Name: Name:5-Aminoindole
Brand: AABLOCKS
SKU: AA003MBF
Rating: 90 (10 reviews)

5-Aminoindole serves as a versatile reactant in the synthesis of various pharmaceutical compounds with diverse biological activities. It is utilized in the preparation of Smac mimetics targeting the BIR2 domain of the anti-apoptotic protein XIAP, cytotoxic and antimitotic agents, insulin-like growth factor 1 receptor inhibitors, antitumoral agents, Factor Xa inhibitors, potential antivascular agents, inhibitors of Gli1-mediated transcription in the Hedgehog pathway, receptor tyrosine kinase inhibitors with antiangiogenic effects, PKCθ inhibitors, and HIV protease inhibitors. This compound's structural motif and functional groups make it a valuable building block in medicinal chemistry, contributing to the development of therapeutics for various diseases and conditions.

Catalog No.: AA003MBF

5192-03-0 | 5-Aminoindole

Pack Size： 100mg

Purity： 98%

in stock

$6.00 $4.00

Pack Size： 250mg

Purity： 98%

in stock

$7.00 $5.00

Pack Size： 1g

Purity： 98%

in stock

$10.00 $7.00

Pack Size： 5g

Purity： 98%

in stock

$26.00 $19.00

Pack Size： 10g

Purity： 95%

in stock

$48.00 $34.00

Pack Size： 25g

Purity： 95%

in stock

$116.00 $81.00

Quantity

- +

Add to Card

Order Now

bulk Quotation Request

Technical Information

Catalog Number: AA003MBF

Chemical Name: 5-Aminoindole

CAS Number: 5192-03-0

Molecular Formula: C8H8N2

Molecular Weight: 132.1625

MDL Number: MFCD00005679

SMILES: Nc1ccc2c(c1)cc[nH]2

NSC Number: 61452

Properties

BP: 354°C at 760 mmHg

Form: Solid

MP: 131-133 °C (dec.)(lit.)

Refractive Index: 1.6013 (estimate)

Stability: Air & Light Sensitive

Storage: Inert atmosphere;Room Temperature;

Complexity: 124

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 10

Hydrogen Bond Acceptor Count: 1

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 0

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 0.7

Literature fold

Title: 5-Aminoindole, a new ligand for hydrophobic charge induction chromatography.

Journal: Journal of chromatography. A20081121

Title: Synthesis and PKCtheta inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles.

Journal: Bioorganic & medicinal chemistry letters20080501

Title: Fourier transform infrared and Raman spectral investigations of 5-aminoindole.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20060501

Title: The use of nonnatural nucleotides to probe the contributions of shape complementarity and pi-electron surface area during DNA polymerization.

Journal: Biochemistry20051004

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology20050601

Title: Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis.

Journal: Journal of medicinal chemistry20040603

Application fold

5-Aminoindole serves as a versatile reactant in the synthesis of various pharmaceutical compounds with diverse biological activities. It is utilized in the preparation of Smac mimetics targeting the BIR2 domain of the anti-apoptotic protein XIAP, cytotoxic and antimitotic agents, insulin-like growth factor 1 receptor inhibitors, antitumoral agents, Factor Xa inhibitors, potential antivascular agents, inhibitors of Gli1-mediated transcription in the Hedgehog pathway, receptor tyrosine kinase inhibitors with antiangiogenic effects, PKCθ inhibitors, and HIV protease inhibitors. This compound's structural motif and functional groups make it a valuable building block in medicinal chemistry, contributing to the development of therapeutics for various diseases and conditions.