5812-07-7,MFCD00118147
Catalog No.:AA01CAJN

5812-07-7 | 3-[4-(dimethylamino)benzylidene]indolin-2-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$123.00   $86.00
- +
10mg
≥98%
in stock  
$219.00   $153.00
- +
25mg
≥98%
in stock  
$436.00   $305.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01CAJN
Chemical Name:
3-[4-(dimethylamino)benzylidene]indolin-2-one
CAS Number:
5812-07-7
Molecular Formula:
C17H16N2O
Molecular Weight:
264.3217
MDL Number:
MFCD00118147
SMILES:
O=C1Nc2c(/C/1=C\c1ccc(cc1)N(C)C)cccc2
NSC Number:
86429
Properties
Computed Properties
 
Complexity:
394  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3  

Literature

Title: Identification of compounds that modulate retinol signaling using a cell-based qHTS assay.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160401

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.

Journal: British journal of pharmacology 20130301

Title: Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.

Journal: Bioorganic & medicinal chemistry 20120715

Title: N⁴-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors.

Journal: Bioorganic & medicinal chemistry 20120115

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents.

Journal: Bioorganic & medicinal chemistry 20100715

Title: Prolonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells.

Journal: Journal of cellular physiology 20100701

Title: Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.

Journal: Bioorganic & medicinal chemistry 20100515

Title: Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.

Journal: Journal of medicinal chemistry 20100225

Title: Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.

Journal: Bioorganic & medicinal chemistry 20100215

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 1. Comparison with conventional ELISA.

Journal: Journal of medicinal chemistry 20041007

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.

Journal: Journal of medicinal chemistry 19980702

Title: L Sun, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603.

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SDS
Tags:5812-07-7 Molecular Formula|5812-07-7 MDL|5812-07-7 SMILES|5812-07-7 3-[4-(dimethylamino)benzylidene]indolin-2-one
Catalog No.: AA01CAJN
5812-07-7,MFCD00118147
5812-07-7 | 3-[4-(dimethylamino)benzylidene]indolin-2-one
Pack Size: 1mg
Purity: ≥98%
in stock
$46.00 $32.00
Pack Size: 5mg
Purity: ≥98%
in stock
$123.00 $86.00
Pack Size: 10mg
Purity: ≥98%
in stock
$219.00 $153.00
Pack Size: 25mg
Purity: ≥98%
in stock
$436.00 $305.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA01CAJN
Chemical Name: 3-[4-(dimethylamino)benzylidene]indolin-2-one
CAS Number: 5812-07-7
Molecular Formula: C17H16N2O
Molecular Weight: 264.3217
MDL Number: MFCD00118147
SMILES: O=C1Nc2c(/C/1=C\c1ccc(cc1)N(C)C)cccc2
NSC Number: 86429
Properties
Complexity: 394  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 20  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3  
Literature fold

Title: Identification of compounds that modulate retinol signaling using a cell-based qHTS assay.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20160401

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal20130415

Title: The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.

Journal: British journal of pharmacology20130301

Title: Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.

Journal: Bioorganic & medicinal chemistry20120715

Title: N⁴-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors.

Journal: Bioorganic & medicinal chemistry20120115

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents.

Journal: Bioorganic & medicinal chemistry20100715

Title: Prolonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells.

Journal: Journal of cellular physiology20100701

Title: Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.

Journal: Bioorganic & medicinal chemistry20100515

Title: Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.

Journal: Journal of medicinal chemistry20100225

Title: Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.

Journal: Bioorganic & medicinal chemistry20100215

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 1. Comparison with conventional ELISA.

Journal: Journal of medicinal chemistry20041007

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.

Journal: Journal of medicinal chemistry19980702

Title: L Sun, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603.

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