonicus by high-speed counter-current chromatography.

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Title: Metabolism and pharmacokinetics of san-huang-xie-xin-tang, a polyphenol-rich chinese medicine formula, in rats and ex-vivo antioxidant activity.

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Title: Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones.

Journal: Bioorganic & medicinal chemistry20110101

Title: Emodin Induces Apoptotic Death in Murine Myelomonocytic Leukemia WEHI-3 Cells In Vitro and Enhances Phagocytosis in Leukemia Mice In Vivo.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol-Induced Toxicity in HepG2/CYP2E1 Cells.

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Title: Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury.

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Title: Is propolis safe as an alternative medicine?

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Title: Anthraquinones of Cissus populnea Guill & Perr (Amplidaceae).

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Title: [The secondary metabolites of the HS-3 Alternaria sp. fungus associated with holothurians].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20101201

Title: Anti-Inflammatory activity of chrysophanol through the suppression of NF-kappaB/caspase-1 activation in vitro and in vivo.

Journal: Molecules (Basel, Switzerland)20100916

Title: [Antimicrobial activity and chemical differences between the two chemotypes of rhubarbs].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20100901

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Journal: Talanta20100815

Title: Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers.

Journal: Journal of pharmaceutical and biomedical analysis20100801

Title: [Determination of aurantio-obtusin and chrysophanol in cassiae semen by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20100801

Title: Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells.

Journal: Molecular nutrition & food research20100701

Title: Qualitative and quantitative analysis of anthraquinone derivatives in rhizomes of tissue culture-raised Rheum emodi Wall. plants.

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Title: Cassia occidentalis L.: a review on its ethnobotany, phytochemical and pharmacological profile.

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Title: [Chemical constituents of Discocleidion rufescens].

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Title: [Studies on the chemical constituents of Kalimeris indica].

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Title: [Liposomal encapsulation of free anthraquinones in rhizoma et radix rhei and its quality control].

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Title: Qualitative and quantitative analysis of traditional Chinese medicine Niu Huang Jie Du Pill using ultra performance liquid chromatography coupled with tunable UV detector and rapid resolution liquid chromatography coupled with time-of-flight tandem mass spectrometry.

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Title: [Chemical constituents from petroleum ether fraction of ethanol extract of Acorus tatarinowii].

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Title: Comparison of raw and processed Radix Polygoni Multiflori (Heshouwu) by high performance liquid chromatography and mass spectrometry.

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Title: Pharmacological properties of the ethanol extract of Muehlenbeckia platyclada (F. Muell.) meisn. leaves.

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Title: Protective effect of the daming capsule on impaired baroreflexes in STZ-induced diabetic rats with hyperlipoidemia.

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Title: Evaluation of extracts from Coccoloba mollis using the Salmonella/microsome system and in vivo tests.

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Title: Induction of defence mechanisms in grapevine leaves by emodin- and anthraquinone-rich plant extracts and their conferred resistance to downy mildew.

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Title: Study on the anthraquinones separated from the cultivation of Trichoderma harzianum strain Th-R16 and their biological activity.

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Title: Effective constituents in Xiexin Decoction for anti-inflammation.

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Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20090801

Title: [Effect of processing on the chemical contents and hepatic and renal toxicity of rhubarb studied by canonical correlation analysis].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20090801

Title: Simultaneous determination of the 10 major components of Da-Cheng-Qi decoction in dog plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20090715

Title: A TD-DFT study on the photo-physicochemical properties of chrysophanol from rheum.

Journal: International journal of molecular sciences20090701

Title: [Identification and determination of major constituents in Polygonum cuspidatum Sieb. et Zucc. by high performance liquid chromatography/electrospray ionization-ion trap-time-of-flight mass spectrometry].

Journal: Se pu = Chinese journal of chromatography20090701

Title: High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.

Journal: Journal of medicinal chemistry20090625

Title: Investigations of free anthraquinones from rhubarb against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats.

Journal: Basic & clinical pharmacology & toxicology20090601

Title: Factors affecting the production of Trichoderma harzianum secondary metabolites during the interaction with different plant pathogens.

Journal: Letters in applied microbiology20090601

Title: [Simultaneous determination of anthraquinones in Liuwei'anxiao capsules by HPLC].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20090601

Title: Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Journal: Journal of bioscience and bioengineering20090301

Title: Quantitative HPLC determination and extraction of anthraquinones in Senna alata leaves.

Journal: Journal of chromatographic science20090301

Title: [Study on the optimal extracion craft of Xiaochuang gel by central composite design-response surface methodology].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20090301

Title: Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.

Journal: Analytica chimica acta20090202

Title: Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro.

Journal: Journal of enzyme inhibition and medicinal chemistry20090201

Title: Profiling the metabolic differences of anthraquinone derivatives using liquid chromatography/tandem mass spectrometry with data-dependent acquisition.

Journal: Rapid communications in mass spectrometry : RCM20090201

Title: Natural products as promising drug candidates for the treatment of hepatitis B and C.

Journal: Acta pharmacologica Sinica20090101

Title: [Studies on chemical constituents of roasted seeds of Cassia obtusifolia].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20090101

Title: Ultrasonic extraction and HPLC determination of anthraquinones, aloe-emodine, emodine, rheine, chrysophanol and physcione, in roots of Polygoni multiflori.

Journal: Phytochemical analysis : PCA20090101

Title: New bioactive compounds from Aloe hijazensis.

Journal: Natural product research20090101

Title: Convergence in the biosynthesis of acetogenic natural products from plants, fungi, and bacteria.

Journal: Phytochemistry20090101

Title: Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats.

Journal: Diabetology & metabolic syndrome20090101

Title: Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models.

Journal: Nutrition research and practice20090101

Title: Is senna laxative use associated to cathartic colon, genotoxicity, or carcinogenicity?

Journal: Journal of toxicology20090101

Title: Antitumor and antimetastatic actions of anthrone-C-glucoside, cassialoin isolated from Cassia garrettiana heartwood in colon 26-bearing mice.

Journal: Cancer science20081101

Title: Anti-diabetic properties of chrysophanol and its glucoside from rhubarb rhizome.

Journal: Biological & pharmaceutical bulletin20081101

Title: Anthraquinone-benzisochromanquinone dimers from the roots of Berchemia floribunda.

Journal: Chemical & pharmaceutical bulletin20080901

Title: Development and validation of a UPLC method for quality control of rhubarb-based medicine: fast simultaneous determination of five anthraquinone derivatives.

Journal: Journal of pharmaceutical and biomedical analysis20080805

Title: Uredinorubellins and caeruleoramularin, photodynamically active anthraquinone derivatives produced by two species of the genus ramularia.

Journal: Journal of natural products20080801

Title: Phenols from the roots of Rheum palmatum attenuate chemotaxis in rat hepatic stellate cells.

Journal: Planta medica20080801

Title: [Studies on chemical constituents from rattan of Polygonum multiflorum].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20080801

Title: Simultaneous determination of anthraquinones in radix Polygoni multiflori by capillary gas chromatography coupled with flame ionization and mass spectrometric detection.

Journal: Journal of chromatography. A20080718

Title: Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives.

Journal: Bioorganic & medicinal chemistry letters20080715

Title: Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671.

Journal: The Journal of antibiotics20080701

Title: Study of interactions of anthraquinones with DNA using ethidium bromide as a fluorescence probe.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20080601

Title: Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones.

Journal: European journal of medicinal chemistry20080601

Title: Anti-proliferative effects of estrogen receptor-modulating compounds isolated from Rheum palmatum.

Journal: Archives of pharmacal research20080601

Title: Novel bioactive metabolites from a marine derived bacterium Nocardia sp. ALAA 2000.

Journal: The Journal of antibiotics20080601

Title: Lipoxygenase inhibitory constituents from rhubarb.

Journal: Archives of pharmacal research20080501

Title: [Studies on chemical constituents and volatile oil of Xiaochengqi decoction].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20080501

Title: Preparation of 1,8-di-O-alkylaloe-emodins and 15-amino-, 15-thiocyano-, and 15-selenocyanochrysophanol derivatives from aloe-emodin and studying their cytotoxic effects.

Journal: Chemical & pharmaceutical bulletin20080401

Title: Purification of hydroxyanthraquinones and cinnamic acid from the roots of Rheum officinale Baill.

Journal: Journal of separation science20080201

Title: [Novel exploration of cathartic pharmacology induced by rhubarb].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20080201

Title: [The studies on the Ku Huang granula technology].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20080201

Title: Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography.

Journal: Talanta20080115

Title: Optimization and validation of a chromatographic method for the simultaneous quantification of six bioactive compounds in Rhizoma et Radix Polygoni Cuspidati.

Journal: The Journal of pharmacy and pharmacology20080101

Title: Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants.

Journal: Journal of natural products20080101

Title: Paeciloxanthone, a new cytotoxic xanthone from the marine mangrove fungus Paecilomyces sp. (Tree1-7).

Journal: Journal of Asian natural products research20080101

Title: Simultaneous determination of eight major bioactive compounds in Dachengqi Tang (DT) by high-performance liquid chromatography.

Journal: Chinese medicine20080101

Title: Anthraquinone pharmacokinetics in Xiexin decoction and the different combinations of its constituent herbs.

Journal: European journal of drug metabolism and pharmacokinetics20080101

Title: Effect of butanol fraction from Cassia tora L. seeds on glycemic control and insulin secretion in diabetic rats.

Journal: Nutrition research and practice20080101

Title: Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin.

Journal: Nutrition research and practice20080101

Title: Large-scale separation of hydroxyanthraquinones from Rheum palmatum L. by pH-zone-refining counter-current chromatography.

Journal: Journal of chromatography. A20071228

Title: Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase.

Journal: Biological & pharmaceutical bulletin20071101

Title: In situ synthesis of molecularly imprinted polymers on glass microspheres in a column.

Journal: Analytical and bioanalytical chemistry20071001

Title: [Study on correlation of soil nutrients and content of active constituents in root of Rumex gmelini].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20071001

Title: Simultaneous determination and pharmacokinetic studies of aloe emodin and chrysophanol in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography.

Journal: Biomedical chromatography : BMC20070701

Title: Monodictyquinone A: a new antimicrobial anthraquinone from a sea urchin-derived fungus Monodictys sp.

Journal: Chemical & pharmaceutical bulletin20070701

Title: Cellular absorption of anthraquinones emodin and chrysophanol in human intestinal Caco-2 cells.

Journal: Bioscience, biotechnology, and biochemistry20070701

Title: Antiprotozoal activity of Senna racemosa.

Journal: Journal of ethnopharmacology20070613

Title: Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis.

Journal: Journal of natural products20070601

Title: Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb.

Journal: Natural product research20070520

Title: Simultaneous quantification of five anthraquinones in rat plasma by high-performance liquid chromatography with fluorescence detection.

Journal: Biomedical chromatography : BMC20070501

Title: Synergistic interaction of physcion and chrysophanol on plant powdery mildew.

Journal: Pest management science20070501

Title: Application of 1-alkyl-3-methylimidazolium-based ionic liquids as background electrolyte in capillary zone electrophoresis for the simultaneous determination of five anthraquinones in Rhubarb.

Journal: Talanta20070430

Title: Polyketide folding in higher plants: biosynthesis of the phenylanthraquinone knipholone.

Journal: The Journal of organic chemistry20070427

Title: Efficient isolation of anthraquinone-derivatives from Trichoderma harzianum ETS 323.

Journal: Journal of biochemical and biophysical methods20070410

Title: [Comparative study on in vitro drug-release between Tuizhang ophthalmic gel and Tuizhang oculentum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20070401

Title: Simultaneous determination of anthraquinones in rhubarb by high-performance liquid chromatography and capillary electrophoresis.

Journal: Journal of chromatography. A20070323

Title: Chemical constituents from the roots of Homonoia riparia.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20070301

Title: Simultaneous analysis of eight bioactive compounds in Danning tablet by HPLC-ESI-MS and HPLC-UV.

Journal: Journal of pharmaceutical and biomedical analysis20070219

Title: Simultaneous determination of eight active components in Chinese medicine 'YIQING' capsule using high-performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis20070104

Title: Rapid separation and determination of structurally related anthraquinones in Rhubarb by pressurized capillary electrochromatography.

Journal: Journal of pharmaceutical and biomedical analysis20070104

Title: Ferulic acid esters from Euphorbia hylonoma.

Journal: Fitoterapia20070101

Title: Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine.

Journal: Journal of ethnobiology and ethnomedicine20070101

Title: Preparative isolation and purification of hydroxyanthraquinones from Rheum tanguticum Maxim. on normal phase silica gel: using a Flash Master Personal system.

Journal: Preparative biochemistry & biotechnology20070101

Title: Identification of natural compounds with anti-hepatitis B virus activity from Rheum palmatum L. ethanol extract.

Journal: Chemotherapy20070101

Title: [Comparative studies on purgative potency among three spieces of certified rhubarb].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20061201

Title: Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L.

Journal: Bioorganic & medicinal chemistry20061015

Title: [Isolation of the chemical constituents from Shuanghuanglian injection and their structural identification].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University20061001

Title: Defensive components in insect eggs: are anthraquinones produced during egg development?

Journal: Journal of chemical ecology20060901

Title: [Induction of hairy roots and anthraquinone production in Rheum palmatum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20060901

Title: Determination of five anthraquinones in medicinal plants by capillary zone electrophoresis with beta-cyclodextrin addition.

Journal: Journal of chromatography. A20060804

Title: Different polyketide folding modes converge to an identical molecular architecture.

Journal: Nature chemical biology20060801

Title: [Study on the selection of crude drugs of rhubarb dispensing granule].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20060401

Title: [Simultaneous determination of three kinds of components in sanhuang tablets by high-performance liquid chromatography].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20060301

Title: Isolation and inhibitory activity against ERK phosphorylation of hydroxyanthraquinones from rhubarb.

Journal: Bioorganic & medicinal chemistry letters20060201

Title: [Simultaneous determination of resveratrol, emodin, chrysophanol, physcion, in root of Polygonam cuspidatum and its extract by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20060201

Title: [Studies on chemical constituents of hairy root of Cassia obtusifolia].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20060201

Title: PTP1B inhibitors from Saussrurea lappa.

Journal: Journal of Asian natural products research20060101

Title: Determination and locational variations in the quantity of hydroxyanthraquinones and their glycosides in rhizomes of Rheum emodi using high-performance liquid chromatography.

Journal: Journal of chromatography. A20051202

Title: Separation and determination of anthraquinones in Cassia obtusifolia (Leguminosae) by micellar electrokinetic capillary electrophoresis.

Journal: Journal of separation science20051101

Title: Antimycobacterial agents from selected Mexican medicinal plants.

Journal: The Journal of pharmacy and pharmacology20050901

Title: Antidiabetic stilbene and anthraquinone derivatives from Rheum undulatum.

Journal: Archives of pharmacal research20050901

Title: [Screening of antineoplastic components in Radix et Rhizoma Rhei using chromatographic fingerprints].

Journal: Se pu = Chinese journal of chromatography20050901

Title: Separation and determination of four active anthraquinones in Chinese herbal preparations by flow injection-capillary electrophoresis.

Journal: Electrophoresis20050801

Title: [A new isoflavone from Huoxue Yiqi Tang].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20050801

Title: Studies on chemical constituents of Rheum glabricaule.

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20050801

Title: [Studies on the chemical constituents in herb of Mentha haplocalyx].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20050701

Title: High-performance thin layer chromatography method for quantitative determination of four major anthraquinone derivatives in Rheum emodi.

Journal: Journal of chromatography. A20050610

Title: Three new isoprenylated flavonoids from the roots of Sophora flavescens.

Journal: Journal of Asian natural products research20050601

Title: [Study on the optimal harvesting time of Rumex gmelini by analyzing the contents of principal components].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20050601

Title: [Influence of processing rhubarb on it's anthraquinone contents].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20050601

Title: Simultaneous determination of anthraquinones in Rhubarb by pressurized liquid extraction and capillary zone electrophoresis.

Journal: Electrophoresis20050501

Title: Simultaneous determination of anthraquinones, their 8-beta-D-glucosides, and sennosides of Rhei Rhizoma by capillary electrophoresis.

Journal: Chemical & pharmaceutical bulletin20050501

Title: PTP1B inhibitors from Ardisia japonica.

Journal: Journal of Asian natural products research20050201

Title: Analysis of the anthraquinones aloe-emodin and aloin by gas chromatography/mass spectrometry.

Journal: International immunopharmacology20041220

Title: Antigenotoxic properties of Cassia tea (Cassia tora L.): mechanism of action and the influence of roasting process.

Journal: Life sciences20041119

Title: [Simultaneous determination of 4 anthraquinones in Kuhuang injection by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20041101

Title: Preparative isolation and purification of hydroxyanthraquinones and cinnamic acid from the chinese medicinal herb Rheum officinale Baill. by high-speed counter-current chromatography.

Journal: Journal of chromatography. A20041015

Title: Chrysophanol glycosides from callus cultures of monocotyledonous Kniphofia spp. (Asphodelaceae).

Journal: Chemical & pharmaceutical bulletin20041001

Title: [Study on releasing rate of chrysophanol from Ruyi Jinhuang plaster].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20040801

Title: [Study on the interactions between four components in Ligusticum chuanxiong rhizome and acceptors on cardiac muscle membrane].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20040701

Title: [Study on qualitative and quantitative methods for yinhuang liangxiao granule].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20040501

Title: Evaluation of Rhubarb using antioxidative activity as an index of pharmacological usefulness.

Journal: Journal of ethnopharmacology20040301

Title: Anthrone and oxanthrone C-glycosides from Picramnia latifolia collected in Peru.

Journal: Journal of natural products20040301

Title: Microbial glycosylation of four free anthraquinones by Absidia coerulea.

Journal: Biotechnology letters20040101

Title: Bhimamycin A to approximately E and bhimanone: isolation, structure elucidation and biological activity of novel quinone antibiotics from a terrestrial Streptomycete.

Journal: The Journal of antibiotics20031101

Title: [Phenolic compounds isolated from rhizoma of Aster tataricus].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20031001

Title: Cynodontin: a fungal metabolite with antifungal properties.

Journal: Journal of agricultural and food chemistry20030813

Title: Sulfemodin 8-O-beta-D-glucoside, a new sulfated anthraquinone glycoside, and antioxidant phenolic compounds from Rheum emodi.

Journal: Journal of natural products20030801

Title: Simultaneous determination of hydroxyanthraquinones in rhubarb and experimental animal bodies by high-performance liquid chromatography.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry20030801

Title: Capillary electrophoresis for simultaneous determination of emodin, chrysophanol, and their 8-beta-D-glucosides.

Journal: Chemical & pharmaceutical bulletin20030401

Title: Transcriptional suppression of the HIV promoter by natural compounds.

Journal: Antiviral research20030301

Title: Determination of active components in rhubarb and study of their hydrophobicity by micellar electrokinetic chromatography.

Journal: Bioorganic & medicinal chemistry letters20030224

Title: Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.

Journal: Biochemical pharmacology20021215

Title: [Determination of six effective components in Rheum by cyclodextrin modified micellar electrokinetic chromatography].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20021001

Title: Antimycobacterial anthraquinone-chromanone compound and diketopiperazine alkaloid from the fungus Chaetomium globosum KMITL-N0802.

Journal: Planta medica20020901

Title: Four new compounds from the seeds of Cassia fistula.

Journal: Journal of natural products20020801

Title: [Studies on the chemical constituents in root of Rheum rhizastachyum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20020401

Title: [Studies on the chemical constituents of the stems of Alyxia sinensis (I)].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20020201

Title: Racemochrysone, a dihydroanthracenone from Senna racemosa.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20020101

Title: Cytotoxicity of natural hydroxyanthraquinones: role of oxidative stress.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20020101

Title: [Study on the quantitative change of anthraquinonoids of Rhei in the preparation of dachengqi].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20020101

Title: Secondary metabolites from Basotho medicinal plants. I. Bulbine narcissifolia.

Journal: Journal of natural products20011001

Title: [Studies on the chemical constituents of Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20011001

Title: Cytotoxicity of Rhamnosylanthraquinones and Rhamnosylanthrones from Rhamnus nepalensis.

Journal: Journal of natural products20010901

Title: Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity.

Journal: Bioorganic & medicinal chemistry letters20010723

Title: [Studies on the anthraquinones of Cassia siamea].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20010701

Title: Antiplasmodial and antioxidant isofuranonaphthoquinones from the roots of Bulbine capitata.

Journal: Planta medica20010601

Title: No induction of chromosomal aberrations in Chinese hamster ovary cells by chrysophanol.

Journal: Mutation research20010531

Title: Inhibitory effects of Cassia tora L. on benzo[a]pyrene-mediated DNA damage toward HepG2 cells.

Journal: Journal of agricultural and food chemistry20010501

Title: Cytotoxic principles from Ventilago leiocarpa.

Journal: Journal of natural products20010501

Title: In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus.

Journal: Antiviral research20010301

Title: Determination of pKa values of anthraquinone compounds by capillary electrophoresis.

Journal: Electrophoresis20010201

Title: Cytotoxic and DNA damage-inducing activities of low molecular weight phenols from rhubarb.

Journal: Anticancer research20010101

Title: Antifungal activity of anthraquinone derivatives from Rheum emodi.

Journal: Journal of ethnopharmacology20000901

Title: Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus.

Journal: Antiviral research19920101

Title: Lee MS, et al. Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. Phytother Res. 2011 Jun;25(6):833-7.

Title: Lim H, et al. Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro. Front Pharmacol. 2016 Dec 8;7:476.

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