Title: Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease.
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Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
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Title: Kavalactone metabolism in rat liver microsomes.
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Title: Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.
Journal: Toxicological sciences : an official journal of the Society of Toxicology20111201
Title: Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro.
Journal: Phytotherapy research : PTR20110301
Title: Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.
Journal: PloS one20110101
Title: Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity.
Journal: Bioorganic & medicinal chemistry letters20091001
Title: High-performance liquid chromatography assays for desmethoxyyangonin, methysticin, kavain and their microsomal metabolites.
Journal: Biomedical chromatography : BMC20090101
Title: Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract.
Journal: International journal of toxicology20090101
Title: Efficacy of extracting solvents to chemical components of kava (Piper methysticum) roots.
Journal: Journal of natural medicines20080401
Title: Permeability studies of Kavalactones using a Caco-2 cell monolayer model.
Journal: Journal of clinical pharmacy and therapeutics20070601
Title: Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum).
Journal: Journal of agricultural and food chemistry20060208
Title: Kavalactones fail to inhibit alcohol dehydrogenase in vitro.
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Title: Mass spectrometry-based screening for inhibitors of beta-amyloid protein aggregation.
Journal: Analytical chemistry20051101
Title: Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro.
Journal: Drug metabolism and disposition: the biological fate of chemicals20051001
Title: Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard.
Journal: Journal of AOAC International20050101
Title: Superheated water chromatography-nuclear magnetic resonance spectroscopy of kava lactones.
Journal: Phytochemical analysis : PCA20050101
Title: Kava does not display metabolic toxicity in a homogeneous cellular assay.
Journal: Planta medica20040401
Title: Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20040101
Title: Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).
Journal: Planta medica20021201
Title: Interaction of various Piper methysticum cultivars with CNS receptors in vitro.
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