60282-87-3,MFCD00867858
Catalog No.:AA00IALM

60282-87-3 | 18,19-Dinorpregna-4,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17a)-

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100mg
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250mg
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  • Technical Information
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Technical Information
Catalog Number:
AA00IALM
Chemical Name:
18,19-Dinorpregna-4,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17a)-
CAS Number:
60282-87-3
Molecular Formula:
C21H26O2
Molecular Weight:
310.4299
MDL Number:
MFCD00867858
SMILES:
C#C[C@]1(O)C=C[C@@H]2[C@]1(CC)CC[C@H]1[C@H]2CCC2=CC(=O)CC[C@H]12
Properties
Properties
 
BP:
462.7°C at 760 mmHg  
Form:
Solid  
MP:
190-192˚C  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
648  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.9  

Synonyms
 
  
Literature

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Journal: Toxicology and applied pharmacology 20160815

Title: Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150601

Title: Ozonation of a mixture of estrogens and progestins in aqueous solution: interpretation of experimental results by computational methods.

Journal: Chemosphere 20121101

Title: Progestin-dependent effect of oral contraceptives on plasma aldosterone/renin ratio.

Journal: Clinical biochemistry 20121101

Title: ACP Journal Club. Hormonal contraceptives with ethinyl estradiol were associated with increased thrombotic stroke and MI.

Journal: Annals of internal medicine 20121016

Title: Acute and long-term estradiol kinetics in smoking postmenopausal women.

Journal: Climacteric : the journal of the International Menopause Society 20121001

Title: 17-Hydroxysteroid dehydrogenase type 5 gene polymorphism (-71A/G HSD17B5 SNP) and treatment with oral contraceptive pills in PCOS women without metabolic comorbidities.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120801

Title: Oral contraception in Denmark 1998-2010.

Journal: Acta obstetricia et gynecologica Scandinavica 20120701

Title: Hormonal contraception and venous thromboembolism.

Journal: Acta obstetricia et gynecologica Scandinavica 20120701

Title: Multi-species comparison of the mechanism of biotransformation of MeO-BDEs to OH-BDEs in fish.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20120615

Title: Thrombotic stroke and myocardial infarction with hormonal contraception.

Journal: The New England journal of medicine 20120614

Title: Continuous low-dose oral contraceptive in the treatment of colorectal endometriosis evaluated by rectal endoscopic ultrasonography.

Journal: Acta obstetricia et gynecologica Scandinavica 20120601

Title: Continuous compared with cyclic oral contraceptives for the treatment of primary dysmenorrhea: a randomized controlled trial.

Journal: Obstetrics and gynecology 20120601

Title: Simultaneous online SPE-LC-MS/MS quantification of six widely used synthetic progestins in human plasma.

Journal: Analytical and bioanalytical chemistry 20120501

Title: Migraine in women: the role of hormones and their impact on vascular diseases.

Journal: The journal of headache and pain 20120401

Title: Contraceptive efficacy and tolerability of ethinylestradiol 20 μg/drospirenone 3 mg in a flexible extended regimen: an open-label, multicentre, randomised, controlled study.

Journal: The journal of family planning and reproductive health care 20120401

Title: Venous and pulmonary thromboembolism and combined hormonal contraceptives. Systematic review and meta-analysis.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20120201

Title: Combined oral contraceptives, venous thromboembolism, and the problem of interpreting large but incomplete datasets.

Journal: The journal of family planning and reproductive health care 20120101

Title: Factor Xa generation by computational modeling: an additional discriminator to thrombin generation evaluation.

Journal: PloS one 20120101

Title: Oral contraceptives modify DNA methylation and monocyte-derived macrophage function.

Journal: Biology of sex differences 20120101

Title: Venous thrombosis in users of non-oral hormonal contraception: follow-up study, Denmark 2001-10.

Journal: BMJ (Clinical research ed.) 20120101

Title: Postoperative depot medroxyprogesterone acetate versus continuous oral contraceptive pills in the treatment of endometriosis-associated pain: a randomized comparative trial.

Journal: Gynecologic and obstetric investigation 20120101

Title: Aromatase gene polymorphism does not influence clinical phenotype and response to oral contraceptive pills in polycystic ovary syndrome women.

Journal: Gynecologic and obstetric investigation 20120101

Title: Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20111201

Title: Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol compared with one containing levonorgestrel and ethinylestradiol on haemostasis, lipids and carbohydrate metabolism.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20111201

Title: Phase of oral contraceptive cycle and endurance capacity of rowers.

Journal: Perceptual and motor skills 20111201

Title: Risk of blood clots higher for oral contraceptives with certain progestins.

Journal: JAMA 20111123

Title: The role of the acquisition methods in the analysis of natural and synthetic steroids and cholic acids by gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20111111

Title: Influence of third-generation oral contraceptives on the complexity analysis and symbolic dynamics of heart rate variability.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20110801

Title: A retrospective case-control study comparing hysteroscopic resection versus hormonal modulation in treating menstrual disorders due to isthmocele.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110601

Title: [Health risks of oral contraceptives].

Journal: Therapeutische Umschau. Revue therapeutique 20110601

Title: [Associated factors with discontinuation use of combined oral contraceptives].

Journal: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 20110601

Title: [Hormonal contraception: a comparison between patients of the private and public health network].

Journal: Ciencia & saude coletiva 20110501

Title: Derivatization and fragmentation pattern analysis of natural and synthetic steroids, as their trimethylsilyl (oxime) ether derivatives by gas chromatography mass spectrometry: analysis of dissolved steroids in wastewater samples.

Journal: Journal of chromatography. A 20110408

Title: Update in women's health for the general internist.

Journal: Journal of general internal medicine 20110201

Title: Drospirenone: high risk of venous thrombosis.

Journal: Prescrire international 20110201

Title: Risk of venous thromboembolism in users of oral contraceptives containing drospirenone or levonorgestrel: nested case-control study based on UK General Practice Research Database.

Journal: BMJ (Clinical research ed.) 20110101

Title: Risk of non-fatal venous thromboembolism in women using oral contraceptives containing drospirenone compared with women using oral contraceptives containing levonorgestrel: case-control study using United States claims data.

Journal: BMJ (Clinical research ed.) 20110101

Title: Endometrial safety of an oral contraceptive containing estradiol valerate and dienogest.

Journal: International journal of women's health 20110101

Title: Contraception in HIV-positive female adolescents.

Journal: AIDS research and therapy 20110101

Title: Deep vein thrombosis in a woman taking oral combined contraceptive pills.

Journal: Journal of pharmacology & pharmacotherapeutics 20110101

Title: State of the Art Review: Emerging Therapies: The Use of Insulin Sensitizers in the Treatment of Adolescents with Polycystic Ovary Syndrome (PCOS).

Journal: International journal of pediatric endocrinology 20110101

Title: Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-9.

Journal: BMJ (Clinical research ed.) 20110101

Title: Effect of oral contraceptives on markers of hyperandrogenism and SHBG in women with polycystic ovary syndrome.

Journal: Contraception 20100901

Title: Changes in apolipoprotein B100-containing lipoprotein metabolism due to an estrogen plus progestin oral contraceptive: a stable isotope kinetic study.

Journal: The Journal of clinical endocrinology and metabolism 20100501

Title: Use of oral contraceptives containing gestodene and risk of venous thromboembolism: outlook 10 years after the third-generation 'pill scare'.

Journal: Contraception 20100501

Title: Hormone-based contraceptive therapy and risk of venous thromboembolism in young women.

Journal: Clinical advances in hematology & oncology : H&O 20100501

Title: Activation of NF-kappaB and COX-2 expression is associated with breakthrough bleeding in patients using oral contraceptives in extended regimens.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100401

Title: Effect of low-dose combined oral contraceptive on aerobic capacity and anaerobic threshold level in active and sedentary young women.

Journal: Contraception 20100401

Title: Development and validation of UPLC-MS/MS method for simultaneous determination of gestodene and ethinyl estradiol in rat plasma.

Journal: Biomedical chromatography : BMC 20100201

Title: Long-term cyclic and continuous oral contraceptive therapy and endometrioma recurrence: a randomized controlled trial.

Journal: Fertility and sterility 20100101

Title: Risk of venous thromboembolism among users of oral contraceptives: a review of two recently published studies.

Journal: The journal of family planning and reproductive health care 20100101

Title: Dysglycemias in pregnancy: from diagnosis to treatment. Brazilian consensus statement.

Journal: Diabetology & metabolic syndrome 20100101

Title: Clinical pharmacology and vascular risk.

Journal: The open neurology journal 20100101

Title: Protrhombotic effects of contraceptives.

Journal: Current pharmaceutical design 20100101

Title: Examining the use of oral contraceptives in the management of acne.

Journal: International journal of women's health 20100101

Title: New low-dose, extended-cycle pills with levonorgestrel and ethinyl estradiol: an evolutionary step in birth control.

Journal: International journal of women's health 20100101

Title: Review of the safety, efficacy and patient acceptability of the combined dienogest/estradiol valerate contraceptive pill.

Journal: International journal of women's health 20100101

Title: The lowest-dose, extended-cycle combined oral contraceptive pill with continuous ethinyl estradiol in the United States: a review of the literature on ethinyl estradiol 20 μg/levonorgestrel 100 μg + ethinyl estradiol 10 μg.

Journal: International journal of women's health 20100101

Title: [Simultaneous determination of gestodene, etonogestrel and ethinylestradiol in plasma by LC-MS/MS following derivatization].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100101

Title: Increased apolipoprotein AI production rate and redistribution of high-density lipoprotein size induced by estrogen plus progestin as oral contraceptive.

Journal: The Journal of clinical endocrinology and metabolism 20091201

Title: Oral hormonal contraceptives affect the concentration and composition of urinary glycosaminoglycans in young women.

Journal: International urogynecology journal and pelvic floor dysfunction 20091101

Title: Recurrence rate of endometrioma after laparoscopic cystectomy: a comparative randomized trial between post-operative hormonal suppression treatment or dietary therapy vs. placebo.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20091101

Title: Effects of two combined oral contraceptives containing ethinyl estradiol 30 microg combined with either gestodene or drospirenone on hemostatic parameters, lipid profiles and blood pressure.

Journal: Archives of gynecology and obstetrics 20090801

Title: Double-layer weekly sustained release transdermal patch containing gestodene and ethinylestradiol.

Journal: International journal of pharmaceutics 20090730

Title: Simultaneous determination of 15 steroidal oral contraceptives in water using solid-phase disk extraction followed by high performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A 20090710

Title: Presence of steroid hormones and antibiotics in surface water of agricultural, suburban and mixed-use areas.

Journal: Environmental monitoring and assessment 20090701

Title: The Transnational study of oral contraceptive cardiovascular safety: history and science.

Journal: Journal of clinical epidemiology 20090601

Title: Validated UPLC method for the fast and sensitive determination of steroid residues in support of cleaning validation in formulation area.

Journal: Journal of pharmaceutical and biomedical analysis 20090405

Title: Is aromatase expression in the endometrium the cause of endometriosis and related infertility?

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20090401

Title: Challenge in the management of endometriosis in the canal of Nuck.

Journal: Fertility and sterility 20090301

Title: Pharmacokinetics, tissue distribution and mass balance of radiolabeled dihydroartemisinin in male rats.

Journal: Malaria journal 20090101

Title: Hormonal contraception and risk of venous thromboembolism: national follow-up study.

Journal: BMJ (Clinical research ed.) 20090101

Title: The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study.

Journal: BMJ (Clinical research ed.) 20090101

Title: Refractory thrombotic thrombocytopenic purpura associated with oral contraceptives and factor V Leiden: a case report.

Journal: Cases journal 20090101

Title: Massive intestinal ischemia, a rare complication of oral contraceptive-induced mesenteric venous thrombosis: a case report and review of literature.

Journal: Cases journal 20090101

Title: Safety, efficacy and patient satisfaction with continuous daily administration of levonorgestrel/ethinylestradiol oral contraceptives.

Journal: Patient preference and adherence 20090101

Title: Oral contraceptives after myomectomy: a short term trial.

Journal: International journal of endocrinology 20090101

Title: [Influence of the very low dose oral contraception on the blood presure, body weight and general condition of the patients].

Journal: Akusherstvo i ginekologiia 20090101

Title: Safety, efficacy, actions, and patient acceptability of drospirenone/ethinyl estradiol contraceptive pills in the treatment of premenstrual dysphoric disorder.

Journal: International journal of women's health 20090101

Title: Ebastine in the light of CONGA recommendations for the development of third-generation antihistamines.

Journal: Journal of asthma and allergy 20090101

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Experimental benefits of sex hormones on vascular function and the outcome of hormone therapy in cardiovascular disease.

Journal: Current cardiology reviews 20081101

Title: Oral contraceptives, hormone therapy and cardiovascular risk.

Journal: Climacteric : the journal of the International Menopause Society 20081001

Title: Evaluation of extended and continuous use oral contraceptives.

Journal: Therapeutics and clinical risk management 20081001

Title: Synchronic release of two hormonal contraceptives for about one month from the PLGA microspheres: in vitro and in vivo studies.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20080807

Title: Effect of two low-dose gestodene containing monophasic oral contraceptives on hemostasis in Bulgarian women.

Journal: Expert opinion on pharmacotherapy 20080801

Title: In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions.

Journal: Basic & clinical pharmacology & toxicology 20080801

Title: Atorvastatin and cardiovascular risk in the elderly--patient considerations.

Journal: Clinical interventions in aging 20080601

Title: Prospective study on the cytological aspects of the nasal respiratory epithelium in premenopausal women taking 30 mcg ethinylestradiol and 3 mg drospirenone oral contraceptive.

Journal: Contraception 20080501

Title: Review of the combined contraceptive vaginal ring, NuvaRing.

Journal: Therapeutics and clinical risk management 20080401

Title: The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20080301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20080101

Title: [Role of milligest in clinical practice].

Journal: Akusherstvo i ginekologiia 20080101

Title: Pharmacological profile of progestins.

Journal: Maturitas 20080101

Title: Classification and pharmacology of progestins.

Journal: Maturitas 20080101

Title: [Modern extremely low dose oral contraception with lindynette 20].

Journal: Akusherstvo i ginekologiia 20080101

Title: [The place of miligest in the clinical practice ].

Journal: Akusherstvo i ginekologiia 20080101

Title: [Modern extremely low dose oral contraception with lindynette 20].

Journal: Akusherstvo i ginekologiia 20080101

Title: Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring.

Journal: Therapeutic drug monitoring 20071201

Title: The influence of smoking on uterine bleeding during continuous and interrupted oral hormone therapy.

Journal: Climacteric : the journal of the International Menopause Society 20071201

Title: Effect of oral contraceptives on thrombin generation measured via calibrated automated thrombography.

Journal: Thrombosis and haemostasis 20071201

Title: Free synthetic and natural estrogen hormones in influent and effluent of three municipal wastewater treatment plants.

Journal: Water environment research : a research publication of the Water Environment Federation 20070901

Title: Ultrasound-induced destruction of low levels of estrogen hormones in aqueous solutions.

Journal: Environmental science & technology 20070815

Title: Combined hormonal contraception and venous thromboembolism.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20070601

Title: Hormonal contraceptives as a risk factor for cerebral venous and sinus thrombosis.

Journal: Acta neurologica Scandinavica 20070501

Title: High performance liquid chromatography/ion-trap mass spectrometry for separation and simultaneous determination of ethynylestradiol, gestodene, levonorgestrel, cyproterone acetate and desogestrel.

Journal: Analytica chimica acta 20070411

Title: The influence of smoking on uterine bleeding during sequential oral hormone therapy.

Journal: Climacteric : the journal of the International Menopause Society 20070401

Title: A full conformational characterization of 13-ethylprogestogens through theoretical calculations and nuclear magnetic resonance spectroscopy.

Journal: The Journal of steroid biochemistry and molecular biology 20070201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20070101

Title: Benefits and risks of hormonal contraception for women.

Journal: GMS health technology assessment 20070101

Title: Does the pill make a difference? Previous maternal use of contraceptive pills and allergic diseases among offspring.

Journal: Allergy 20061201

Title: Coronary artery disease in women: a review on prevention, pathophysiology, diagnosis, and treatment.

Journal: Vascular health and risk management 20061201

Title: Cytological aspects of the nasal respiratory epithelium in reproductive-age women taking oral contraceptives.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20061201

Title: The effect of progesterone, testosterone and synthetic progestogens on growth factor- and estradiol-treated human cancerous and benign breast cells.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20061101

Title: [Clinical experience of combined oral contraceptives of low doses in Mexico].

Journal: Ginecologia y obstetricia de Mexico 20061101

Title: Response of the female vocal quality and resonance in professional voice users taking oral contraceptive pills: a multiparameter approach.

Journal: The Laryngoscope 20061001

Title: Birth control pills and nonprofessional voice: acoustic analyses.

Journal: Journal of speech, language, and hearing research : JSLHR 20061001

Title: Effect of the menstrual cycle and oral contraceptives on aromatase and cyclooxygenase-2 expression in adenomyosis.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20061001

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20061001

Title: A double blind randomized control trial, comparing effect of drospirenone and gestodene to sexual desire and libido.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20061001

Title: Comparison profiles of cycle control, side effects and sexual satisfaction of three hormonal contraceptives.

Journal: Contraception 20060901

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060901

Title: Venous thrombosis and oral contraceptives: current status.

Journal: Women's health (London, England) 20060901

Title: Structure elucidation of new compounds from acidic treatment of the progestins gestodene and drospirenone.

Journal: Steroids 20060801

Title: Risk of cardiovascular diseases with oral contraceptives.

Journal: Mymensingh medical journal : MMJ 20060701

Title: Risk of nonfatal venous thromboembolism with oral contraceptives containing norgestimate or desogestrel compared with oral contraceptives containing levonorgestrel.

Journal: Contraception 20060601

Title: Longitudinal evaluation of perimenopausal bone loss: effects of different low dose oral contraceptive preparations on bone mineral density.

Journal: Maturitas 20060520

Title: Effects of two different oral contraceptives on total body water: a randomized study.

Journal: Contraception 20060401

Title: Oral, more than transdermal, oestrogen therapy lowers asymmetric dimethylarginine in healthy postmenopausal women: a randomized, placebo-controlled study.

Journal: Journal of internal medicine 20060201

Title: Cyclooxygenase-2 expression in the endometrium and its relationship to bleeding in users of continuous oral contraceptives.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20060201

Title: Treating acne with oral contraceptives: use of lower doses.

Journal: Contraception 20060101

Title: Prospective, open-label, noncomparative study to assess cycle control, safety and acceptability of a new oral contraceptive containing gestodene 60 microg and ethinylestradiol 15 microg (Minesse).

Journal: Contraception 20060101

Title: Effect of a combined oral contraceptive containing 20 microg ethinyl estradiol and 75 microg gestodene on hemostatic parameters.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20060101

Title: Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.

Journal: Clinical pharmacology and therapeutics 20051001

Title: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

Journal: Current drug metabolism 20051001

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20050901

Title: Different oral contraceptives and voice quality--an observational study.

Journal: Contraception 20050501

Title: Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4.

Journal: Therapeutics and clinical risk management 20050301

Title: Association between sex hormone-binding globulin levels and activated protein C resistance in explaining the risk of thrombosis in users of oral contraceptives containing different progestogens.

Journal: Human reproduction (Oxford, England) 20050201

Title: Evaluation of lipid profile in adolescents during long-term use of combined oral hormonal contraceptives.

Journal: Contraception 20050201

Title: Effects of an oral contraceptive containing drospirenone on bone turnover and bone mineral density.

Journal: Obstetrics and gynecology 20050101

Title: Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.

Journal: Clinical pharmacokinetics 20050101

Title: Estrogen, progesterone, and cardiovascular health: when shall we complete the puzzle?

Journal: Menopause (New York, N.Y.) 20050101

Title: Effects of transdermal and oral postmenopausal hormone therapy on vascular function: a randomized, placebo-controlled study in healthy postmenopausal women.

Journal: Menopause (New York, N.Y.) 20050101

Title: Clinical and metabolic aspects of the continuous use of a contraceptive association of ethinyl estradiol (30 microg) and gestodene (75 microg).

Journal: Contraception 20041101

Title: Risk of venous thromboembolic disease associated with hormonal contraceptives and hormone replacement therapy: a clinical review.

Journal: Archives of internal medicine 20041011

Title: Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4.

Journal: Current drug metabolism 20041001

Title: High serum prostate-specific antigen concentrations in hirsute women do not decrease with treatment by the combination of spironolactone and the contraceptive pill.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20041001

Title: Combined ethinylestradiol/gestodene contraceptive patch: two-center, open-label study of ovulation inhibition, acceptability and safety over two cycles in female volunteers.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20040901

Title: Clinical profile of contraceptive progestins.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20040901

Title: Flutamide-metformin plus an oral contraceptive (OC) for young women with polycystic ovary syndrome: switch from third- to fourth-generation OC reduces body adiposity.

Journal: Human reproduction (Oxford, England) 20040801

Title: A prospective open-label study to evaluate the effects of the oral contraceptive Harmonet (gestodene75/EE20) on body fat.

Journal: Contraception 20040701

Title: [Third-generation oral contraceptives--how big is the risk of venous thrombosis?].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20040603

Title: Serum resistin levels in women taking combined oral contraceptives containing desogestrel or gestodene.

Journal: Contraception 20040601

Title: Comparative evaluation of androgen and progesterone receptor transcription selectivity indices of 19-nortestosterone-derived progestins.

Journal: The Journal of steroid biochemistry and molecular biology 20040601

Title: The role of combined oral contraceptives in the management of acne and seborrhea.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20040601

Title: Plasma concentrations of endogenous hormones during one regular treatment cycle with a low-dose oral contraceptive and during two cycles with deliberate omission of two tablets.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040601

Title: Pharmacological profile of progestins.

Journal: Maturitas 20040415

Title: Effect of a low-dose ethinylestradiol and gestodene in combination on the frequency of micronuclei in human peripheral blood lymphocytes of healthy women in vivo.

Journal: Contraception 20040401

Title: Long term use of oral contraceptives without thrombosis in patients with FV Leiden polymorphism: a study of 37 patients (2 homozygous and 35 heterozygous).

Journal: Journal of thrombosis and thrombolysis 20040401

Title: Sexual behavior of women taking low-dose oral contraceptive containing 15 microg ethinylestradiol/60 microg gestodene.

Journal: Contraception 20040301

Title: Oral contraception does not alter single dose saquinavir pharmacokinetics in women.

Journal: British journal of clinical pharmacology 20040301

Title: [The effectiveness and acceptability of oral contraceptives (Logest), containing 20 micrograms ethinylestradiol and 75 micrograms gestodene].

Journal: Ginekologia polska 20040301

Title: Third generation oral contraceptive use and cardiovascular risk factors.

Journal: Atherosclerosis 20040201

Title: Associated response in bone and lipids during hormone replacement therapy.

Journal: Maturitas 20040120

Title: Adrenal adenoma and normal androgen levels in a young woman with polycystic ovaries: a case of idiopathic hirsutism?

Journal: Journal of endocrinological investigation 20040101

Title: [The effect of two low dose oral contraceptive with gestodene on the systems of natural inhibitors of coagulation].

Journal: Akusherstvo i ginekologiia 20040101

Title: Classification and pharmacology of progestins.

Journal: Maturitas 20031210

Title: Carpal tunnel syndrome and oral contraceptive drugs: risk or protective factor?

Journal: Journal of the peripheral nervous system : JPNS 20031201

Title: Effects of low-dose oral and transdermal estrogen replacement therapy on hemostatic factors in healthy postmenopausal women: a randomized placebo-controlled study.

Journal: American journal of obstetrics and gynecology 20031101

Title: The truth about oral contraceptives and venous thromboembolism.

Journal: The Journal of reproductive medicine 20031101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20031001

Title: Effects of oral and transdermal low-dose estrogen therapy on echocardiographic parameters of cardiac function.

Journal: Fertility and sterility 20030901

Title: A screening study on the liability of eight different female sex steroids to inhibit CYP2C9, 2C19 and 3A4 activities in human liver microsomes.

Journal: Pharmacology & toxicology 20030801

Title: Lack of difference among progestins on the anti-atherogenic effect of ethinyl estradiol: a rabbit study.

Journal: Human reproduction (Oxford, England) 20030701

Title: Effect of oral and transdermal estrogen replacement therapy on hemostatic variables associated with venous thrombosis: a randomized, placebo-controlled study in postmenopausal women.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20030601

Title: Effects of a low-dose and ultra-low-dose combined oral contraceptive use on bone turnover and bone mineral density in young fertile women: a prospective controlled randomized study.

Journal: Contraception 20030501

Title: A 13-month multicenter clinical experience of a low-dose monophasic oral contraceptive containing 20 microg ethinylestradiol and 75 microg gestodene in Latin American women.

Journal: Contraception 20030501

Title: Do oral contraceptives improve vocal quality? Limited trial on low-dose formulations.

Journal: Obstetrics and gynecology 20030401

Title: Changes in prescription patterns of oral contraceptives in a northern Italian province: relation with venous thromboembolism.

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20030401

Title: The effects of seven monophasic oral contraceptive regimens on hemostatic variables: conclusions from a large randomized multicenter study.

Journal: Contraception 20030301

Title: Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin.

Journal: Toxicology letters 20030203

Title: Influence of the third generation pill controversy on prescriptions for oral contraceptives among first time users: population based study.

Journal: BMJ (Clinical research ed.) 20030201

Title: A randomized placebo-controlled study of the effect of transdermal vs. oral estradiol with or without gestodene on homocysteine levels.

Journal: Fertility and sterility 20030201

Title: The effect of progesterone and synthetic progestins on serum- and estradiol-stimulated proliferation of human breast cancer cells.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030201

Title: Changes of hemostatic variables during oral contraceptive use.

Journal: Seminars in vascular medicine 20030201

Title: Venous and arterial thrombosis during oral contraceptive use: risks and risk factors.

Journal: Seminars in vascular medicine 20030201

Title: Low-dose combination of flutamide, metformin and an oral contraceptive for non-obese, young women with polycystic ovary syndrome.

Journal: Human reproduction (Oxford, England) 20030101

Title: Auditory brainstem response in premenopausal women taking oral contraceptives.

Journal: Human reproduction (Oxford, England) 20030101

Title: Thromboembolic disease and present oral contraception.

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20030101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20030101

Title: Oral, more than transdermal, estrogen therapy improves lipids and lipoprotein(a) in postmenopausal women: a randomized, placebo-controlled study.

Journal: Menopause (New York, N.Y.) 20030101

Title: [Effect and control of oral contraceptive Minesse (15 mkg EE/60 mkg Gestoden) on menstrual cycle and body weight].

Journal: Akusherstvo i ginekologiia 20030101

Title: The effect of 17beta-estradiol on endothelial and inflammatory markers in postmenopausal women: a randomized, controlled trial.

Journal: Atherosclerosis 20021201

Title: A comparison of cycle control, efficacy, and side effects among healthy Thai women between two low-dose oral contraceptives containing 20 microg ethinylestradio1/75 microg gestodene (Meliane) and 30 microg ethinylestradio1/75 microg gestodene (Gynera).

Journal: Contraception 20021201

Title: Randomized controlled study of the influence of two low estrogen dose oral contraceptives containing gestodene or desogestrel on carbohydrate metabolism.

Journal: Contraception 20021201

Title: Effects of transdermal and oral oestrogen replacement therapy on C-reactive protein levels in postmenopausal women: a randomised, placebo-controlled trial.

Journal: Thrombosis and haemostasis 20021001

Title: Effects of two oral contraceptives on plasma levels of nitric oxide, homocysteine, and lipid metabolism.

Journal: Metabolism: clinical and experimental 20020901

Title: Effects of low-dose OCs on weight in women with Central European nutritional habits and lifestyle.

Journal: Contraception 20020901

Title: Fertilisation and implantation failure in an oral contraceptive user.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20020805

Title: Genetic polymorphisms modify the response of factor VII to oral contraceptive use: an example of gene-environment interaction.

Journal: Vascular pharmacology 20020801

Title: Pro-inflammatory effects of oestrogens during use of oral contraceptives and hormone replacement treatment.

Journal: Vascular pharmacology 20020801

Title: Determination of steroid hormones in oral contraceptives by high-performance liquid chromatography.

Journal: Drug development and industrial pharmacy 20020701

Title: Can changes in sex hormone binding globulin predict the risk of venous thromboembolism with combined oral contraceptive pills?

Journal: Acta obstetricia et gynecologica Scandinavica 20020601

Title: Clinical risk factors for venous thromboembolus in users of the combined oral contraceptive pill.

Journal: British journal of clinical pharmacology 20020601

Title: [Low-dose combination oral contraceptives use in women with uterine leiomyomas].

Journal: Minerva ginecologica 20020601

Title: Risk of Arterial Thrombosis in Relation to Oral Contraceptives (RATIO) study: oral contraceptives and the risk of ischemic stroke.

Journal: Stroke 20020501

Title: Number of years since menopause: spontaneous bone loss is dependent but response to hormone replacement therapy is independent.

Journal: Bone 20020401

Title: Oral contraceptives and venous thromboembolism: which are the safest preparations available?

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20020401

Title: Oral contraceptives and venous thromboembolism: a five-year national case-control study.

Journal: Contraception 20020301

Title: Contraceptives and cerebral thrombosis: a five-year national case-control study.

Journal: Contraception 20020301

Title: Long-term effects of combined oral contraceptives on markers of endothelial function and lipids in healthy premenopausal women.

Journal: Contraception 20020301

Title: Female hormones and thrombosis.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20020201

Title: Effect of postmenopausal hormone replacement on atherosclerosis in femoral arteries.

Journal: Maturitas 20020130

Title: Triphasic oral contraceptives: review and comparison of various regimens.

Journal: Fertility and sterility 20020101

Title: Prothrombotic effects and clinical implications of third-generation oral contraceptives use.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20020101

Title: Venous thromboembolism and oral contraceptives: current status and clinical implications.

Journal: Treatments in endocrinology 20020101

Title: Oral contraceptives and the risk of myocardial infarction.

Journal: The New England journal of medicine 20011220

Title: Sex steroids used in hormonal treatment increase vascular procoagulant activity by inducing thrombin receptor (PAR-1) expression: role of the glucocorticoid receptor.

Journal: Circulation 20011204

Title: Influence of 17beta-oestradiol on blood pressure of postmenopausal women at high vascular risk.

Journal: Journal of hypertension 20011201

Title: Third-generation progestogen type influences hemostatic changes caused by oral contraceptives in Brazilian women.

Journal: Contraception 20011201

Title: Body weight change during use of a monophasic oral contraceptive containing 20 microg ethinylestradiol and 75 microg gestodene with a comparison of the women who completed versus those who prematurely discontinued intake.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20011201

Title: Transactivation of progestin- and estrogen-responsive promoters by 19-nor progestins in African Green Monkey Kidney CV1 cells.

Journal: Endocrine 20011201

Title: A prospective study evidencing rhinomanometric and olfactometric outcomes in women taking oral contraceptives.

Journal: Human reproduction (Oxford, England) 20011101

Title: A double-blind comparative study of the effects of a 23-day oral contraceptive regimen with 20 microg ethinyl estradiol and 75 microg gestodene and a 21-day regimen with 30 microg ethinyl estradiol and 75 microg gestodene on hemostatic variables, lipids, and carbohydrate metabolism.

Journal: Contraception 20011001

Title: Dose finding in a low-dose 21-day combined oral contraceptive containing gestodene.

Journal: Contraception 20011001

Title: A-ring reduced metabolites of 19-nor synthetic progestins as subtype selective agonists for ER alpha.

Journal: Endocrinology 20010901

Title: [New gestagens--advantages and disadvantages].

Journal: Therapeutische Umschau. Revue therapeutique 20010901

Title: Evaluation of plasma levels of renin-aldosterone and blood pressure in women over 35 years treated with new oral contraceptives.

Journal: Contraception 20010901

Title: Open, multicenter comparison of efficacy, cycle control, and tolerability of a 23-day oral contraceptive regimen with 20 microg ethinyl estradiol and 75 microg gestodene and a 21-day regimen with 20 microg ethinyl estradiol and 150 microg desogestrel.

Journal: Contraception 20010901

Title: Blood pressure stability in a normotensive population during intake of a monophasic oral contraceptive containing 20 microg ethinylestradiol and 75 g gestodene.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20010901

Title: Clinical trial of a monophasic estroprogestin oral formulation containing 20 micrograms ethinyl estradiol and 75 micrograms gestodene.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20010801

Title: Double-blind, multicenter comparison of efficacy, cycle control, and tolerability of a 23-day versus a 21-day low-dose oral contraceptive regimen containing 20 microg ethinyl estradiol and 75 microg gestodene.

Journal: Contraception 20010801

Title: Risk of venous thromboembolism from oral contraceptives containing gestodene and desogestrel versus levonorgestrel: a meta-analysis and formal sensitivity analysis.

Journal: Contraception 20010801

Title: Third generation oral contraceptives and risk of venous thrombosis: meta-analysis.

Journal: BMJ (Clinical research ed.) 20010721

Title: Different methods for the determination of gestodene, and cyproterone acetate in raw material and dosage forms.

Journal: Journal of pharmaceutical and biomedical analysis 20010601

Title: A prospective randomized controlled study comparing two doses of gestodene in cyclic combined HRT preparations on endometrial physiology.

Journal: Human reproduction (Oxford, England) 20010601

Title: A 12-month clinical investigation with a 24-day regimen containing 15 microg ethinylestradiol plus 60 microg gestodene with respect to hemostasis and cycle control.

Journal: Contraception 20010601

Title: In vitro metabolism of gestodene in target organs: formation of A-ring reduced derivatives with oestrogenic activity.

Journal: European journal of pharmacology 20010413

Title: Oral contraceptives, thrombosis and haemostasis.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20010401

Title: Non-protein bound dienogest in serum and salivary dienogest in women taking the oral contraceptives Certostat and Valette.

Journal: Die Pharmazie 20010401

Title: Practices of prescribing oral contraceptives in Poland.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20010301

Title: Effect of oral postmenopausal hormone replacement on progression of atherosclerosis : a randomized, controlled trial.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20010201

Title: What is the risk of venous thromboembolism (VTE) among women taking third-generation oral contraceptives (OCs) in comparison with those taking contraceptives containing levonorgestrel?

Journal: The Journal of family practice 20010201

Title: Contraception with the latest estroprogestagens in women suffering from systemic lupus erythematosus.

Journal: Minerva ginecologica 20010201

Title: Charcoal treatment and risk of escape ovulation in oral contraceptive users.

Journal: Human reproduction (Oxford, England) 20010101

Title: The possible role of enterohepatic cycling on bioavailability of norethisterone and gestodene in women using combined oral contraceptives.

Journal: Contraception 20010101

Title: Lack of effect of alcohol on ethinylestradiol in premenopausal women.

Journal: Contraception 20010101

Title: Effects of two oral contraceptives, containing 30 or 20 microg of ethinyl estradiol in combination with gestodene, on blood coagulation and fibrinolysis in Brazilian women.

Journal: International journal of fertility and women's medicine 20010101

Title: Evidence that treatment with monophasic oral contraceptive formulations containing ethinylestradiol plus gestodene reduces bone resorption in young women.

Journal: Contraception 20000401

Title: Venous thromboembolic disease and combined oral contraceptives: A re-analysis of the MediPlus database.

Journal: Human reproduction (Oxford, England) 19990601

Title: Department of health changes advice on third generation pills.

Journal: BMJ (Clinical research ed.) 19990417

Title: Increased risk of cerebral venous sinus thrombosis with third-generation oral contraceptives. Cerebral Venous Sinus Thrombosis Study Group.

Journal: Lancet (London, England) 19980509

Title: Identification of enzymes involved in the metabolism of atrazine, terbuthylazine, ametryne, and terbutryne in human liver microsomes.

Journal: Chemical research in toxicology 19970901

Title: Increased levels of activated factor VII and decreased plasma protein S activity and circulating thrombomodulin during use of oral contraceptives.

Journal: Thrombosis and haemostasis 19961101

Title: Desogestrel, gestodene contraceptives may carry greater thromboembolic risk.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 19960201

Title: Third generation oral contraceptives and risk of venous thromboembolic disorders: an international case-control study. Transnational Research Group on Oral Contraceptives and the Health of Young Women.

Journal: BMJ (Clinical research ed.) 19960113

Title: Risk of idiopathic cardiovascular death and nonfatal venous thromboembolism in women using oral contraceptives with differing progestagen components.

Journal: Lancet (London, England) 19951216

Title: The effect on blood pressure of a monophasic oral contraceptive containing ethinylestradiol and gestodene.

Journal: Contraception 19950601

Title: The sulfoxidation of the hexachlorobutadiene metabolite N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine is catalyzed by human cytochrome P450 3A enzymes.

Journal: Chemical research in toxicology 19950101

Title: Comparison of two triphasic oral contraceptives containing either gestodene or norethindrone: a randomized, controlled trial.

Journal: Contraception 19931001

Title: Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4'-methylene-bis(2-chloroaniline).

Journal: Carcinogenesis 19920201

Title: The new pills: awaiting the next generation of oral contraceptives.

Journal: Family planning perspectives 19920101

Title: Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae.

Journal: Biochemistry 19901225

Title: Long-term experience with a low-dose oral contraceptive.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 19901201

Title: A double-blind comparison of the efficacy and acceptability of Femodene and Microgynon-30.

Journal: European journal of obstetrics, gynecology, and reproductive biology 19900301

Title: A multicenter clinical evaluation of a new monophasic combination: Minulet (gestodene and ethinyl estradiol).

Journal: International journal of fertility 19890901

Title: Comparison of two monophasic oral contraceptives: gestodene/ethinyl estradiol versus desogestrel/ethinyl estradiol.

Journal: International journal of fertility 19890901

Title: Spona, J. and J. Huber, Pharmacological and endocrine profiles of gestodene. Int J Fertil, 1987. 32 Suppl: p. 6-14.

Title: Pollow, K., et al., Lack of binding of gestodene to estrogen receptor in human breast cancer tissue. Eur J Cancer, 1990. 26(5): p. 608-10.

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Tags:60282-87-3 Molecular Formula|60282-87-3 MDL|60282-87-3 SMILES|60282-87-3 18,19-Dinorpregna-4,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17a)-
Catalog No.: AA00IALM
60282-87-3,MFCD00867858
60282-87-3 | 18,19-Dinorpregna-4,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17a)-
Pack Size: 50mg
Purity: ≥98%
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$63.00 $44.00
Pack Size: 100mg
Purity: ≥98%
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$120.00 $84.00
Pack Size: 250mg
Purity: ≥98%
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$230.00 $161.00
Pack Size: 1g
Purity: >98.0%(HPLC)(qNMR)
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$523.00 $366.00
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Technical Information
Catalog Number: AA00IALM
Chemical Name: 18,19-Dinorpregna-4,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17a)-
CAS Number: 60282-87-3
Molecular Formula: C21H26O2
Molecular Weight: 310.4299
MDL Number: MFCD00867858
SMILES: C#C[C@]1(O)C=C[C@@H]2[C@]1(CC)CC[C@H]1[C@H]2CCC2=CC(=O)CC[C@H]12
Properties
BP: 462.7°C at 760 mmHg  
Form: Solid  
MP: 190-192˚C  
Storage: Keep in dry area;-20 ℃;  
Complexity: 648  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 6  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 23  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.9  
87:   
Literature fold

Title: Several synthetic progestins disrupt the glial cell specific-brain aromatase expression in developing zebra fish.

Journal: Toxicology and applied pharmacology20160815

Title: Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20150601

Title: Ozonation of a mixture of estrogens and progestins in aqueous solution: interpretation of experimental results by computational methods.

Journal: Chemosphere20121101

Title: Progestin-dependent effect of oral contraceptives on plasma aldosterone/renin ratio.

Journal: Clinical biochemistry20121101

Title: ACP Journal Club. Hormonal contraceptives with ethinyl estradiol were associated with increased thrombotic stroke and MI.

Journal: Annals of internal medicine20121016

Title: Acute and long-term estradiol kinetics in smoking postmenopausal women.

Journal: Climacteric : the journal of the International Menopause Society20121001

Title: 17-Hydroxysteroid dehydrogenase type 5 gene polymorphism (-71A/G HSD17B5 SNP) and treatment with oral contraceptive pills in PCOS women without metabolic comorbidities.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology20120801

Title: Oral contraception in Denmark 1998-2010.

Journal: Acta obstetricia et gynecologica Scandinavica20120701

Title: Hormonal contraception and venous thromboembolism.

Journal: Acta obstetricia et gynecologica Scandinavica20120701

Title: Multi-species comparison of the mechanism of biotransformation of MeO-BDEs to OH-BDEs in fish.

Journal: Aquatic toxicology (Amsterdam, Netherlands)20120615

Title: Thrombotic stroke and myocardial infarction with hormonal contraception.

Journal: The New England journal of medicine20120614

Title: Continuous low-dose oral contraceptive in the treatment of colorectal endometriosis evaluated by rectal endoscopic ultrasonography.

Journal: Acta obstetricia et gynecologica Scandinavica20120601

Title: Continuous compared with cyclic oral contraceptives for the treatment of primary dysmenorrhea: a randomized controlled trial.

Journal: Obstetrics and gynecology20120601

Title: Simultaneous online SPE-LC-MS/MS quantification of six widely used synthetic progestins in human plasma.

Journal: Analytical and bioanalytical chemistry20120501

Title: Migraine in women: the role of hormones and their impact on vascular diseases.

Journal: The journal of headache and pain20120401

Title: Contraceptive efficacy and tolerability of ethinylestradiol 20 μg/drospirenone 3 mg in a flexible extended regimen: an open-label, multicentre, randomised, controlled study.

Journal: The journal of family planning and reproductive health care20120401

Title: Venous and pulmonary thromboembolism and combined hormonal contraceptives. Systematic review and meta-analysis.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception20120201

Title: Combined oral contraceptives, venous thromboembolism, and the problem of interpreting large but incomplete datasets.

Journal: The journal of family planning and reproductive health care20120101

Title: Factor Xa generation by computational modeling: an additional discriminator to thrombin generation evaluation.

Journal: PloS one20120101

Title: Oral contraceptives modify DNA methylation and monocyte-derived macrophage function.

Journal: Biology of sex differences20120101

Title: Venous thrombosis in users of non-oral hormonal contraception: follow-up study, Denmark 2001-10.

Journal: BMJ (Clinical research ed.)20120101

Title: Postoperative depot medroxyprogesterone acetate versus continuous oral contraceptive pills in the treatment of endometriosis-associated pain: a randomized comparative trial.

Journal: Gynecologic and obstetric investigation20120101

Title: Aromatase gene polymorphism does not influence clinical phenotype and response to oral contraceptive pills in polycystic ovary syndrome women.

Journal: Gynecologic and obstetric investigation20120101

Title: Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception20111201

Title: Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol compared with one containing levonorgestrel and ethinylestradiol on haemostasis, lipids and carbohydrate metabolism.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception20111201

Title: Phase of oral contraceptive cycle and endurance capacity of rowers.

Journal: Perceptual and motor skills20111201

Title: Risk of blood clots higher for oral contraceptives with certain progestins.

Journal: JAMA20111123

Title: The role of the acquisition methods in the analysis of natural and synthetic steroids and cholic acids by gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A20111111

Title: Influence of third-generation oral contraceptives on the complexity analysis and symbolic dynamics of heart rate variability.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception20110801

Title: A retrospective case-control study comparing hysteroscopic resection versus hormonal modulation in treating menstrual disorders due to isthmocele.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology20110601

Title: [Health risks of oral contraceptives].

Journal: Therapeutische Umschau. Revue therapeutique20110601

Title: [Associated factors with discontinuation use of combined oral contraceptives].

Journal: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia20110601

Title: [Hormonal contraception: a comparison between patients of the private and public health network].

Journal: Ciencia & saude coletiva20110501

Title: Derivatization and fragmentation pattern analysis of natural and synthetic steroids, as their trimethylsilyl (oxime) ether derivatives by gas chromatography mass spectrometry: analysis of dissolved steroids in wastewater samples.

Journal: Journal of chromatography. A20110408

Title: Update in women's health for the general internist.

Journal: Journal of general internal medicine20110201

Title: Drospirenone: high risk of venous thrombosis.

Journal: Prescrire international20110201

Title: Risk of venous thromboembolism in users of oral contraceptives containing drospirenone or levonorgestrel: nested case-control study based on UK General Practice Research Database.

Journal: BMJ (Clinical research ed.)20110101

Title: Risk of non-fatal venous thromboembolism in women using oral contraceptives containing drospirenone compared with women using oral contraceptives containing levonorgestrel: case-control study using United States claims data.

Journal: BMJ (Clinical research ed.)20110101

Title: Endometrial safety of an oral contraceptive containing estradiol valerate and dienogest.

Journal: International journal of women's health20110101

Title: Contraception in HIV-positive female adolescents.

Journal: AIDS research and therapy20110101

Title: Deep vein thrombosis in a woman taking oral combined contraceptive pills.

Journal: Journal of pharmacology & pharmacotherapeutics20110101

Title: State of the Art Review: Emerging Therapies: The Use of Insulin Sensitizers in the Treatment of Adolescents with Polycystic Ovary Syndrome (PCOS).

Journal: International journal of pediatric endocrinology20110101

Title: Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-9.

Journal: BMJ (Clinical research ed.)20110101

Title: Effect of oral contraceptives on markers of hyperandrogenism and SHBG in women with polycystic ovary syndrome.

Journal: Contraception20100901

Title: Changes in apolipoprotein B100-containing lipoprotein metabolism due to an estrogen plus progestin oral contraceptive: a stable isotope kinetic study.

Journal: The Journal of clinical endocrinology and metabolism20100501

Title: Use of oral contraceptives containing gestodene and risk of venous thromboembolism: outlook 10 years after the third-generation 'pill scare'.

Journal: Contraception20100501

Title: Hormone-based contraceptive therapy and risk of venous thromboembolism in young women.

Journal: Clinical advances in hematology & oncology : H&O20100501

Title: Activation of NF-kappaB and COX-2 expression is associated with breakthrough bleeding in patients using oral contraceptives in extended regimens.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology20100401

Title: Effect of low-dose combined oral contraceptive on aerobic capacity and anaerobic threshold level in active and sedentary young women.

Journal: Contraception20100401

Title: Development and validation of UPLC-MS/MS method for simultaneous determination of gestodene and ethinyl estradiol in rat plasma.

Journal: Biomedical chromatography : BMC20100201

Title: Long-term cyclic and continuous oral contraceptive therapy and endometrioma recurrence: a randomized controlled trial.

Journal: Fertility and sterility20100101

Title: Risk of venous thromboembolism among users of oral contraceptives: a review of two recently published studies.

Journal: The journal of family planning and reproductive health care20100101

Title: Dysglycemias in pregnancy: from diagnosis to treatment. Brazilian consensus statement.

Journal: Diabetology & metabolic syndrome20100101

Title: Clinical pharmacology and vascular risk.

Journal: The open neurology journal20100101

Title: Protrhombotic effects of contraceptives.

Journal: Current pharmaceutical design20100101

Title: Examining the use of oral contraceptives in the management of acne.

Journal: International journal of women's health20100101

Title: New low-dose, extended-cycle pills with levonorgestrel and ethinyl estradiol: an evolutionary step in birth control.

Journal: International journal of women's health20100101

Title: Review of the safety, efficacy and patient acceptability of the combined dienogest/estradiol valerate contraceptive pill.

Journal: International journal of women's health20100101

Title: The lowest-dose, extended-cycle combined oral contraceptive pill with continuous ethinyl estradiol in the United States: a review of the literature on ethinyl estradiol 20 μg/levonorgestrel 100 μg + ethinyl estradiol 10 μg.

Journal: International journal of women's health20100101

Title: [Simultaneous determination of gestodene, etonogestrel and ethinylestradiol in plasma by LC-MS/MS following derivatization].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20100101

Title: Increased apolipoprotein AI production rate and redistribution of high-density lipoprotein size induced by estrogen plus progestin as oral contraceptive.

Journal: The Journal of clinical endocrinology and metabolism20091201

Title: Oral hormonal contraceptives affect the concentration and composition of urinary glycosaminoglycans in young women.

Journal: International urogynecology journal and pelvic floor dysfunction20091101

Title: Recurrence rate of endometrioma after laparoscopic cystectomy: a comparative randomized trial between post-operative hormonal suppression treatment or dietary therapy vs. placebo.

Journal: European journal of obstetrics, gynecology, and reproductive biology20091101

Title: Effects of two combined oral contraceptives containing ethinyl estradiol 30 microg combined with either gestodene or drospirenone on hemostatic parameters, lipid profiles and blood pressure.

Journal: Archives of gynecology and obstetrics20090801

Title: Double-layer weekly sustained release transdermal patch containing gestodene and ethinylestradiol.

Journal: International journal of pharmaceutics20090730

Title: Simultaneous determination of 15 steroidal oral contraceptives in water using solid-phase disk extraction followed by high performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A20090710

Title: Presence of steroid hormones and antibiotics in surface water of agricultural, suburban and mixed-use areas.

Journal: Environmental monitoring and assessment20090701

Title: The Transnational study of oral contraceptive cardiovascular safety: history and science.

Journal: Journal of clinical epidemiology20090601

Title: Validated UPLC method for the fast and sensitive determination of steroid residues in support of cleaning validation in formulation area.

Journal: Journal of pharmaceutical and biomedical analysis20090405

Title: Is aromatase expression in the endometrium the cause of endometriosis and related infertility?

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology20090401

Title: Challenge in the management of endometriosis in the canal of Nuck.

Journal: Fertility and sterility20090301

Title: Pharmacokinetics, tissue distribution and mass balance of radiolabeled dihydroartemisinin in male rats.

Journal: Malaria journal20090101

Title: Hormonal contraception and risk of venous thromboembolism: national follow-up study.

Journal: BMJ (Clinical research ed.)20090101

Title: The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study.

Journal: BMJ (Clinical research ed.)20090101

Title: Refractory thrombotic thrombocytopenic purpura associated with oral contraceptives and factor V Leiden: a case report.

Journal: Cases journal20090101

Title: Massive intestinal ischemia, a rare complication of oral contraceptive-induced mesenteric venous thrombosis: a case report and review of literature.

Journal: Cases journal20090101

Title: Safety, efficacy and patient satisfaction with continuous daily administration of levonorgestrel/ethinylestradiol oral contraceptives.

Journal: Patient preference and adherence20090101

Title: Oral contraceptives after myomectomy: a short term trial.

Journal: International journal of endocrinology20090101

Title: [Influence of the very low dose oral contraception on the blood presure, body weight and general condition of the patients].

Journal: Akusherstvo i ginekologiia20090101

Title: Safety, efficacy, actions, and patient acceptability of drospirenone/ethinyl estradiol contraceptive pills in the treatment of premenstrual dysphoric disorder.

Journal: International journal of women's health20090101

Title: Ebastine in the light of CONGA recommendations for the development of third-generation antihistamines.

Journal: Journal of asthma and allergy20090101

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry20081113

Title: Experimental benefits of sex hormones on vascular function and the outcome of hormone therapy in cardiovascular disease.

Journal: Current cardiology reviews20081101

Title: Oral contraceptives, hormone therapy and cardiovascular risk.

Journal: Climacteric : the journal of the International Menopause Society20081001

Title: Evaluation of extended and continuous use oral contraceptives.

Journal: Therapeutics and clinical risk management20081001

Title: Synchronic release of two hormonal contraceptives for about one month from the PLGA microspheres: in vitro and in vivo studies.

Journal: Journal of controlled release : official journal of the Controlled Release Society20080807

Title: Effect of two low-dose gestodene containing monophasic oral contraceptives on hemostasis in Bulgarian women.

Journal: Expert opinion on pharmacotherapy20080801

Title: In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions.

Journal: Basic & clinical pharmacology & toxicology20080801

Title: Atorvastatin and cardiovascular risk in the elderly--patient considerations.

Journal: Clinical interventions in aging20080601

Title: Prospective study on the cytological aspects of the nasal respiratory epithelium in premenopausal women taking 30 mcg ethinylestradiol and 3 mg drospirenone oral contraceptive.

Journal: Contraception20080501

Title: Review of the combined contraceptive vaginal ring, NuvaRing.

Journal: Therapeutics and clinical risk management20080401

Title: The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology20080301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20080101

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Title: Pharmacological profile of progestins.

Journal: Maturitas20080101

Title: Classification and pharmacology of progestins.

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Title: [Modern extremely low dose oral contraception with lindynette 20].

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Title: [The place of miligest in the clinical practice ].

Journal: Akusherstvo i ginekologiia20080101

Title: [Modern extremely low dose oral contraception with lindynette 20].

Journal: Akusherstvo i ginekologiia20080101

Title: Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring.

Journal: Therapeutic drug monitoring20071201

Title: The influence of smoking on uterine bleeding during continuous and interrupted oral hormone therapy.

Journal: Climacteric : the journal of the International Menopause Society20071201

Title: Effect of oral contraceptives on thrombin generation measured via calibrated automated thrombography.

Journal: Thrombosis and haemostasis20071201

Title: Free synthetic and natural estrogen hormones in influent and effluent of three municipal wastewater treatment plants.

Journal: Water environment research : a research publication of the Water Environment Federation20070901

Title: Ultrasound-induced destruction of low levels of estrogen hormones in aqueous solutions.

Journal: Environmental science & technology20070815

Title: Combined hormonal contraception and venous thromboembolism.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception20070601

Title: Hormonal contraceptives as a risk factor for cerebral venous and sinus thrombosis.

Journal: Acta neurologica Scandinavica20070501

Title: High performance liquid chromatography/ion-trap mass spectrometry for separation and simultaneous determination of ethynylestradiol, gestodene, levonorgestrel, cyproterone acetate and desogestrel.

Journal: Analytica chimica acta20070411

Title: The influence of smoking on uterine bleeding during sequential oral hormone therapy.

Journal: Climacteric : the journal of the International Menopause Society20070401

Title: A full conformational characterization of 13-ethylprogestogens through theoretical calculations and nuclear magnetic resonance spectroscopy.

Journal: The Journal of steroid biochemistry and molecular biology20070201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20070101

Title: Benefits and risks of hormonal contraception for women.

Journal: GMS health technology assessment20070101

Title: Does the pill make a difference? Previous maternal use of contraceptive pills and allergic diseases among offspring.

Journal: Allergy20061201

Title: Coronary artery disease in women: a review on prevention, pathophysiology, diagnosis, and treatment.

Journal: Vascular health and risk management20061201

Title: Cytological aspects of the nasal respiratory epithelium in reproductive-age women taking oral contraceptives.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception20061201

Title: The effect of progesterone, testosterone and synthetic progestogens on growth factor- and estradiol-treated human cancerous and benign breast cells.

Journal: European journal of obstetrics, gynecology, and reproductive biology20061101

Title: [Clinical experience of combined oral contraceptives of low doses in Mexico].

Journal: Ginecologia y obstetricia de Mexico20061101

Title: Response of the female vocal quality and resonance in professional voice users taking oral contraceptive pills: a multiparameter approach.

Journal: The Laryngoscope20061001

Title: Birth control pills and nonprofessional voice: acoustic analyses.

Journal: Journal of speech, language, and hearing research : JSLHR20061001

Title: Effect of the menstrual cycle and oral contraceptives on aromatase and cyclooxygenase-2 expression in adenomyosis.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology20061001

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20061001

Title: A double blind randomized control trial, comparing effect of drospirenone and gestodene to sexual desire and libido.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet20061001

Title: Comparison profiles of cycle control, side effects and sexual satisfaction of three hormonal contraceptives.

Journal: Contraception20060901

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20060901

Title: Venous thrombosis and oral contraceptives: current status.

Journal: Women's health (London, England)20060901

Title: Structure elucidation of new compounds from acidic treatment of the progestins gestodene and drospirenone.

Journal: Steroids20060801

Title: Risk of cardiovascular diseases with oral contraceptives.

Journal: Mymensingh medical journal : MMJ20060701

Title: Risk of nonfatal venous thromboembolism with oral contraceptives containing norgestimate or desogestrel compared with oral contraceptives containing levonorgestrel.

Journal: Contraception20060601

Title: Longitudinal evaluation of perimenopausal bone loss: effects of different low dose oral contraceptive preparations on bone mineral density.

Journal: Maturitas20060520

Title: Effects of two different oral contraceptives on total body water: a randomized study.

Journal: Contraception20060401

Title: Oral, more than transdermal, oestrogen therapy lowers asymmetric dimethylarginine in healthy postmenopausal women: a randomized, placebo-controlled study.

Journal: Journal of internal medicine20060201

Title: Cyclooxygenase-2 expression in the endometrium and its relationship to bleeding in users of continuous oral contraceptives.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology20060201

Title: Treating acne with oral contraceptives: use of lower doses.

Journal: Contraception20060101

Title: Prospective, open-label, noncomparative study to assess cycle control, safety and acceptability of a new oral contraceptive containing gestodene 60 microg and ethinylestradiol 15 microg (Minesse).

Journal: Contraception20060101

Title: Effect of a combined oral contraceptive containing 20 microg ethinyl estradiol and 75 microg gestodene on hemostatic parameters.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology20060101

Title: Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.

Journal: Clinical pharmacology and therapeutics20051001

Title: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

Journal: Current drug metabolism20051001

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20050901

Title: Different oral contraceptives and voice quality--an observational study.

Journal: Contraception20050501

Title: Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4.

Journal: Therapeutics and clinical risk management20050301

Title: Association between sex hormone-binding globulin levels and activated protein C resistance in explaining the risk of thrombosis in users of oral contraceptives containing different progestogens.

Journal: Human reproduction (Oxford, England)20050201

Title: Evaluation of lipid profile in adolescents during long-term use of combined oral hormonal contraceptives.

Journal: Contraception20050201

Title: Effects of an oral contraceptive containing drospirenone on bone turnover and bone mineral density.

Journal: Obstetrics and gynecology20050101

Title: Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.

Journal: Clinical pharmacokinetics20050101

Title: Estrogen, progesterone, and cardiovascular health: when shall we complete the puzzle?

Journal: Menopause (New York, N.Y.)20050101

Title: Effects of transdermal and oral postmenopausal hormone therapy on vascular function: a randomized, placebo-controlled study in healthy postmenopausal women.

Journal: Menopause (New York, N.Y.)20050101

Title: Clinical and metabolic aspects of the continuous use of a contraceptive association of ethinyl estradiol (30 microg) and gestodene (75 microg).

Journal: Contraception20041101

Title: Risk of venous thromboembolic disease associated with hormonal contraceptives and hormone replacement therapy: a clinical review.

Journal: Archives of internal medicine20041011

Title: Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4.

Journal: Current drug metabolism20041001

Title: High serum prostate-specific antigen concentrations in hirsute women do not decrease with treatment by the combination of spironolactone and the contraceptive pill.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology20041001

Title: Combined ethinylestradiol/gestodene contraceptive patch: two-center, open-label study of ovulation inhibition, acceptability and safety over two cycles in female volunteers.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception20040901

Title: Clinical profile of contraceptive progestins.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception20040901

Title: Flutamide-metformin plus an oral contraceptive (OC) for young women with polycystic ovary syndrome: switch from third- to fourth-generation OC reduces body adiposity.

Journal: Human reproduction (Oxford, England)20040801

Title: A prospective open-label study to evaluate the effects of the oral contraceptive Harmonet (gestodene75/EE20) on body fat.

Journal: Contraception20040701

Title: [Third-generation oral contraceptives--how big is the risk of venous thrombosis?].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke20040603

Title: Serum resistin levels in women taking combined oral contraceptives containing desogestrel or gestodene.

Journal: Contraception20040601

Title: Comparative evaluation of androgen and progesterone receptor transcription selectivity indices of 19-nortestosterone-derived progestins.

Journal: The Journal of steroid biochemistry and molecular biology20040601

Title: The role of combined oral contraceptives in the management of acne and seborrhea.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception20040601

Title: Plasma concentrations of endogenous hormones during one regular treatment cycle with a low-dose oral contraceptive and during two cycles with deliberate omission of two tablets.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology20040601

Title: Pharmacological profile of progestins.

Journal: Maturitas20040415

Title: Effect of a low-dose ethinylestradiol and gestodene in combination on the frequency of micronuclei in human peripheral blood lymphocytes of healthy women in vivo.

Journal: Contraception20040401

Title: Long term use of oral contraceptives without thrombosis in patients with FV Leiden polymorphism: a study of 37 patients (2 homozygous and 35 heterozygous).

Journal: Journal of thrombosis and thrombolysis20040401

Title: Sexual behavior of women taking low-dose oral contraceptive containing 15 microg ethinylestradiol/60 microg gestodene.

Journal: Contraception20040301

Title: Oral contraception does not alter single dose saquinavir pharmacokinetics in women.

Journal: British journal of clinical pharmacology20040301

Title: [The effectiveness and acceptability of oral contraceptives (Logest), containing 20 micrograms ethinylestradiol and 75 micrograms gestodene].

Journal: Ginekologia polska20040301

Title: Third generation oral contraceptive use and cardiovascular risk factors.

Journal: Atherosclerosis20040201

Title: Associated response in bone and lipids during hormone replacement therapy.

Journal: Maturitas20040120

Title: Adrenal adenoma and normal androgen levels in a young woman with polycystic ovaries: a case of idiopathic hirsutism?

Journal: Journal of endocrinological investigation20040101

Title: [The effect of two low dose oral contraceptive with gestodene on the systems of natural inhibitors of coagulation].

Journal: Akusherstvo i ginekologiia20040101

Title: Classification and pharmacology of progestins.

Journal: Maturitas20031210

Title: Carpal tunnel syndrome and oral contraceptive drugs: risk or protective factor?

Journal: Journal of the peripheral nervous system : JPNS20031201

Title: Effects of low-dose oral and transdermal estrogen replacement therapy on hemostatic factors in healthy postmenopausal women: a randomized placebo-controlled study.

Journal: American journal of obstetrics and gynecology20031101

Title: The truth about oral contraceptives and venous thromboembolism.

Journal: The Journal of reproductive medicine20031101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20031001

Title: Effects of oral and transdermal low-dose estrogen therapy on echocardiographic parameters of cardiac function.

Journal: Fertility and sterility20030901

Title: A screening study on the liability of eight different female sex steroids to inhibit CYP2C9, 2C19 and 3A4 activities in human liver microsomes.

Journal: Pharmacology & toxicology20030801

Title: Lack of difference among progestins on the anti-atherogenic effect of ethinyl estradiol: a rabbit study.

Journal: Human reproduction (Oxford, England)20030701

Title: Effect of oral and transdermal estrogen replacement therapy on hemostatic variables associated with venous thrombosis: a randomized, placebo-controlled study in postmenopausal women.

Journal: Arteriosclerosis, thrombosis, and vascular biology20030601

Title: Effects of a low-dose and ultra-low-dose combined oral contraceptive use on bone turnover and bone mineral density in young fertile women: a prospective controlled randomized study.

Journal: Contraception20030501

Title: A 13-month multicenter clinical experience of a low-dose monophasic oral contraceptive containing 20 microg ethinylestradiol and 75 microg gestodene in Latin American women.

Journal: Contraception20030501

Title: Do oral contraceptives improve vocal quality? Limited trial on low-dose formulations.

Journal: Obstetrics and gynecology20030401

Title: Changes in prescription patterns of oral contraceptives in a northern Italian province: relation with venous thromboembolism.

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis20030401

Title: The effects of seven monophasic oral contraceptive regimens on hemostatic variables: conclusions from a large randomized multicenter study.

Journal: Contraception20030301

Title: Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin.

Journal: Toxicology letters20030203

Title: Influence of the third generation pill controversy on prescriptions for oral contraceptives among first time users: population based study.

Journal: BMJ (Clinical research ed.)20030201

Title: A randomized placebo-controlled study of the effect of transdermal vs. oral estradiol with or without gestodene on homocysteine levels.

Journal: Fertility and sterility20030201

Title: The effect of progesterone and synthetic progestins on serum- and estradiol-stimulated proliferation of human breast cancer cells.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme20030201

Title: Changes of hemostatic variables during oral contraceptive use.

Journal: Seminars in vascular medicine20030201

Title: Venous and arterial thrombosis during oral contraceptive use: risks and risk factors.

Journal: Seminars in vascular medicine20030201

Title: Low-dose combination of flutamide, metformin and an oral contraceptive for non-obese, young women with polycystic ovary syndrome.

Journal: Human reproduction (Oxford, England)20030101

Title: Auditory brainstem response in premenopausal women taking oral contraceptives.

Journal: Human reproduction (Oxford, England)20030101

Title: Thromboembolic disease and present oral contraception.

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis20030101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20030101

Title: Oral, more than transdermal, estrogen therapy improves lipids and lipoprotein(a) in postmenopausal women: a randomized, placebo-controlled study.

Journal: Menopause (New York, N.Y.)20030101

Title: [Effect and control of oral contraceptive Minesse (15 mkg EE/60 mkg Gestoden) on menstrual cycle and body weight].

Journal: Akusherstvo i ginekologiia20030101

Title: The effect of 17beta-estradiol on endothelial and inflammatory markers in postmenopausal women: a randomized, controlled trial.

Journal: Atherosclerosis20021201

Title: A comparison of cycle control, efficacy, and side effects among healthy Thai women between two low-dose oral contraceptives containing 20 microg ethinylestradio1/75 microg gestodene (Meliane) and 30 microg ethinylestradio1/75 microg gestodene (Gynera).

Journal: Contraception20021201

Title: Randomized controlled study of the influence of two low estrogen dose oral contraceptives containing gestodene or desogestrel on carbohydrate metabolism.

Journal: Contraception20021201

Title: Effects of transdermal and oral oestrogen replacement therapy on C-reactive protein levels in postmenopausal women: a randomised, placebo-controlled trial.

Journal: Thrombosis and haemostasis20021001

Title: Effects of two oral contraceptives on plasma levels of nitric oxide, homocysteine, and lipid metabolism.

Journal: Metabolism: clinical and experimental20020901

Title: Effects of low-dose OCs on weight in women with Central European nutritional habits and lifestyle.

Journal: Contraception20020901

Title: Fertilisation and implantation failure in an oral contraceptive user.

Journal: European journal of obstetrics, gynecology, and reproductive biology20020805

Title: Genetic polymorphisms modify the response of factor VII to oral contraceptive use: an example of gene-environment interaction.

Journal: Vascular pharmacology20020801

Title: Pro-inflammatory effects of oestrogens during use of oral contraceptives and hormone replacement treatment.

Journal: Vascular pharmacology20020801

Title: Determination of steroid hormones in oral contraceptives by high-performance liquid chromatography.

Journal: Drug development and industrial pharmacy20020701

Title: Can changes in sex hormone binding globulin predict the risk of venous thromboembolism with combined oral contraceptive pills?

Journal: Acta obstetricia et gynecologica Scandinavica20020601

Title: Clinical risk factors for venous thromboembolus in users of the combined oral contraceptive pill.

Journal: British journal of clinical pharmacology20020601

Title: [Low-dose combination oral contraceptives use in women with uterine leiomyomas].

Journal: Minerva ginecologica20020601

Title: Risk of Arterial Thrombosis in Relation to Oral Contraceptives (RATIO) study: oral contraceptives and the risk of ischemic stroke.

Journal: Stroke20020501

Title: Number of years since menopause: spontaneous bone loss is dependent but response to hormone replacement therapy is independent.

Journal: Bone20020401

Title: Oral contraceptives and venous thromboembolism: which are the safest preparations available?

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis20020401

Title: Oral contraceptives and venous thromboembolism: a five-year national case-control study.

Journal: Contraception20020301

Title: Contraceptives and cerebral thrombosis: a five-year national case-control study.

Journal: Contraception20020301

Title: Long-term effects of combined oral contraceptives on markers of endothelial function and lipids in healthy premenopausal women.

Journal: Contraception20020301

Title: Female hormones and thrombosis.

Journal: Arteriosclerosis, thrombosis, and vascular biology20020201

Title: Effect of postmenopausal hormone replacement on atherosclerosis in femoral arteries.

Journal: Maturitas20020130

Title: Triphasic oral contraceptives: review and comparison of various regimens.

Journal: Fertility and sterility20020101

Title: Prothrombotic effects and clinical implications of third-generation oral contraceptives use.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis20020101

Title: Venous thromboembolism and oral contraceptives: current status and clinical implications.

Journal: Treatments in endocrinology20020101

Title: Oral contraceptives and the risk of myocardial infarction.

Journal: The New England journal of medicine20011220

Title: Sex steroids used in hormonal treatment increase vascular procoagulant activity by inducing thrombin receptor (PAR-1) expression: role of the glucocorticoid receptor.

Journal: Circulation20011204

Title: Influence of 17beta-oestradiol on blood pressure of postmenopausal women at high vascular risk.

Journal: Journal of hypertension20011201

Title: Third-generation progestogen type influences hemostatic changes caused by oral contraceptives in Brazilian women.

Journal: Contraception20011201

Title: Body weight change during use of a monophasic oral contraceptive containing 20 microg ethinylestradiol and 75 microg gestodene with a comparison of the women who completed versus those who prematurely discontinued intake.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception20011201

Title: Transactivation of progestin- and estrogen-responsive promoters by 19-nor progestins in African Green Monkey Kidney CV1 cells.

Journal: Endocrine20011201

Title: A prospective study evidencing rhinomanometric and olfactometric outcomes in women taking oral contraceptives.

Journal: Human reproduction (Oxford, England)20011101

Title: A double-blind comparative study of the effects of a 23-day oral contraceptive regimen with 20 microg ethinyl estradiol and 75 microg gestodene and a 21-day regimen with 30 microg ethinyl estradiol and 75 microg gestodene on hemostatic variables, lipids, and carbohydrate metabolism.

Journal: Contraception20011001

Title: Dose finding in a low-dose 21-day combined oral contraceptive containing gestodene.

Journal: Contraception20011001

Title: A-ring reduced metabolites of 19-nor synthetic progestins as subtype selective agonists for ER alpha.

Journal: Endocrinology20010901

Title: [New gestagens--advantages and disadvantages].

Journal: Therapeutische Umschau. Revue therapeutique20010901

Title: Evaluation of plasma levels of renin-aldosterone and blood pressure in women over 35 years treated with new oral contraceptives.

Journal: Contraception20010901

Title: Open, multicenter comparison of efficacy, cycle control, and tolerability of a 23-day oral contraceptive regimen with 20 microg ethinyl estradiol and 75 microg gestodene and a 21-day regimen with 20 microg ethinyl estradiol and 150 microg desogestrel.

Journal: Contraception20010901

Title: Blood pressure stability in a normotensive population during intake of a monophasic oral contraceptive containing 20 microg ethinylestradiol and 75 g gestodene.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception20010901

Title: Clinical trial of a monophasic estroprogestin oral formulation containing 20 micrograms ethinyl estradiol and 75 micrograms gestodene.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology20010801

Title: Double-blind, multicenter comparison of efficacy, cycle control, and tolerability of a 23-day versus a 21-day low-dose oral contraceptive regimen containing 20 microg ethinyl estradiol and 75 microg gestodene.

Journal: Contraception20010801

Title: Risk of venous thromboembolism from oral contraceptives containing gestodene and desogestrel versus levonorgestrel: a meta-analysis and formal sensitivity analysis.

Journal: Contraception20010801

Title: Third generation oral contraceptives and risk of venous thrombosis: meta-analysis.

Journal: BMJ (Clinical research ed.)20010721

Title: Different methods for the determination of gestodene, and cyproterone acetate in raw material and dosage forms.

Journal: Journal of pharmaceutical and biomedical analysis20010601

Title: A prospective randomized controlled study comparing two doses of gestodene in cyclic combined HRT preparations on endometrial physiology.

Journal: Human reproduction (Oxford, England)20010601

Title: A 12-month clinical investigation with a 24-day regimen containing 15 microg ethinylestradiol plus 60 microg gestodene with respect to hemostasis and cycle control.

Journal: Contraception20010601

Title: In vitro metabolism of gestodene in target organs: formation of A-ring reduced derivatives with oestrogenic activity.

Journal: European journal of pharmacology20010413

Title: Oral contraceptives, thrombosis and haemostasis.

Journal: European journal of obstetrics, gynecology, and reproductive biology20010401

Title: Non-protein bound dienogest in serum and salivary dienogest in women taking the oral contraceptives Certostat and Valette.

Journal: Die Pharmazie20010401

Title: Practices of prescribing oral contraceptives in Poland.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception20010301

Title: Effect of oral postmenopausal hormone replacement on progression of atherosclerosis : a randomized, controlled trial.

Journal: Arteriosclerosis, thrombosis, and vascular biology20010201

Title: What is the risk of venous thromboembolism (VTE) among women taking third-generation oral contraceptives (OCs) in comparison with those taking contraceptives containing levonorgestrel?

Journal: The Journal of family practice20010201

Title: Contraception with the latest estroprogestagens in women suffering from systemic lupus erythematosus.

Journal: Minerva ginecologica20010201

Title: Charcoal treatment and risk of escape ovulation in oral contraceptive users.

Journal: Human reproduction (Oxford, England)20010101

Title: The possible role of enterohepatic cycling on bioavailability of norethisterone and gestodene in women using combined oral contraceptives.

Journal: Contraception20010101

Title: Lack of effect of alcohol on ethinylestradiol in premenopausal women.

Journal: Contraception20010101

Title: Effects of two oral contraceptives, containing 30 or 20 microg of ethinyl estradiol in combination with gestodene, on blood coagulation and fibrinolysis in Brazilian women.

Journal: International journal of fertility and women's medicine20010101

Title: Evidence that treatment with monophasic oral contraceptive formulations containing ethinylestradiol plus gestodene reduces bone resorption in young women.

Journal: Contraception20000401

Title: Venous thromboembolic disease and combined oral contraceptives: A re-analysis of the MediPlus database.

Journal: Human reproduction (Oxford, England)19990601

Title: Department of health changes advice on third generation pills.

Journal: BMJ (Clinical research ed.)19990417

Title: Increased risk of cerebral venous sinus thrombosis with third-generation oral contraceptives. Cerebral Venous Sinus Thrombosis Study Group.

Journal: Lancet (London, England)19980509

Title: Identification of enzymes involved in the metabolism of atrazine, terbuthylazine, ametryne, and terbutryne in human liver microsomes.

Journal: Chemical research in toxicology19970901

Title: Increased levels of activated factor VII and decreased plasma protein S activity and circulating thrombomodulin during use of oral contraceptives.

Journal: Thrombosis and haemostasis19961101

Title: Desogestrel, gestodene contraceptives may carry greater thromboembolic risk.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists19960201

Title: Third generation oral contraceptives and risk of venous thromboembolic disorders: an international case-control study. Transnational Research Group on Oral Contraceptives and the Health of Young Women.

Journal: BMJ (Clinical research ed.)19960113

Title: Risk of idiopathic cardiovascular death and nonfatal venous thromboembolism in women using oral contraceptives with differing progestagen components.

Journal: Lancet (London, England)19951216

Title: The effect on blood pressure of a monophasic oral contraceptive containing ethinylestradiol and gestodene.

Journal: Contraception19950601

Title: The sulfoxidation of the hexachlorobutadiene metabolite N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine is catalyzed by human cytochrome P450 3A enzymes.

Journal: Chemical research in toxicology19950101

Title: Comparison of two triphasic oral contraceptives containing either gestodene or norethindrone: a randomized, controlled trial.

Journal: Contraception19931001

Title: Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4'-methylene-bis(2-chloroaniline).

Journal: Carcinogenesis19920201

Title: The new pills: awaiting the next generation of oral contraceptives.

Journal: Family planning perspectives19920101

Title: Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae.

Journal: Biochemistry19901225

Title: Long-term experience with a low-dose oral contraceptive.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology19901201

Title: A double-blind comparison of the efficacy and acceptability of Femodene and Microgynon-30.

Journal: European journal of obstetrics, gynecology, and reproductive biology19900301

Title: A multicenter clinical evaluation of a new monophasic combination: Minulet (gestodene and ethinyl estradiol).

Journal: International journal of fertility19890901

Title: Comparison of two monophasic oral contraceptives: gestodene/ethinyl estradiol versus desogestrel/ethinyl estradiol.

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Title: Spona, J. and J. Huber, Pharmacological and endocrine profiles of gestodene. Int J Fertil, 1987. 32 Suppl: p. 6-14.

Title: Pollow, K., et al., Lack of binding of gestodene to estrogen receptor in human breast cancer tissue. Eur J Cancer, 1990. 26(5): p. 608-10.

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656-53-1
4-Methyl-5-thiazolylethyl acetate
AA00IBFH | MFCD00005338
67284-56-4
67284-56-4
Trans-4'-cyano-[1,1'-biphenyl]-4-yl 4-ethylcyclohexanecarboxylate
AA00IBMA | MFCD09751067
68774-77-6
68774-77-6
8-Chloro-[1,2,4]triazolo[4,3-a]pyrazine
AA00IBSK | MFCD08272086
702664-43-5
702664-43-5
4-(2,4-Dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2h)-yl)butanoic acid
AA00IBYH | MFCD04063015
720693-08-3
720693-08-3
4-[(6-Chloropyridin-2-yl)carbonyl]morpholine
AA00IC54 | MFCD16698133
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