56776-01-3,MFCD00214398
Catalog No.:AA00IA1K

56776-01-3 | Tulobuterol, HCl

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Purity
Availability
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100mg
>98.0%(T)(HPLC)
in stock  
$30.00   $21.00
- +
250mg
≥98%
in stock  
$55.00   $38.00
- +
500mg
≥98%
in stock  
$96.00   $67.00
- +
1g
≥98%
in stock  
$172.00   $120.00
- +
5g
≥98%
in stock  
$583.00   $408.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00IA1K
Chemical Name:
Tulobuterol, HCl
CAS Number:
56776-01-3
Molecular Formula:
C12H19Cl2NO
Molecular Weight:
264.1914
MDL Number:
MFCD00214398
SMILES:
OC(c1ccccc1Cl)CNC(C)(C)C.Cl
NSC Number:
758643
Properties
Computed Properties
 
Complexity:
191  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  

Literature

Title: β2-adrenergic receptor haplotype may be associated with susceptibility to desensitization to long-acting β2-agonists in COPD patients.

Journal: Lung 20120801

Title: Transdermal tulobuterol patch, a long-actingβ(2)-agonist.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20120601

Title: [Clinical effects of budesonide/formoterol combination drug in elder patients with asthma compared with budesonide plus tulobuterol patch combination treatment].

Journal: Arerugi = [Allergy] 20120601

Title: Influence of 1-D silica nanotubes as drug adsorbent on release behaviors of tulobuterol-loaded porous microcapsules.

Journal: Colloids and surfaces. B, Biointerfaces 20120401

Title: Evaluation of the predicted time-concentration profile of serum tulobuterol in human after transdermal application.

Journal: Chemical & pharmaceutical bulletin 20120101

Title: Study of the physicochemical properties of tulobuterol dry syrups using taste and smell sensors.

Journal: Chemical & pharmaceutical bulletin 20120101

Title: [Questionnaire survey on the change of asthmatic response, adverse events and product usability due to drug switching between name-brand and generic tulobuterol tapes].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20120101

Title: Effects of the tulobuterol patch on the treatment of acute asthma exacerbations in young children.

Journal: Allergy and asthma proceedings 20120101

Title: Effects of inhaled tiotropium plus transdermal tulobuterol versus tiotropium alone on impulse oscillation system (IOS)-assessed measures of peripheral airway resistance and reactance, lung function and quality of life in patients with COPD: a randomized crossover study.

Journal: Pulmonary pharmacology & therapeutics 20111001

Title: [Model analysis of tulobuterol patch formulations to explain the influence of drug release rate and transdermal transfer rate on the plasma concentration profile].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Effect of porous silica on sustained release behaviors of pH sensitive pluronic F127/poly(acrylic acid) hydrogels containing tulobuterol.

Journal: Colloids and surfaces. B, Biointerfaces 20101015

Title: Characterization and release behaviors of porous PCL/Eudragit RS microcapsules containing tulobuterol.

Journal: Colloids and surfaces. B, Biointerfaces 20100401

Title: Additive effects of transdermal tulobuterol to inhaled tiotropium in patients with COPD.

Journal: Respiratory medicine 20100201

Title: Comparative study of skin permeation profiles between brand and generic tulobuterol patches.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Effects of the addition of Beta2-agonist tulobuterol patches to inhaled corticosteroid in patients with asthma.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20091201

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Tulobuterol patch maintains diaphragm muscle contractility for over twenty-four hours in a mouse model of sepsis.

Journal: The Tohoku journal of experimental medicine 20090801

Title: Detection of tulobuterol crystal in transdermal patches using terahertz pulsed spectroscopy and imaging.

Journal: Die Pharmazie 20090601

Title: Comparison of adherence and efficacy between inhaled salmeterol and transdermal tulobuterol patch in elderly patients with chronic obstructive pulmonary disorder.

Journal: Journal of the American Geriatrics Society 20090501

Title: Chemical mapping of tulobuterol in transdermal tapes using microscopic laser Raman spectroscopy.

Journal: Die Pharmazie 20090301

Title: Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease.

Journal: Pulmonary pharmacology & therapeutics 20081201

Title: Cough and transdermal long-acting beta2 agonist in Japan.

Journal: Respiratory medicine 20081001

Title: Characterization of monolithic matrix patch system containing tulobuterol.

Journal: Archives of pharmacal research 20080801

Title: Comparison of bronchodilatory properties of transdermal and inhaled long-acting beta 2-agonists.

Journal: Pulmonary pharmacology & therapeutics 20080101

Title: Clinical efficacy of the transdermal tulobuterol patch in patients with chronic obstructive pulmonary disease: a comparison with slow-release theophylline.

Journal: Internal medicine (Tokyo, Japan) 20080101

Title: Bioequivalence of marketed transdermal delivery systems for tulobuterol.

Journal: Biological & pharmaceutical bulletin 20070801

Title: Transdermal treatment with tulobuterol increases isometric contractile properties of diaphragm muscle in mice.

Journal: The Tohoku journal of experimental medicine 20070701

Title: [Simultaneous determination of nine beta2-agonists residues in urines by ultra performance liquid chromatography-electrospray tandem mass spectrometry].

Journal: Wei sheng yan jiu = Journal of hygiene research 20070701

Title: Addition of transdermal or inhaled long-acting Beta2-agonists in adult asthmatic patients treated with inhaled corticosteroids: switchover study from tulobuterol patch to salmeterol dry powder inhaler.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20070301

Title: Improvement of pulmonary function and dyspnea by tiotropium in COPD patients using a transdermal beta(2)-agonist.

Journal: Pulmonary pharmacology & therapeutics 20070101

Title: [The efficacy and safety of tulobuterol tape in mild and moderate persistent asthma patients].

Journal: Zhonghua nei ke za zhi 20070101

Title: Treatment with beta2-adrenoceptor agonist in vivo induces human clock gene, Per1, mRNA expression in peripheral blood.

Journal: Chronobiology international 20070101

Title: Comparison of the effects of tulobuterol patch and salmeterol in moderate to severe asthma.

Journal: Clinical and experimental pharmacology & physiology 20061101

Title: Comparison of the clinical efficacy of salmeterol and sustained-release tulobuterol (patch) on inadequately controlled asthma patients on inhaled corticosteroids.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20060901

Title: The use of patch formulation of tulobuterol, a long-acting beta2-adrenoreceptor agonist, in the treatment of severe pediatric asthma.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060601

Title: Differential effects of short-acting beta2-agonists on human granulocyte functions.

Journal: International archives of allergy and immunology 20060101

Title: High-performance liquid chromatography electrospray ionization mass spectrometry determination of tulobuterol in rabbit's plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20050207

Title: Determination of beta-agonist residues in bovine urine using liquid chromatography-tandem mass spectrometry.

Journal: Journal of AOAC International 20050101

Title: Alteration of the circadian rhythm in peak expiratory flow of nocturnal asthma following nighttime transdermal beta2-adrenoceptor agonist tulobuterol chronotherapy.

Journal: Chronobiology international 20050101

Title: Clinical efficacy and safety of transdermal tulobuterol in the treatment of stable COPD: an open-label comparison with inhaled salmeterol.

Journal: Treatments in respiratory medicine 20050101

Title: [Patchs: the success of transdermal administration].

Journal: Revue de l'infirmiere 20040401

Title: [Clinical evaluation of tulobuterol patch in patients with mild or moderate persistent bronchial asthma-effects of long-term treatment on airway inflammation and hypersensitivity].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20040201

Title: Clinical evaluation of a transdermal therapeutic system of the beta2-agonist tulobuterol in patients with mild or moderate persistent bronchial asthma.

Journal: Arzneimittel-Forschung 20040101

Title: Effects of a nitro compound patch on neuropathy in Churg-Strauss syndrome.

Journal: Allergy 20030701

Title: Effects of sustained-release tulobuterol on asthma control and beta-adrenoceptor function.

Journal: Clinical and experimental pharmacology & physiology 20021201

Title: [Development of transdermal formulation of tulobuterol for the treatment of bronchial asthma].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20020101

Title: [Japanese guideline for the diagnosis and management of bronchial asthma (1998)--its results and reversion].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20011001

Title: [Long-acting beta 2-stimulants].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20011001

Title: Quantitative determination of clenbuterol, salbutamol and tulobuterol enantiomers by capillary electrophoresis.

Journal: Fresenius' journal of analytical chemistry 20010201

Title: Clinical characteristics of asthmatic patients prescribed various beta-agonist metered-dose inhalers at Yamagata University Hospital.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010101

Title: Induction and reduction of muscle tremor upon acute and repeated administration of the beta 2-agonists terbutaline, salbutamol and tulobuterol.

Journal: International journal of clinical pharmacology, therapy, and toxicology 19871201

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SDS
Historical Records
Tags:56776-01-3 Molecular Formula|56776-01-3 MDL|56776-01-3 SMILES|56776-01-3 Tulobuterol, HCl
Catalog No.: AA00IA1K
56776-01-3,MFCD00214398
56776-01-3 | Tulobuterol, HCl
Pack Size: 100mg
Purity: >98.0%(T)(HPLC)
in stock
$30.00 $21.00
Pack Size: 250mg
Purity: ≥98%
in stock
$55.00 $38.00
Pack Size: 500mg
Purity: ≥98%
in stock
$96.00 $67.00
Pack Size: 1g
Purity: ≥98%
in stock
$172.00 $120.00
Pack Size: 5g
Purity: ≥98%
in stock
$583.00 $408.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00IA1K
Chemical Name: Tulobuterol, HCl
CAS Number: 56776-01-3
Molecular Formula: C12H19Cl2NO
Molecular Weight: 264.1914
MDL Number: MFCD00214398
SMILES: OC(c1ccccc1Cl)CNC(C)(C)C.Cl
NSC Number: 758643
Properties
Complexity: 191  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 16  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: β2-adrenergic receptor haplotype may be associated with susceptibility to desensitization to long-acting β2-agonists in COPD patients.

Journal: Lung20120801

Title: Transdermal tulobuterol patch, a long-actingβ(2)-agonist.

Journal: Allergology international : official journal of the Japanese Society of Allergology20120601

Title: [Clinical effects of budesonide/formoterol combination drug in elder patients with asthma compared with budesonide plus tulobuterol patch combination treatment].

Journal: Arerugi = [Allergy]20120601

Title: Influence of 1-D silica nanotubes as drug adsorbent on release behaviors of tulobuterol-loaded porous microcapsules.

Journal: Colloids and surfaces. B, Biointerfaces20120401

Title: Evaluation of the predicted time-concentration profile of serum tulobuterol in human after transdermal application.

Journal: Chemical & pharmaceutical bulletin20120101

Title: Study of the physicochemical properties of tulobuterol dry syrups using taste and smell sensors.

Journal: Chemical & pharmaceutical bulletin20120101

Title: [Questionnaire survey on the change of asthmatic response, adverse events and product usability due to drug switching between name-brand and generic tulobuterol tapes].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20120101

Title: Effects of the tulobuterol patch on the treatment of acute asthma exacerbations in young children.

Journal: Allergy and asthma proceedings20120101

Title: Effects of inhaled tiotropium plus transdermal tulobuterol versus tiotropium alone on impulse oscillation system (IOS)-assessed measures of peripheral airway resistance and reactance, lung function and quality of life in patients with COPD: a randomized crossover study.

Journal: Pulmonary pharmacology & therapeutics20111001

Title: [Model analysis of tulobuterol patch formulations to explain the influence of drug release rate and transdermal transfer rate on the plasma concentration profile].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Effect of porous silica on sustained release behaviors of pH sensitive pluronic F127/poly(acrylic acid) hydrogels containing tulobuterol.

Journal: Colloids and surfaces. B, Biointerfaces20101015

Title: Characterization and release behaviors of porous PCL/Eudragit RS microcapsules containing tulobuterol.

Journal: Colloids and surfaces. B, Biointerfaces20100401

Title: Additive effects of transdermal tulobuterol to inhaled tiotropium in patients with COPD.

Journal: Respiratory medicine20100201

Title: Comparative study of skin permeation profiles between brand and generic tulobuterol patches.

Journal: Biological & pharmaceutical bulletin20100101

Title: Effects of the addition of Beta2-agonist tulobuterol patches to inhaled corticosteroid in patients with asthma.

Journal: Allergology international : official journal of the Japanese Society of Allergology20091201

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: Tulobuterol patch maintains diaphragm muscle contractility for over twenty-four hours in a mouse model of sepsis.

Journal: The Tohoku journal of experimental medicine20090801

Title: Detection of tulobuterol crystal in transdermal patches using terahertz pulsed spectroscopy and imaging.

Journal: Die Pharmazie20090601

Title: Comparison of adherence and efficacy between inhaled salmeterol and transdermal tulobuterol patch in elderly patients with chronic obstructive pulmonary disorder.

Journal: Journal of the American Geriatrics Society20090501

Title: Chemical mapping of tulobuterol in transdermal tapes using microscopic laser Raman spectroscopy.

Journal: Die Pharmazie20090301

Title: Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease.

Journal: Pulmonary pharmacology & therapeutics20081201

Title: Cough and transdermal long-acting beta2 agonist in Japan.

Journal: Respiratory medicine20081001

Title: Characterization of monolithic matrix patch system containing tulobuterol.

Journal: Archives of pharmacal research20080801

Title: Comparison of bronchodilatory properties of transdermal and inhaled long-acting beta 2-agonists.

Journal: Pulmonary pharmacology & therapeutics20080101

Title: Clinical efficacy of the transdermal tulobuterol patch in patients with chronic obstructive pulmonary disease: a comparison with slow-release theophylline.

Journal: Internal medicine (Tokyo, Japan)20080101

Title: Bioequivalence of marketed transdermal delivery systems for tulobuterol.

Journal: Biological & pharmaceutical bulletin20070801

Title: Transdermal treatment with tulobuterol increases isometric contractile properties of diaphragm muscle in mice.

Journal: The Tohoku journal of experimental medicine20070701

Title: [Simultaneous determination of nine beta2-agonists residues in urines by ultra performance liquid chromatography-electrospray tandem mass spectrometry].

Journal: Wei sheng yan jiu = Journal of hygiene research20070701

Title: Addition of transdermal or inhaled long-acting Beta2-agonists in adult asthmatic patients treated with inhaled corticosteroids: switchover study from tulobuterol patch to salmeterol dry powder inhaler.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma20070301

Title: Improvement of pulmonary function and dyspnea by tiotropium in COPD patients using a transdermal beta(2)-agonist.

Journal: Pulmonary pharmacology & therapeutics20070101

Title: [The efficacy and safety of tulobuterol tape in mild and moderate persistent asthma patients].

Journal: Zhonghua nei ke za zhi20070101

Title: Treatment with beta2-adrenoceptor agonist in vivo induces human clock gene, Per1, mRNA expression in peripheral blood.

Journal: Chronobiology international20070101

Title: Comparison of the effects of tulobuterol patch and salmeterol in moderate to severe asthma.

Journal: Clinical and experimental pharmacology & physiology20061101

Title: Comparison of the clinical efficacy of salmeterol and sustained-release tulobuterol (patch) on inadequately controlled asthma patients on inhaled corticosteroids.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma20060901

Title: The use of patch formulation of tulobuterol, a long-acting beta2-adrenoreceptor agonist, in the treatment of severe pediatric asthma.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology20060601

Title: Differential effects of short-acting beta2-agonists on human granulocyte functions.

Journal: International archives of allergy and immunology20060101

Title: High-performance liquid chromatography electrospray ionization mass spectrometry determination of tulobuterol in rabbit's plasma.

Journal: Journal of pharmaceutical and biomedical analysis20050207

Title: Determination of beta-agonist residues in bovine urine using liquid chromatography-tandem mass spectrometry.

Journal: Journal of AOAC International20050101

Title: Alteration of the circadian rhythm in peak expiratory flow of nocturnal asthma following nighttime transdermal beta2-adrenoceptor agonist tulobuterol chronotherapy.

Journal: Chronobiology international20050101

Title: Clinical efficacy and safety of transdermal tulobuterol in the treatment of stable COPD: an open-label comparison with inhaled salmeterol.

Journal: Treatments in respiratory medicine20050101

Title: [Patchs: the success of transdermal administration].

Journal: Revue de l'infirmiere20040401

Title: [Clinical evaluation of tulobuterol patch in patients with mild or moderate persistent bronchial asthma-effects of long-term treatment on airway inflammation and hypersensitivity].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20040201

Title: Clinical evaluation of a transdermal therapeutic system of the beta2-agonist tulobuterol in patients with mild or moderate persistent bronchial asthma.

Journal: Arzneimittel-Forschung20040101

Title: Effects of a nitro compound patch on neuropathy in Churg-Strauss syndrome.

Journal: Allergy20030701

Title: Effects of sustained-release tulobuterol on asthma control and beta-adrenoceptor function.

Journal: Clinical and experimental pharmacology & physiology20021201

Title: [Development of transdermal formulation of tulobuterol for the treatment of bronchial asthma].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20020101

Title: [Japanese guideline for the diagnosis and management of bronchial asthma (1998)--its results and reversion].

Journal: Nihon rinsho. Japanese journal of clinical medicine20011001

Title: [Long-acting beta 2-stimulants].

Journal: Nihon rinsho. Japanese journal of clinical medicine20011001

Title: Quantitative determination of clenbuterol, salbutamol and tulobuterol enantiomers by capillary electrophoresis.

Journal: Fresenius' journal of analytical chemistry20010201

Title: Clinical characteristics of asthmatic patients prescribed various beta-agonist metered-dose inhalers at Yamagata University Hospital.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20010101

Title: Induction and reduction of muscle tremor upon acute and repeated administration of the beta 2-agonists terbutaline, salbutamol and tulobuterol.

Journal: International journal of clinical pharmacology, therapy, and toxicology19871201

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