Title: Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.
Journal: PloS one20150101
Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Journal: The Biochemical journal20130415
Title: MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1.
Journal: Experimental cell research20120310
Title: Targeting Mnks for cancer therapy.
Journal: Oncotarget20120201
Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Journal: Nature biotechnology20111101
Title: Identification of new inhibitors of protein kinase R guided by statistical modeling.
Journal: Bioorganic & medicinal chemistry letters20110701
Title: MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma.
Journal: Cancer research20110315
Title: Mnk mediates integrin α6β4-dependent eIF4E phosphorylation and translation of VEGF mRNA.
Journal: Molecular cancer research : MCR20101201
Title: The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival.
Journal: Cancer biology & therapy20101001
Title: Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.
Journal: Journal of medicinal chemistry20100923
Title: Pro-inflammatory cytokine release in keratinocytes is mediated through the MAPK signal-integrating kinases.
Journal: Experimental dermatology20080601
Title: Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2.
Journal: The Journal of biological chemistry20080502
Title: MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages.
Journal: American journal of physiology. Gastrointestinal and liver physiology20080201
Title: The selectivity of protein kinase inhibitors: a further update.
Journal: The Biochemical journal20071215
Title: Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis.
Journal: Genes to cells : devoted to molecular & cellular mechanisms20071001
Title: Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line.
Journal: Journal of leukocyte biology20060201
Title: Adenovirus-induced extracellular signal-regulated kinase phosphorylation during the late phase of infection enhances viral protein levels and virus progeny.
Journal: Cancer research20060201
Title: Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages.
Journal: Cytokine20060107
Title: Shiga toxins activate translational regulation pathways in intestinal epithelial cells.
Journal: Cellular signalling20050701
Title: Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2).
Journal: The Biochemical journal20050615
Title: Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities.
Journal: Cancer research20041201
Title: Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells.
Journal: Circulation research20031212
Title: Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated protein kinase 2a/p38.
Journal: Cellular signalling20030801
Title: Phosphorylation of eukaryotic initiation factor (eIF) 4E is not required for de novo protein synthesis following recovery from hypertonic stress in human kidney cells.
Journal: The Journal of biological chemistry20020906
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry20020419
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Title: Ishida M, et al. Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells. Circ Res. 2003 Dec 12;93(12):1218-24. Epub 2003 Nov 6
Title: Chrestensen CA, et al. Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis. Genes Cells. 2007 Oct;12(10):1133-40.
Title: Lim S, et al. Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2298-307
