53-95-2,MFCD00869474
Catalog No.:AA00DYMK

53-95-2 | Hydroxyacetylaminofluorene

This product is typically in stock,please click "Inquire" below or
contact us at [email protected] for pricing and availability information.
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00DYMK
Chemical Name:
Hydroxyacetylaminofluorene
CAS Number:
53-95-2
Molecular Formula:
C15H13NO2
Molecular Weight:
239.2692
MDL Number:
MFCD00869474
SMILES:
CC(=O)N(c1ccc2c(c1)Cc1c2cccc1)O
NSC Number:
46522
Properties
Computed Properties
 
Complexity:
331  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.7  

Literature

Title: PET/CT imaging of c-Myc transgenic mice identifies the genotoxic N-nitroso-diethylamine as carcinogen in a short-term cancer bioassay.

Journal: PloS one 20120101

Title: Smoking and COX-2 functional polymorphisms interact to increase the risk of gastric cardia adenocarcinoma in Chinese population.

Journal: PloS one 20110101

Title: Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse.

Journal: PloS one 20110101

Title: New short term prediction method for chemical carcinogenicity by hepatic transcript profiling following 28-day toxicity tests in rats.

Journal: Cancer informatics 20110101

Title: Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines.

Journal: Chemical research in toxicology 20091201

Title: Regulation of sulfotransferase and UDP-glucuronosyltransferase gene expression by the PPARs.

Journal: PPAR research 20090101

Title: Oxidative transformation of 2-acetylaminofluorene by a chemical model for cytochrome P450: A water-insoluble porphyrin and tert-butyl hydroperoxide.

Journal: Bioorganic & medicinal chemistry 20080715

Title: Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene.

Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20071201

Title: ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue rats treated with N-hydroxy-2-acetylaminofluorene.

Journal: Mutagenesis 20061101

Title: Irreversible inactivation of arylamine N-acetyltransferases in the presence of N-hydroxy-4-acetylaminobiphenyl: a comparison of human and hamster enzymes.

Journal: Chemical research in toxicology 20050201

Title: Genetic polymorphism of the N-acetyltransferase 2 gene, and susceptibility to prostate cancer: a pilot study in north Indian population.

Journal: BMC urology 20050101

Title: Mass spectrometric investigation of the mechanism of inactivation of hamster arylamine N-acetyltransferase 1 by N-hydroxy-2-acetylaminofluorene.

Journal: Chemical research in toxicology 20040301

Title: Use of nucleotide excision repair-deficient mice as a model for chemically induced lung cancer.

Journal: Methods in molecular medicine 20030101

Title: Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium.

Journal: Pharmacogenetics 20021201

Title: Differential effects of non-genotoxic carcinogens and proliferating agents on cell growth, survival and apoptosis in hepatic cells in vitro.

Journal: Life sciences 20011109

Title: Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.

Journal: Biological & pharmaceutical bulletin 20011101

Title: Induction of -2 frameshift mutations by 2-nitrofluorene, N-hydroxyacetylaminofluorene, and N-2-acetylaminofluorene in reversion assays in Escherichia coli strains differing in permeability and acetyltransferase activity.

Journal: Mutation research 20010627

Title: The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines.

Journal: Carcinogenesis 20010601

Title: Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorene-treated Big Blue rats.

Journal: Environmental and molecular mutagenesis 20010101

Title: Gene- and tissue-specificity of mutation in Big Blue rats treated with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene.

Journal: Environmental and molecular mutagenesis 20010101

Title: Reduction of hydroxamic acids to the corresponding amides catalyzed by rabbit blood.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20000501

Title: Sulphonation of N-hydroxy-2-acetylaminofluorene by human dehydroepiandrosterone sulphotransferase.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20000301

Title: Molecular cloning and expression of a cDNA encoding an olfactory-specific mouse phenol sulphotransferase.

Journal: The Biochemical journal 19980501

Title: p53 protein expression by hepatocarcinogens in the rat liver and its potential role in mitoinhibition of normal hepatocytes as a mechanism of hepatic tumour promotion.

Journal: Carcinogenesis 19970501

Title: Abnormal neurulation induced by 7-hydroxy-2-acetylaminofluorene and acetaminophen: evidence for catechol metabolites as proximate dysmorphogens.

Journal: Toxicology and applied pharmacology 19891201

Title: Modulation of the embryotoxicity and cytotoxicity elicited by 7-hydroxy-2-acetylaminofluorene and acetaminophen via deacetylation.

Journal: Toxicology and applied pharmacology 19890301

Title: Glutathione status and the incidence of neural tube defects elicited by direct acting teratogens in vitro.

Journal: Teratology 19880601

Title: N-hydroxy-2-acetylaminofluorene as effective inhibitor of aldehyde oxidase.

Journal: Biochemical and biophysical research communications 19860716

Title: Different responses to phenobarbital promotion in the development of gamma-glutamyltranspeptidase-positive foci in the liver of rats initiated with diethylnitrosamine, N-hydroxy-2-acetyl-aminofluorene and aflatoxin B1.

Journal: Japanese journal of cancer research : Gann 19850101

Title: Chronic toxicity of azathioprine and the effect of this immunosuppressant on liver tumor induction by the carcinogen N-hydroxy-N-2-fluorenylacetamide.

Journal: Toxicology and applied pharmacology 19700901

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Tags:53-95-2 Molecular Formula|53-95-2 MDL|53-95-2 SMILES|53-95-2 Hydroxyacetylaminofluorene
Catalog No.: AA00DYMK
53-95-2,MFCD00869474
53-95-2 | Hydroxyacetylaminofluorene
This product is typically in stock,please click "Inquire" below or contact us at [email protected]for pricing and availability information.
Inquire
Technical Information
Catalog Number: AA00DYMK
Chemical Name: Hydroxyacetylaminofluorene
CAS Number: 53-95-2
Molecular Formula: C15H13NO2
Molecular Weight: 239.2692
MDL Number: MFCD00869474
SMILES: CC(=O)N(c1ccc2c(c1)Cc1c2cccc1)O
NSC Number: 46522
Properties
Complexity: 331  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 18  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.7  
Literature fold

Title: PET/CT imaging of c-Myc transgenic mice identifies the genotoxic N-nitroso-diethylamine as carcinogen in a short-term cancer bioassay.

Journal: PloS one20120101

Title: Smoking and COX-2 functional polymorphisms interact to increase the risk of gastric cardia adenocarcinoma in Chinese population.

Journal: PloS one20110101

Title: Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse.

Journal: PloS one20110101

Title: New short term prediction method for chemical carcinogenicity by hepatic transcript profiling following 28-day toxicity tests in rats.

Journal: Cancer informatics20110101

Title: Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines.

Journal: Chemical research in toxicology20091201

Title: Regulation of sulfotransferase and UDP-glucuronosyltransferase gene expression by the PPARs.

Journal: PPAR research20090101

Title: Oxidative transformation of 2-acetylaminofluorene by a chemical model for cytochrome P450: A water-insoluble porphyrin and tert-butyl hydroperoxide.

Journal: Bioorganic & medicinal chemistry20080715

Title: Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene.

Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)20071201

Title: ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue rats treated with N-hydroxy-2-acetylaminofluorene.

Journal: Mutagenesis20061101

Title: Irreversible inactivation of arylamine N-acetyltransferases in the presence of N-hydroxy-4-acetylaminobiphenyl: a comparison of human and hamster enzymes.

Journal: Chemical research in toxicology20050201

Title: Genetic polymorphism of the N-acetyltransferase 2 gene, and susceptibility to prostate cancer: a pilot study in north Indian population.

Journal: BMC urology20050101

Title: Mass spectrometric investigation of the mechanism of inactivation of hamster arylamine N-acetyltransferase 1 by N-hydroxy-2-acetylaminofluorene.

Journal: Chemical research in toxicology20040301

Title: Use of nucleotide excision repair-deficient mice as a model for chemically induced lung cancer.

Journal: Methods in molecular medicine20030101

Title: Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium.

Journal: Pharmacogenetics20021201

Title: Differential effects of non-genotoxic carcinogens and proliferating agents on cell growth, survival and apoptosis in hepatic cells in vitro.

Journal: Life sciences20011109

Title: Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.

Journal: Biological & pharmaceutical bulletin20011101

Title: Induction of -2 frameshift mutations by 2-nitrofluorene, N-hydroxyacetylaminofluorene, and N-2-acetylaminofluorene in reversion assays in Escherichia coli strains differing in permeability and acetyltransferase activity.

Journal: Mutation research20010627

Title: The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines.

Journal: Carcinogenesis20010601

Title: Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorene-treated Big Blue rats.

Journal: Environmental and molecular mutagenesis20010101

Title: Gene- and tissue-specificity of mutation in Big Blue rats treated with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene.

Journal: Environmental and molecular mutagenesis20010101

Title: Reduction of hydroxamic acids to the corresponding amides catalyzed by rabbit blood.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20000501

Title: Sulphonation of N-hydroxy-2-acetylaminofluorene by human dehydroepiandrosterone sulphotransferase.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20000301

Title: Molecular cloning and expression of a cDNA encoding an olfactory-specific mouse phenol sulphotransferase.

Journal: The Biochemical journal19980501

Title: p53 protein expression by hepatocarcinogens in the rat liver and its potential role in mitoinhibition of normal hepatocytes as a mechanism of hepatic tumour promotion.

Journal: Carcinogenesis19970501

Title: Abnormal neurulation induced by 7-hydroxy-2-acetylaminofluorene and acetaminophen: evidence for catechol metabolites as proximate dysmorphogens.

Journal: Toxicology and applied pharmacology19891201

Title: Modulation of the embryotoxicity and cytotoxicity elicited by 7-hydroxy-2-acetylaminofluorene and acetaminophen via deacetylation.

Journal: Toxicology and applied pharmacology19890301

Title: Glutathione status and the incidence of neural tube defects elicited by direct acting teratogens in vitro.

Journal: Teratology19880601

Title: N-hydroxy-2-acetylaminofluorene as effective inhibitor of aldehyde oxidase.

Journal: Biochemical and biophysical research communications19860716

Title: Different responses to phenobarbital promotion in the development of gamma-glutamyltranspeptidase-positive foci in the liver of rats initiated with diethylnitrosamine, N-hydroxy-2-acetyl-aminofluorene and aflatoxin B1.

Journal: Japanese journal of cancer research : Gann19850101

Title: Chronic toxicity of azathioprine and the effect of this immunosuppressant on liver tumor induction by the carcinogen N-hydroxy-N-2-fluorenylacetamide.

Journal: Toxicology and applied pharmacology19700901

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