Title: Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial.

Journal: The Lancet. Neurology20170701

Title: Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma.

Journal: Cell death & disease20170701

Title: Edaravone attenuates brain damage in rats after acute CO poisoning through inhibiting apoptosis and oxidative stress.

Journal: Environmental toxicology20160301

Title: Edaravone alleviates Alzheimer's disease-type pathologies and cognitive deficits.

Journal: Proceedings of the National Academy of Sciences of the United States of America20150421

Title: Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse.

Journal: PloS one20150101

Title: Edaravone inhibits hypoxia-induced trophoblast-soluble Fms-like tyrosine kinase 1 expression: a possible therapeutic approach to preeclampsia.

Journal: Placenta20140701

Title: Role of cytochrome P450-dependent monooxygenases and polymorphic variants of GSTT1 and GSTM1 genes in the formation of brain lesions in individuals chronically exposed to mercury.

Journal: Bulletin of experimental biology and medicine20131101

Title: Differential induction of cytochrome P450 isoforms and peroxisomal proliferation by cyfluthrin in male Wistar rats.

Journal: Toxicology letters20130704

Title: The optical properties, synthesis and characterization of novel 5-aryl-3-benzimidazolyl-1-phenyl-pyrazoline derivatives.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20121201

Title: Simple pyrazoline and pyrazole 'turn on' fluorescent sensors selective for Cd2+ and Zn2+ in MeCN.

Journal: Organic & biomolecular chemistry20121128

Title: A highly sensitive fluorescent probe based on simple pyrazoline for Zn2+ in living neuron cells.

Journal: Organic & biomolecular chemistry20121121

Title: Optimized removal of dissolved organic carbon and trace organic contaminants during combined ozonation and artificial groundwater recharge.

Journal: Water research20121115

Title: Stroke in a child safely treated with intravenous tissue plasminogen activator and edaravone, a free radical scavenger.

Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association20121101

Title: Transplacental transfer of oseltamivir carboxylate.

Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians20121101

Title: Edaravone protects cortical neurons from apoptosis by inhibiting the translocation of BAX and Increasing the interaction between 14-3-3 and p-BAD.

Journal: The International journal of neuroscience20121101

Title: The synthesis, crystal structure and enhanced blue fluorescence emission of novel antipyrine derivatives.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20121101

Title: Synthesis and biological evaluation of chalcone derivatives (mini review).

Journal: Mini reviews in medicinal chemistry20121101

Title: Synthesis, structure, photo-responsive properties of 4-(2-fluorobenzylideneamino)antipyrine: a combined experimental and theoretical study.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20121101

Title: Protective effects of MCI-186 on transplantation of bone marrow stromal cells in rat ischemic stroke model.

Journal: Neuroscience20121025

Title: Synthesis of new 4-thiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity.

Journal: Journal of medicinal chemistry20121025

Title: Explicit spectral response of the geometrical isomers of a bio-active pyrazoline derivative encapsulated in β-cyclodextrin nanocavity: a photophysical and quantum chemical analysis.

Journal: The journal of physical chemistry. A20121025

Title: Application of organogels as oral controlled release formulations of hydrophilic drugs.

Journal: International journal of pharmaceutics20121015

Title: Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant.

Journal: Experimental and molecular pathology20121001

Title: Antioxidant treatment with edaravone or taurine ameliorates diabetes-induced testicular dysfunction in the rat.

Journal: Molecular and cellular biochemistry20121001

Title: Reactive oxygen species and the MEK/ERK pathway are involved in the toxicity of clostridium perfringens α-toxin, a prototype bacterial phospholipase C.

Journal: The Journal of infectious diseases20121001

Title: Synthesis, antitumor, cytotoxic and antioxidant evaluation of some new pyrazolotriazines attached to antipyrine moiety.

Journal: European journal of medicinal chemistry20121001

Title: Mass spectrometric O-glycan analysis after combined O-glycan release by beta-elimination and 1-phenyl-3-methyl-5-pyrazolone labeling.

Journal: Biochimica et biophysica acta20120901

Title: Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy.

Journal: Journal of cellular and molecular medicine20120901

Title: Synthesis, spectral studies and antimicrobial activities of some 2-naphthyl pyrazoline derivatives.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20120901

Title: Clinical trials assessing ototopical agents in the treatment of pain associated with acute otitis media in children.

Journal: International journal of pediatric otorhinolaryngology20120901

Title: Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives.

Journal: Bioorganic & medicinal chemistry letters20120901

Title: 1-[3-(4-Fluoro-phen-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

Journal: Acta crystallographica. Section E, Structure reports online20120901

Title: Perfluorocarbon-facilitated CNS oxygen toxicity in rats: reversal by edaravone.

Journal: Brain research20120830

Title: Crystal structure, spectra properties and comparative studies on a 2-pyrazoline derivative.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20120801

Title: A hypothesis: Edaravone exert cardioprotection partly via modulation of adiponectin.

Journal: Medical hypotheses20120801

Title: Synthesis and synergistic antifungal activities of a pyrazoline based ligand and its copper(II) and nickel(II) complexes with conventional antifungals.

Journal: Microbial pathogenesis20120801

Title: Edaravone ameliorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat.

Journal: Molecular and cellular biochemistry20120801

Title: Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors.

Journal: European journal of medicinal chemistry20120801

Title: Edaravone inhibits apoptosis caused by ischemia/reperfusion injury in a porcine hepatectomy model.

Journal: World journal of gastroenterology20120721

Title: Discovery and modification of sulfur-containing heterocyclic pyrazoline derivatives as potential novel class of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors.

Journal: Bioorganic & medicinal chemistry letters20120715

Title: Synthesis, spectroscopic characteristic of novel fluorescent dyes of pyrazoline compounds.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20120701

Title: Postmortem drug concentration intervals for the non-intoxicated state - A review.

Journal: Journal of forensic and legal medicine20120701

Title: Stereospecific intramolecular C-H amination of 1-aza-2-azoniaallene salts.

Journal: Journal of the American Chemical Society20120620

Title: A somatostatin analogue, octreotide, ameliorates intestinal ischemia-reperfusion injury through the early induction of heme oxygenase-1.

Journal: The Journal of surgical research20120615

Title: Screening and human health risk assessment of pharmaceuticals and their transformation products in Dutch surface waters and drinking water.

Journal: The Science of the total environment20120615

Title: Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage.

Journal: Pharmaceutical research20120601

Title: Free-radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats.

Journal: Journal of vascular surgery20120601

Title: The effect of edaravone on ischemia-reperfusion injury in rat ovary.

Journal: European journal of obstetrics, gynecology, and reproductive biology20120601

Title: Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20120601

Title: Phase I clinical study of edaravone in healthy Chinese volunteers: safety and pharmacokinetics of single or multiple intravenous infusions.

Journal: Drugs in R&D20120601

Title: Synthesis and biological evaluation of novel pyrazoline derivatives as anti-inflammatory and antioxidant agents.

Journal: Archives of pharmacal research20120601

Title: Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.

Journal: Bioorganic & medicinal chemistry20120515

Title: Discharge of solubilized and Dectin-1-reactive β-glucan from macrophage cells phagocytizing insoluble β-glucan particles: involvement of reactive oxygen species (ROS)-driven degradation.

Journal: Biochemical and biophysical research communications20120504

Title: Effect of Ginkgo biloba special extract EGb 761® on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers.

Journal: European journal of clinical pharmacology20120501

Title: Meta-analysis of data from human ex vivo placental perfusion studies on genotoxic and immunotoxic agents within the integrated European project NewGeneris.

Journal: Placenta20120501

Title: Transformation of phenazone-type drugs during chlorination.

Journal: Water research20120501

Title: CYP450-dependent biotransformation of the insecticide fipronil into fipronil sulfone can mediate fipronil-induced thyroid disruption in rats.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20120501

Title: Kallikrein gene transfer induces angiogenesis and further improves regional cerebral blood flow in the early period after cerebral ischemia/reperfusion in rats.

Journal: CNS neuroscience & therapeutics20120501

Title: Italian guidelines for primary headaches: 2012 revised version.

Journal: The journal of headache and pain20120501

Title: The predominance of type I oligosaccharides is a feature specific to human breast milk.

Journal: Advances in nutrition (Bethesda, Md.)20120501

Title: [Neuroprotective effects of combined pretreatment with edaravone and propofol on neonatal rat cerebral cortical neurons with ischemia/reperfusion injury in vitro].

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue20120501

Title: 1-[3-(Anthracen-9-yl)-5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

Journal: Acta crystallographica. Section E, Structure reports online20120501

Title: What is the role of free radical scavengers in acute stroke?

Journal: JPMA. The Journal of the Pakistan Medical Association20120501

Title: Phenylobacterium muchangponense sp. nov., isolated from beach soil, and emended description of the genus Phenylobacterium.

Journal: International journal of systematic and evolutionary microbiology20120401

Title: Quantitative liver function tests improve the prediction of clinical outcomes in chronic hepatitis C: results from the Hepatitis C Antiviral Long-term Treatment Against Cirrhosis Trial.

Journal: Hepatology (Baltimore, Md.)20120401

Title: Glucuronidation of edaravone by human liver and kidney microsomes: biphasic kinetics and identification of UGT1A9 as the major UDP-glucuronosyltransferase isoform.

Journal: Drug metabolism and disposition: the biological fate of chemicals20120401

Title: Synthesis of D-ring-substituted (5'R)- and (5'S)-17β-pyrazolinylandrostene epimers and comparison of their potential anticancer activities.

Journal: Steroids20120401

Title: Current advances in detection and treatment of babesiosis.

Journal: Current medicinal chemistry20120401

Title: 1-[3-(4-Chloro-phen-yl)-5-(4-meth-oxy-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

Journal: Acta crystallographica. Section E, Structure reports online20120401

Title: 1-[3-(4-Chloro-phen-yl)-5-(4-meth-oxy-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]butan-1-one.

Journal: Acta crystallographica. Section E, Structure reports online20120401

Title: 1-(1,3-Benzothia-zol-2-yl)-3-phenyl-2-pyrazoline.

Journal: Acta crystallographica. Section E, Structure reports online20120401

Title: Polysaccharide peptides from Coriolus versicolor competitively inhibit model cytochrome P450 enzyme probe substrates metabolism in human liver microsomes.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20120315

Title: Synthesis and in vitro antifungal evaluation of 1,3,5-trisubstituted-2-pyrazoline derivatives.

Journal: Chemical biology & drug design20120301

Title: Recent advances in the therapeutic applications of pyrazolines.

Journal: Expert opinion on therapeutic patents20120301

Title: Paracetamol in critical illness: a review.

Journal: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine20120301

Title: 1-[5-(4-Chloro-phen-yl)-3-(4-hy-droxy-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]-ethanone.

Journal: Acta crystallographica. Section E, Structure reports online20120301

Title: 5-(4-Eth-oxy-phen-yl)-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothio-amide.

Journal: Acta crystallographica. Section E, Structure reports online20120301

Title: Oxidative stress and benefits of antioxidant agents in acute and chronic hepatitis.

Journal: Hepatitis monthly20120301

Title: Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients--a preliminary study.

Journal: Journal of the neurological sciences20120215

Title: Assessment of groundwater pollution in Tokyo using PPCPs as sewage markers.

Journal: Environmental science & technology20120207

Title: Modifying neurorepair and neuroregenerative factors with tPA and edaravone after transient middle cerebral artery occlusion in rat brain.

Journal: Brain research20120203

Title: Lower rim 1,3-di{4-antipyrine}amide conjugate of calix[4]arene: synthesis, characterization, and selective recognition of Hg2+ and its sensitivity toward pyrimidine bases.

Journal: The Journal of organic chemistry20120203

Title: Effects of edaravone, a free radical scavenger, on serum levels of inflammatory biomarkers in acute brain infarction.

Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association20120201

Title: Prediction and evaluation of fetal toxicity induced by NSAIDs using transplacental kinetic parameters obtained from human placental perfusion studies.

Journal: British journal of clinical pharmacology20120201

Title: Thermal solvent-free synthesis of chromonyl chalcones, pyrazolines and their in vitro antibacterial, antifungal activities.

Journal: Journal of enzyme inhibition and medicinal chemistry20120201

Title: Combination of reactive oxygen species and tissue-type plasminogen activator enhances the induction of gelatinase B in brain endothelial cells.

Journal: The International journal of neuroscience20120201

Title: 3-(4-Chloro-phen-yl)-5-(thio-phen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothio-amide.

Journal: Acta crystallographica. Section E, Structure reports online20120201

Title: (2E)-1-(3,4-Dichloro-phen-yl)-3-(2-hy-droxy-phen-yl)prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online20120201

Title: On the inter-instrument and the inter-laboratory transferability of a tandem mass spectral reference library. 3. Focus on ion trap and upfront CID.

Journal: Journal of mass spectrometry : JMS20120201

Title: A novel flow-injection analysis system for evaluation of antioxidants by using sodium dichloroisocyanurate as a source of hypochlorite anion.

Journal: Drug discoveries & therapeutics20120201

Title: On the outstanding antioxidant capacity of edaravone derivatives through single electron transfer reactions.

Journal: The journal of physical chemistry. B20120126

Title: Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs.

Journal: Bioorganic & medicinal chemistry20120115

Title: Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury.

Journal: Neuroscience20120110

Title: Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils.

Journal: Neuroscience letters20120106

Title: Docetaxel pharmacokinetics and its correlation with two in vivo probes for cytochrome P450 enzymes: the C(14)-erythromycin breath test and the antipyrine clearance test.

Journal: Cancer chemotherapy and pharmacology20120101

Title: Effect of Fasciola hepatica proteins on the functioning of rat hepatocytes.

Journal: Parasitology research20120101

Title: Validation of an HPLC method for the simultaneous determination of diminazene diaceturate and phenazone in injectable veterinary granules and bulk powders.

Journal: Pakistan journal of pharmaceutical sciences20120101

Title: Chemical and biological evaluation of some new antipyrine derivatives with particular properties.

Journal: Bioorganic chemistry20120101

Title: Kallolide A acetate pyrazoline.

Journal: Acta crystallographica. Section E, Structure reports online20120101

Title: (1E,4E)-1-(3-Nitro-phen-yl)-5-phenyl-penta-1,4-dien-3-one.

Journal: Acta crystallographica. Section E, Structure reports online20120101

Title: Gender differences in pharmacokinetics of antipyrine in a simulated weightlessness rat model.

Journal: Aviation, space, and environmental medicine20120101

Title: Effect of edaravone on Aβ1-40 induced enhancement of voltage-gated calcium channel current.

Journal: CNS neuroscience & therapeutics20120101

Title: In vitro placental model optimization for nanoparticle transport studies.

Journal: International journal of nanomedicine20120101

Title: Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice.

Journal: Journal of pharmacological sciences20120101

Title: Immunological response as a source to variability in drug metabolism and transport.

Journal: Frontiers in pharmacology20120101

Title: Validated HPLC Method for Concurrent Determination of Antipyrine, Carbamazepine, Furosemide and Phenytoin and its Application in Assessment of Drug Permeability through Caco-2 Cell Monolayers.

Journal: Scientia pharmaceutica20120101

Title: Comprehensive and facile synthesis of some functionalized bis-heterocyclic compounds containing a thieno[2,3-b]thiophene motif.

Journal: International journal of molecular sciences20120101

Title: [Determination of the optimal ROI setting position of the input function for the ⁹⁹mTc-ethyl cysteinate dimmer brain uptake ratio method].

Journal: Nihon Hoshasen Gijutsu Gakkai zasshi20120101

Title: The safety of cruciferous plants in humans: a systematic review.

Journal: Journal of biomedicine & biotechnology20120101

Title: The analgesic effect of different antidepressants combined with aspirin on thermally induced pain in Albino mice.

Journal: The Libyan journal of medicine20120101

Title: Binuclear Cu(II) and Co(II) Complexes of Tridentate Heterocyclic Shiff Base Derived from Salicylaldehyde with 4-Aminoantipyrine.

Journal: Bioinorganic chemistry and applications20120101

Title: Weekly intra-amniotic IGF-1 treatment increases growth of growth-restricted ovine fetuses and up-regulates placental amino acid transporters.

Journal: PloS one20120101

Title: Antitumor, Analgesic, and Anti-inflammatory Activities of Synthesized Pyrazolines.

Journal: Journal of young pharmacists : JYP20120101

Title: Density functional theory (DFT) study of edaravone derivatives as antioxidants.

Journal: International journal of molecular sciences20120101

Title: Robust calibration models to predict antipyrine content in various kinds of packaged hospital powder preparations by using near-infrared spectroscopy.

Journal: Bio-medical materials and engineering20120101

Title: Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina.

Journal: Investigative ophthalmology & visual science20111228

Title: Pregnenolone derivatives as potential anticancer agents.

Journal: Steroids20111220

Title: Synthesis and antihepatotoxic activity of 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-substituted-phenyl-4,5-dihydro-1H-pyrazole derivatives.

Journal: Bioorganic & medicinal chemistry letters20111215

Title: Edaravone for acute ischaemic stroke.

Journal: The Cochrane database of systematic reviews20111207

Title: Discovery of novel methanone derivatives acting as antimycobacterial agents.

Journal: Journal of enzyme inhibition and medicinal chemistry20111201

Title: Beyond neurological disease: new targets for edaravone (Review).

Journal: International journal of molecular medicine20111201

Title: Experimental and theoretical study of two new pyrazoline derivatives based on dibenzofuran.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20111201

Title: Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma.

Journal: Journal of veterinary science20111201

Title: (E)-1-(4,4''-Difluoro-5'-meth-oxy-1,1':3',1''-terphenyl-4'-yl)-3-(6-meth-oxy-naphthalen-2-yl)prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online20111201

Title: 5-(4-Meth-oxy-phen-yl)-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothio-amide.

Journal: Acta crystallographica. Section E, Structure reports online20111201

Title: A tale of two polymorphic pharmaceuticals: pyrithyldione and propyphenazone and their 1937 co-crystal patent.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)20111125

Title: Gold(I)-catalyzed formation of 3-pyrazolines through cycloaddition of diaziridine to alkynes.

Journal: Organic letters20111104

Title: Optimization of monosaccharide determination using anthranilic acid and 1-phenyl-3-methyl-5-pyrazolone for gastropod analysis.

Journal: Analytical biochemistry20111101

Title: Relative quantitation of glycans using stable isotopic labels 1-(d0/d5) phenyl-3-methyl-5-pyrazolone by mass spectrometry.

Journal: Analytical biochemistry20111101

Title: The transfer of 6-mercaptopurine in the dually perfused human placenta.

Journal: Reproductive toxicology (Elmsford, N.Y.)20111101

Title: One-pot nonreductive O-glycan release and labeling with 1-phenyl-3-methyl-5-pyrazolone followed by ESI-MS analysis.

Journal: Proteomics20111101

Title: 3-(4-Meth-oxy-phen-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde.

Journal: Acta crystallographica. Section E, Structure reports online20111101

Title: (2E)-1-(2,5-Dimeth-oxy-phen-yl)-3-(3-nitro-phen-yl)prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online20111101

Title: [Therapeutic time window for ischemic stroke].

Journal: Rinsho shinkeigaku = Clinical neurology20111101

Title: Acquired platinum resistance enhances tumour angiogenesis through angiotensin II type 1 receptor in bladder cancer.

Journal: British journal of cancer20111025

Title: Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20111015

Title: Characterization of phenazone transformation products on light-activated TiO2 surface by high-resolution mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM20111015

Title: Transfer of repaglinide in the dually perfused human placenta and the role of organic anion transporting polypeptides (OATPs).

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20111009

Title: Preparation of starch-based pellets by hot-melt extrusion.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V20111001

Title: The specific free radical scavenger edaravone suppresses fibrosis in the bleomycin-induced and tight skin mouse models of systemic sclerosis.

Journal: Arthritis and rheumatism20111001

Title: Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with EUK-134 or edaravone.

Journal: Developmental neuroscience20111001

Title: Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats.

Journal: Journal of neurotrauma20111001

Title: Passage of 4-nonylphenol across the human placenta.

Journal: Placenta20111001

Title: New method for absolute spinal cord ischemia protection in rabbits.

Journal: Journal of vascular surgery20111001

Title: 4-[2-(2-Meth-oxy-phen-yl)hydrazinyl-idene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-1-carbothio-amide.

Journal: Acta crystallographica. Section E, Structure reports online20111001

Title: Edaravone-loaded liposome eyedrops protect against light-induced retinal damage in mice.

Journal: Investigative ophthalmology & visual science20110921

Title: Singlet oxygen is essential for neutrophil extracellular trap formation.

Journal: Biochemical and biophysical research communications20110916

Title: Analytical strategy for the confirmatory analysis of the non-steroidal anti-inflammatory drugs firocoxib, propyphenazone, ramifenazone and piroxicam in bovine plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis20110910

Title: Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion.

Journal: Toxicology letters20110910

Title: Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V20110901

Title: Ionization energies, proton affinities, and pKa values of a large series of edaravone derivatives: implication for their free radical scavenging activity.

Journal: The journal of physical chemistry. B20110901

Title: Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents.

Journal: European journal of medicinal chemistry20110901

Title: Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates.

Journal: Archiv der Pharmazie20110801

Title: ESI HRMS(n) fragmentation pathways of phenazone, an N-heterocyclic drug compound.

Journal: Journal of mass spectrometry : JMS20110801

Title: 1-(4-Methyl-phenyl-sulfon-yl)-5-phenyl-4,5-dihydro-1H-pyrazole.

Journal: Acta crystallographica. Section E, Structure reports online20110801

Title: 3,5-Bis(4-meth-oxy-phen-yl)-4,5-dihydro-isoxazole.

Journal: Acta crystallographica. Section E, Structure reports online20110801

Title: Effects of CYP1A2 gene polymorphisms on antipyrine CYP1A2-dependent metabolism.

Journal: Bulletin of experimental biology and medicine20110801

Title: Comparison of polysaccharides from different Dendrobium using saccharide mapping.

Journal: Journal of pharmaceutical and biomedical analysis20110715

Title: Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies.

Journal: Bioorganic & medicinal chemistry letters20110715

Title: Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20110701

Title: Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia.

Journal: Current molecular medicine20110701

Title: A review on various heterocyclic moieties and their antitubercular activity.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie20110701

Title: 1,5-Dimethyl-4-(1-methyl-3-oxo-3-phenylprop-1-enyl-amino)-2-phenyl-1H-pyrazol-3(2H)-one.

Journal: Acta crystallographica. Section E, Structure reports online20110701

Title: [Preparation of rivastigmine liposome and its pharmacokinetics in rats after intranasal administration].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20110701

Title: In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice.

Journal: Brain research20110623

Title: New treatment of free-radical scavenger in adrenoleukodystrophy.

Journal: Journal of clinical pharmacy and therapeutics20110601

Title: Edaravone ameliorates diabetes-induced dysfunction of NO-induced relaxation in corpus cavernosum smooth muscle in the rat.

Journal: The journal of sexual medicine20110601

Title: 3,5-Bis(4-fluoro-phen-yl)-4,5-dihydro-1H-pyrazole-1-carbaldehyde.

Journal: Acta crystallographica. Section E, Structure reports online20110601

Title: Edaravone alleviates delayed neuronal death and long-dated cognitive dysfunction of hippocampus after transient focal ischemia in Wistar rat brains.

Journal: Neuroscience20110519

Title: Conformations of antipyrines.

Journal: The journal of physical chemistry. A20110512

Title: Acute inferior myocardial infarction with low atrial rhythm due to propyphenazone: Kounis syndrome.

Journal: International journal of cardiology20110505

Title: Edaravone, an ROS scavenger, ameliorates photoreceptor cell death after experimental retinal detachment.

Journal: Investigative ophthalmology & visual science20110501

Title: C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation.

Journal: Arteriosclerosis, thrombosis, and vascular biology20110501

Title: Solid-phase treatment with the fungus Trametes versicolor substantially reduces pharmaceutical concentrations and toxicity from sewage sludge.

Journal: Bioresource technology20110501

Title: Translational stroke research of the combination of thrombolysis and antioxidant therapy.

Journal: Stroke20110501

Title: Relationship between lipophilicity and absorption from the liver surface of paraben derivatives and antipyrine in rats.

Journal: The Journal of pharmacy and pharmacology20110501

Title: [Future neuroprotective strategies in the post-thrombolysis era--neurovascular unit protection and vascular endothelial protection].

Journal: Rinsho shinkeigaku = Clinical neurology20110501

Title: Modulation of the foreign body reaction for implants in the subcutaneous space: microdialysis probes as localized drug delivery/sampling devices.

Journal: Journal of diabetes science and technology20110501

Title: Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity.

Journal: The Journal of biological chemistry20110415

Title: Importance of physicochemical properties for the design of new pesticides.

Journal: Journal of agricultural and food chemistry20110413

Title: Self-medication of migraine and tension-type headache: summary of the evidence-based recommendations of the Deutsche Migräne und Kopfschmerzgesellschaft (DMKG), the Deutsche Gesellschaft für Neurologie (DGN), the Österreichische Kopfschmerzgesellschaft (ÖKSG) and the Schweizerische Kopfwehgesellschaft (SKG).

Journal: The journal of headache and pain20110401

Title: Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation.

Journal: Neuroscience research20110401

Title: Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis.

Journal: Drug metabolism and disposition: the biological fate of chemicals20110401

Title: Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation.

Journal: Bioorganic & medicinal chemistry letters20110401

Title: Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats.

Journal: The Journal of pharmacy and pharmacology20110401

Title: Edaravone, a hydroxyl radical scavenger, ameliorates the severity of pulmonary hypertension in a porcine model of neonatal sepsis.

Journal: The Tohoku journal of experimental medicine20110401

Title: Validated HPLC method for determination of caffeine level in human plasma using synthetic plasma: application to bioavailability studies.

Journal: Journal of chromatographic science20110401

Title: Prevalence and patterns of nitrosatable drug use among U.S. women during early pregnancy.

Journal: Birth defects research. Part A, Clinical and molecular teratology20110401

Title: 3,5-Bis(4-methyl-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.

Journal: Acta crystallographica. Section E, Structure reports online20110401

Title: 2-Phenyl-8,9,10,11-tetra-hydro-1-benzo-thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine.

Journal: Acta crystallographica. Section E, Structure reports online20110401

Title: [Stimulative effect of edaravone on growth of neuronal stem cells and precursor cells following lesioning of hippocampal dentate gyrus].

Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology20110401

Title: The use of convection-enhanced delivery with liposomal toxins in neurooncology.

Journal: Toxins20110401

Title: Transfer of PAMAM dendrimers across human placenta: prospects of its use as drug carrier during pregnancy.

Journal: Journal of controlled release : official journal of the Controlled Release Society20110330

Title: Feasibility study for functional test battery of SOD transgenic rat (H46R) and evaluation of edaravone, a free radical scavenger.

Journal: Brain research20110325

Title: A new in situ brain perfusion flow correction method for lipophilic drugs based on the pH-dependent Crone-Renkin equation.

Journal: Pharmaceutical research20110301

Title: [Effects of edaravone on glial fibrillary acidic protein and interleukin-lβ expression and neuronal apoptosis in juvenile rat hippocampus after status convulsion].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics20110301

Title: [Separation of 1-phenyl-3-methyl-5-pyrazolone derivatives of traditional Chinese medicine oligosaccharides by capillary zone electrophoresis].

Journal: Se pu = Chinese journal of chromatography20110301

Title: Edaravone for acute intracerebral haemorrhage.

Journal: The Cochrane database of systematic reviews20110216

Title: Effects of GABA(A) receptor blockade on regional cerebral blood flow and blood-brain barrier disruption in focal cerebral ischemia.

Journal: Journal of the neurological sciences20110215

Title: OH radical scavenging activity of Edaravone: mechanism and kinetics.

Journal: The journal of physical chemistry. B20110210

Title: Towards a selected reaction monitoring mass spectrometry fingerprint approach for the screening of oligosaccharidoses.

Journal: Analytica chimica acta20110207

Title: Spontaneous intracerebral hemorrhage associated with ingestion of isometheptine containing anti-migraine medication.

Journal: Clinical neurology and neurosurgery20110201

Title: Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone.

Journal: Bioorganic chemistry20110201

Title: Effects of continuous intravenous infusion of MCI-186 on functional recovery after spinal cord injury in rats.

Journal: Journal of neurotrauma20110201

Title: Donor antioxidant strategy prolongs cardiac allograft survival by attenuating tissue dendritic cell immunogenicity(†).

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20110201

Title: 3,5-Bis(4-meth-oxy-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.

Journal: Acta crystallographica. Section E, Structure reports online20110201

Title: (2E)-3-(3-Bromo-4-meth-oxy-phen-yl)-1-(pyridin-2-yl)prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online20110201

Title: 1-[5-(Anthracen-9-yl)-3-(4-nitro-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one.

Journal: Acta crystallographica. Section E, Structure reports online20110201

Title: 3-[5-(2,4-Dichloro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-4-hy-droxy-2H-chromen-2-one.

Journal: Acta crystallographica. Section E, Structure reports online20110201

Title: CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease.

Journal: Journal of immunology (Baltimore, Md. : 1950)20110115

Title: Synthesis and anti-bacterial activities of a bis-chalcone derived from thiophene and its bis-cyclized products.

Journal: Molecules (Basel, Switzerland)20110112

Title: Synthesis, reactions and biological evaluation of some new naphtho[2,1-b]furan derivatives bearing a pyrazole nucleus.

Journal: Molecules (Basel, Switzerland)20110105

Title: Effect of edaravone on the estimated glomerular filtration rate in patients with acute ischemic stroke and chronic kidney disease.

Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association20110101

Title: A combined treatment for acute larger lacunar-type infarction.

Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association20110101

Title: The synthesis, X-ray crystal structure and optical properties of novel 5-aryl-3-ferrocenyl-1-pyridazinyl-pyrazoline derivatives.

Journal: Journal of fluorescence20110101

Title: Edaravone, a free radical scavenger, promotes engraftment of intraportally transplanted islet cells.

Journal: Pancreas20110101

Title: Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat?

Journal: International immunopharmacology20110101

Title: Effect of a free radical scavenger, edaravone, on free radical reactions: related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model.

Journal: Acta neurochirurgica. Supplement20110101

Title: Pulse radiolysis study on free radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2: A comparative study on edaravone derivatives.

Journal: Journal of radiation research20110101

Title: Placental transfer of the insulin analog glargine in the ex vivo perfused placental cotyledon model.

Journal: Endocrine research20110101

Title: Effects of edaravone on a rat model of punch-drunk syndrome.

Journal: Neurologia medico-chirurgica20110101

Title: Microwave assisted solvent free synthesis of 1,3-diphenylpropenones.

Journal: Chemistry Central journal20110101

Title: Cerebral changes occurring in arginase and dimethylarginine dimethylaminohydrolase (DDAH) in a rat model of sleeping sickness.

Journal: PloS one20110101

Title: [Effects of edaravone on the expression of GRP78, Caspase-12, and neuron apoptosis in juvenile rat hippocampus after status convulsive].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics20110101

Title: Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model.

Journal: Journal of burn care & research : official publication of the American Burn Association20110101

Title: Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke.

Journal: BMC neurology20110101

Title: 1-[5-(Anthracen-9-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

Journal: Acta crystallographica. Section E, Structure reports online20110101

Title: Solid-phase extraction of antipyrine dye for spectrophotometric determination of phenolic compounds in water.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry20110101

Title: Erythema multiforme due to antitubercular drugs.

Journal: Lung India : official organ of Indian Chest Society20110101

Title: Edaravone guards dopamine neurons in a rotenone model for Parkinson's disease.

Journal: PloS one20110101

Title: Conformationally constrained histidines in the design of peptidomimetics: strategies for the χ-space control.

Journal: International journal of molecular sciences20110101

Title: Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

Journal: Journal of pharmacy & bioallied sciences20110101

Title: Age-related changes in the hepatic pharmacology and toxicology of paracetamol.

Journal: Current gerontology and geriatrics research20110101

Title: Novel benzimidazole derivatives as expected anticancer agents.

Journal: Acta poloniae pharmaceutica20110101

Title: Antioxidant therapy: current status and future prospects.

Journal: Current medicinal chemistry20110101

Title: Mapping functional brain activation using [14C]-iodoantipyrine in male serotonin transporter knockout mice.

Journal: PloS one20110101

Title: Basophil activation test for investigation of IgE-mediated mechanisms in drug hypersensitivity.

Journal: Journal of visualized experiments : JoVE20110101

Title: Electrocardiographic and biochemical evidence for the cardioprotective effect of antioxidants in acute doxorubicin-induced cardiotoxicity in the beagle dogs.

Journal: Biological & pharmaceutical bulletin20110101

Title: Infrared imaging and spectral-domain optical coherence tomography findings correlate with microperimetry in acute macular neuroretinopathy: a case report.

Journal: Journal of medical case reports20110101

Title: The state of the art of pyrazole derivatives as monoamine oxidase inhibitors and antidepressant/anticonvulsant agents.

Journal: Current medicinal chemistry20110101

Title: A facile synthesis and anticancer activity evaluation of spiro[thiazolidinone-isatin] conjugates.

Journal: Scientia pharmaceutica20110101

Title: [Dynamics of antipirin test at patients with alcoholic liver disease on the background of metadoksin drug receiving].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology20110101

Title: Detection and quantification of citrullinated chemokines.

Journal: PloS one20110101

Title: Chemical exposure as etiology in developmental origin of adult onset human cancer.

Journal: Frontiers in pharmacology20110101

Title: Edaravone attenuates impairment of synaptic plasticity in granule cell layer of the dentate gyrus following traumatic brain injury.

Journal: The Kurume medical journal20110101

Title: Protective effects of edaravone on experimental spinal cord injury in rats.

Journal: Pediatric neurosurgery20110101

Title: Pharmacogenetics and gender association with psychotic episodes on nortriptyline lower doses: patient cases.

Journal: ISRN pharmaceutics20110101

Title: Design, synthesis, and pharmacological activity of nonallergenic pyrazolone-type antipyretic analgesics.

Journal: Journal of medicinal chemistry20101223

Title: Edaravone: a new therapeutic approach for the treatment of acute stroke.

Journal: Medical hypotheses20101201

Title: Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes.

Journal: Biomaterials20101201

Title: Drug structure-transport relationships.

Journal: Journal of pharmacokinetics and pharmacodynamics20101201

Title: [ERK1/2 mediates edaravone-triggered protection against myocardial damage induced by isoprenaline in H9c2 cells].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University20101201

Title: 3',7',7'-Trimethyl-1'-phenyl-5',6',7',8'-tetra-hydro-spiro-[indoline-3,4'-(1H,4H-pyrazolo-[3,4-b]chromene)]-2,5'-dione.

Journal: Acta crystallographica. Section E, Structure reports online20101201

Title: 2-[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino]-1-methyl-2-oxoethyl pyrrolidine-1-carbodithio-ate.

Journal: Acta crystallographica. Section E, Structure reports online20101201

Title: 1-[5-(4-Meth-oxy-phen-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

Journal: Acta crystallographica. Section E, Structure reports online20101201

Title: A free-radical scavenger protects the neural progenitor cells in the dentate subgranular zone of the hippocampus from cell death after X-irradiation.

Journal: Neuroscience letters20101112

Title: Investigation of microdialysis sampling calibration approaches for lipophilic analytes: doxorubicin.

Journal: Journal of pharmaceutical and biomedical analysis20101102

Title: Synthesis and biological evaluation of N-antipyrine-4-substituted amino-3-chloromaleimide derivatives.

Journal: European journal of medicinal chemistry20101101

Title: Cyclization of some carbothioamide derivatives containing antipyrine and triazole moieties and investigation of their antimicrobial activities.

Journal: European journal of medicinal chemistry20101101

Title: Synthesis and molluscicidal evaluation of some new pyrazole, isoxazole, pyridine, pyrimidine, 1,4-thiazine and 1,3,4-thiadiazine derivatives incorporating benzofuran moiety.

Journal: European journal of medicinal chemistry20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Free radical scavenger edaravone administration protects against tissue plasminogen activator induced oxidative stress and blood brain barrier damage.

Journal: Current neurovascular research20101101

Title: Human health risk assessment of pharmaceuticals in water: issues and challenges ahead.

Journal: International journal of environmental research and public health20101101

Title: 4-[(E)-3-Meth-oxy-5-nitro-4-(4-nitro-benz-yloxy)benzyl-idene-amino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one.

Journal: Acta crystallographica. Section E, Structure reports online20101101

Title: 5-(Anthracen-9-yl)-3-(4-nitro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.

Journal: Acta crystallographica. Section E, Structure reports online20101101

Title: [Concept of branch atheromatous disease (BAD) and its clinical significance].

Journal: Rinsho shinkeigaku = Clinical neurology20101101

Title: Gene network analysis to determine the effects of antioxidant treatment in a rat model of neonatal hypoxic-ischemic encephalopathy.

Journal: Journal of molecular neuroscience : MN20101001

Title: Relationships between solid dispersion preparation process, particle size and drug release--an NMR and NMR microimaging study.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V20101001

Title: Synthesis, characterization, antiamoebic activity and cytotoxicity of novel series of pyrazoline derivatives bearing quinoline tail.

Journal: European journal of medicinal chemistry20101001

Title: 2-[5-(1,3-Benzodioxol-5-yl)-3-ferrocenyl-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thia-zole.

Journal: Acta crystallographica. Section E, Structure reports online20101001

Title: 1-{5-[4-(Hex-yloxy)phen-yl]-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl}ethanone.

Journal: Acta crystallographica. Section E, Structure reports online20101001

Title: Systemic administration of a free radical scavenger, edaravone, protects against light-induced photoreceptor degeneration in the mouse retina.

Journal: European journal of pharmacology20100910

Title: New pyrazoline derivatives and their antidepressant activity.

Journal: European journal of medicinal chemistry20100901

Title: Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo.

Journal: Heart and vessels20100901

Title: The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis.

Journal: Free radical research20100901

Title: Effects of edaravone on muscle atrophy and locomotor function in patients with ischemic stroke: a randomized controlled pilot study.

Journal: Drugs in R&D20100901

Title: Development and validation of an HPLC method for simultaneous determination of trimethoprim and sulfamethoxazole in human plasma.

Journal: European journal of drug metabolism and pharmacokinetics20100901

Title: 2-Amino-5-methyl-pyridinium 2-hy-droxy-benzoate.

Journal: Acta crystallographica. Section E, Structure reports online20100901

Title: Ethyl 2-[(Z)-2-benzyl-hydrazin-1-yl-idene]-2-bromo-acetate.

Journal: Acta crystallographica. Section E, Structure reports online20100901

Title: Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.

Journal: Journal of medicinal chemistry20100826

Title: Placental transfer and DNA binding of benzo(a)pyrene in human placental perfusion.

Journal: Toxicology letters20100816

Title: Discovery and optimization of pyrazoline compounds as B-Raf inhibitors.

Journal: Bioorganic & medicinal chemistry letters20100815

Title: Quality assessment of a placental perfusion protocol.

Journal: Reproductive toxicology (Elmsford, N.Y.)20100801

Title: Preparation of some pyrazoline derivatives and evaluation of their antifungal activities.

Journal: Journal of enzyme inhibition and medicinal chemistry20100801

Title: Synthesis of novel alpha-pyranochalcones and pyrazoline derivatives as Plasmodium falciparum growth inhibitors.

Journal: Bioorganic & medicinal chemistry letters20100801

Title: Investigation of the microbial degradation of phenazone-type drugs and their metabolites by natural biofilms derived from river water using liquid chromatography/tandem mass spectrometry (LC-MS/MS).

Journal: Water research20100801

Title: 1-(3'-[125I]Iodophenyl)-3-methy-2-pyrazolin-5-one: preparation, solution stability, and biodistribution in normal mice.

Journal: Chemical & pharmaceutical bulletin20100801

Title: Di-μ-chlorido-bis-{chlorido[(R)/(S)-1,5-di-phenyl-3-(2-pyridyl-κN)-2-pyrazoline-κN]zinc(II)}.

Journal: Acta crystallographica. Section E, Structure reports online20100801

Title: 3,5-Bis(4-fluoro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.

Journal: Acta crystallographica. Section E, Structure reports online20100801

Title: 1-[3,5-Bis(4-chloro-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

Journal: Acta crystallographica. Section E, Structure reports online20100801

Title: 4-[(1-Hy-droxy-2-naphth-yl)methyl-ene-amino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one.

Journal: Acta crystallographica. Section E, Structure reports online20100801

Title: Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations.

Journal: Cancer letters20100701

Title: A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy?

Journal: Expert opinion on pharmacotherapy20100701

Title: Toxicokinetics of the food-toxin IQ in human placental perfusion is not affected by ABCG2 or xenobiotic metabolism.

Journal: Placenta20100701

Title: VUV photon-induced ionization/dissociation of antipyrine and propyphenazone: mass spectrometric and theoretical insights.

Journal: Journal of mass spectrometry : JMS20100701

Title: Protective effect of edaravone against renal ischemia/reperfusion injury and compared with ischemic postconditioning in rats.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20100701

Title: 1,5-Dimethyl-4-{[1-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl-idene)eth-yl]amino}-2-phenyl-1H-pyrazol-3(2H)-one.

Journal: Acta crystallographica. Section E, Structure reports online20100701

Title: 1-[3-(2-Nitro-phen-yl)-5-phenyl-2-pyrazolin-1-yl]ethanone.

Journal: Acta crystallographica. Section E, Structure reports online20100701

Title: 4-{(E)-[2-(4-Iodo-but-oxy)benzyl-idene]amino}-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one.

Journal: Acta crystallographica. Section E, Structure reports online20100701

Title: A novel method for inducing focal ischemia in vitro.

Journal: Journal of neuroscience methods20100630

Title: A novel rodent model of reperfusion injury following occlusion of the middle cerebral artery.

Journal: Journal of neuroscience methods20100630

Title: Scavenging activity of aminoantipyrines against hydroxyl radical.

Journal: European journal of medicinal chemistry20100601

Title: Long-term calibration considerations during subcutaneous microdialysis sampling in mobile rats.

Journal: Biomaterials20100601

Title: Transplacental transfer and biotransformation of genistein in human placenta.

Journal: Placenta20100601

Title: 3,5-Bis(4-bromo-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.

Journal: Acta crystallographica. Section E, Structure reports online20100601

Title: 4-[(Z)-Allyl-amino-(phen-yl)methyl-ene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one.

Journal: Acta crystallographica. Section E, Structure reports online20100601

Title: (E)-5-[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino-meth-yl]-2-methoxy-phenyl 4-bromo-benzene-sulfonate.

Journal: Acta crystallographica. Section E, Structure reports online20100601

Title: 2-Amino-5-chloro-pyridinium salicylate.

Journal: Acta crystallographica. Section E, Structure reports online20100601

Title: Two-column sequential injection chromatography--new approach for fast and effective analysis and its comparison with gradient elution chromatography.

Journal: Analytica chimica acta20100523

Title: Edaravone directly reacts with singlet oxygen and protects cells from attack.

Journal: Life sciences20100522

Title: Is the mechanisms of fipronil-induced thyroid disruption specific of the rat: Re-evaluation of fipronil thyroid toxicity in sheep?

Journal: Toxicology letters20100504

Title: Transplacental transfer and metabolism of bupropion.

Title: The effects of isoflurane pretreatment on cerebral blood flow, capillary permeability, and oxygen consumption in focal cerebral ischemia in rats.

Journal: Anesthesia and analgesia20100501

Title: Antimicrobial activity of new 4,6-disubstituted pyrimidine, pyrazoline, and pyran derivatives.

Journal: Archives of pharmacal research20100501

Title: (4Z)-4-[(Cyclo-propyl-amino)(phen-yl)methyl-ene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one.

Journal: Acta crystallographica. Section E, Structure reports online20100501

Title: Transfer of bisphenol A across the human placenta.

Journal: American journal of obstetrics and gynecology20100401

Title: [A comparative study on the protection effect of nerve growth factor and edaravone pretreatment against cerebral ischemia/reperfusion injury].

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue20100401

Title: [Effect of edaravone on extracellular signal-regulated kinase 1/2 pathway following severe traumatic brain injury in rats].

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue20100401

Title: [Development of a new HPLC technique for analyzing monosaccharide composition and its application in the quality control of Silybum marianum polysaccharide].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20100401

Title: Determination of pharmaceuticals in river water by column switching of large sample volumes and liquid chromatography-diode array detection, assisted by chemometrics: an integrated approach to green analytical methodologies.

Journal: Journal of chromatography. A20100326

Title: Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury.

Journal: European journal of pharmacology20100325

Title: Hochuekkito, a Kampo (traditional Japanese herbal) Medicine, Enhances Mucosal IgA Antibody Response in Mice Immunized with Antigen-entrapped Biodegradable Microparticles.

Journal: Evidence-based complementary and alternative medicine : eCAM20100301

Title: Protective effect of edaravone, a free-radical scavenger, on ischaemia-reperfusion injury in the rat testis.

Journal: BJU international20100301

Title: Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanisms.

Journal: Antioxidants & redox signaling20100301

Title: Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation.

Journal: Neuroscience research20100301

Title: Barrier capacity of human placenta for nanosized materials.

Journal: Environmental health perspectives20100301

Title: Experimental and theoretical studies on o-, m- and p-chlorobenzylideneaminoantipyrines.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20100301

Title: Application of photo-fenton as a tertiary treatment of emerging contaminants in municipal wastewater.

Journal: Environmental science & technology20100301

Title: Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies.

Journal: Bioorganic & medicinal chemistry20100301

Title: N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system.

Journal: Anesthesia and analgesia20100301

Title: [Protection of edaravone on neurons and its effects on the expression of interleukin-lbeta in juvenile rat hippocampus following status convulsion].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics20100301

Title: Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats.

Journal: The Journal of pharmacy and pharmacology20100301

Title: 3-Chloro-6-{4-[3-(trifluoro-meth-yl)phen-yl]piperazin-1-yl}pyridazine.

Journal: Acta crystallographica. Section E, Structure reports online20100301

Title: 1-[3,5-Bis(4-fluoro-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone.

Journal: Acta crystallographica. Section E, Structure reports online20100301

Title: Does the concomitant intra-arterial injection of asialoerythropoietin and edaravone mitigate ischaemic mucosal damage after acute superior mesenteric artery thromboembolism in a rabbit autologous fibrin clot model?

Journal: The British journal of radiology20100201

Title: Edaravone, a free radical scavenger, in the treatment of idiopathic sudden sensorineural hearing loss with profound hearing loss.

Journal: Auris, nasus, larynx20100201

Title: Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats.

Journal: Neurochemical research20100201

Title: Metal-based biologically active agents: Synthesis, characterization, antibacterial and antileukemia activity evaluation of Cu(II), V(IV) and Ni(II) complexes with antipyrine-derived compounds.

Journal: European journal of medicinal chemistry20100201

Title: Absorption and distribution of etoricoxib in plasma, CSF, and wound tissue in patients following hip surgery--a pilot study.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20100201

Title: 6-Chloro-3-[5-(4-fluoro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-2-methyl-4-phenyl-quinoline.

Journal: Acta crystallographica. Section E, Structure reports online20100201

Title: The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20100131

Title: Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro.

Journal: Brain research20100111

Title: Mapping selective neuronal loss and microglial activation in the salvaged neocortical penumbra in the rat.

Journal: NeuroImage20100101

Title: Fenofibrate improves cerebral blood flow after middle cerebral artery occlusion in mice.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20100101

Title: Insulin glargine safety in pregnancy: a transplacental transfer study.

Journal: Diabetes care20100101

Title: Degradation of fifteen emerging contaminants at microg L(-1) initial concentrations by mild solar photo-Fenton in MWTP effluents.

Journal: Water research20100101

Title: Pyrazoline bearing benzimidazoles: search for anticancer agent.

Journal: European journal of medicinal chemistry20100101

Title: Vibrational spectroscopic study of o-, m- and p-hydroxybenzylideneaminoantipyrines.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20100101

Title: Small temperature variations alter edaravone-induced neuroprotection of cortical cultures exposed to prolonged hypoxic episodes.

Journal: British journal of anaesthesia20100101

Title: Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studies.

Journal: Bioorganic & medicinal chemistry letters20100101

Title: Endogenous reactive oxygen species are essential for proliferation of neural stem/progenitor cells.

Journal: Neurochemistry international20100101

Title: Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.

Journal: Bioorganic & medicinal chemistry letters20100101

Title: Investigation of the intestinal permeability and first-pass metabolism of drugs in cynomolgus monkeys using single-pass intestinal perfusion.

Journal: Biological & pharmaceutical bulletin20100101

Title: Effect of edaravone on ischemia/reperfusion injury in rat urinary bladder--changes in smooth muscle cell phenotype and contractile function.

Journal: Aktuelle Urologie20100101

Title: A novel administration route of edaravone--II: mucosal absorption of edaravone from edaravone/hydroxypropyl-beta-cyclodextrin complex solution including L-cysteine and sodium hydrogen sulfite.

Journal: Pharmacology20100101

Title: Effects of fentanyl pretreatment on regional cerebral blood flow in focal cerebral ischemia in rats.

Journal: Pharmacology20100101

Title: Does functional outcome in acute ischaemic stroke patients correlate with the amount of free-radical scavenger treatment? A retrospective study of edaravone therapy.

Journal: Clinical drug investigation20100101

Title: Psychiatric comorbidity and suicide risk in patients with chronic migraine.

Journal: Neuropsychiatric disease and treatment20100101

Title: Clinical research on liver reserve function by 13C-phenylalanine breath test in aged patients with chronic liver diseases.

Journal: BMC geriatrics20100101

Title: Placental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system: an experimental study.

Journal: Environmental health : a global access science source20100101

Title: Absorption of lisdexamfetamine dimesylate and its enzymatic conversion to d-amphetamine.

Journal: Neuropsychiatric disease and treatment20100101

Title: Adsorption and quantum chemical studies on the inhibition potentials of some thiosemicarbazides for the corrosion of mild steel in acidic medium.

Journal: International journal of molecular sciences20100101

Title: In vitro studies of ferric carboxymaltose on placental permeability using the dual perfusion model of human placenta.

Journal: Arzneimittel-Forschung20100101

Title: Evaluation of In Vitro Activity of Essential Oils against Trypanosoma brucei brucei and Trypanosoma evansi.

Journal: Journal of parasitology research20100101

Title: Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve.

Journal: Molecular vision20100101

Title: Protective effect of edaravone against PrP106-126-induced PC12 cell death.

Journal: Journal of biochemical and molecular toxicology20100101

Title: Antidiarrhoea and toxicological evaluation of the leaf extract of Dissotis rotundifolia Triana (Melastomataceae).

Journal: BMC complementary and alternative medicine20100101

Title: Antibiotic Treatment of Dogs and Cats during Pregnancy.

Journal: Veterinary medicine international20100101

Title: Synthesis and Antimicrobial Activity of 2-[2-(2,6-dichloro phenyl)amino]benzyl-3-(5-substituted phenyl-4,5-dihydro-1H-pyrazol-3-yl-amino)-6,8-dibromoquinazolin-4(3H)ones.

Journal: Journal of young pharmacists : JYP20100101

Title: Senna occidentalis leaf extract possesses antitrypanosomal activity and ameliorates the trypanosome-induced anemia and organ damage.

Journal: Pharmacognosy research20100101

Title: Synthesis and Biological Evaluation of Chalcones having Heterosubstituent(s).

Journal: Indian journal of pharmaceutical sciences20100101

Title: A novel electrochemical sensor for probing doxepin created on a glassy carbon electrode modified with poly(4-amino- benzoic acid)/multi-walled carbon nanotubes composite film.

Journal: Sensors (Basel, Switzerland)20100101

Title: Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4.

Journal: Biochemical and biophysical research communications20091225

Title: Edaravone, a novel free radical scavenger, reduces high-mobility group box 1 and prolongs survival in a neonatal sepsis model.

Journal: Shock (Augusta, Ga.)20091201

Title: Long-lasting enhancement of CYP activity after discontinuation of repeated administration of phenobarbital in dogs.

Journal: Research in veterinary science20091201

Title: Influence of perfusate composition on drug disposition in the in-situ perfused rat lung.

Journal: International journal of pharmaceutics20091201

Title: Contribution and limit of the model of perfused cotyledon to the study of placental transfer of drugs. Example of a protease inhibitor of HIV: nelfinavir.

Journal: European journal of obstetrics, gynecology, and reproductive biology20091201

Title: Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.

Journal: Bioorganic & medicinal chemistry letters20091201

Title: Effect of edaravone on plasma monocyte chemoattractant protein-1 levels in patients with acute myocardial infarction.

Journal: Journal of cardiology20091201

Title: [The protective effect of edaravone on the treatment of sepsis in rats].

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue20091201

Title: 5-Bromo-2-[5-(4-nitro-phen-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]pyrimidine.

Journal: Acta crystallographica. Section E, Structure reports online20091201

Title: The characteristics of enriched nitrifier culture in the degradation of selected pharmaceutically active compounds.

Journal: Journal of hazardous materials20091115

Title: Correlation between in vitro dissolution profiles from enteric-coated dosage forms and in vivo absorption in rats for high-solubility and high-permeability model drugs.

Journal: Journal of pharmaceutical sciences20091101

Title: Coupling of solid-phase microextraction with micellar desorption and high performance liquid chromatography for the determination of pharmaceutical residues in environmental liquid samples.

Journal: Biomedical chromatography : BMC20091101

Title: Biological activities of pyrazoline derivatives--a recent development.

Journal: Recent patents on anti-infective drug discovery20091101

Title: The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury.

Journal: Neurotoxicity research20091101

Title: Edaravone (MCI-186) is effective as a free radical scavenger following arteriovenous sheathotomy for treatment of macular oedema associated with branch retinal vein occlusion.

Journal: The British journal of ophthalmology20091101

Title: At the biological modeling and simulation frontier.

Journal: Pharmaceutical research20091101

Title: Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy.

Journal: Journal of forensic and legal medicine20091101

Title: Phenylpyrazolone derivatives inhibit gastric emptying in rats by a capsaicin-sensitive afferent pathway.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas20091101

Title: (4Z)-4-[(4-Methoxy-benzyl-amino)(phen-yl)methyl-ene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one.

Journal: Acta crystallographica. Section E, Structure reports online20091101

Title: 4-[1-Acetyl-3-(4-methoxy-phen-yl)-2-pyrazolin-5-yl]phenol.

Journal: Acta crystallographica. Section E, Structure reports online20091101

Title: Facile synthesis of stapled, structurally reinforced peptide helices via a photoinduced intramolecular 1,3-dipolar cycloaddition reaction.

Journal: Chemical communications (Cambridge, England)20091007

Title: Changes of expression of glucose transporters in the fetal lamb brain after MCI-186 administration to the maternal circulation with 10-min persistent umbilical cord occlusion.

Title: Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury.

Journal: Muscle & nerve20091001

Title: Modeling placental transport: correlation of in vitro BeWo cell permeability and ex vivo human placental perfusion.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20091001

Title: Poly(ADP-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting HIF.

Journal: Journal of neurochemistry20091001

Title: Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.

Journal: Bioorganic & medicinal chemistry20091001

Title: [Synthesis and spectrum of novel pyrazoline fluorescent compounds].

Journal: Guang pu xue yu guang pu fen xi = Guang pu20091001

Title: Edaravone, a free radical scavenger, retards the development of amygdala kindling in rats.

Journal: Neuroscience letters20090925

Title: Experimental and theoretical comparative studies on two 2-pyrazoline derivatives.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20090915

Title: Antifibrotic effect of edaravone in rat liver cirrhosis induced by dimethylnitrosamine.

Journal: Clinical and experimental medicine20090901

Title: Mechanistic insight into neurotoxicity of tissue plasminogen activator-induced thrombolysis products in a rat intraluminal middle cerebral artery occlusion model.

Journal: Journal of neurotrauma20090901

Title: Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: preventive effect of edaravone, a free-radical scavenger.

Journal: BJU international20090901

Title: Accumulation of oxidative stress around the stroke-like lesions of MELAS patients.

Journal: Mitochondrion20090901

Title: Experimental and theoretical studies on vibrational spectra of 4-(2-furanylmethyleneamino)antipyrine, 4-benzylideneaminoantipyrine and 4-cinnamilideneaminoantipyrine.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20090901

Title: Development of cardiac dysfunction induced by repetitive transient myocardial ischemia is inhibited by edaravone in conscious rats.

Journal: Clinical and experimental pharmacology & physiology20090901

Title: Sex differences in functional brain activation during noxious visceral stimulation in rats.

Journal: Pain20090901

Title: Targeted analysis of protein citrullination using chemical modification and tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM20090901

Title: Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes.

Journal: Chemical research in toxicology20090901

Title: Effects of some 1,3,5-trisubstitued-2-pyrazoline derivatives on depression and anxiety parameters of mice.

Journal: Archives of pharmacal research20090901

Title: 4-{(Z)-(sec-Butyl-amino)(phen-yl)methyl-ene}-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one.