57808-65-8,MFCD00661151
Catalog No.:AA0035XA

57808-65-8 | Closantel

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Purity
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25mg
99+%
in stock  
$6.00   $4.00
- +
250mg
99+%
in stock  
$12.00   $8.00
- +
1g
99+%
in stock  
$24.00   $17.00
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5g
99+%
in stock  
$48.00   $34.00
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25g
99+%
in stock  
$166.00   $117.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0035XA
Chemical Name:
Closantel
CAS Number:
57808-65-8
Molecular Formula:
C22H14Cl2I2N2O2
Molecular Weight:
663.0737
MDL Number:
MFCD00661151
SMILES:
N#CC(c1ccccc1Cl)c1cc(C)c(cc1Cl)NC(=O)c1cc(I)cc(c1O)I
Properties
Properties
 
BP:
590.5°C at 760 mmHg  
Form:
Solid  
MP:
217.8°  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
652  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
7.2  

Literature

Title: Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast.

Journal: Journal of biomolecular screening 20160401

Title: Evaluation of the comparative efficacy of a moxidectin plus triclabendazole pour-on solution against adult and immature liver fluke, Fasciola hepatica, in cattle.

Journal: Veterinary parasitology 20121026

Title: Emergency slaughter of casualty cattle increases the prevalence of anthelmintic drug residues in muscle.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120801

Title: On farm evaluation of the coproantigen ELISA and coproantigen reduction test in Scottish sheep naturally infected with Fasciola hepatica.

Journal: Veterinary parasitology 20120706

Title: Multidrug and multispecies resistance in sheep flocks from São Paulo state, Brazil.

Journal: Veterinary parasitology 20120608

Title: Efficacy of monepantel and anthelmintic combinations against multiple-resistant Haemonchus contortus in sheep, including characterisation of the nematode isolate.

Journal: Veterinary parasitology 20120525

Title: Ivermectin residue depletion in food producing species and its presence in animal foodstuffs with a view to human safety.

Journal: Current pharmaceutical biotechnology 20120501

Title: Introgression of ivermectin resistance genes into a susceptible Haemonchus contortus strain by multiple backcrossing.

Journal: PLoS pathogens 20120201

Title: An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide.

Journal: Toxicology letters 20120105

Title: New insight into immunity and immunopathology of Rickettsial diseases.

Journal: Clinical & developmental immunology 20120101

Title: Anthelmintic drug residues in beef: UPLC-MS/MS method validation, European retail beef survey, and associated exposure and risk assessments.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120101

Title: Integrating fasciolosis control in the dry cow management: the effect of closantel treatment on milk production.

Journal: PloS one 20120101

Title: A computational analysis of the binding mode of closantel as inhibitor of the Onchocerca volvulus chitinase: insights on macrofilaricidal drug design.

Journal: Journal of computer-aided molecular design 20111201

Title: Inhibition of the signal transduction through the AtoSC system by histidine kinase inhibitors in Escherichia coli.

Journal: Cellular signalling 20110801

Title: The efficacy of trichlorphon and naphthalophos against multiple anthelmintic-resistant nematodes of naturally infected sheep in Argentina.

Journal: Parasitology research 20110801

Title: Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina).

Journal: Veterinary parasitology 20110610

Title: Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus.

Journal: Journal of medicinal chemistry 20110609

Title: Determination of closantel and rafoxanide in animal tissues by online anionic mixed-mode solid-phase extraction followed by isotope dilution liquid chromatography tandem mass spectrometry.

Journal: Journal of separation science 20110601

Title: Stability during cooking of anthelmintic veterinary drug residues in beef.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20110201

Title: Multiple resistance to anthelmintics by Haemonchus contortus and Trichostrongylus colubriformis in sheep in Brazil.

Journal: Parasitology international 20101201

Title: Nasal bots...a fascinating world!

Journal: Veterinary parasitology 20101124

Title: A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility.

Journal: PLoS neglected tropical diseases 20101101

Title: Multiple resistance of gastrointestinal nematodes to nine different drugs in a sheep flock in southern Brazil.

Journal: Veterinary parasitology 20101011

Title: Interaction of anthelmintic drugs with P-glycoprotein in recombinant LLC-PK1-mdr1a cells.

Journal: Chemico-biological interactions 20100805

Title: Anthelmintic efficacy and management practices in sheep farms from the state of Rio de Janeiro, Brazil.

Journal: Veterinary parasitology 20100624

Title: Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.

Journal: PLoS neglected tropical diseases 20100601

Title: Polioencephalomalacia associated with closantel overdosage in a goat.

Journal: Journal of the South African Veterinary Association 20100601

Title: Screening of closantel and rafoxanide in animal muscles by HPLC with fluorescence detection and confirmation using MS.

Journal: Journal of separation science 20100201

Title: Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes.

Journal: BMC veterinary research 20100101

Title: Quantitative analysis of closantel and rafoxanide in bovine and ovine muscles by high-performance liquid chromatography with fluorescence detection.

Journal: Journal of AOAC International 20100101

Title: Multi-residue determination of phenolic and salicylanilide anthelmintics and related compounds in bovine kidney by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A 20091113

Title: The comparative efficacy of four anthelmintics against a natural acquired Fasciola hepatica infection in hill sheep flock in the west of Ireland.

Journal: Veterinary parasitology 20091014

Title: Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.

Journal: PLoS neglected tropical diseases 20090701

Title: The potential to control Haemonchus contortus in indigenous South African goats with copper oxide wire particles.

Journal: Veterinary parasitology 20090610

Title: Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.

Journal: PloS one 20090101

Title: [Evaluation of the efficacy of antihelmintics compounds on parasitics gastrointestinal nematodes (Strongyloidea) of goats].

Journal: Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria 20080901

Title: The efficacy of an ivermectin/closantel injection against experimentally induced infections and field infections with gastrointestinal nematodes and liver fluke in cattle.

Journal: Veterinary parasitology 20080817

Title: A comparison of the efficacy of doramectin, closantel and levamisole in the treatment of the 'oriental eye fluke', Philophthalmus gralli, in commercially reared ostriches (Struthio camelus).

Journal: Journal of the South African Veterinary Association 20080601

Title: Determination of closantel residues in milk and animal tissues by HPLC with fluorescence detection and SPE with oasis MAX cartridges.

Journal: Journal of chromatographic science 20080401

Title: Efficacy of 3 anthelmintics in communally grazed sheep as reflected by faecal egg count reduction tests in a semi-arid area of South Africa.

Journal: Journal of the South African Veterinary Association 20080301

Title: Comparison of the time required to administer three different fluke and worm combination products to commercial beef cattle at housing.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20080101

Title: Validated method for determination of ultra-trace closantel residues in bovine tissues and milk by solid-phase extraction and liquid chromatography-electrospray ionization-tandem mass spectrometry.

Journal: Journal of chromatography. A 20071221

Title: Purification, reconstitution, and characterization of the CpxRAP envelope stress system of Escherichia coli.

Journal: The Journal of biological chemistry 20070323

Title: Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea).

Journal: Bioorganic & medicinal chemistry letters 20070215

Title: Myelin vacuolation, optic neuropathy and retinal degeneration after closantel overdosage in sheep and in a goat.

Journal: Journal of comparative pathology 20070101

Title: The effect of a parenteral ivermectin/closantel injection on the growth and reproductive development of early immature Fasciola hepatica in cattle.

Journal: Veterinary parasitology 20061130

Title: Analysis of OSPAR priority pharmaceuticals using high-performance liquid chromatography-electrospray ionisation tandem mass spectrometry.

Journal: Journal of chromatography. A 20061117

Title: Closantel toxicosis in kid goats.

Journal: The Veterinary record 20061021

Title: Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel.

Journal: Cellular microbiology 20060801

Title: Pharmacokinetics of a novel closantel/ivermectin injection in cattle.

Journal: Journal of veterinary pharmacology and therapeutics 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Anthelmintic activity of Azadirachta indica A. Juss against sheep gastrointestinal nematodes.

Journal: Veterinary parasitology 20060430

Title: Rift Valley fever in small ruminants, Senegal, 2003.

Journal: Emerging infectious diseases 20051101

Title: Epidemiology of Oestrus ovis infection of sheep in Argentina's Western Pampas.

Journal: Parasite (Paris, France) 20041201

Title: Field trial on the efficacy of an experimental fasciolicide compared with some commercial compounds in naturally infected cattle.

Journal: Parasitology research 20030901

Title: The relationship between nasal myiasis and the prevalence of enzootic nasal tumours and the effects of treatment of Oestrus ovis and milk production in dairy ewes of Roquefort cheese area.

Journal: Veterinary parasitology 20030418

Title: Evolution of high-level, multiple anthelmintic resistance on a sheep farm in Malaysia.

Journal: Tropical animal health and production 20030201

Title: Strategic use of moxidectin or closantel in combination with levamisole in the control of nematodes of sheep in the highlands of central Kenya.

Journal: Acta tropica 20021101

Title: Strategic control of gastrointestinal nematodes of sheep in the highlands of central Kenya.

Journal: The Onderstepoort journal of veterinary research 20020901

Title: Blindness in lambs due to inadvertent closantel overdose.

Journal: The Veterinary record 20020706

Title: Reduced efficacy of ivermectin, abamectin and moxidectin against field isolates of Haemonchus contortus.

Journal: Australian veterinary journal 20011201

Title: Anthelmintic resistance on an organized sheep farm in India.

Journal: Tropical animal health and production 20010701

Title: Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72.

Title: Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72.

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Tags:57808-65-8 Molecular Formula|57808-65-8 MDL|57808-65-8 SMILES|57808-65-8 Closantel
Catalog No.: AA0035XA
57808-65-8,MFCD00661151
57808-65-8 | Closantel
Pack Size: 25mg
Purity: 99+%
in stock
$6.00 $4.00
Pack Size: 250mg
Purity: 99+%
in stock
$12.00 $8.00
Pack Size: 1g
Purity: 99+%
in stock
$24.00 $17.00
Pack Size: 5g
Purity: 99+%
in stock
$48.00 $34.00
Pack Size: 25g
Purity: 99+%
in stock
$166.00 $117.00
Quantity
- +
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Technical Information
Catalog Number: AA0035XA
Chemical Name: Closantel
CAS Number: 57808-65-8
Molecular Formula: C22H14Cl2I2N2O2
Molecular Weight: 663.0737
MDL Number: MFCD00661151
SMILES: N#CC(c1ccccc1Cl)c1cc(C)c(cc1Cl)NC(=O)c1cc(I)cc(c1O)I
Properties
BP: 590.5°C at 760 mmHg  
Form: Solid  
MP: 217.8°  
Storage: Keep in dry area;2-8℃;  
Complexity: 652  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 30  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: 7.2  
Literature fold

Title: Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast.

Journal: Journal of biomolecular screening20160401

Title: Evaluation of the comparative efficacy of a moxidectin plus triclabendazole pour-on solution against adult and immature liver fluke, Fasciola hepatica, in cattle.

Journal: Veterinary parasitology20121026

Title: Emergency slaughter of casualty cattle increases the prevalence of anthelmintic drug residues in muscle.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment20120801

Title: On farm evaluation of the coproantigen ELISA and coproantigen reduction test in Scottish sheep naturally infected with Fasciola hepatica.

Journal: Veterinary parasitology20120706

Title: Multidrug and multispecies resistance in sheep flocks from São Paulo state, Brazil.

Journal: Veterinary parasitology20120608

Title: Efficacy of monepantel and anthelmintic combinations against multiple-resistant Haemonchus contortus in sheep, including characterisation of the nematode isolate.

Journal: Veterinary parasitology20120525

Title: Ivermectin residue depletion in food producing species and its presence in animal foodstuffs with a view to human safety.

Journal: Current pharmaceutical biotechnology20120501

Title: Introgression of ivermectin resistance genes into a susceptible Haemonchus contortus strain by multiple backcrossing.

Journal: PLoS pathogens20120201

Title: An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide.

Journal: Toxicology letters20120105

Title: New insight into immunity and immunopathology of Rickettsial diseases.

Journal: Clinical & developmental immunology20120101

Title: Anthelmintic drug residues in beef: UPLC-MS/MS method validation, European retail beef survey, and associated exposure and risk assessments.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment20120101

Title: Integrating fasciolosis control in the dry cow management: the effect of closantel treatment on milk production.

Journal: PloS one20120101

Title: A computational analysis of the binding mode of closantel as inhibitor of the Onchocerca volvulus chitinase: insights on macrofilaricidal drug design.

Journal: Journal of computer-aided molecular design20111201

Title: Inhibition of the signal transduction through the AtoSC system by histidine kinase inhibitors in Escherichia coli.

Journal: Cellular signalling20110801

Title: The efficacy of trichlorphon and naphthalophos against multiple anthelmintic-resistant nematodes of naturally infected sheep in Argentina.

Journal: Parasitology research20110801

Title: Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina).

Journal: Veterinary parasitology20110610

Title: Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus.

Journal: Journal of medicinal chemistry20110609

Title: Determination of closantel and rafoxanide in animal tissues by online anionic mixed-mode solid-phase extraction followed by isotope dilution liquid chromatography tandem mass spectrometry.

Journal: Journal of separation science20110601

Title: Stability during cooking of anthelmintic veterinary drug residues in beef.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment20110201

Title: Multiple resistance to anthelmintics by Haemonchus contortus and Trichostrongylus colubriformis in sheep in Brazil.

Journal: Parasitology international20101201

Title: Nasal bots...a fascinating world!

Journal: Veterinary parasitology20101124

Title: A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility.

Journal: PLoS neglected tropical diseases20101101

Title: Multiple resistance of gastrointestinal nematodes to nine different drugs in a sheep flock in southern Brazil.

Journal: Veterinary parasitology20101011

Title: Interaction of anthelmintic drugs with P-glycoprotein in recombinant LLC-PK1-mdr1a cells.

Journal: Chemico-biological interactions20100805

Title: Anthelmintic efficacy and management practices in sheep farms from the state of Rio de Janeiro, Brazil.

Journal: Veterinary parasitology20100624

Title: Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.

Journal: PLoS neglected tropical diseases20100601

Title: Polioencephalomalacia associated with closantel overdosage in a goat.

Journal: Journal of the South African Veterinary Association20100601

Title: Screening of closantel and rafoxanide in animal muscles by HPLC with fluorescence detection and confirmation using MS.

Journal: Journal of separation science20100201

Title: Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes.

Journal: BMC veterinary research20100101

Title: Quantitative analysis of closantel and rafoxanide in bovine and ovine muscles by high-performance liquid chromatography with fluorescence detection.

Journal: Journal of AOAC International20100101

Title: Multi-residue determination of phenolic and salicylanilide anthelmintics and related compounds in bovine kidney by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A20091113

Title: The comparative efficacy of four anthelmintics against a natural acquired Fasciola hepatica infection in hill sheep flock in the west of Ireland.

Journal: Veterinary parasitology20091014

Title: Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.

Journal: PLoS neglected tropical diseases20090701

Title: The potential to control Haemonchus contortus in indigenous South African goats with copper oxide wire particles.

Journal: Veterinary parasitology20090610

Title: Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.

Journal: PloS one20090101

Title: [Evaluation of the efficacy of antihelmintics compounds on parasitics gastrointestinal nematodes (Strongyloidea) of goats].

Journal: Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria20080901

Title: The efficacy of an ivermectin/closantel injection against experimentally induced infections and field infections with gastrointestinal nematodes and liver fluke in cattle.

Journal: Veterinary parasitology20080817

Title: A comparison of the efficacy of doramectin, closantel and levamisole in the treatment of the 'oriental eye fluke', Philophthalmus gralli, in commercially reared ostriches (Struthio camelus).

Journal: Journal of the South African Veterinary Association20080601

Title: Determination of closantel residues in milk and animal tissues by HPLC with fluorescence detection and SPE with oasis MAX cartridges.

Journal: Journal of chromatographic science20080401

Title: Efficacy of 3 anthelmintics in communally grazed sheep as reflected by faecal egg count reduction tests in a semi-arid area of South Africa.

Journal: Journal of the South African Veterinary Association20080301

Title: Comparison of the time required to administer three different fluke and worm combination products to commercial beef cattle at housing.

Journal: Veterinary therapeutics : research in applied veterinary medicine20080101

Title: Validated method for determination of ultra-trace closantel residues in bovine tissues and milk by solid-phase extraction and liquid chromatography-electrospray ionization-tandem mass spectrometry.

Journal: Journal of chromatography. A20071221

Title: Purification, reconstitution, and characterization of the CpxRAP envelope stress system of Escherichia coli.

Journal: The Journal of biological chemistry20070323

Title: Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea).

Journal: Bioorganic & medicinal chemistry letters20070215

Title: Myelin vacuolation, optic neuropathy and retinal degeneration after closantel overdosage in sheep and in a goat.

Journal: Journal of comparative pathology20070101

Title: The effect of a parenteral ivermectin/closantel injection on the growth and reproductive development of early immature Fasciola hepatica in cattle.

Journal: Veterinary parasitology20061130

Title: Analysis of OSPAR priority pharmaceuticals using high-performance liquid chromatography-electrospray ionisation tandem mass spectrometry.

Journal: Journal of chromatography. A20061117

Title: Closantel toxicosis in kid goats.

Journal: The Veterinary record20061021

Title: Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel.

Journal: Cellular microbiology20060801

Title: Pharmacokinetics of a novel closantel/ivermectin injection in cattle.

Journal: Journal of veterinary pharmacology and therapeutics20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Anthelmintic activity of Azadirachta indica A. Juss against sheep gastrointestinal nematodes.

Journal: Veterinary parasitology20060430

Title: Rift Valley fever in small ruminants, Senegal, 2003.

Journal: Emerging infectious diseases20051101

Title: Epidemiology of Oestrus ovis infection of sheep in Argentina's Western Pampas.

Journal: Parasite (Paris, France)20041201

Title: Field trial on the efficacy of an experimental fasciolicide compared with some commercial compounds in naturally infected cattle.

Journal: Parasitology research20030901

Title: The relationship between nasal myiasis and the prevalence of enzootic nasal tumours and the effects of treatment of Oestrus ovis and milk production in dairy ewes of Roquefort cheese area.

Journal: Veterinary parasitology20030418

Title: Evolution of high-level, multiple anthelmintic resistance on a sheep farm in Malaysia.

Journal: Tropical animal health and production20030201

Title: Strategic use of moxidectin or closantel in combination with levamisole in the control of nematodes of sheep in the highlands of central Kenya.

Journal: Acta tropica20021101

Title: Strategic control of gastrointestinal nematodes of sheep in the highlands of central Kenya.

Journal: The Onderstepoort journal of veterinary research20020901

Title: Blindness in lambs due to inadvertent closantel overdose.

Journal: The Veterinary record20020706

Title: Reduced efficacy of ivermectin, abamectin and moxidectin against field isolates of Haemonchus contortus.

Journal: Australian veterinary journal20011201

Title: Anthelmintic resistance on an organized sheep farm in India.

Journal: Tropical animal health and production20010701

Title: Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72.

Title: Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72.

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