Name: Name:1-Ethylpiperazine
Brand: AABLOCKS
SKU: AA0032OI
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA0032OI

Chemical Name: 1-Ethylpiperazine

CAS Number: 5308-25-8

Molecular Formula: C6H14N2

Molecular Weight: 114.1888

MDL Number: MFCD00059912

SMILES: CCN1CCNCC1

NSC Number: 60707

Properties

BP: 156°C at 760 mmHg

Form: Liquid

MP: -60 °C

Refractive Index: n20/D 1.469(lit.)

Solubility: soluble

Stability: Air Sensitive

Storage: Inert atmosphere;Room Temperature;

Complexity: 57.5

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 8

Hydrogen Bond Acceptor Count: 2

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 1

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 0

Literature fold

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Journal: European journal of medicinal chemistry20120901

Title: Radical pathway in catecholase activity with zinc-based model complexes of compartmental ligands.

Journal: Inorganic chemistry20120820

Title: 3-(Adamantan-1-yl)-1-[(4-ethyl-piperazin-1-yl)meth-yl]-4-[(E)-(4-hy-droxy-benzyl-idene)amino]-1H-1,2,4-triazole-5(4H)-thione.

Journal: Acta crystallographica. Section E, Structure reports online20120301

Title: Synthesis and biological evaluation of some thiazolidinones as antimicrobial agents.

Journal: European journal of medicinal chemistry20120201

Title: N-(4-Chloro-phen-yl)-4-ethyl-piperazine-1-carboxamide.

Journal: Acta crystallographica. Section E, Structure reports online20111001

Title: The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter.

Journal: PloS one20110101

Title: (S)-3-Chloro-4-(4-ethyl-piperazin-1-yl)-5-[(1R,2S,5R)-2-isopropyl-5-methyl-cyclo-hex-yloxy]furan-2(5H)-one.

Journal: Acta crystallographica. Section E, Structure reports online20100801

Title: Binary complexes of tertiary amines with phenylacetylene. Dispersion wins over electrostatics.

Journal: Physical chemistry chemical physics : PCCP20100621

Title: Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents.

Journal: Bioorganic & medicinal chemistry letters20100115

Title: Catechol oxidase activity of a series of new dinuclear copper(II) complexes with 3,5-DTBC and TCC as substrates: syntheses, X-ray crystal structures, spectroscopic characterization of the adducts and kinetic studies.

Journal: Inorganic chemistry20080818

Title: Copper(I) cyanide networks: synthesis, structure, and luminescence behavior. Part 2. Piperazine ligands and hexamethylenetetramine.

Journal: Inorganic chemistry20080804

Title: Synthesis and biological activity of functionalized indole-2-carboxylates, triazino- and pyridazino-indoles.

Journal: Archiv der Pharmazie20080501

Title: Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac.

Journal: Journal of pharmaceutical and biomedical analysis20080313

Title: Identification of a novel vardenafil analogue in herbal product.

Journal: Journal of pharmaceutical and biomedical analysis20080313

Title: Determination of analogs of sildenafil and vardenafil in foods by column liquid chromatography with a photodiode array detector, mass spectrometry, and nuclear magnetic resonance spectrometry.

Journal: Journal of AOAC International20080101

Title: Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates.

Journal: Indian journal of pharmaceutical sciences20080101

Title: Structure determination of new analogues of vardenafil and sildenafil in dietary supplements.

Journal: Food additives and contaminants20070201

Title: Use of liquid chromatography-mass spectrometry and a hydrolytic technique for the detection and structure elucidation of a novel synthetic vardenafil designer drug added illegally to a 'natural' herbal dietary supplement.

Journal: Journal of chromatography. A20060825

Title: Patterns of metabolites produced from the fluoroquinolone enrofloxacin by basidiomycetes indigenous to agricultural sites.

Journal: Applied microbiology and biotechnology20060601

Title: Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents.

Journal: American journal of therapeutics20060101

Title: Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.

Journal: Bioorganic & medicinal chemistry letters20050615

Title: Structure determination of a sildenafil analogue contained in commercial herb drinks.

Journal: Magnetic resonance in chemistry : MRC20041201

Title: Structure elucidation of sildenafil analogues in herbal products.

Journal: Food additives and contaminants20040801

Application fold

1-Ethylpiperazine is a chemical compound commonly employed as a building block in organic synthesis. Its versatile nature allows it to participate in various synthetic reactions, including the preparation of pharmaceutical intermediates and complex molecules.

In particular, 1-Ethylpiperazine serves as a key starting material in the synthesis of bioactive compounds such as 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride. These compounds are important in medicinal chemistry and may exhibit pharmacological properties.

Additionally, 1-Ethylpiperazine finds utility in other synthetic routes and applications beyond the examples provided, owing to its ability to act as a nucleophilic amine and form stable complexes with various electrophiles. Its inclusion in organic synthesis enables the construction of diverse molecular structures, making it valuable in the pharmaceutical, agrochemical, and materials science industries.

5308-25-8 | 1-Ethylpiperazine