Name: Name:2-cyano-3-(1-phenylindol-3-yl)acrylate
Brand: AABLOCKS
SKU: AA00EBJB
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00EBJB

Chemical Name: 2-cyano-3-(1-phenylindol-3-yl)acrylate

CAS Number: 56396-35-1

Molecular Formula: C18H12N2O2

Molecular Weight: 288.3001

MDL Number: MFCD19443867

SMILES: N#CC(=Cc1cn(c2c1cccc2)c1ccccc1)C(=O)O

Properties

BP: 448.6°C at 760 mmHg

Form: Solid

MP: 235-238°C

Storage: Keep in dry area;2-8℃;

Complexity: 499

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 1

Formal Charge: 0

Heavy Atom Count: 22

Hydrogen Bond Acceptor Count: 3

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 3

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.5

Literature fold

Title: Protection by exogenous pyruvate through a mechanism related to monocarboxylate transporters against cell death induced by hydrogen peroxide in cultured rat cortical neurons.

Journal: Journal of neurochemistry20050401

Title: Interleukin-1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1.

Journal: Blood19971015

Title: Tenidap inhibits replication of the human immunodeficiency virus-1 in cultured cells.

Journal: Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association19970101

Title: Halestrap AP. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J. 1975 April; 148(1): 85-96.

Title: Wiemer EA, et al. The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. Biochem J. 1995 Dec 1;312 ( Pt 2):479-84.

Title: Hinoi E, et al. A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol Pharmacol. 2006 Sep;70(3):925-35. Epub 2006 Jun 9.

Title: Patterson JN, et al. Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated secretion. J Biol Chem. 2014 May 9;289(19):13335-46.

Title: Zhong Y, et al. Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro. Oncotarget. 2015 Nov 10;6(35):37758-69.

56396-35-1 | 2-cyano-3-(1-phenylindol-3-yl)acrylate