501-30-4,MFCD00006580
Catalog No.:AA00I8VI

501-30-4 | 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-

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Purity
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25g
≥98%
in stock  
$10.00   $7.00
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100g
≥98%
in stock  
$31.00   $22.00
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500g
98%
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$100.00   $70.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00I8VI
Chemical Name:
4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-
CAS Number:
501-30-4
Molecular Formula:
C6H6O4
Molecular Weight:
142.1094
MDL Number:
MFCD00006580
SMILES:
OCc1occ(c(=O)c1)O
NSC Number:
1942
Properties
Computed Properties
 
Complexity:
214  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-0.9  

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Title: Preventive Therapy of Experimental Colitis with Selected iron Chelators and Anti-oxidants.

Journal: International journal of preventive medicine 20120301

Title: Rapid screening of enzyme inhibitors using profiling of enzyme-metabolite assay by HPLC (PREMA-HPLC).

Journal: Journal of enzyme inhibition and medicinal chemistry 20120201

Title: Cellular fusion and whitening effect of a chitosan derivative coated liposome.

Journal: Colloids and surfaces. B, Biointerfaces 20120201

Title: Effects of koji fermented phenolic compounds on the oxidative stability of fish miso.

Journal: Journal of food science 20120201

Title: 1-(3-Hy-droxy-phen-yl)-3-(3-meth-oxy-phenyl)thio-urea.

Journal: Acta crystallographica. Section E, Structure reports online 20120201

Title: Topical hypopigmenting agents for pigmentary disorders and their mechanisms of action.

Journal: Annals of dermatology 20120201

Title: ChLae1 and ChVel1 regulate T-toxin production, virulence, oxidative stress response, and development of the maize pathogen Cochliobolus heterostrophus.

Journal: PLoS pathogens 20120201

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Journal: Marine drugs 20120201

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Journal: Natural product communications 20120201

Title: Structure-activity relationship of naphthaldehydethiosemicarbazones in melanogenesis inhibition.

Journal: Bioorganic & medicinal chemistry letters 20120115

Title: Decolorization of Remazol Brilliant Blue R by a purified laccase of Polyporus brumalis.

Journal: Applied biochemistry and biotechnology 20120101

Title: Metabolite profiling and bioactivity of rice koji fermented by Aspergillus strains.

Journal: Journal of microbiology and biotechnology 20120101

Title: A unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani.

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Title: Online Coupling of Lab-on-Valve Format to Amperometry Based on Polyvinylpyrrolidone-Doped Carbon Paste Electrode and Its Application to the Analysis of Morin.

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Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Complications of blepharoplasty: prevention and management.

Journal: Plastic surgery international 20120101

Title: Effects of cosmetic formulations containing hydroxyacids on sun-exposed skin: current applications and future developments.

Journal: Dermatology research and practice 20120101

Title: Metabolomics-based optimal koji fermentation for tyrosinase inhibition supplemented with Astragalus radix.

Journal: Bioscience, biotechnology, and biochemistry 20120101

Title: Newer and upcoming therapies for melasma.

Journal: Indian journal of dermatology, venereology and leprology 20120101

Title: Effects of known phenoloxidase inhibitors on hemocyanin-derived phenoloxidase from Limulus polyphemus.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20120101

Title: Aspergillus bertholletius sp. nov. from Brazil nuts.

Journal: PloS one 20120101

Title: Skin-whitening effects of Mediterranean herbal extracts by in vitro and in vivo models.

Journal: Journal of cosmetic science 20120101

Title: Depigmenting effect of Kojic acid esters in hyperpigmented B16F1 melanoma cells.

Journal: Journal of biomedicine & biotechnology 20120101

Title: Inhibitory activity of novel kojic acid derivative containing trolox moiety on melanogenesis.

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Title: N-(4-Hy-droxy-phen-yl)-3,4,5-trimeth-oxy-benzamide.

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Title: Development of a sensitive and selective kojic acid sensor based on molecularly imprinted polymer modified electrode in the lab-on-valve system.

Journal: Talanta 20111015

Title: Development of an autonomous detector for sensing of nerve agents based on functionalized silicon nanowire field-effect transistors.

Journal: Talanta 20111015

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Journal: Biofouling 20110901

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Journal: Journal of bioscience and bioengineering 20110701

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Title: Ficus deltoidea (Mas cotek) extract exerted anti-melanogenic activity by preventing tyrosinase activity in vitro and by suppressing tyrosinase gene expression in B16F1 melanoma cells.

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Title: Kojic acid, a secondary metabolite from Aspergillus sp., acts as an inducer of macrophage activation.

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Journal: European journal of medicinal chemistry 20110401

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Title: Identification and categorization of liver toxicity markers induced by a related pair of drugs.

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Journal: Indian journal of dermatology, venereology and leprology 20110101

Title: Flavusides A and B, antibacterial cerebrosides from the marine-derived fungus Aspergillus flavus.

Journal: Chemical & pharmaceutical bulletin 20110101

Title: Aspergillus oryzae laeA regulates kojic acid synthesis genes.

Journal: Bioscience, biotechnology, and biochemistry 20110101

Title: Loss of msnA, a putative stress regulatory gene, in Aspergillus parasiticus and Aspergillus flavus increased production of conidia, aflatoxins and kojic acid.

Journal: Toxins 20110101

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Journal: International journal of molecular sciences 20110101

Title: Bioactive compounds, antioxidant, xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected agro-industrial by-products.

Journal: International journal of molecular sciences 20110101

Title: Melanogenesis inhibitory activity of two generic drugs: cinnarizine and trazodone in mouse B16 melanoma cells.

Journal: International journal of molecular sciences 20110101

Title: A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol.

Journal: Bioorganic & medicinal chemistry letters 20101215

Title: Indium(III) chloride catalyzed three-component coupling reaction: a novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents.

Journal: Bioorganic & medicinal chemistry letters 20101215

Title: Tyrosinase inhibitory effect of benzoic acid derivatives and their structure-activity relationships.

Journal: Journal of enzyme inhibition and medicinal chemistry 20101201

Title: Identification and characterization of genes responsible for biosynthesis of kojic acid, an industrially important compound from Aspergillus oryzae.

Journal: Fungal genetics and biology : FG & B 20101201

Title: Bond-based 2D quadratic fingerprints in QSAR studies: virtual and in vitro tyrosinase inhibitory activity elucidation.

Journal: Chemical biology & drug design 20101201

Title: Biological activities of phenolic compounds isolated from galls of Terminalia chebula Retz. (Combretaceae).

Journal: Natural product research 20101201

Title: 1-(4-Hy-droxy-phen-yl)-3-(3,4,5-tri-methoxy-phen-yl)thio-urea.

Journal: Acta crystallographica. Section E, Structure reports online 20101201

Title: Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties.

Journal: Bioorganic & medicinal chemistry letters 20101115

Title: Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.

Journal: Bioorganic & medicinal chemistry 20101115

Title: N-(3,5-dihydroxybenzoyl)-6-hydroxytryptamine as a novel human tyrosinase inhibitor that inactivates the enzyme in cooperation with l-3,4-dihydroxyphenylalanine.

Journal: Chemical & pharmaceutical bulletin 20101101

Title: Purification and physiochemical characterization of melanin pigment from Klebsiella sp. GSK.

Journal: Journal of microbiology and biotechnology 20101101

Title: N-(2,5-Dimeth-oxy-phen-yl)-N'-(4-hy-droxy-pheneth-yl)urea.

Journal: Acta crystallographica. Section E, Structure reports online 20101101

Title: Synthesis and biological evaluation of a novel series of bis-salicylaldehydes as mushroom tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20101015

Title: Isolation and identification of radical scavenging and tyrosinase inhibition of polyphenols from Tibouchina semidecandra L.

Journal: Journal of agricultural and food chemistry 20101013

Title: Kojic acid derivatives as histamine H(3) receptor ligands.

Journal: Chemical & pharmaceutical bulletin 20101001

Title: 1-(2-Hy-droxy-eth-yl)-3-(3-meth-oxy-phen-yl)thio-urea.

Journal: Acta crystallographica. Section E, Structure reports online 20101001

Title: A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities.

Journal: European journal of medicinal chemistry 20100901

Title: Modern approach to topical treatment of aging skin.

Journal: Collegium antropologicum 20100901

Title: Evaluation of a kojic acid, emblica extract, and glycolic acid formulation compared with hydroquinone 4% for skin lightening.

Journal: Cutis 20100901

Title: N-(3,4-Difluoro-phen-yl)-N'-(2,5-di-methoxy-phen-yl)urea.

Journal: Acta crystallographica. Section E, Structure reports online 20100901

Title: N-(2,5-Dimeth-oxy-phen-yl)-N'-[4-(2-hy-droxy-eth-yl)phen-yl]urea.

Journal: Acta crystallographica. Section E, Structure reports online 20100901

Title: A newly synthesized, potent tyrosinase inhibitor: 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol.

Journal: Bioorganic & medicinal chemistry letters 20100815

Title: p-coumaric acid not only inhibits human tyrosinase activity in vitro but also melanogenesis in cells exposed to UVB.

Journal: Phytotherapy research : PTR 20100801

Title: Identification of a potent and noncytotoxic inhibitor of melanin production.

Journal: Bioorganic & medicinal chemistry 20100801

Title: Free radical scavenging and tyrosinase inhibition activity of oils and sericin extracted from Thai native silkworms (Bombyx mori).

Journal: Pharmaceutical biology 20100801

Title: 1-(2,5-Dimeth-oxy-phen-yl)-3-(2-hy-droxy-eth-yl)urea.

Journal: Acta crystallographica. Section E, Structure reports online 20100801

Title: (-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant.

Journal: Bioorganic & medicinal chemistry 20100715

Title: Malten, a new synthetic molecule showing in vitro antiproliferative activity against tumour cells and induction of complex DNA structural alterations.

Journal: British journal of cancer 20100713

Title: Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color.

Journal: The Journal of clinical and aesthetic dermatology 20100701

Title: Synthesis and biological activity of oxadiazole and triazolothiadiazole derivatives as tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20100615

Title: Leucoderma after use of a skin-lightening cream containing kojic dipalmitate, liquorice root extract and Mitracarpus scaber extract.

Journal: Clinical and experimental dermatology 20100601

Title: Hybrids of 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2) and various anti-oxidants as cancer chemopreventive agents.

Journal: European journal of medicinal chemistry 20100601

Title: Baicalein inhibits melanogenesis through activation of the ERK signaling pathway.

Journal: International journal of molecular medicine 20100601

Title: New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.

Journal: Bioorganic & medicinal chemistry 20100601

Title: Tyrosinase inhibitory constituents from the roots of Morus nigra: a structure-activity relationship study.

Journal: Journal of agricultural and food chemistry 20100512

Title: Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone.

Journal: European journal of medicinal chemistry 20100501

Title: Iron(III) and aluminum(III) complexes with hydroxypyrone ligands aimed to design kojic acid derivatives with new perspectives.

Journal: Journal of inorganic biochemistry 20100501

Title: N-(3,4-Difluoro-phen-yl)-3,4,5-trimethoxy-benzamide.

Journal: Acta crystallographica. Section E, Structure reports online 20100501

Title: A gas chromatography-mass spectrometric method to determine skin-whitening agents in cosmetic products.

Journal: Talanta 20100415

Title: A modulatory effect of novel kojic acid derivatives on cancer cell proliferation and macrophage activation.

Journal: Die Pharmazie 20100401

Title: Stemphol galactoside, a new stemphol derivative isolated from the tropical endophytic fungus Gaeumannomyces amomi.

Journal: Natural product communications 20100401

Title: Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells.

Journal: Bioorganic & medicinal chemistry 20100315

Title: Anticonvulsant and neurotoxicity evaluation of some novel kojic acids and allomaltol derivatives.

Journal: Archiv der Pharmazie 20100301

Title: Inhibitory effect of novel tetrahydropyrimidine-2(1H)-thiones on melanogenesis.

Journal: Bioorganic & medicinal chemistry 20100201

Title: Production of hesperetin glycosides by Xanthomonas campestris and cyclodextrin glucanotransferase and their anti-allergic activities.

Journal: Nutrients 20100201

Title: Enhanced cell permeability of kojic acid-phenylalanine amide with metal complex.

Journal: Bioorganic & medicinal chemistry letters 20100115

Title: Tyrosinase inhibitory constituents from the stems of Maackia fauriei.

Journal: Phytotherapy research : PTR 20100101

Title: Pigmented contact dermatitis due to kojic acid. A paradoxical side effect of a skin lightener.

Journal: Contact dermatitis 20100101

Title: Synthesis and anticonvulsant activity of new kojic acid derivatives.

Journal: Arzneimittel-Forschung 20100101

Title: Inhibitory effect of hydroxyindoles and their analogues on human melanoma tyrosinase.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20100101

Title: Inhibitory effects of 2-amino-3H-phenoxazin-3-one on the melanogenesis of murine B16 melanoma cell line.

Journal: Bioscience, biotechnology, and biochemistry 20100101

Title: Tyrosinase-expressing neuronal cell line as in vitro model of Parkinson's disease.

Journal: International journal of molecular sciences 20100101

Title: Investigation of the possible biological activities of a poisonous South African plant; Hyaenanche globosa (Euphorbiaceae).

Journal: Pharmacognosy magazine 20100101

Title: Quasi-drugs developed in Japan for the prevention or treatment of hyperpigmentary disorders.

Journal: International journal of molecular sciences 20100101

Title: Volatile profiling reveals intracellular metabolic changes in Aspergillus parasiticus: veA regulates branched chain amino acid and ethanol metabolism.

Journal: BMC biochemistry 20100101

Title: Effect of combination of taurine and azelaic acid on antimelanogenesis in murine melanoma cells.

Journal: Journal of biomedical science 20100101

Title: Molecular modeling of peroxidase and polyphenol oxidase: substrate specificity and active site comparison.

Journal: International journal of molecular sciences 20100101

Title: Is the comet assay a sensitive procedure for detecting genotoxicity?

Journal: Journal of nucleic acids 20100101

Title: Final report of the safety assessment of Kojic acid as used in cosmetics.

Journal: International journal of toxicology 20100101

Title: Ultrastructural assessments of the melanosome distribution patterns and pigmentation features in human epidermal cells after UV irradiation and kojic acid treatment.

Journal: International journal of cosmetic science 20091201

Title: Different therapeutic modalities for treatment of melasma.

Journal: Journal of cosmetic dermatology 20091201

Title: The hunt for natural skin whitening agents.

Journal: International journal of molecular sciences 20091201

Title: Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae.

Journal: Toxins 20091201

Title: Chemical constituents of the endophytic fungus Lecythophora sp. isolated from Alyxia reinwardtii.

Journal: Natural product communications 20091101

Title: An evaluation of extracts of five traditional medicinal plants from Iran on the inhibition of mushroom tyrosinase activity and scavenging of free radicals.

Journal: International journal of cosmetic science 20091001

Title: Kojic acid-amino acid conjugates as tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20091001

Title: Purification and characterization of neoagarotetraose from hydrolyzed agar.

Journal: Journal of microbiology and biotechnology 20091001

Title: Evaluation of depigmenting activity by 8-hydroxydaidzein in mouse B16 melanoma cells and human volunteers.

Journal: International journal of molecular sciences 20091001

Title: Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090901

Title: Variations in IC(50) values with purity of mushroom tyrosinase.

Journal: International journal of molecular sciences 20090901

Title: Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration.

Journal: International journal of molecular sciences 20090901

Title: Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells.

Journal: Bioorganic & medicinal chemistry 20090815

Title: Chemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus.

Journal: Journal of agricultural and food chemistry 20090812

Title: Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities.

Journal: European journal of medicinal chemistry 20090801

Title: N-[(Dihydroxyphenyl)acyl]serotonins as potent inhibitors of tyrosinase from mouse and human melanoma cells.

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: [Tyrosinase inhibition of Potentilla bifurca].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801

Title: Novel 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents.

Journal: Bioorganic & medicinal chemistry 20090715

Title: Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.

Journal: Bioorganic & medicinal chemistry 20090715

Title: Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins.

Journal: Bioorganic & medicinal chemistry 20090701

Title: A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats.

Journal: The Journal of toxicological sciences 20090601

Title: An updated review of tyrosinase inhibitors.

Journal: International journal of molecular sciences 20090601

Title: Management of hyperpigmentation in darker racial ethnic groups.

Journal: Seminars in cutaneous medicine and surgery 20090601

Title: Inhibitory effect of phlorotannins isolated from Ecklonia cava on mushroom tyrosinase activity and melanin formation in mouse B16F10 melanoma cells.

Journal: Journal of agricultural and food chemistry 20090527

Title: Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives.

Journal: European journal of medicinal chemistry 20090501

Title: [Tyrosinase inhibitor from Angelica dahurica roots].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090501

Title: Human hair follicle pigmentary unit as a direct target for modulators of melanogenesis, as studied by [14C]-2-thiouracil incorporation.

Journal: Experimental dermatology 20090401

Title: Determination of kojic acid based on the interface enhancement effects of carbon nanotube/alizarin red S modified electrode.

Journal: Colloids and surfaces. B, Biointerfaces 20090401

Title: Radioprotective effects of kojic acid against mortality induced by gamma irradiation in mice.

Journal: Saudi medical journal 20090401

Title: Occurence and bioactivities of funicone-related compounds.

Journal: International journal of molecular sciences 20090401

Title: Photoinduced linkage isomerism of {RuNO}(6) complexes with bioligands and related chelators.

Journal: Dalton transactions (Cambridge, England : 2003) 20090214

Title: Identification of tumor promotion marker genes for predicting tumor promoting potential of chemicals in BALB/c 3T3 cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090201

Title: 4-Hydroxy-phenyl 4-fluoro-benzoate.

Journal: Acta crystallographica. Section E, Structure reports online 20090201

Title: Synthesis of tyrosinase inhibitory (4-oxo-4H-pyran-2-yl)acrylic acid ester derivatives.

Journal: Bioorganic & medicinal chemistry letters 20090101

Title: PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase.

Journal: Bioorganic & medicinal chemistry letters 20090101

Title: Inhibitory effect of 2,4,2',4'-tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on tyrosinase activity and melanin biosynthesis.

Journal: Biological & pharmaceutical bulletin 20090101

Title: Synthesis of 4-pyridone-3-sulfate and an improved synthesis of 3-hydroxy-4-pyridone.

Journal: Chemistry Central journal 20090101

Title: Impact on facial rejuvenation with dermatological preparations.

Journal: Clinical interventions in aging 20090101

Title: Optimization of enzymatic synthesis of palm-based kojic acid ester using response surface methodology.

Journal: Journal of oleo science 20090101

Title: A fruit quality gene map of Prunus.

Journal: BMC genomics 20090101

Title: A study comparing chemical peeling using modified Jessner's solution and 15% trichloroacetic Acid versus 15% trichloroacetic acid in the treatment of melasma.

Journal: Indian journal of dermatology 20090101

Title: Topical treatment of melasma.

Journal: Indian journal of dermatology 20090101

Title: Conference Report: ACSICON 2008.

Journal: Journal of cutaneous and aesthetic surgery 20090101

Title: Isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent.

Journal: Molecular nutrition & food research 20081201

Title: Inhibitory effect of Cucumis sativus on melanin production in melanoma B16 cells by downregulation of tyrosinase expression.

Journal: Planta medica 20081201

Title: Atom- and bond-based 2D TOMOCOMD-CARDD approach and ligand-based virtual screening for the drug discovery of new tyrosinase inhibitors.

Journal: Journal of biomolecular screening 20081201

Title: Hypothesis: can kojic acid prevent xanthelasma formation?

Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20081201

Title: Antityrosinase and antioxidant effects of ent-kaurane diterpenes from leaves of Broussonetia papyrifera.

Journal: Journal of natural products 20081101

Title: Tyrosinase inhibition by extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening.

Journal: Journal of ethnopharmacology 20081028

Title: Molecular design of potent tyrosinase inhibitors having the bibenzyl skeleton.

Journal: Bioorganic & medicinal chemistry letters 20081001

Title: Screening of Nepalese crude drugs traditionally used to treat hyperpigmentation: in vitro tyrosinase inhibition.

Journal: International journal of cosmetic science 20081001

Title: Proteomics analysis of kojic acid treated A375 human malignant melanoma cells.

Journal: Journal of proteome research 20080901

Title: 1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane, a novel tyrosinase inhibitor with strong depigmenting effects.

Journal: Chemical & pharmaceutical bulletin 20080901

Title: Studying the anti-tyrosinase effect of Arbutus andrachne L. extracts.

Journal: International journal of cosmetic science 20080801

Title: Enhanced expression of laccase during the degradation of endocrine disrupting chemicals in Trametes versicolor.

Journal: Journal of microbiology (Seoul, Korea) 20080801

Title: Removal of estrogenic activity from endocrine-disrupting chemicals by purified laccase of Phlebia tremellosa.

Journal: FEMS microbiology letters 20080701

Title: Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation.

Journal: Bioorganic & medicinal chemistry letters 20080615

Title: Rapid analysis of fungal cultures and dried figs for secondary metabolites by LC/TOF-MS.

Journal: Analytica chimica acta 20080609

Title: N-(3,4-Difluoro-phen-yl)-3,4-dimethoxy-benzene-sulfonamide.

Journal: Acta crystallographica. Section E, Structure reports online 20080601

Title: In vitro antiproliferative and cytotoxic activities of novel kojic acid derivatives: 5-benzyloxy-2-selenocyanatomethyl- and 5-methoxy-2-selenocyanatomethyl-4-pyranone.

Journal: Journal of applied toxicology : JAT 20080501

Title: Inhibitory effects of cinnamic acid on melanin biosynthesis in skin.

Journal: Biological & pharmaceutical bulletin 20080501

Title: Concurrent administration of ascorbic acid enhances liver tumor-promoting activity of kojic acid in rats.

Journal: The Journal of toxicological sciences 20080501

Title: A new tyrosinase inhibitor from Crinum yemense as potential treatment for hyperpigmentation.

Journal: Die Pharmazie 20080501

Title: A rapid and reliable size-exclusion chromatographic method for determination of kojic dipalmitate in skin-whitening cosmetic products.

Journal: Talanta 20080415

Title: Synthesis and characterization of a novel macrocyclic chelator with 3-hydroxy-4-pyrone chelating arms and its complexes with medicinally important metals.

Journal: Inorganic chemistry 20080407

Title: Kinetic properties of catecholoxidase activity of tarantula hemocyanin.

Journal: The FEBS journal 20080401

Title: Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.

Journal: Nature chemical biology 20080401

Title: Anthraquinones from Polygonum cuspidatum as tyrosinase inhibitors for dermal use.

Journal: Phytotherapy research : PTR 20080401

Title: The use of botanical extracts as topical skin-lightening agents for the improvement of skin pigmentation disorders.

Journal: The journal of investigative dermatology. Symposium proceedings 20080401

Title: Two novel aflatoxin-producing Aspergillus species from Argentinean peanuts.

Journal: International journal of systematic and evolutionary microbiology 20080301

Title: Host-parasitoid interaction as affected by interkingdom competition.

Journal: Oecologia 20080201

Title: Mycotoxins in botanicals and dried fruits: a review.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20080201

Title: 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry 20080201

Title: pH-dependent inhibition of mushroom tyrosinase by N-substituted N-nitrosohydroxylamines.

Journal: Journal of enzyme inhibition and medicinal chemistry 20080201

Title: Down-regulation of tyrosinase expression by acetylsalicylic acid in murine B16 melanoma.

Journal: Biological & pharmaceutical bulletin 20080101

Title: Evaluation of the effect of Thai breadfruit's heartwood extract on melanogenesis-inhibitory and antioxidation activities.

Journal: Journal of cosmetic science 20080101

Title: Antidiabetic Bis-Maltolato-OxoVanadium(IV): conversion of inactive trans- to bioactive cis-BMOV for possible binding to target PTP-1B.

Journal: Drug design, development and therapy 20080101

Title: QYAG5 Q-switched Nd:YAG Laser Treatment of Nevus of Ota: An Indian Study of 50 Patients.

Journal: Journal of cutaneous and aesthetic surgery 20080101

Title: Mir-434-5p mediates skin whitening and lightening.

Journal: Clinical, cosmetic and investigational dermatology 20080101

Title: Discovery of small-molecule inhibitors of tyrosinase.

Journal: Bioorganic & medicinal chemistry letters 20071215

Title: Tyrosinase inhibitory pentacyclic triterpenes and analgesic and spasmolytic activities of methanol extracts of Rhododendron collettianum.

Journal: Phytotherapy research : PTR 20071101

Title: Piceatannol inhibits melanogenesis by its antioxidative actions.

Journal: Biological & pharmaceutical bulletin 20071101

Title: Glycine inhibits melanogenesis in vitro and causes hypopigmentation in vivo.

Journal: Biological & pharmaceutical bulletin 20071101

Title: N-trans-feruloyltyramine as a melanin biosynthesis inhibitor.

Journal: Biological & pharmaceutical bulletin 20071001

Title: X-ray absorption analysis of the active site of Streptomyces antibioticus Tyrosinase upon binding of transition state analogue inhibitors.

Journal: Archives of biochemistry and biophysics 20070915

Title: 4-(6-Hydroxy-2-naphthyl)-1,3-bezendiol: a potent, new tyrosinase inhibitor.

Journal: Biological & pharmaceutical bulletin 20070901

Title: Enhancement of hepatocellular proliferative activity of kojic acid in mice by a simultaneous administration of ascorbic acid.

Journal: The Journal of veterinary medical science 20070901

Title: Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus.

Journal: Microbiology (Reading, England) 20070801

Title: Therapeutical approaches in melasma.

Journal: Dermatologic clinics 20070701

Title: Preparative isolation and identification of tyrosinase inhibitors from the seeds of Garcinia kola by high-speed counter-current chromatography.

Journal: Journal of chromatography. A 20070601

Title: Experimental design and capillary electrophoresis for simultaneous analysis of arbutin, kojic acid and hydroquinone in cosmetics.

Journal: Journal of pharmaceutical and biomedical analysis 20070509

Title: Kojic acid -absence of tumor-initiating activity in rat liver, and of carcinogenic and photo-genotoxic potential in mouse skin.

Journal: The Journal of toxicological sciences 20070501

Title: Prediction of tyrosinase inhibition activity using atom-based bilinear indices.

Journal: ChemMedChem 20070401

Title: Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds.

Journal: Pigment cell research 20070401

Title: Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry 20070315

Title: Schistosome egg production is dependent upon the activities of two developmentally regulated tyrosinases.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070301

Title: Modulating effects of a novel skin-lightening agent, alpha-lipoic acid derivative, on melanin production by the formation of DOPA conjugate products.

Journal: Bioorganic & medicinal chemistry 20070301

Title: Inhibitory compound of tyrosinase activity from the sprout of Polygonum hydropiper L. (Benitade).

Journal: Biological & pharmaceutical bulletin 20070301

Title: TOMOCOMD-CARDD descriptors-based virtual screening of tyrosinase inhibitors: evaluation of different classification model combinations using bond-based linear indices.

Journal: Bioorganic & medicinal chemistry 20070201

Title: Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase.

Journal: Bioorganic & medicinal chemistry letters 20070115

Title: Combining high-performance liquid chromatography with on-line microdialysis sampling for the simultaneous determination of ascorbyl glucoside, kojic acid, and niacinamide in bleaching cosmetics.

Journal: Analytica chimica acta 20070102

Title: Kojic acid and its manganese and zinc complexes as potential radioprotective agents.

Journal: Bioorganic & medicinal chemistry letters 20070101

Title: Post TLC developing technique for tyrosinase inhibitor detection.

Journal: Biomedical chromatography : BMC 20070101

Title: Kojic acid-tripeptide amide as a new tyrosinase inhibitor.

Journal: Biopolymers 20070101

Title: Dragon method for finding novel tyrosinase inhibitors: Biosilico identification and experimental in vitro assays.

Journal: European journal of medicinal chemistry 20070101

Title: Speciation of M+3-hydroxypyrone chelation complexes by electrospray ionization ion trap and Fourier transform ion cyclotron resonance mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Comparison of estimation capabilities of response surface methodology (RSM) with artificial neural network (ANN) in lipase-catalyzed synthesis of palm-based wax ester.

Journal: BMC biotechnology 20070101

Title: Comparison of bipyridyl, maltol and kojic acid action as organic vanadium ligands on activity of galactosyltransferase (EC 2.4.1.38), some physiological parameters and ultrastructure of Golgi complexes in rat hepatocytes.

Journal: Folia histochemica et cytobiologica 20070101

Title: Skin lightening preparations and the hydroquinone controversy.

Journal: Dermatologic therapy 20070101

Title: Polyphasic taxonomy of Aspergillus section Candidi based on molecular, morphological and physiological data.

Journal: Studies in mycology 20070101

Title: The treatment of melasma: a review of clinical trials.

Journal: Journal of the American Academy of Dermatology 20061201

Title: From miso, saké and shoyu to cosmetics: a century of science for kojic acid.

Journal: Natural product reports 20061201

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent.

Journal: Bioorganic & medicinal chemistry letters 20061101

Title: Tyrosinase inhibition studies of cycloartane and cucurbitane glycosides and their structure-activity relationships.

Journal: Bioorganic & medicinal chemistry 20060901

Title: Oxazolones: new tyrosinase inhibitors; synthesis and their structure-activity relationships.

Journal: Bioorganic & medicinal chemistry 20060901

Title: Inhibitory effect of ammonium tetrathiotungstate on tyrosinase and its kinetic mechanism.

Journal: Chemical & pharmaceutical bulletin 20060901

Title: Artocarpus lakoocha heartwood extract as a novel cosmetic ingredient: evaluation of the in vitro anti-tyrosinase and in vivo skin whitening activities.

Journal: International journal of cosmetic science 20060801

Title: Synthesis of pterocellin A.

Journal: Organic letters 20060608

Title: Four psychrotolerant species with high chemical diversity consistently producing cycloaspeptide A, Penicillium jamesonlandense sp. nov., Penicillium ribium sp. nov., Penicillium soppii and Penicillium lanosum.

Journal: International journal of systematic and evolutionary microbiology 20060601

Title: Topical application of gamma-tocopherol derivative prevents UV-induced skin pigmentation.

Journal: Biological & pharmaceutical bulletin 20060601

Title: Potent tyrosinase inhibitors from Trifolium balansae.

Journal: Natural product research 20060601

Title: N-Benzylbenzamides: a new class of potent tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20060515

Title: Absence of in vivo genotoxic potential and tumor initiation activity of kojic acid in the rat thyroid.

Journal: Toxicology 20060515

Title: Absence of liver tumor-initiating activity of kojic acid in mice.

Journal: Archives of toxicology 20060501

Title: Analogues of N-hydroxycinnamoylphenalkylamides as inhibitors of human melanocyte-tyrosinase.

Journal: Bioorganic & medicinal chemistry letters 20060415

Title: Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes.

Journal: Pigment cell research 20060401

Title: Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells.

Journal: Biological & pharmaceutical bulletin 20060401

Title: Hen egg white lysozyme as an inhibitor of mushroom tyrosinase.

Journal: FEBS letters 20060320

Title: Regulation of melanin synthesis by selenium-containing carbohydrates.

Journal: Chemical & pharmaceutical bulletin 20060301

Title: Synthesis of tyrosinase inhibitory kojic acid derivative.

Journal: Archiv der Pharmazie 20060301

Title: Tyrosinase inhibitory cycloartane type triterpenoids from the methanol extract of the whole plant of Amberboa ramosa Jafri and their structure-activity relationship.

Journal: Bioorganic & medicinal chemistry 20060215

Title: Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression.

Journal: Pigment cell research 20060201

Title: Tetraketones: a new class of tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry 20060115

Title: New tyrosinase inhibitors selected by atomic linear indices-based classification models.

Journal: Bioorganic & medicinal chemistry letters 20060115

Title: Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes.

Journal: Journal of medicinal chemistry 20060112

Title: Plasma phenoloxidase of the larval tobacco budworm, Heliothis virescens, is virucidal.

Journal: Journal of insect science (Online) 20060101

Title: Examination of 1,5-anhydro-D-fructose and the enolone ascopyrone P, metabolites of the anhydrofructose pathway of glycogen and starch degradation, for their possible application in fruits, vegetables, and beverages as antibrowning agents.

Journal: Journal of agricultural and food chemistry 20051130

Title: Identifying 6,7,4'-trihydroxyisoflavone as a potent tyrosinase inhibitor.

Journal: Bioscience, biotechnology, and biochemistry 20051001

Title: DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency.

Journal: Experimental dermatology 20050801

Title: Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells.

Journal: Journal of agricultural and food chemistry 20050727

Title: The entrapment of kojic oleate in bilayer vesicles.

Journal: International journal of pharmaceutics 20050714

Title: Tyrosinase inhibition studies of diterpenoid alkaloids and their derivatives: structure-activity relationships.

Journal: Natural product research 20050701

Title: Potent inhibitory effects of N-aryl S-alkylthiocarbamate derivatives on the dopa oxidase activity of mushroom tyrosinase.

Journal: Chemical & pharmaceutical bulletin 20050701

Title: Taxonomic comparison of three different groups of aflatoxin producers and a new efficient producer of aflatoxin B1, sterigmatocystin and 3-O-methylsterigmatocystin, Aspergillus rambellii sp. nov.

Journal: Systematic and applied microbiology 20050701

Title: Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats. A study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS).

Journal: Mutation research 20050606

Title: Repeated-batch production of kojic acid in a cell-retention fermenter using Aspergillus oryzae M3B9.

Journal: Journal of industrial microbiology & biotechnology 20050601

Title: Allergic contact dermatitis due to kojic acid.

Journal: Dermatitis : contact, atopic, occupational, drug 20050601

Title: Inhibition of tyrosinase activity by N,N-unsubstituted selenourea derivatives.

Journal: Biological & pharmaceutical bulletin 20050501

Title: Myrothenones A and B, cyclopentenone derivatives with tyrosinase inhibitory activity from the marine-derived fungus Myrothecium sp.

Journal: Chemical & pharmaceutical bulletin 20050401

Title: Synthesis of methyl ether analogues of sildenafil (Viagra) possessing tyrosinase inhibitory potential.

Journal: Chemistry & biodiversity 20050401

Title: Fungal populations and mycotoxins in silage in Assiut and Sohag governorates in Egypt, with a special reference to characteristic Aspergilli toxins.

Journal: Mycopathologia 20050201

Title: Probing the interaction of kojic acid antibiotics with iron(III) chloride by using electrospray tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica.

Journal: Bioscience, biotechnology, and biochemistry 20050101

Title: Topical methimazole as a new treatment for postinflammatory hyperpigmentation: report of the first case.

Journal: Dermatology (Basel, Switzerland) 20050101

Title: Spotlight turns on cosmetics for Asian skin.

Journal: Nature 20041223

Title: Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies.

Journal: Chemical & pharmaceutical bulletin 20041201

Title: Piperlonguminine from Piper longum with inhibitory effects on alpha-melanocyte-stimulating hormone-induced melanogenesis in melanoma B16 cells.

Journal: Planta medica 20041201

Title: Tyrosinase inhibitors isolated from the edible brown alga Ecklonia stolonifera.

Journal: Archives of pharmacal research 20041201

Title: Prenylated flavonoids as tyrosinase inhibitors.

Journal: Archives of pharmacal research 20041101

Title: Emericella venezuelensis, a new species with stellate ascospores producing sterigmatocystin and aflatoxin B1.

Journal: Systematic and applied microbiology 20041101

Title: [Simultaneous determination of magnesium L-ascorbyl-2-phosphate, arbutin and kojic acid in cosmetics by reversed-phase high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20041101

Title: Enhancement of hepatocarcinogenesis by kojic acid in rat two-stage models after initiation with N-bis(2-hydroxypropyl)nitrosamine or N-diethylnitrosamine.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040901

Title: Combining induced mutation and protoplasting for strain improvement of Aspergillus oryzae for kojic acid production.

Journal: Biotechnology letters 20040701

Title: Solid-phase synthesis of kojic acid-tripeptides and their tyrosinase inhibitory activity, storage stability, and toxicity.

Journal: Bioorganic & medicinal chemistry letters 20040607

Title: Production of toxic metabolites in Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei: justification of mycotoxin testing in food grade enzyme preparations derived from the three fungi.

Journal: Regulatory toxicology and pharmacology : RTP 20040401

Title: Antityrosinase principles and constituents of the petals of Crocus sativus.

Journal: Journal of natural products 20040301

Title: (-)-Epigallocatechin-3-gallate and hinokitiol reduce melanin synthesis via decreased MITF production.

Journal: Archives of pharmacal research 20040301

Title: Kojic acid and its derivatives: history and present state of art.

Journal: Central European journal of public health 20040301

Title: Effects of kojic acid on oxidative damage and on iron and trace element level in iron-overloaded mice and rats.

Journal: Central European journal of public health 20040301

Title: An assessment of the genotoxicity and human health risk of topical use of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one].

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040101

Title: Tetrapetalone A, a novel lipoxygenase inhibitor from Streptomyces sp.

Journal: Bioscience, biotechnology, and biochemistry 20040101

Title: Management of dyschromias in ethnic skin.

Journal: Dermatologic therapy 20040101

Title: Photostability of naturally occurring whitening agents in cosmetic microemulsions.

Journal: Journal of cosmetic science 20040101

Title: Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines.

Journal: Anticancer research 20040101

Title: Optimal management of recalcitrant disorders of hyperpigmentation in dark-skinned patients.

Journal: American journal of clinical dermatology 20040101

Title: Topical agents used in the management of hyperpigmentation.

Journal: Skin therapy letter 20040101

Title: Enzymatic synthesis of structured lipids.

Journal: Advances in biochemical engineering/biotechnology 20040101

Title: Utilizing combination therapy to optimize melasma outcomes.

Journal: Journal of drugs in dermatology : JDD 20040101

Title: Morphology and biochemical activity of rat liver golgi complexes after pretreatment with bis(kojato)oxovanadium(IV) or kojic acid alone.

Journal: Polish journal of pathology : official journal of the Polish Society of Pathologists 20040101

Title: Synthesis of new glycyrrhetinic acid (GA) derivatives and their effects on tyrosinase activity.

Journal: Bioorganic & medicinal chemistry 20031201

Title: Tyrosinase inhibitory prenylated flavonoids from Sophora flavescens.

Journal: Biological & pharmaceutical bulletin 20030901

Title: Constituents from the leaves of Phellodendron amurense var. wilsonii and their bioactivity.

Journal: Journal of natural products 20030901

Title: Identification of oxidation product of arbutin in mushroom tyrosinase assay system.

Journal: Bioorganic & medicinal chemistry letters 20030721

Title: Reconstituted 3-dimensional human skin of various ethnic origins as an in vitro model for studies of pigmentation.

Journal: Analytical biochemistry 20030715

Title: Acetophenone derivatives from Acronychia pedunculata.

Journal: Journal of natural products 20030701

Title: Inhibitory effects of resveratrol derivatives from dipterocarpaceae plants on tyrosinase activity.

Journal: Bioscience, biotechnology, and biochemistry 20030701

Title: Gamma-pyrone derivatives, kojic acid methyl ethers from a marine-derived fungus Alternaria [correction of Altenaria] sp.

Journal: Archives of pharmacal research 20030701

Title: [Analysis of kojic acid in Aspergillus oryzae ferment by ion-pair reversed-phase high performance liquid chromatography].

Journal: Wei sheng yan jiu = Journal of hygiene research 20030701

Title: A new continuous spectrophotometric assay method for DOPA oxidase activity of tyrosinase.

Journal: Journal of protein chemistry 20030701

Title: Hepatocellular tumor induction in heterozygous p53-deficient CBA mice by a 26-week dietary administration of kojic acid.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030601

Title: Effects of 3-isobutyl-1-methylxanthine and kojic acid on cocultures and skin equivalents composed of HaCaT cells and human melanocytes.

Journal: Archives of dermatological research 20030601

Title: Photorejuvenation of the forearms by treating hyperpigmented lesions with intense pulsed light source: a case report.

Journal: Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology 20030601

Title: Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity.

Journal: Planta medica 20030601

Title: Regioselective synthesis of kojic acid esters by Bacillus subtilis protease.

Journal: Biotechnology letters 20030601

Title: Manganese-based complexes of radical scavengers as neuroprotective agents.

Journal: Bioorganic & medicinal chemistry 20030515

Title: Effects of mycotoxins, kojic acid and oxalic acid, on biological fitness of Lygus hesperus (Heteroptera: Miridae).

Journal: Journal of invertebrate pathology 20030501

Title: Downregulation of NF-kappaB activation in human keratinocytes by melanogenic inhibitors.

Journal: Journal of dermatological science 20030501

Title: Kinobeon A as a potent tyrosinase inhibitor from cell culture of safflower: in vitro comparisons of kinobeon A with other putative inhibitors.

Journal: Planta medica 20030501

Title: Mushroom tyrosinase inhibitory activity of esculetin isolated from seeds of Euphorbia lathyris L.

Journal: Bioscience, biotechnology, and biochemistry 20030301

Title: Gnetol as a potent tyrosinase inhibitor from genus Gnetum.

Journal: Bioscience, biotechnology, and biochemistry 20030301

Title: Spectroscopic characterization of the electronic changes in the active site of Streptomyces antibioticus tyrosinase upon binding of transition state analogue inhibitors.

Journal: The Journal of biological chemistry 20030227

Title: Development of 5-[(3-aminopropyl)phosphinooxy]-2-(hydroxymethyl)-4H-pyran-4-one as a novel whitening agent.

Journal: Chemical & pharmaceutical bulletin 20030201

Title: Mycotoxin production and evolutionary relationships among species of Aspergillus section Clavati.

Journal: Antonie van Leeuwenhoek 20030101

Title: Inhibitory effects of 1,3-selenazol-4-one derivatives on mushroom tyrosinase.

Journal: Chemical & pharmaceutical bulletin 20021201

Title: Effects of kojic acid on thyroidal functions in rats by single-dose administration and in cultured rat thyroid cells (FRTL-5 cells).

Journal: The Journal of toxicological sciences 20021201

Title: New antibiotics miyakamides produced by a fungus.

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Title: Identification and quantitative analysis of kojic acid and arbutine in skin-whitening cosmetics.

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Title: Improvement of production of Kojic acid by a mutant strain Aspergillus oryzae, MK107-39.

Journal: Journal of bioscience and bioengineering 20010101

Title: Kojic acid production in an airlift bioreactor using partially hydrolyzed raw corn starch.

Journal: Journal of bioscience and bioengineering 20010101

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Title: Wei X, et al. Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways. Exp Eye Res. 2018 Dec 28;180:174-183.

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SDS
Tags:501-30-4 Molecular Formula|501-30-4 MDL|501-30-4 SMILES|501-30-4 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-
Catalog No.: AA00I8VI
501-30-4,MFCD00006580
501-30-4 | 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-
Pack Size: 25g
Purity: ≥98%
in stock
$10.00 $7.00
Pack Size: 100g
Purity: ≥98%
in stock
$31.00 $22.00
Pack Size: 500g
Purity: 98%
in stock
$100.00 $70.00
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Technical Information
Catalog Number: AA00I8VI
Chemical Name: 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-
CAS Number: 501-30-4
Molecular Formula: C6H6O4
Molecular Weight: 142.1094
MDL Number: MFCD00006580
SMILES: OCc1occ(c(=O)c1)O
NSC Number: 1942
Properties
Complexity: 214  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 10  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -0.9  
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Title: Baicalein inhibits melanogenesis through activation of the ERK signaling pathway.

Journal: International journal of molecular medicine20100601

Title: New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.

Journal: Bioorganic & medicinal chemistry20100601

Title: Tyrosinase inhibitory constituents from the roots of Morus nigra: a structure-activity relationship study.

Journal: Journal of agricultural and food chemistry20100512

Title: Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone.

Journal: European journal of medicinal chemistry20100501

Title: Iron(III) and aluminum(III) complexes with hydroxypyrone ligands aimed to design kojic acid derivatives with new perspectives.

Journal: Journal of inorganic biochemistry20100501

Title: N-(3,4-Difluoro-phen-yl)-3,4,5-trimethoxy-benzamide.

Journal: Acta crystallographica. Section E, Structure reports online20100501

Title: A gas chromatography-mass spectrometric method to determine skin-whitening agents in cosmetic products.

Journal: Talanta20100415

Title: A modulatory effect of novel kojic acid derivatives on cancer cell proliferation and macrophage activation.

Journal: Die Pharmazie20100401

Title: Stemphol galactoside, a new stemphol derivative isolated from the tropical endophytic fungus Gaeumannomyces amomi.

Journal: Natural product communications20100401

Title: Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells.

Journal: Bioorganic & medicinal chemistry20100315

Title: Anticonvulsant and neurotoxicity evaluation of some novel kojic acids and allomaltol derivatives.

Journal: Archiv der Pharmazie20100301

Title: Inhibitory effect of novel tetrahydropyrimidine-2(1H)-thiones on melanogenesis.

Journal: Bioorganic & medicinal chemistry20100201

Title: Production of hesperetin glycosides by Xanthomonas campestris and cyclodextrin glucanotransferase and their anti-allergic activities.

Journal: Nutrients20100201

Title: Enhanced cell permeability of kojic acid-phenylalanine amide with metal complex.

Journal: Bioorganic & medicinal chemistry letters20100115

Title: Tyrosinase inhibitory constituents from the stems of Maackia fauriei.

Journal: Phytotherapy research : PTR20100101

Title: Pigmented contact dermatitis due to kojic acid. A paradoxical side effect of a skin lightener.

Journal: Contact dermatitis20100101

Title: Synthesis and anticonvulsant activity of new kojic acid derivatives.

Journal: Arzneimittel-Forschung20100101

Title: Inhibitory effect of hydroxyindoles and their analogues on human melanoma tyrosinase.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20100101

Title: Inhibitory effects of 2-amino-3H-phenoxazin-3-one on the melanogenesis of murine B16 melanoma cell line.

Journal: Bioscience, biotechnology, and biochemistry20100101

Title: Tyrosinase-expressing neuronal cell line as in vitro model of Parkinson's disease.

Journal: International journal of molecular sciences20100101

Title: Investigation of the possible biological activities of a poisonous South African plant; Hyaenanche globosa (Euphorbiaceae).

Journal: Pharmacognosy magazine20100101

Title: Quasi-drugs developed in Japan for the prevention or treatment of hyperpigmentary disorders.

Journal: International journal of molecular sciences20100101

Title: Volatile profiling reveals intracellular metabolic changes in Aspergillus parasiticus: veA regulates branched chain amino acid and ethanol metabolism.

Journal: BMC biochemistry20100101

Title: Effect of combination of taurine and azelaic acid on antimelanogenesis in murine melanoma cells.

Journal: Journal of biomedical science20100101

Title: Molecular modeling of peroxidase and polyphenol oxidase: substrate specificity and active site comparison.

Journal: International journal of molecular sciences20100101

Title: Is the comet assay a sensitive procedure for detecting genotoxicity?

Journal: Journal of nucleic acids20100101

Title: Final report of the safety assessment of Kojic acid as used in cosmetics.

Journal: International journal of toxicology20100101

Title: Ultrastructural assessments of the melanosome distribution patterns and pigmentation features in human epidermal cells after UV irradiation and kojic acid treatment.

Journal: International journal of cosmetic science20091201

Title: Different therapeutic modalities for treatment of melasma.

Journal: Journal of cosmetic dermatology20091201

Title: The hunt for natural skin whitening agents.

Journal: International journal of molecular sciences20091201

Title: Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae.

Journal: Toxins20091201

Title: Chemical constituents of the endophytic fungus Lecythophora sp. isolated from Alyxia reinwardtii.

Journal: Natural product communications20091101

Title: An evaluation of extracts of five traditional medicinal plants from Iran on the inhibition of mushroom tyrosinase activity and scavenging of free radicals.

Journal: International journal of cosmetic science20091001

Title: Kojic acid-amino acid conjugates as tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters20091001

Title: Purification and characterization of neoagarotetraose from hydrolyzed agar.

Journal: Journal of microbiology and biotechnology20091001

Title: Evaluation of depigmenting activity by 8-hydroxydaidzein in mouse B16 melanoma cells and human volunteers.

Journal: International journal of molecular sciences20091001

Title: Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20090901

Title: Variations in IC(50) values with purity of mushroom tyrosinase.

Journal: International journal of molecular sciences20090901

Title: Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration.

Journal: International journal of molecular sciences20090901

Title: Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells.

Journal: Bioorganic & medicinal chemistry20090815

Title: Chemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus.

Journal: Journal of agricultural and food chemistry20090812

Title: Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities.

Journal: European journal of medicinal chemistry20090801

Title: N-[(Dihydroxyphenyl)acyl]serotonins as potent inhibitors of tyrosinase from mouse and human melanoma cells.

Journal: Bioorganic & medicinal chemistry letters20090801

Title: [Tyrosinase inhibition of Potentilla bifurca].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20090801

Title: Novel 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents.

Journal: Bioorganic & medicinal chemistry20090715

Title: Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.

Journal: Bioorganic & medicinal chemistry20090715

Title: Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins.

Journal: Bioorganic & medicinal chemistry20090701

Title: A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats.

Journal: The Journal of toxicological sciences20090601

Title: An updated review of tyrosinase inhibitors.

Journal: International journal of molecular sciences20090601

Title: Management of hyperpigmentation in darker racial ethnic groups.

Journal: Seminars in cutaneous medicine and surgery20090601

Title: Inhibitory effect of phlorotannins isolated from Ecklonia cava on mushroom tyrosinase activity and melanin formation in mouse B16F10 melanoma cells.

Journal: Journal of agricultural and food chemistry20090527

Title: Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives.

Journal: European journal of medicinal chemistry20090501

Title: [Tyrosinase inhibitor from Angelica dahurica roots].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20090501

Title: Human hair follicle pigmentary unit as a direct target for modulators of melanogenesis, as studied by [14C]-2-thiouracil incorporation.

Journal: Experimental dermatology20090401

Title: Determination of kojic acid based on the interface enhancement effects of carbon nanotube/alizarin red S modified electrode.

Journal: Colloids and surfaces. B, Biointerfaces20090401

Title: Radioprotective effects of kojic acid against mortality induced by gamma irradiation in mice.

Journal: Saudi medical journal20090401

Title: Occurence and bioactivities of funicone-related compounds.

Journal: International journal of molecular sciences20090401

Title: Photoinduced linkage isomerism of {RuNO}(6) complexes with bioligands and related chelators.

Journal: Dalton transactions (Cambridge, England : 2003)20090214

Title: Identification of tumor promotion marker genes for predicting tumor promoting potential of chemicals in BALB/c 3T3 cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20090201

Title: 4-Hydroxy-phenyl 4-fluoro-benzoate.

Journal: Acta crystallographica. Section E, Structure reports online20090201

Title: Synthesis of tyrosinase inhibitory (4-oxo-4H-pyran-2-yl)acrylic acid ester derivatives.

Journal: Bioorganic & medicinal chemistry letters20090101

Title: PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase.

Journal: Bioorganic & medicinal chemistry letters20090101

Title: Inhibitory effect of 2,4,2',4'-tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on tyrosinase activity and melanin biosynthesis.

Journal: Biological & pharmaceutical bulletin20090101

Title: Synthesis of 4-pyridone-3-sulfate and an improved synthesis of 3-hydroxy-4-pyridone.

Journal: Chemistry Central journal20090101

Title: Impact on facial rejuvenation with dermatological preparations.

Journal: Clinical interventions in aging20090101

Title: Optimization of enzymatic synthesis of palm-based kojic acid ester using response surface methodology.

Journal: Journal of oleo science20090101

Title: A fruit quality gene map of Prunus.

Journal: BMC genomics20090101

Title: A study comparing chemical peeling using modified Jessner's solution and 15% trichloroacetic Acid versus 15% trichloroacetic acid in the treatment of melasma.

Journal: Indian journal of dermatology20090101

Title: Topical treatment of melasma.

Journal: Indian journal of dermatology20090101

Title: Conference Report: ACSICON 2008.

Journal: Journal of cutaneous and aesthetic surgery20090101

Title: Isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent.

Journal: Molecular nutrition & food research20081201

Title: Inhibitory effect of Cucumis sativus on melanin production in melanoma B16 cells by downregulation of tyrosinase expression.

Journal: Planta medica20081201

Title: Atom- and bond-based 2D TOMOCOMD-CARDD approach and ligand-based virtual screening for the drug discovery of new tyrosinase inhibitors.

Journal: Journal of biomolecular screening20081201

Title: Hypothesis: can kojic acid prevent xanthelasma formation?

Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia20081201

Title: Antityrosinase and antioxidant effects of ent-kaurane diterpenes from leaves of Broussonetia papyrifera.

Journal: Journal of natural products20081101

Title: Tyrosinase inhibition by extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening.

Journal: Journal of ethnopharmacology20081028

Title: Molecular design of potent tyrosinase inhibitors having the bibenzyl skeleton.

Journal: Bioorganic & medicinal chemistry letters20081001

Title: Screening of Nepalese crude drugs traditionally used to treat hyperpigmentation: in vitro tyrosinase inhibition.

Journal: International journal of cosmetic science20081001

Title: Proteomics analysis of kojic acid treated A375 human malignant melanoma cells.

Journal: Journal of proteome research20080901

Title: 1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane, a novel tyrosinase inhibitor with strong depigmenting effects.

Journal: Chemical & pharmaceutical bulletin20080901

Title: Studying the anti-tyrosinase effect of Arbutus andrachne L. extracts.

Journal: International journal of cosmetic science20080801

Title: Enhanced expression of laccase during the degradation of endocrine disrupting chemicals in Trametes versicolor.

Journal: Journal of microbiology (Seoul, Korea)20080801

Title: Removal of estrogenic activity from endocrine-disrupting chemicals by purified laccase of Phlebia tremellosa.

Journal: FEMS microbiology letters20080701

Title: Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation.

Journal: Bioorganic & medicinal chemistry letters20080615

Title: Rapid analysis of fungal cultures and dried figs for secondary metabolites by LC/TOF-MS.

Journal: Analytica chimica acta20080609

Title: N-(3,4-Difluoro-phen-yl)-3,4-dimethoxy-benzene-sulfonamide.

Journal: Acta crystallographica. Section E, Structure reports online20080601

Title: In vitro antiproliferative and cytotoxic activities of novel kojic acid derivatives: 5-benzyloxy-2-selenocyanatomethyl- and 5-methoxy-2-selenocyanatomethyl-4-pyranone.

Journal: Journal of applied toxicology : JAT20080501

Title: Inhibitory effects of cinnamic acid on melanin biosynthesis in skin.

Journal: Biological & pharmaceutical bulletin20080501

Title: Concurrent administration of ascorbic acid enhances liver tumor-promoting activity of kojic acid in rats.

Journal: The Journal of toxicological sciences20080501

Title: A new tyrosinase inhibitor from Crinum yemense as potential treatment for hyperpigmentation.

Journal: Die Pharmazie20080501

Title: A rapid and reliable size-exclusion chromatographic method for determination of kojic dipalmitate in skin-whitening cosmetic products.

Journal: Talanta20080415

Title: Synthesis and characterization of a novel macrocyclic chelator with 3-hydroxy-4-pyrone chelating arms and its complexes with medicinally important metals.

Journal: Inorganic chemistry20080407

Title: Kinetic properties of catecholoxidase activity of tarantula hemocyanin.

Journal: The FEBS journal20080401

Title: Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.

Journal: Nature chemical biology20080401

Title: Anthraquinones from Polygonum cuspidatum as tyrosinase inhibitors for dermal use.

Journal: Phytotherapy research : PTR20080401

Title: The use of botanical extracts as topical skin-lightening agents for the improvement of skin pigmentation disorders.

Journal: The journal of investigative dermatology. Symposium proceedings20080401

Title: Two novel aflatoxin-producing Aspergillus species from Argentinean peanuts.

Journal: International journal of systematic and evolutionary microbiology20080301

Title: Host-parasitoid interaction as affected by interkingdom competition.

Journal: Oecologia20080201

Title: Mycotoxins in botanicals and dried fruits: a review.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment20080201

Title: 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry20080201

Title: pH-dependent inhibition of mushroom tyrosinase by N-substituted N-nitrosohydroxylamines.

Journal: Journal of enzyme inhibition and medicinal chemistry20080201

Title: Down-regulation of tyrosinase expression by acetylsalicylic acid in murine B16 melanoma.

Journal: Biological & pharmaceutical bulletin20080101

Title: Evaluation of the effect of Thai breadfruit's heartwood extract on melanogenesis-inhibitory and antioxidation activities.

Journal: Journal of cosmetic science20080101

Title: Antidiabetic Bis-Maltolato-OxoVanadium(IV): conversion of inactive trans- to bioactive cis-BMOV for possible binding to target PTP-1B.

Journal: Drug design, development and therapy20080101

Title: QYAG5 Q-switched Nd:YAG Laser Treatment of Nevus of Ota: An Indian Study of 50 Patients.

Journal: Journal of cutaneous and aesthetic surgery20080101

Title: Mir-434-5p mediates skin whitening and lightening.

Journal: Clinical, cosmetic and investigational dermatology20080101

Title: Discovery of small-molecule inhibitors of tyrosinase.

Journal: Bioorganic & medicinal chemistry letters20071215

Title: Tyrosinase inhibitory pentacyclic triterpenes and analgesic and spasmolytic activities of methanol extracts of Rhododendron collettianum.

Journal: Phytotherapy research : PTR20071101

Title: Piceatannol inhibits melanogenesis by its antioxidative actions.

Journal: Biological & pharmaceutical bulletin20071101

Title: Glycine inhibits melanogenesis in vitro and causes hypopigmentation in vivo.

Journal: Biological & pharmaceutical bulletin20071101

Title: N-trans-feruloyltyramine as a melanin biosynthesis inhibitor.

Journal: Biological & pharmaceutical bulletin20071001

Title: X-ray absorption analysis of the active site of Streptomyces antibioticus Tyrosinase upon binding of transition state analogue inhibitors.

Journal: Archives of biochemistry and biophysics20070915

Title: 4-(6-Hydroxy-2-naphthyl)-1,3-bezendiol: a potent, new tyrosinase inhibitor.

Journal: Biological & pharmaceutical bulletin20070901

Title: Enhancement of hepatocellular proliferative activity of kojic acid in mice by a simultaneous administration of ascorbic acid.

Journal: The Journal of veterinary medical science20070901

Title: Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus.

Journal: Microbiology (Reading, England)20070801

Title: Therapeutical approaches in melasma.

Journal: Dermatologic clinics20070701

Title: Preparative isolation and identification of tyrosinase inhibitors from the seeds of Garcinia kola by high-speed counter-current chromatography.

Journal: Journal of chromatography. A20070601

Title: Experimental design and capillary electrophoresis for simultaneous analysis of arbutin, kojic acid and hydroquinone in cosmetics.

Journal: Journal of pharmaceutical and biomedical analysis20070509

Title: Kojic acid -absence of tumor-initiating activity in rat liver, and of carcinogenic and photo-genotoxic potential in mouse skin.

Journal: The Journal of toxicological sciences20070501

Title: Prediction of tyrosinase inhibition activity using atom-based bilinear indices.

Journal: ChemMedChem20070401

Title: Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds.

Journal: Pigment cell research20070401

Title: Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry20070315

Title: Schistosome egg production is dependent upon the activities of two developmentally regulated tyrosinases.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20070301

Title: Modulating effects of a novel skin-lightening agent, alpha-lipoic acid derivative, on melanin production by the formation of DOPA conjugate products.

Journal: Bioorganic & medicinal chemistry20070301

Title: Inhibitory compound of tyrosinase activity from the sprout of Polygonum hydropiper L. (Benitade).

Journal: Biological & pharmaceutical bulletin20070301

Title: TOMOCOMD-CARDD descriptors-based virtual screening of tyrosinase inhibitors: evaluation of different classification model combinations using bond-based linear indices.

Journal: Bioorganic & medicinal chemistry20070201

Title: Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase.

Journal: Bioorganic & medicinal chemistry letters20070115

Title: Combining high-performance liquid chromatography with on-line microdialysis sampling for the simultaneous determination of ascorbyl glucoside, kojic acid, and niacinamide in bleaching cosmetics.

Journal: Analytica chimica acta20070102

Title: Kojic acid and its manganese and zinc complexes as potential radioprotective agents.

Journal: Bioorganic & medicinal chemistry letters20070101

Title: Post TLC developing technique for tyrosinase inhibitor detection.

Journal: Biomedical chromatography : BMC20070101

Title: Kojic acid-tripeptide amide as a new tyrosinase inhibitor.

Journal: Biopolymers20070101

Title: Dragon method for finding novel tyrosinase inhibitors: Biosilico identification and experimental in vitro assays.

Journal: European journal of medicinal chemistry20070101

Title: Speciation of M+3-hydroxypyrone chelation complexes by electrospray ionization ion trap and Fourier transform ion cyclotron resonance mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM20070101

Title: Comparison of estimation capabilities of response surface methodology (RSM) with artificial neural network (ANN) in lipase-catalyzed synthesis of palm-based wax ester.

Journal: BMC biotechnology20070101

Title: Comparison of bipyridyl, maltol and kojic acid action as organic vanadium ligands on activity of galactosyltransferase (EC 2.4.1.38), some physiological parameters and ultrastructure of Golgi complexes in rat hepatocytes.

Journal: Folia histochemica et cytobiologica20070101

Title: Skin lightening preparations and the hydroquinone controversy.

Journal: Dermatologic therapy20070101

Title: Polyphasic taxonomy of Aspergillus section Candidi based on molecular, morphological and physiological data.

Journal: Studies in mycology20070101

Title: The treatment of melasma: a review of clinical trials.

Journal: Journal of the American Academy of Dermatology20061201

Title: From miso, saké and shoyu to cosmetics: a century of science for kojic acid.

Journal: Natural product reports20061201

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling20061101

Title: Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent.

Journal: Bioorganic & medicinal chemistry letters20061101

Title: Tyrosinase inhibition studies of cycloartane and cucurbitane glycosides and their structure-activity relationships.

Journal: Bioorganic & medicinal chemistry20060901

Title: Oxazolones: new tyrosinase inhibitors; synthesis and their structure-activity relationships.

Journal: Bioorganic & medicinal chemistry20060901

Title: Inhibitory effect of ammonium tetrathiotungstate on tyrosinase and its kinetic mechanism.

Journal: Chemical & pharmaceutical bulletin20060901

Title: Artocarpus lakoocha heartwood extract as a novel cosmetic ingredient: evaluation of the in vitro anti-tyrosinase and in vivo skin whitening activities.

Journal: International journal of cosmetic science20060801

Title: Synthesis of pterocellin A.

Journal: Organic letters20060608

Title: Four psychrotolerant species with high chemical diversity consistently producing cycloaspeptide A, Penicillium jamesonlandense sp. nov., Penicillium ribium sp. nov., Penicillium soppii and Penicillium lanosum.

Journal: International journal of systematic and evolutionary microbiology20060601

Title: Topical application of gamma-tocopherol derivative prevents UV-induced skin pigmentation.

Journal: Biological & pharmaceutical bulletin20060601

Title: Potent tyrosinase inhibitors from Trifolium balansae.

Journal: Natural product research20060601

Title: N-Benzylbenzamides: a new class of potent tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters20060515

Title: Absence of in vivo genotoxic potential and tumor initiation activity of kojic acid in the rat thyroid.

Journal: Toxicology20060515

Title: Absence of liver tumor-initiating activity of kojic acid in mice.

Journal: Archives of toxicology20060501

Title: Analogues of N-hydroxycinnamoylphenalkylamides as inhibitors of human melanocyte-tyrosinase.

Journal: Bioorganic & medicinal chemistry letters20060415

Title: Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes.

Journal: Pigment cell research20060401

Title: Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells.

Journal: Biological & pharmaceutical bulletin20060401

Title: Hen egg white lysozyme as an inhibitor of mushroom tyrosinase.

Journal: FEBS letters20060320

Title: Regulation of melanin synthesis by selenium-containing carbohydrates.

Journal: Chemical & pharmaceutical bulletin20060301

Title: Synthesis of tyrosinase inhibitory kojic acid derivative.

Journal: Archiv der Pharmazie20060301

Title: Tyrosinase inhibitory cycloartane type triterpenoids from the methanol extract of the whole plant of Amberboa ramosa Jafri and their structure-activity relationship.

Journal: Bioorganic & medicinal chemistry20060215

Title: Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression.

Journal: Pigment cell research20060201

Title: Tetraketones: a new class of tyrosinase inhibitors.

Journal: Bioorganic & medicinal chemistry20060115

Title: New tyrosinase inhibitors selected by atomic linear indices-based classification models.

Journal: Bioorganic & medicinal chemistry letters20060115

Title: Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes.

Journal: Journal of medicinal chemistry20060112

Title: Plasma phenoloxidase of the larval tobacco budworm, Heliothis virescens, is virucidal.

Journal: Journal of insect science (Online)20060101

Title: Examination of 1,5-anhydro-D-fructose and the enolone ascopyrone P, metabolites of the anhydrofructose pathway of glycogen and starch degradation, for their possible application in fruits, vegetables, and beverages as antibrowning agents.

Journal: Journal of agricultural and food chemistry20051130

Title: Identifying 6,7,4'-trihydroxyisoflavone as a potent tyrosinase inhibitor.

Journal: Bioscience, biotechnology, and biochemistry20051001

Title: DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency.

Journal: Experimental dermatology20050801

Title: Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells.

Journal: Journal of agricultural and food chemistry20050727

Title: The entrapment of kojic oleate in bilayer vesicles.

Journal: International journal of pharmaceutics20050714

Title: Tyrosinase inhibition studies of diterpenoid alkaloids and their derivatives: structure-activity relationships.

Journal: Natural product research20050701

Title: Potent inhibitory effects of N-aryl S-alkylthiocarbamate derivatives on the dopa oxidase activity of mushroom tyrosinase.

Journal: Chemical & pharmaceutical bulletin20050701

Title: Taxonomic comparison of three different groups of aflatoxin producers and a new efficient producer of aflatoxin B1, sterigmatocystin and 3-O-methylsterigmatocystin, Aspergillus rambellii sp. nov.

Journal: Systematic and applied microbiology20050701

Title: Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats. A study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS).

Journal: Mutation research20050606

Title: Repeated-batch production of kojic acid in a cell-retention fermenter using Aspergillus oryzae M3B9.

Journal: Journal of industrial microbiology & biotechnology20050601

Title: Allergic contact dermatitis due to kojic acid.

Journal: Dermatitis : contact, atopic, occupational, drug20050601

Title: Inhibition of tyrosinase activity by N,N-unsubstituted selenourea derivatives.

Journal: Biological & pharmaceutical bulletin20050501

Title: Myrothenones A and B, cyclopentenone derivatives with tyrosinase inhibitory activity from the marine-derived fungus Myrothecium sp.

Journal: Chemical & pharmaceutical bulletin20050401

Title: Synthesis of methyl ether analogues of sildenafil (Viagra) possessing tyrosinase inhibitory potential.

Journal: Chemistry & biodiversity20050401

Title: Fungal populations and mycotoxins in silage in Assiut and Sohag governorates in Egypt, with a special reference to characteristic Aspergilli toxins.

Journal: Mycopathologia20050201

Title: Probing the interaction of kojic acid antibiotics with iron(III) chloride by using electrospray tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM20050101

Title: Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica.

Journal: Bioscience, biotechnology, and biochemistry20050101

Title: Topical methimazole as a new treatment for postinflammatory hyperpigmentation: report of the first case.

Journal: Dermatology (Basel, Switzerland)20050101

Title: Spotlight turns on cosmetics for Asian skin.

Journal: Nature20041223

Title: Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies.

Journal: Chemical & pharmaceutical bulletin20041201

Title: Piperlonguminine from Piper longum with inhibitory effects on alpha-melanocyte-stimulating hormone-induced melanogenesis in melanoma B16 cells.

Journal: Planta medica20041201

Title: Tyrosinase inhibitors isolated from the edible brown alga Ecklonia stolonifera.

Journal: Archives of pharmacal research20041201

Title: Prenylated flavonoids as tyrosinase inhibitors.

Journal: Archives of pharmacal research20041101

Title: Emericella venezuelensis, a new species with stellate ascospores producing sterigmatocystin and aflatoxin B1.

Journal: Systematic and applied microbiology20041101

Title: [Simultaneous determination of magnesium L-ascorbyl-2-phosphate, arbutin and kojic acid in cosmetics by reversed-phase high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography20041101

Title: Enhancement of hepatocarcinogenesis by kojic acid in rat two-stage models after initiation with N-bis(2-hydroxypropyl)nitrosamine or N-diethylnitrosamine.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20040901

Title: Combining induced mutation and protoplasting for strain improvement of Aspergillus oryzae for kojic acid production.

Journal: Biotechnology letters20040701

Title: Solid-phase synthesis of kojic acid-tripeptides and their tyrosinase inhibitory activity, storage stability, and toxicity.

Journal: Bioorganic & medicinal chemistry letters20040607

Title: Production of toxic metabolites in Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei: justification of mycotoxin testing in food grade enzyme preparations derived from the three fungi.

Journal: Regulatory toxicology and pharmacology : RTP20040401

Title: Antityrosinase principles and constituents of the petals of Crocus sativus.

Journal: Journal of natural products20040301

Title: (-)-Epigallocatechin-3-gallate and hinokitiol reduce melanin synthesis via decreased MITF production.

Journal: Archives of pharmacal research20040301

Title: Kojic acid and its derivatives: history and present state of art.

Journal: Central European journal of public health20040301

Title: Effects of kojic acid on oxidative damage and on iron and trace element level in iron-overloaded mice and rats.

Journal: Central European journal of public health20040301

Title: An assessment of the genotoxicity and human health risk of topical use of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one].

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20040101

Title: Tetrapetalone A, a novel lipoxygenase inhibitor from Streptomyces sp.

Journal: Bioscience, biotechnology, and biochemistry20040101

Title: Management of dyschromias in ethnic skin.

Journal: Dermatologic therapy20040101

Title: Photostability of naturally occurring whitening agents in cosmetic microemulsions.

Journal: Journal of cosmetic science20040101

Title: Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines.

Journal: Anticancer research20040101

Title: Optimal management of recalcitrant disorders of hyperpigmentation in dark-skinned patients.

Journal: American journal of clinical dermatology20040101

Title: Topical agents used in the management of hyperpigmentation.

Journal: Skin therapy letter20040101

Title: Enzymatic synthesis of structured lipids.

Journal: Advances in biochemical engineering/biotechnology20040101

Title: Utilizing combination therapy to optimize melasma outcomes.

Journal: Journal of drugs in dermatology : JDD20040101

Title: Morphology and biochemical activity of rat liver golgi complexes after pretreatment with bis(kojato)oxovanadium(IV) or kojic acid alone.

Journal: Polish journal of pathology : official journal of the Polish Society of Pathologists20040101

Title: Synthesis of new glycyrrhetinic acid (GA) derivatives and their effects on tyrosinase activity.

Journal: Bioorganic & medicinal chemistry20031201

Title: Tyrosinase inhibitory prenylated flavonoids from Sophora flavescens.

Journal: Biological & pharmaceutical bulletin20030901

Title: Constituents from the leaves of Phellodendron amurense var. wilsonii and their bioactivity.

Journal: Journal of natural products20030901

Title: Identification of oxidation product of arbutin in mushroom tyrosinase assay system.

Journal: Bioorganic & medicinal chemistry letters20030721

Title: Reconstituted 3-dimensional human skin of various ethnic origins as an in vitro model for studies of pigmentation.

Journal: Analytical biochemistry20030715

Title: Acetophenone derivatives from Acronychia pedunculata.

Journal: Journal of natural products20030701

Title: Inhibitory effects of resveratrol derivatives from dipterocarpaceae plants on tyrosinase activity.

Journal: Bioscience, biotechnology, and biochemistry20030701

Title: Gamma-pyrone derivatives, kojic acid methyl ethers from a marine-derived fungus Alternaria [correction of Altenaria] sp.

Journal: Archives of pharmacal research20030701

Title: [Analysis of kojic acid in Aspergillus oryzae ferment by ion-pair reversed-phase high performance liquid chromatography].

Journal: Wei sheng yan jiu = Journal of hygiene research20030701

Title: A new continuous spectrophotometric assay method for DOPA oxidase activity of tyrosinase.

Journal: Journal of protein chemistry20030701

Title: Hepatocellular tumor induction in heterozygous p53-deficient CBA mice by a 26-week dietary administration of kojic acid.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20030601

Title: Effects of 3-isobutyl-1-methylxanthine and kojic acid on cocultures and skin equivalents composed of HaCaT cells and human melanocytes.

Journal: Archives of dermatological research20030601

Title: Photorejuvenation of the forearms by treating hyperpigmented lesions with intense pulsed light source: a case report.

Journal: Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology20030601

Title: Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity.

Journal: Planta medica20030601

Title: Regioselective synthesis of kojic acid esters by Bacillus subtilis protease.

Journal: Biotechnology letters20030601

Title: Manganese-based complexes of radical scavengers as neuroprotective agents.

Journal: Bioorganic & medicinal chemistry20030515

Title: Effects of mycotoxins, kojic acid and oxalic acid, on biological fitness of Lygus hesperus (Heteroptera: Miridae).

Journal: Journal of invertebrate pathology20030501

Title: Downregulation of NF-kappaB activation in human keratinocytes by melanogenic inhibitors.

Journal: Journal of dermatological science20030501

Title: Kinobeon A as a potent tyrosinase inhibitor from cell culture of safflower: in vitro comparisons of kinobeon A with other putative inhibitors.

Journal: Planta medica20030501

Title: Mushroom tyrosinase inhibitory activity of esculetin isolated from seeds of Euphorbia lathyris L.

Journal: Bioscience, biotechnology, and biochemistry20030301

Title: Gnetol as a potent tyrosinase inhibitor from genus Gnetum.

Journal: Bioscience, biotechnology, and biochemistry20030301

Title: Spectroscopic characterization of the electronic changes in the active site of Streptomyces antibioticus tyrosinase upon binding of transition state analogue inhibitors.

Journal: The Journal of biological chemistry20030227

Title: Development of 5-[(3-aminopropyl)phosphinooxy]-2-(hydroxymethyl)-4H-pyran-4-one as a novel whitening agent.

Journal: Chemical & pharmaceutical bulletin20030201

Title: Mycotoxin production and evolutionary relationships among species of Aspergillus section Clavati.

Journal: Antonie van Leeuwenhoek20030101

Title: Inhibitory effects of 1,3-selenazol-4-one derivatives on mushroom tyrosinase.

Journal: Chemical & pharmaceutical bulletin20021201

Title: Effects of kojic acid on thyroidal functions in rats by single-dose administration and in cultured rat thyroid cells (FRTL-5 cells).

Journal: The Journal of toxicological sciences20021201

Title: New antibiotics miyakamides produced by a fungus.

Journal: The Journal of antibiotics20021101

Title: Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes.

Journal: Cellular signalling20020901

Title: Structural basis and mechanism of the inhibition of the type-3 copper protein tyrosinase from Streptomyces antibioticus by halide ions.

Journal: The Journal of biological chemistry20020823

Title: Redefining the skin's pigmentary system with a novel tyrosinase assay.

Journal: Pigment cell research20020801

Title: Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis.

Journal: Biological & pharmaceutical bulletin20020801

Title: Different complexation properties of some hydroxy keto heterocycles toward beryllium(II) in aqueous solutions: experimental and theoretical studies.

Journal: Inorganic chemistry20020729

Title: Functional analysis of the copper-dependent quercetin 2,3-dioxygenase. 1. Ligand-induced coordination changes probed by X-ray crystallography: inhibition, ordering effect, and mechanistic insights.

Journal: Biochemistry20020625

Title: A melanocyte-keratinocyte coculture model to assess regulators of pigmentation in vitro.

Journal: Analytical biochemistry20020615

Title: Nobiletin as a tyrosinase inhibitor from the peel of Citrus fruit.

Journal: Biological & pharmaceutical bulletin20020601

Title: Oxyresveratrol and hydroxystilbene compounds. Inhibitory effect on tyrosinase and mechanism of action.

Journal: The Journal of biological chemistry20020503

Title: Stability of the new antileukemic 4-pyranone derivative, BTMP, using HPLC and LC-MS analyses.

Journal: Die Pharmazie20020401

Title: Oxidation of kojic acid catalyzed by manganese peroxidase from Ceriporiopsis subvermispora in the absence of hydrogen peroxide.

Journal: Applied biochemistry and biotechnology20020401

Title: Mushroom tyrosinase inhibition activity of some chromones.

Journal: Chemical & pharmaceutical bulletin20020301

Title: Time course study of substrate utilization by Aspergillus flavus in medium simulating corn (Zea mays) kernels.

Journal: Journal of agricultural and food chemistry20020130

Title: The skin-lightening effects of artocarpin on UVB-induced pigmentation.

Journal: Planta medica20020101

Title: Assessment of topical hypopigmenting agents on solar lentigines of Asian women.

Journal: Dermatology (Basel, Switzerland)20020101

Title: New combined treatment of hypermelanosis: analytical studies on efficacy and stability improvement.

Journal: International journal of cosmetic science20011201

Title: The antioxidant action of Polypodium leucotomos extract and kojic acid: reactions with reactive oxygen species.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas20011101

Title: A new dimeric stilbene with tyrosinase inhibitiory activity from Artocarpus gomezianus.

Journal: Journal of natural products20011101

Title: Synthesis and structural characterization of tin(II) and zinc(II) derivatives of cyclic alpha-hydroxyketones, including the structures of Sn(maltol)(2), Sn(tropolone)(2), Zn(tropolone)(2), and Zn(hinokitiol)(2).

Journal: Inorganic chemistry20010813

Title: Kojic acid, a potential inhibitor of NF-kappaB activation in transfectant human HaCaT and SCC-13 cells.

Journal: Archives of pharmacal research20010801

Title: Identification and quantitative analysis of kojic acid and arbutine in skin-whitening cosmetics.

Journal: International journal of cosmetic science20010801

Title: Dose-threshold for thyroid tumor-promoting effects of orally administered kojic acid in rats after initiation with N-bis(2-hydroxypropyl) nitrosamine.

Journal: The Journal of toxicological sciences20010501

Title: Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells.

Journal: Pigment cell research20010401

Title: Evaluation of health aspects of kojic acid in food.

Journal: Regulatory toxicology and pharmacology : RTP20010201

Title: Prevention of the photodamage in the hairless mouse dorsal skin by kojic acid as an iron chelator.

Journal: European journal of pharmacology20010105

Title: Phytotoxicity of pathogenic fungi and their mycotoxins to cereal seedling viability.

Journal: Acta microbiologica et immunologica Hungarica20010101

Title: Simultaneous determination of magnesium L-ascorbyl-2-phosphate and kojic acid in cosmetic bleaching products by using a microbore column and ion-pair liquid chromatography.

Journal: Journal of AOAC International20010101

Title: Kojic acid reduces the cytotoxic effects of sulfur mustard on cultures containing human melanoma cells in vitro.

Journal: Journal of applied toxicology : JAT20010101

Title: Some thyrotropic agents.

Journal: IARC monographs on the evaluation of carcinogenic risks to humans20010101

Title: Improvement of production of Kojic acid by a mutant strain Aspergillus oryzae, MK107-39.

Journal: Journal of bioscience and bioengineering20010101

Title: Kojic acid production in an airlift bioreactor using partially hydrolyzed raw corn starch.

Journal: Journal of bioscience and bioengineering20010101

Title: Functional glucosylation of kojic acid and daidzein with the Eucalyptus membrane-associated UDP-glucosyltransferase reaction system.

Journal: Journal of bioscience and bioengineering20010101

Title: Wei X, et al. Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways. Exp Eye Res. 2018 Dec 28;180:174-183.

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