546-06-5,MFCD00016752
Catalog No.:AA003OYR

546-06-5 | Conessine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
50mg
≥98%
in stock  
$172.00   $120.00
- +
100mg
≥98%
in stock  
$326.00   $228.00
- +
250mg
≥98%
in stock  
$720.00   $504.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003OYR
Chemical Name:
Conessine
CAS Number:
546-06-5
Molecular Formula:
C24H40N2
Molecular Weight:
356.5878
MDL Number:
MFCD00016752
SMILES:
CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C
Properties
Properties
 
Form:
Solid  
MP:
119 - 124°C  
Storage:
-20 ℃;Inert atmosphere;  

Computed Properties
 
Complexity:
609  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.9  

Literature

Title: International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.

Journal: Pharmacological reviews 20150701

Title: Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica.

Journal: Malaria journal 20130101

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships.

Journal: Life sciences 20120614

Title: Antimicrobial activity of the methanolic bark extract of Holarrhena pubescens (Buch. Ham), its fractions and the pure compound conessine.

Journal: Natural product research 20120101

Title: Novel chalcone-based fluorescent human histamine h(3) receptor ligands as pharmacological tools.

Journal: Frontiers in systems neuroscience 20120101

Title: Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani.

Journal: Biological chemistry 20111201

Title: Anti-malarial activity of Holarrhena antidysenterica and Viola canescens, plants traditionally used against malaria in the Garhwal region of north-west Himalaya.

Journal: Malaria journal 20110101

Title: Identification of novel functional inhibitors of acid sphingomyelinase.

Journal: PloS one 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Acute cardiac toxicity of nerium oleander/indicum poisoning (kaner) poisoning.

Journal: Heart views : the official journal of the Gulf Heart Association 20100101

Title: Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships.

Journal: Journal of medicinal chemistry 20090813

Title: Piperidine variations in search for non-imidazole histamine H(3) receptor ligands.

Journal: Bioorganic & medicinal chemistry 20080915

Title: The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.

Journal: Journal of medicinal chemistry 20080911

Title: Novel H3 receptor antagonists with improved pharmacokinetic profiles.

Journal: Bioorganic & medicinal chemistry letters 20080715

Title: The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.

Journal: Bioorganic & medicinal chemistry 20080715

Title: A new family of H3 receptor antagonists based on the natural product Conessine.

Journal: Bioorganic & medicinal chemistry letters 20080215

Title: High-performance thin layer chromatography method for estimation of conessine in herbal extract and pharmaceutical dosage formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20080122

Title: Chromatographic analysis of Kutajarista--an ayurvedic polyherbal formulation.

Journal: Phytochemical analysis : PCA 20080101

Title: Development and validation of a visible absorption densitometry method for quantitation of conessine in Holarrhena antidysenterica (Kurchi).

Journal: Journal of AOAC International 20080101

Title: Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells.

Journal: BMC pharmacology 20080101

Title: Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL.

Journal: Chemical & pharmaceutical bulletin 20070601

Title: A new family of histamine H3 receptor antagonists based on a natural product: discovery, SAR, and properties of the series.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20070401

Title: Antibacterial activities of the extracts and conessine from Holarrhena floribunda G. Don. (Apocynaceae).

Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM 20070101

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.

Journal: Bioorganic & medicinal chemistry letters 20050516

Title: Highly enantioselective construction of fused pyrrolidine systems that contain a quaternary stereocenter: concise formal synthesis of (+)-conessine.

Journal: Angewandte Chemie (International ed. in English) 20040503

Title: Steroid hormone activity of flavonoids and related compounds.

Journal: Breast cancer research and treatment 20000701

Title: Déjà vu guides the way to new antimicrobial steroid.

Journal: Science (New York, N.Y.) 19930219

Title: Squalamine: an aminosterol antibiotic from the shark.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19930215

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:546-06-5 Molecular Formula|546-06-5 MDL|546-06-5 SMILES|546-06-5 Conessine
Catalog No.: AA003OYR
546-06-5,MFCD00016752
546-06-5 | Conessine
Pack Size: 50mg
Purity: ≥98%
in stock
$172.00 $120.00
Pack Size: 100mg
Purity: ≥98%
in stock
$326.00 $228.00
Pack Size: 250mg
Purity: ≥98%
in stock
$720.00 $504.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA003OYR
Chemical Name: Conessine
CAS Number: 546-06-5
Molecular Formula: C24H40N2
Molecular Weight: 356.5878
MDL Number: MFCD00016752
SMILES: CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C
Properties
Form: Solid  
MP: 119 - 124°C  
Storage: -20 ℃;Inert atmosphere;  
Complexity: 609  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 8  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 26  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.9  
Literature fold

Title: International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.

Journal: Pharmacological reviews20150701

Title: Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica.

Journal: Malaria journal20130101

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry20121115

Title: Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships.

Journal: Life sciences20120614

Title: Antimicrobial activity of the methanolic bark extract of Holarrhena pubescens (Buch. Ham), its fractions and the pure compound conessine.

Journal: Natural product research20120101

Title: Novel chalcone-based fluorescent human histamine h(3) receptor ligands as pharmacological tools.

Journal: Frontiers in systems neuroscience20120101

Title: Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani.

Journal: Biological chemistry20111201

Title: Anti-malarial activity of Holarrhena antidysenterica and Viola canescens, plants traditionally used against malaria in the Garhwal region of north-west Himalaya.

Journal: Malaria journal20110101

Title: Identification of novel functional inhibitors of acid sphingomyelinase.

Journal: PloS one20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Acute cardiac toxicity of nerium oleander/indicum poisoning (kaner) poisoning.

Journal: Heart views : the official journal of the Gulf Heart Association20100101

Title: Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships.

Journal: Journal of medicinal chemistry20090813

Title: Piperidine variations in search for non-imidazole histamine H(3) receptor ligands.

Journal: Bioorganic & medicinal chemistry20080915

Title: The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.

Journal: Journal of medicinal chemistry20080911

Title: Novel H3 receptor antagonists with improved pharmacokinetic profiles.

Journal: Bioorganic & medicinal chemistry letters20080715

Title: The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.

Journal: Bioorganic & medicinal chemistry20080715

Title: A new family of H3 receptor antagonists based on the natural product Conessine.

Journal: Bioorganic & medicinal chemistry letters20080215

Title: High-performance thin layer chromatography method for estimation of conessine in herbal extract and pharmaceutical dosage formulations.

Journal: Journal of pharmaceutical and biomedical analysis20080122

Title: Chromatographic analysis of Kutajarista--an ayurvedic polyherbal formulation.

Journal: Phytochemical analysis : PCA20080101

Title: Development and validation of a visible absorption densitometry method for quantitation of conessine in Holarrhena antidysenterica (Kurchi).

Journal: Journal of AOAC International20080101

Title: Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells.

Journal: BMC pharmacology20080101

Title: Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL.

Journal: Chemical & pharmaceutical bulletin20070601

Title: A new family of histamine H3 receptor antagonists based on a natural product: discovery, SAR, and properties of the series.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20070401

Title: Antibacterial activities of the extracts and conessine from Holarrhena floribunda G. Don. (Apocynaceae).

Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM20070101

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling20061101

Title: Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.

Journal: Bioorganic & medicinal chemistry letters20050516

Title: Highly enantioselective construction of fused pyrrolidine systems that contain a quaternary stereocenter: concise formal synthesis of (+)-conessine.

Journal: Angewandte Chemie (International ed. in English)20040503

Title: Steroid hormone activity of flavonoids and related compounds.

Journal: Breast cancer research and treatment20000701

Title: Déjà vu guides the way to new antimicrobial steroid.

Journal: Science (New York, N.Y.)19930219

Title: Squalamine: an aminosterol antibiotic from the shark.

Journal: Proceedings of the National Academy of Sciences of the United States of America19930215

Building Blocks More >
3400-45-1
3400-45-1
Cyclopentanecarboxylic acid
AA003P3M | MFCD00001371
381716-33-2
381716-33-2
D-GALACTOSE 1-[2-(2-AZIDOETHOXY)ETHOXYETHYL]-2,3,4,6-TETRA-O-ACETATE
AA003P78 | MFCD28016268
7795-87-1
7795-87-1
Phosphoric acid di-n-decyl ester
AA003PBQ | MFCD00015062
1069-08-5
1069-08-5
DIETHYLPHOSPHORAMIDOUS DICHLORIDE
AA003PFK | MFCD00013614
598-64-1
598-64-1
DIMETHYLDITHIOCARBAMIC ACID DIMETHYLAMMONIUM SALT
AA003PKG | MFCD00067267
8005-52-5
8005-52-5
Direct yellow 44
AA003PO8 | MFCD00059960
556-03-6
556-03-6
DL-tyrosine
AA003PRY | MFCD00063074
5356-83-2
5356-83-2
Ethoxydimethylvinylsilane
AA003PW5 | MFCD00009070
55750-49-7
55750-49-7
Ethyl 2,5-dioxopyrrole-1-carboxylate
AA003PZT | MFCD16619570
96617-71-9
96617-71-9
Ethyl 3,5-bis(trifluoromethyl)benzoate
AA003Q3T | MFCD01320684
Submit
© 2017 AA BLOCKS, INC. All rights reserved.