5442-12-6,MFCD00213361
Catalog No.:AA00DE7M

5442-12-6 | Norcantharidin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5g
analytical standard,≥98%
in stock  
$427.00   $299.00
- +
25g
analytical standard,≥98%
in stock  
$1,409.00   $987.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00DE7M
Chemical Name:
Norcantharidin
CAS Number:
5442-12-6
Molecular Formula:
C8H8O4
Molecular Weight:
168.1467
MDL Number:
MFCD00213361
SMILES:
O=C1OC(=O)C2C1C1CCC2O1
Properties
Computed Properties
 
Complexity:
246  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
4  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-0.1  

Literature

Title: Norcantharidin induce apoptosis in human nasopharyngeal carcinoma through caspase and mitochondrial pathway.

Journal: Environmental toxicology 20180301

Title: Suppression of lymphangiogenesis in human lymphatic endothelial cells by simultaneously blocking VEGF-C and VEGF-D/VEGFR-3 with norcantharidin.

Journal: International journal of oncology 20121101

Title: Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular carcinoma cells by transcriptional repression of Mcl-1.

Journal: Cellular signalling 20120901

Title: Norcantharidin triggers cell death and DNA damage through S-phase arrest and ROS-modulated apoptotic pathways in TSGH 8301 human urinary bladder carcinoma cells.

Journal: International journal of oncology 20120901

Title: Induction of apoptosis in human Hep3B hepatoma cells by norcantharidin through a p53 independent pathway via TRAIL/DR5 signal transduction.

Journal: Chinese journal of integrative medicine 20120901

Title: Preparation, characterization and anticancer activity of norcantharidin-loaded poly(ethylene glycol)-poly(caprolactone) amphiphilic block copolymer micelles.

Journal: Die Pharmazie 20120901

Title: Synthesis and anticancer activity of a series of norcantharidin analogues.

Journal: European journal of medicinal chemistry 20120801

Title: Determination of norcantharidin in mouse tissues by liquid chromatography coupled to tandem mass spectrometry and its tissue distribution study.

Journal: Arzneimittel-Forschung 20120601

Title: Synthesis of optically pure norcantharidin analogue NCA-01, a highly selective protein phosphatase 2B inhibitor, and its derivatives.

Journal: Chemistry, an Asian journal 20120601

Title: Norcantharidin: a potential antiangiogenic agent for gallbladder cancers in vitro and in vivo.

Journal: International journal of oncology 20120501

Title: Bis(2-amino-benzothia-zol-3-ium) bis-(7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato-κ(3)O(2),O(3),O(7))nickelate(II) hexa-hydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20120501

Title: Bis(2-amino-benzothia-zol-3-ium) bis-(7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato-κ(3)O(2),O(3),O(7))zincate hexa-hydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20120501

Title: exo,exo-4-(2-Hy-droxy-eth-yl)-10-oxa-4-aza-tricyclo-[5.2.1.0]dec-8-ene-3,5-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20120301

Title: [Effect of norcantharidin on the expression of FN, Col IV and TGF-β1 mRNA and protein in HK-2 cells induced by high glucose].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20120301

Title: [Effects of norcantharidin on lipopolysaccharide-induced hepatocyte injury in vitro].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20120301

Title: Norcantharidin, a protective therapeutic agent in renal tubulointerstitial fibrosis.

Journal: Molecular and cellular biochemistry 20120201

Title: catena-Poly[[diaqua-cobalt(II)]-μ(2)-7-oxa-bicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato-κO,O,O:O].

Journal: Acta crystallographica. Section E, Structure reports online 20120201

Title: 4-(3,5-Dioxo-10-oxa-4-aza-tricyclo-[5.2.1.0]decan-4-yl)-10-oxa-4-aza-tricyclo-[5.2.1.0]decane-3,5-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20120201

Title: Cantharidin and norcantharidin inhibit caprine luteal cell steroidogenesis in vitro.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120101

Title: Norcantharidin impairs medulloblastoma growth by inhibition of Wnt/β-catenin signaling.

Journal: Journal of neuro-oncology 20120101

Title: Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-kB activity.

Journal: PloS one 20120101

Title: Norcantharidin anti-angiogenesis activity possibly through an endothelial cell pathway in human colorectal cancer.

Journal: Asian Pacific journal of cancer prevention : APJCP 20120101

Title: Uptake and transport of a novel anticancer drug-delivery system: lactosyl-norcantharidin-associated N-trimethyl chitosan nanoparticles across intestinal Caco-2 cell monolayers.

Journal: International journal of nanomedicine 20120101

Title: Small-molecule synthetic compound norcantharidin reverses multi-drug resistance by regulating Sonic hedgehog signaling in human breast cancer cells.

Journal: PloS one 20120101

Title: Pharmacokinetics, tissue distribution, and metabolites of a polyvinylpyrrolidone-coated norcantharidin chitosan nanoparticle formulation in rats and mice, using LC-MS/MS.

Journal: International journal of nanomedicine 20120101

Title: Novel norcantharidin-loaded liver targeting chitosan nanoparticles to enhance intestinal absorption.

Journal: International journal of nanomedicine 20120101

Title: Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Norcantharidin Induces HL-60 Cells Apoptosis In Vitro.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Norcantharidin facilitates LPS-mediated immune responses by up-regulation of AKT/NF-κB signaling in macrophages.

Journal: PloS one 20120101

Title: Norcantharidin inhibits proliferation and fibronectin expression of HK-2 cells induced by albumin in vitro.

Journal: Cell biology international 20111201

Title: Norcantharidin inhibits the expression of extracellular matrix and TGF-β1 in HK-2 cells induced by high glucose independent of calcineurin signal pathway.

Journal: Laboratory investigation; a journal of technical methods and pathology 20111201

Title: Norcantharidin induces melanoma cell apoptosis through activation of TR3 dependent pathway.

Journal: Cancer biology & therapy 20111201

Title: [Norcantharidin potentialize the chemosensitivity of adriamycin through the NF-κB/IκBα signaling pathway].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20111201

Title: 3A4, a new potential target for B and myeloid lineage leukemias.

Journal: Journal of drug targeting 20111101

Title: Norcantharidin analogues: a patent review (2006 - 2010).

Journal: Expert opinion on therapeutic patents 20111101

Title: Norcantharidin modulates development of dendritic cells and prolongs skin allograft survival.

Journal: Transplantation 20111027

Title: A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis.

Journal: PLoS genetics 20111001

Title: Poly[[(2,2'-bipyridine)(μ(3)-7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato)cadmium] monohydrate].

Journal: Acta crystallographica. Section E, Structure reports online 20111001

Title: Norcantharimide analogues possessing terminal phosphate esters and their anti-cancer activity.

Journal: Bioorganic & medicinal chemistry 20110915

Title: Triaqua-(7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato-κO,O,O)cobalt(II) monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20110801

Title: exo-4-[(1H-Benzimidazol-2-yl)meth-yl]-10-oxa-4-aza-tricyclo-[5.2.1.0]decane-3,5-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20110801

Title: Tyr306 near the C-terminus of protein phosphatase-1 affects enzyme stability and inhibitor binding.

Journal: IUBMB life 20110701

Title: Separation and identification of norcantharidin metabolites in vivo by GC-MS method.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110615

Title: Norcantharidin analogues with nematocidal activity in Haemonchus contortus.

Journal: Bioorganic & medicinal chemistry letters 20110601

Title: Norcantharidin induces apoptosis of breast cancer cells: involvement of activities of mitogen activated protein kinases and signal transducers and activators of transcription.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110401

Title: Norcantharidin induces cell cycle arrest and inhibits progression of human leukemic Jurkat T cells through mitogen-activated protein kinase-mediated regulation of interleukin-2 production.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110201

Title: The anti-proliferative effects of norcantharidin on human HepG2 cells in cell culture.

Journal: Molecular biology reports 20110101

Title: Norcantharidin attenuates tubulointerstitial fibrosis in rat models with diabetic nephropathy.

Journal: Renal failure 20110101

Title: Herbal medicine and hepatocellular carcinoma: applications and challenges.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: E4BP4 facilitates glucocorticoid-evoked apoptosis of human leukemic CEM cells via upregulation of Bim.

Journal: Journal of molecular signaling 20110101

Title: Chitosan derivatives with antimicrobial, antitumour and antioxidant activities--a review.

Journal: Current pharmaceutical design 20110101

Title: The antiplasmodial activity of norcantharidin analogs.

Journal: Bioorganic & medicinal chemistry letters 20101115

Title: Targeting of the B-lineage leukemia stem cells and their progeny with norcantharidin encapsulated liposomes modified with a novel CD19 monoclonal antibody 2E8 in vitro.

Journal: Journal of drug targeting 20101101

Title: Evaluation of anti-Wnt/β-catenin signaling agents by pGL4-TOP transfected stable cells with a luciferase reporter system.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20101001

Title: Study on norcantharidin-induced apoptosis in SMMC-7721 cells through mitochondrial pathways.

Journal: Chinese journal of integrative medicine 20101001

Title: Therapeutic effects of cantharidin analogues without bridging ether oxygen on human hepatocellular carcinoma cells.

Journal: European journal of medicinal chemistry 20100901

Title: [Molecular mechanism of norcantharidin inducing apoptosis in liver cancer cells].

Journal: Zhonghua yi xue za zhi 20100810

Title: Inhibitory effects of norcantharidin against human lung cancer cell growth and migration.

Journal: Cytotechnology 20100801

Title: Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20100801

Title: [Norcantharidin inhibits DNA replication initiation protein Cdc6 in cancer cells].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100801

Title: Tris(2-amino-1,3-thia-zole-κN)(7-oxa-bicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato-κO,O,O)cadmium(II) dihydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20100801

Title: Poly[bis-(1H-imidazole)bis-(μ(2)-1H-imidazolido)bis-(μ(2)-7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato)trizinc(II)].

Journal: Acta crystallographica. Section E, Structure reports online 20100601

Title: (3aRS,4SR,7RS,7aSR)-2-(Tricyclo-[3.3.1.1]decan-1-yl)-4,5,6,7-tetra-hydro-4,7-epoxy-isoindoline-1,3-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20100601

Title: Synthesis and biological activity of Delta-5,6-norcantharimides: importance of the 5,6-bridge.

Journal: European journal of medicinal chemistry 20100501

Title: Norcantharidin-associated galactosylated chitosan nanoparticles for hepatocyte-targeted delivery.

Journal: Nanomedicine : nanotechnology, biology, and medicine 20100401

Title: Involvement of caspase and MAPK activities in norcantharidin-induced colorectal cancer cell apoptosis.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100401

Title: [Norcantharidin induces apoptosis in SMMC-7721 cells via the c-Jun-NH2-terminal kinase signaling pathways].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100201

Title: [Inhibition of the replication of HIV-1 by norcantharidin in vitro].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100201

Title: Involvement of mitochondrial pathway in NCTD-induced cytotoxicity in human hepG2 cells.

Journal: Journal of experimental & clinical cancer research : CR 20100101

Title: Norcantharidin induces HT-29 colon cancer cell apoptosis through the alphavbeta6-extracellular signal-related kinase signaling pathway.

Journal: Cancer science 20091201

Title: A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells.

Journal: Chemico-biological interactions 20091030

Title: Norcantharidin is a small-molecule synthetic compound with anti-angiogenesis effect.

Journal: Life sciences 20091021

Title: Synthesis, characterization, DNA-binding and antiproliferative activity of Nd(III) complexes with N-(nitrogen heterocyclic) norcantharidin acylamide acid.

Journal: Journal of fluorescence 20090901

Title: Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin.

Journal: Journal of medicinal chemistry 20090813

Title: Tris(1H-imidazole-κN)(7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato-κO,O,O)cobalt(II) 3.35-hydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20090801

Title: Poly[bis-(1H-imidazole)(μ(3)-7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato)cadmium(II)].

Journal: Acta crystallographica. Section E, Structure reports online 20090701

Title: catena-Poly[[diaqua-nickel(II)]-μ-7-oxabicyclo-[2.2.1]heptane-2,3-di-carboxyl-ato].

Journal: Acta crystallographica. Section E, Structure reports online 20090701

Title: rac-7-Oxabicyclo-[2.2.1]heptane-2,3-dicarboxylic acid-2-amino-1,3,4-thia-diazole-water (1/1/1).

Journal: Acta crystallographica. Section E, Structure reports online 20090701

Title: The effect of cantharidins on leukemic stem cells.

Journal: International journal of cancer 20090501

Title: Suppression of growth of highly-metastatic human breast cancer cells by norcantharidin and its mechanisms of action.

Journal: Cytotechnology 20090401

Title: Suppression of growth of highly-metastatic human breast cancer cells by norcantharidin and its mechanisms of action.

Journal: Cytotechnology 20090401

Title: Effects of theanine on growth of human lung cancer and leukemia cells as well as migration and invasion of human lung cancer cells.

Journal: Cytotechnology 20090401

Title: Norcantharidin reduced cyclins and cytokines production in human peripheral blood mononuclear cells.

Journal: Life sciences 20090213

Title: catena-Poly[[diaqua-copper(II)]-μ-7-oxa-bicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato].

Journal: Acta crystallographica. Section E, Structure reports online 20090201

Title: 8-Phenyl-10-oxa-8-aza-tricyclo-[4.3.0.1]decane-7,9-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20090201

Title: Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action.

Journal: Molecular cancer 20090101

Title: Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?

Journal: Cell communication and signaling : CCS 20090101

Title: Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition.

Journal: ChemMedChem 20081201

Title: Formation mechanism and release behavior of poly(epsilon-caprolactone) microspheres containing disodium norcantharidate.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080801

Title: The 1:1 cocrystal of rac-7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxylic acid and 2-amino-benzothia-zole.

Journal: Acta crystallographica. Section E, Structure reports online 20080801

Title: [Preparation of the immunotoxin 2E8-norcantharidin and its targeting killing effect in vitro].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20080701

Title: Disodium norcantharidate-loaded poly(epsilon-caprolactone) microspheres II. Modification of morphology and release behavior.

Journal: International journal of pharmaceutics 20080402

Title: Disodium norcantharidate loaded poly(epsilon-caprolactone) microspheres I. Preparation and evaluation.

Journal: International journal of pharmaceutics 20080227

Title: [Synthesis and anticancer activity of norcantharidin-galactose derivatives].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080201

Title: Determination and pharmacokinetic study of norcantharidin in human serum by HPLC-MS/MS method.

Journal: Biomedical chromatography : BMC 20080101

Title: Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells.

Journal: Anti-cancer drugs 20080101

Title: Norcantharidin ameliorates proteinuria, associated tubulointerstitial inflammation and fibrosis in protein overload nephropathy.

Journal: American journal of nephrology 20080101

Title: Synthesis and biological evaluation of norcantharidin analogues: towards PP1 selectivity.

Journal: Bioorganic & medicinal chemistry 20071201

Title: Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation.

Journal: Bioorganic & medicinal chemistry 20070915

Title: Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070901

Title: [Preparation and characterization of solid lipid nanoparticles of norcantharidin].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070901

Title: Heterocyclic substituted cantharidin and norcantharidin analogues--synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity.

Journal: Bioorganic & medicinal chemistry letters 20070615

Title: [Pharmacokinetics and biodistribution of 3H-norcantharidin in mice].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070501

Title: [Effect of norcantharidin's derivative Nd3 on proliferation of human ovarian cancer cell line SKOV3 and its possible mechanisms].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20070401

Title: Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20070201

Title: [Comparison of acute toxicity of two preparations of norcantharidin in mice].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070101

Title: Molecular biology of cantharidin in cancer cells.

Journal: Chinese medicine 20070101

Title: Novel polymeric microspheres containing norcantharidin for chemoembolization.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20061101

Title: A less irritant norcantharidin lipid microspheres: formulation and drug distribution.

Journal: International journal of pharmaceutics 20061012

Title: [In vitro and in vivo assesemet of sodium norcantharidin lipid microsphere].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060801

Title: [Effects of interventional therapy with norcantharidin microsphere on hepatoma in rats and its mechanism].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20060701

Title: [Anti-tumor mechanism of norcantharidin for the implanted tumors of human gallbladder carcinoma in nude mice in vivo].

Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] 20060501

Title: [Effects of norcantharidin on angiogenesis of human gallbladder carcinoma and its anti-angiogenic mechanisms].

Journal: Zhonghua yi xue za zhi 20060314

Title: Norcantharidin inhibits DNA replication and induces apoptosis with the cleavage of initiation protein Cdc6 in HL-60 cells.

Journal: Anti-cancer drugs 20060301

Title: [Anti-tumor effect of ethanol extracts from Thymus quinquecostatus Celak on human leukemia cell line].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20050901

Title: Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells.

Journal: World journal of gastroenterology 20050428

Title: Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells.

Journal: Anti-cancer drugs 20050301

Title: Mitogen-activated protein kinase-dependent apoptosis in norcan-tharidin-treated A375-S2 cells is proceeded by the activation of protein kinase C.

Journal: Chinese medical journal 20050205

Title: Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio.

Journal: Cancer letters 20050110

Title: In vitro assessment of renal toxicity and inflammatory events of two protein phosphatase inhibitors cantharidin and nor-cantharidin.

Journal: Basic & clinical pharmacology & toxicology 20050101

Title: An investigation on liver-targeting microemulsions of norcantharidin.

Journal: Drug delivery 20050101

Title: Norcantharidin induces apoptosis in HeLa cells through caspase, MAPK, and mitochondrial pathways.

Journal: Acta pharmacologica Sinica 20041101

Title: Influence of norcantharidin on proliferation, proliferation-related gene proteins proliferating cell nuclear antigen and Ki-67 of human gallbladder carcinoma GBC-SD cells.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20041101

Title: Norcantharidin induces human melanoma A375-S2 cell apoptosis through mitochondrial and caspase pathways.

Journal: Journal of Korean medical science 20040801

Title: [Studies on the liver targeting of norcantharindin microemulsion].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040801

Title: [The in vitro effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells and its mechanism].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20040501

Title: Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity.

Journal: Bioorganic & medicinal chemistry letters 20040419

Title: Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells.

Journal: British journal of pharmacology 20031001

Title: [Advances in the study of Cantharidin and its derivatives].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030601

Title: Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines.

Journal: Bioorganic chemistry 20030201

Title: Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratinocytes.

Journal: Oral oncology 20030101

Title: Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells.

Journal: International journal of cancer 20020710

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Induction of apoptosis by norcantharidin in human colorectal carcinoma cell lines: involvement of the CD95 receptor/ligand.

Journal: Journal of cancer research and clinical oncology 20020401

Title: The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design?

Journal: Anti-cancer drug design 20011201

Title: Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.

Journal: Bioorganic & medicinal chemistry letters 20011119

Title: Potential new antitumor agents from an innovative combination of demethylcantharidin, a modified traditional Chinese medicine, with a platinum moiety.

Journal: Journal of medicinal chemistry 20010621

Title: Effect of norcantharidin on N-acetyltransferase activity in HepG2 cells.

Journal: The American journal of Chinese medicine 20010101

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Tags:5442-12-6 Molecular Formula|5442-12-6 MDL|5442-12-6 SMILES|5442-12-6 Norcantharidin
Catalog No.: AA00DE7M
5442-12-6,MFCD00213361
5442-12-6 | Norcantharidin
Pack Size: 5g
Purity: analytical standard,≥98%
in stock
$427.00 $299.00
Pack Size: 25g
Purity: analytical standard,≥98%
in stock
$1,409.00 $987.00
Quantity
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Technical Information
Catalog Number: AA00DE7M
Chemical Name: Norcantharidin
CAS Number: 5442-12-6
Molecular Formula: C8H8O4
Molecular Weight: 168.1467
MDL Number: MFCD00213361
SMILES: O=C1OC(=O)C2C1C1CCC2O1
Properties
Complexity: 246  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 12  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 4  
Undefined Bond Stereocenter Count: 0  
XLogP3: -0.1  
Literature fold

Title: Norcantharidin induce apoptosis in human nasopharyngeal carcinoma through caspase and mitochondrial pathway.

Journal: Environmental toxicology20180301

Title: Suppression of lymphangiogenesis in human lymphatic endothelial cells by simultaneously blocking VEGF-C and VEGF-D/VEGFR-3 with norcantharidin.

Journal: International journal of oncology20121101

Title: Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular carcinoma cells by transcriptional repression of Mcl-1.

Journal: Cellular signalling20120901

Title: Norcantharidin triggers cell death and DNA damage through S-phase arrest and ROS-modulated apoptotic pathways in TSGH 8301 human urinary bladder carcinoma cells.

Journal: International journal of oncology20120901

Title: Induction of apoptosis in human Hep3B hepatoma cells by norcantharidin through a p53 independent pathway via TRAIL/DR5 signal transduction.

Journal: Chinese journal of integrative medicine20120901

Title: Preparation, characterization and anticancer activity of norcantharidin-loaded poly(ethylene glycol)-poly(caprolactone) amphiphilic block copolymer micelles.

Journal: Die Pharmazie20120901

Title: Synthesis and anticancer activity of a series of norcantharidin analogues.

Journal: European journal of medicinal chemistry20120801

Title: Determination of norcantharidin in mouse tissues by liquid chromatography coupled to tandem mass spectrometry and its tissue distribution study.

Journal: Arzneimittel-Forschung20120601

Title: Synthesis of optically pure norcantharidin analogue NCA-01, a highly selective protein phosphatase 2B inhibitor, and its derivatives.

Journal: Chemistry, an Asian journal20120601

Title: Norcantharidin: a potential antiangiogenic agent for gallbladder cancers in vitro and in vivo.

Journal: International journal of oncology20120501

Title: Bis(2-amino-benzothia-zol-3-ium) bis-(7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato-κ(3)O(2),O(3),O(7))nickelate(II) hexa-hydrate.

Journal: Acta crystallographica. Section E, Structure reports online20120501

Title: Bis(2-amino-benzothia-zol-3-ium) bis-(7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato-κ(3)O(2),O(3),O(7))zincate hexa-hydrate.

Journal: Acta crystallographica. Section E, Structure reports online20120501

Title: exo,exo-4-(2-Hy-droxy-eth-yl)-10-oxa-4-aza-tricyclo-[5.2.1.0]dec-8-ene-3,5-dione.

Journal: Acta crystallographica. Section E, Structure reports online20120301

Title: [Effect of norcantharidin on the expression of FN, Col IV and TGF-β1 mRNA and protein in HK-2 cells induced by high glucose].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences20120301

Title: [Effects of norcantharidin on lipopolysaccharide-induced hepatocyte injury in vitro].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences20120301

Title: Norcantharidin, a protective therapeutic agent in renal tubulointerstitial fibrosis.

Journal: Molecular and cellular biochemistry20120201

Title: catena-Poly[[diaqua-cobalt(II)]-μ(2)-7-oxa-bicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato-κO,O,O:O].

Journal: Acta crystallographica. Section E, Structure reports online20120201

Title: 4-(3,5-Dioxo-10-oxa-4-aza-tricyclo-[5.2.1.0]decan-4-yl)-10-oxa-4-aza-tricyclo-[5.2.1.0]decane-3,5-dione.

Journal: Acta crystallographica. Section E, Structure reports online20120201

Title: Cantharidin and norcantharidin inhibit caprine luteal cell steroidogenesis in vitro.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie20120101

Title: Norcantharidin impairs medulloblastoma growth by inhibition of Wnt/β-catenin signaling.

Journal: Journal of neuro-oncology20120101

Title: Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-kB activity.

Journal: PloS one20120101

Title: Norcantharidin anti-angiogenesis activity possibly through an endothelial cell pathway in human colorectal cancer.

Journal: Asian Pacific journal of cancer prevention : APJCP20120101

Title: Uptake and transport of a novel anticancer drug-delivery system: lactosyl-norcantharidin-associated N-trimethyl chitosan nanoparticles across intestinal Caco-2 cell monolayers.

Journal: International journal of nanomedicine20120101

Title: Small-molecule synthetic compound norcantharidin reverses multi-drug resistance by regulating Sonic hedgehog signaling in human breast cancer cells.

Journal: PloS one20120101

Title: Pharmacokinetics, tissue distribution, and metabolites of a polyvinylpyrrolidone-coated norcantharidin chitosan nanoparticle formulation in rats and mice, using LC-MS/MS.

Journal: International journal of nanomedicine20120101

Title: Novel norcantharidin-loaded liver targeting chitosan nanoparticles to enhance intestinal absorption.

Journal: International journal of nanomedicine20120101

Title: Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Norcantharidin Induces HL-60 Cells Apoptosis In Vitro.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Norcantharidin facilitates LPS-mediated immune responses by up-regulation of AKT/NF-κB signaling in macrophages.

Journal: PloS one20120101

Title: Norcantharidin inhibits proliferation and fibronectin expression of HK-2 cells induced by albumin in vitro.

Journal: Cell biology international20111201

Title: Norcantharidin inhibits the expression of extracellular matrix and TGF-β1 in HK-2 cells induced by high glucose independent of calcineurin signal pathway.

Journal: Laboratory investigation; a journal of technical methods and pathology20111201

Title: Norcantharidin induces melanoma cell apoptosis through activation of TR3 dependent pathway.

Journal: Cancer biology & therapy20111201

Title: [Norcantharidin potentialize the chemosensitivity of adriamycin through the NF-κB/IκBα signaling pathway].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi20111201

Title: 3A4, a new potential target for B and myeloid lineage leukemias.

Journal: Journal of drug targeting20111101

Title: Norcantharidin analogues: a patent review (2006 - 2010).

Journal: Expert opinion on therapeutic patents20111101

Title: Norcantharidin modulates development of dendritic cells and prolongs skin allograft survival.

Journal: Transplantation20111027

Title: A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis.

Journal: PLoS genetics20111001

Title: Poly[[(2,2'-bipyridine)(μ(3)-7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato)cadmium] monohydrate].

Journal: Acta crystallographica. Section E, Structure reports online20111001

Title: Norcantharimide analogues possessing terminal phosphate esters and their anti-cancer activity.

Journal: Bioorganic & medicinal chemistry20110915

Title: Triaqua-(7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato-κO,O,O)cobalt(II) monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online20110801

Title: exo-4-[(1H-Benzimidazol-2-yl)meth-yl]-10-oxa-4-aza-tricyclo-[5.2.1.0]decane-3,5-dione.

Journal: Acta crystallographica. Section E, Structure reports online20110801

Title: Tyr306 near the C-terminus of protein phosphatase-1 affects enzyme stability and inhibitor binding.

Journal: IUBMB life20110701

Title: Separation and identification of norcantharidin metabolites in vivo by GC-MS method.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20110615

Title: Norcantharidin analogues with nematocidal activity in Haemonchus contortus.

Journal: Bioorganic & medicinal chemistry letters20110601

Title: Norcantharidin induces apoptosis of breast cancer cells: involvement of activities of mitogen activated protein kinases and signal transducers and activators of transcription.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20110401

Title: Norcantharidin induces cell cycle arrest and inhibits progression of human leukemic Jurkat T cells through mitogen-activated protein kinase-mediated regulation of interleukin-2 production.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20110201

Title: The anti-proliferative effects of norcantharidin on human HepG2 cells in cell culture.

Journal: Molecular biology reports20110101

Title: Norcantharidin attenuates tubulointerstitial fibrosis in rat models with diabetic nephropathy.

Journal: Renal failure20110101

Title: Herbal medicine and hepatocellular carcinoma: applications and challenges.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: E4BP4 facilitates glucocorticoid-evoked apoptosis of human leukemic CEM cells via upregulation of Bim.

Journal: Journal of molecular signaling20110101

Title: Chitosan derivatives with antimicrobial, antitumour and antioxidant activities--a review.

Journal: Current pharmaceutical design20110101

Title: The antiplasmodial activity of norcantharidin analogs.

Journal: Bioorganic & medicinal chemistry letters20101115

Title: Targeting of the B-lineage leukemia stem cells and their progeny with norcantharidin encapsulated liposomes modified with a novel CD19 monoclonal antibody 2E8 in vitro.

Journal: Journal of drug targeting20101101

Title: Evaluation of anti-Wnt/β-catenin signaling agents by pGL4-TOP transfected stable cells with a luciferase reporter system.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas20101001

Title: Study on norcantharidin-induced apoptosis in SMMC-7721 cells through mitochondrial pathways.

Journal: Chinese journal of integrative medicine20101001

Title: Therapeutic effects of cantharidin analogues without bridging ether oxygen on human hepatocellular carcinoma cells.

Journal: European journal of medicinal chemistry20100901

Title: [Molecular mechanism of norcantharidin inducing apoptosis in liver cancer cells].

Journal: Zhonghua yi xue za zhi20100810

Title: Inhibitory effects of norcantharidin against human lung cancer cell growth and migration.

Journal: Cytotechnology20100801

Title: Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT20100801

Title: [Norcantharidin inhibits DNA replication initiation protein Cdc6 in cancer cells].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University20100801

Title: Tris(2-amino-1,3-thia-zole-κN)(7-oxa-bicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato-κO,O,O)cadmium(II) dihydrate.

Journal: Acta crystallographica. Section E, Structure reports online20100801

Title: Poly[bis-(1H-imidazole)bis-(μ(2)-1H-imidazolido)bis-(μ(2)-7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato)trizinc(II)].

Journal: Acta crystallographica. Section E, Structure reports online20100601

Title: (3aRS,4SR,7RS,7aSR)-2-(Tricyclo-[3.3.1.1]decan-1-yl)-4,5,6,7-tetra-hydro-4,7-epoxy-isoindoline-1,3-dione.

Journal: Acta crystallographica. Section E, Structure reports online20100601

Title: Synthesis and biological activity of Delta-5,6-norcantharimides: importance of the 5,6-bridge.

Journal: European journal of medicinal chemistry20100501

Title: Norcantharidin-associated galactosylated chitosan nanoparticles for hepatocyte-targeted delivery.

Journal: Nanomedicine : nanotechnology, biology, and medicine20100401

Title: Involvement of caspase and MAPK activities in norcantharidin-induced colorectal cancer cell apoptosis.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20100401

Title: [Norcantharidin induces apoptosis in SMMC-7721 cells via the c-Jun-NH2-terminal kinase signaling pathways].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology20100201

Title: [Inhibition of the replication of HIV-1 by norcantharidin in vitro].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20100201

Title: Involvement of mitochondrial pathway in NCTD-induced cytotoxicity in human hepG2 cells.

Journal: Journal of experimental & clinical cancer research : CR20100101

Title: Norcantharidin induces HT-29 colon cancer cell apoptosis through the alphavbeta6-extracellular signal-related kinase signaling pathway.

Journal: Cancer science20091201

Title: A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells.

Journal: Chemico-biological interactions20091030

Title: Norcantharidin is a small-molecule synthetic compound with anti-angiogenesis effect.

Journal: Life sciences20091021

Title: Synthesis, characterization, DNA-binding and antiproliferative activity of Nd(III) complexes with N-(nitrogen heterocyclic) norcantharidin acylamide acid.

Journal: Journal of fluorescence20090901

Title: Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin.

Journal: Journal of medicinal chemistry20090813

Title: Tris(1H-imidazole-κN)(7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato-κO,O,O)cobalt(II) 3.35-hydrate.

Journal: Acta crystallographica. Section E, Structure reports online20090801

Title: Poly[bis-(1H-imidazole)(μ(3)-7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato)cadmium(II)].

Journal: Acta crystallographica. Section E, Structure reports online20090701

Title: catena-Poly[[diaqua-nickel(II)]-μ-7-oxabicyclo-[2.2.1]heptane-2,3-di-carboxyl-ato].

Journal: Acta crystallographica. Section E, Structure reports online20090701

Title: rac-7-Oxabicyclo-[2.2.1]heptane-2,3-dicarboxylic acid-2-amino-1,3,4-thia-diazole-water (1/1/1).

Journal: Acta crystallographica. Section E, Structure reports online20090701

Title: The effect of cantharidins on leukemic stem cells.

Journal: International journal of cancer20090501

Title: Suppression of growth of highly-metastatic human breast cancer cells by norcantharidin and its mechanisms of action.

Journal: Cytotechnology20090401

Title: Suppression of growth of highly-metastatic human breast cancer cells by norcantharidin and its mechanisms of action.

Journal: Cytotechnology20090401

Title: Effects of theanine on growth of human lung cancer and leukemia cells as well as migration and invasion of human lung cancer cells.

Journal: Cytotechnology20090401

Title: Norcantharidin reduced cyclins and cytokines production in human peripheral blood mononuclear cells.

Journal: Life sciences20090213

Title: catena-Poly[[diaqua-copper(II)]-μ-7-oxa-bicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato].

Journal: Acta crystallographica. Section E, Structure reports online20090201

Title: 8-Phenyl-10-oxa-8-aza-tricyclo-[4.3.0.1]decane-7,9-dione.

Journal: Acta crystallographica. Section E, Structure reports online20090201

Title: Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action.

Journal: Molecular cancer20090101

Title: Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?

Journal: Cell communication and signaling : CCS20090101

Title: Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition.

Journal: ChemMedChem20081201

Title: Formation mechanism and release behavior of poly(epsilon-caprolactone) microspheres containing disodium norcantharidate.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V20080801

Title: The 1:1 cocrystal of rac-7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxylic acid and 2-amino-benzothia-zole.

Journal: Acta crystallographica. Section E, Structure reports online20080801

Title: [Preparation of the immunotoxin 2E8-norcantharidin and its targeting killing effect in vitro].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics20080701

Title: Disodium norcantharidate-loaded poly(epsilon-caprolactone) microspheres II. Modification of morphology and release behavior.

Journal: International journal of pharmaceutics20080402

Title: Disodium norcantharidate loaded poly(epsilon-caprolactone) microspheres I. Preparation and evaluation.

Journal: International journal of pharmaceutics20080227

Title: [Synthesis and anticancer activity of norcantharidin-galactose derivatives].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20080201

Title: Determination and pharmacokinetic study of norcantharidin in human serum by HPLC-MS/MS method.

Journal: Biomedical chromatography : BMC20080101

Title: Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells.

Journal: Anti-cancer drugs20080101

Title: Norcantharidin ameliorates proteinuria, associated tubulointerstitial inflammation and fibrosis in protein overload nephropathy.

Journal: American journal of nephrology20080101

Title: Synthesis and biological evaluation of norcantharidin analogues: towards PP1 selectivity.

Journal: Bioorganic & medicinal chemistry20071201

Title: Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation.

Journal: Bioorganic & medicinal chemistry20070915

Title: Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20070901

Title: [Preparation and characterization of solid lipid nanoparticles of norcantharidin].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20070901

Title: Heterocyclic substituted cantharidin and norcantharidin analogues--synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity.

Journal: Bioorganic & medicinal chemistry letters20070615

Title: [Pharmacokinetics and biodistribution of 3H-norcantharidin in mice].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20070501

Title: [Effect of norcantharidin's derivative Nd3 on proliferation of human ovarian cancer cell line SKOV3 and its possible mechanisms].

Journal: Ai zheng = Aizheng = Chinese journal of cancer20070401

Title: Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT20070201

Title: [Comparison of acute toxicity of two preparations of norcantharidin in mice].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine20070101

Title: Molecular biology of cantharidin in cancer cells.

Journal: Chinese medicine20070101

Title: Novel polymeric microspheres containing norcantharidin for chemoembolization.

Journal: Journal of controlled release : official journal of the Controlled Release Society20061101

Title: A less irritant norcantharidin lipid microspheres: formulation and drug distribution.

Journal: International journal of pharmaceutics20061012

Title: [In vitro and in vivo assesemet of sodium norcantharidin lipid microsphere].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20060801

Title: [Effects of interventional therapy with norcantharidin microsphere on hepatoma in rats and its mechanism].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine20060701

Title: [Anti-tumor mechanism of norcantharidin for the implanted tumors of human gallbladder carcinoma in nude mice in vivo].

Journal: Zhonghua wai ke za zhi [Chinese journal of surgery]20060501

Title: [Effects of norcantharidin on angiogenesis of human gallbladder carcinoma and its anti-angiogenic mechanisms].

Journal: Zhonghua yi xue za zhi20060314

Title: Norcantharidin inhibits DNA replication and induces apoptosis with the cleavage of initiation protein Cdc6 in HL-60 cells.

Journal: Anti-cancer drugs20060301

Title: [Anti-tumor effect of ethanol extracts from Thymus quinquecostatus Celak on human leukemia cell line].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine20050901

Title: Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells.

Journal: World journal of gastroenterology20050428

Title: Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells.

Journal: Anti-cancer drugs20050301

Title: Mitogen-activated protein kinase-dependent apoptosis in norcan-tharidin-treated A375-S2 cells is proceeded by the activation of protein kinase C.

Journal: Chinese medical journal20050205

Title: Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio.

Journal: Cancer letters20050110

Title: In vitro assessment of renal toxicity and inflammatory events of two protein phosphatase inhibitors cantharidin and nor-cantharidin.

Journal: Basic & clinical pharmacology & toxicology20050101

Title: An investigation on liver-targeting microemulsions of norcantharidin.

Journal: Drug delivery20050101

Title: Norcantharidin induces apoptosis in HeLa cells through caspase, MAPK, and mitochondrial pathways.

Journal: Acta pharmacologica Sinica20041101

Title: Influence of norcantharidin on proliferation, proliferation-related gene proteins proliferating cell nuclear antigen and Ki-67 of human gallbladder carcinoma GBC-SD cells.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT20041101

Title: Norcantharidin induces human melanoma A375-S2 cell apoptosis through mitochondrial and caspase pathways.

Journal: Journal of Korean medical science20040801

Title: [Studies on the liver targeting of norcantharindin microemulsion].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20040801

Title: [The in vitro effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells and its mechanism].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology]20040501

Title: Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity.

Journal: Bioorganic & medicinal chemistry letters20040419

Title: Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells.

Journal: British journal of pharmacology20031001

Title: [Advances in the study of Cantharidin and its derivatives].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20030601

Title: Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines.

Journal: Bioorganic chemistry20030201

Title: Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratinocytes.

Journal: Oral oncology20030101

Title: Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells.

Journal: International journal of cancer20020710

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Induction of apoptosis by norcantharidin in human colorectal carcinoma cell lines: involvement of the CD95 receptor/ligand.

Journal: Journal of cancer research and clinical oncology20020401

Title: The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design?

Journal: Anti-cancer drug design20011201

Title: Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.

Journal: Bioorganic & medicinal chemistry letters20011119

Title: Potential new antitumor agents from an innovative combination of demethylcantharidin, a modified traditional Chinese medicine, with a platinum moiety.

Journal: Journal of medicinal chemistry20010621

Title: Effect of norcantharidin on N-acetyltransferase activity in HepG2 cells.

Journal: The American journal of Chinese medicine20010101

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