Title: Serotonin 5-HT(6) Receptor Antagonists in Alzheimer's Disease: Therapeutic Rationale and Current Development Status.
Journal: CNS drugs20170101
Title: Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.
Journal: Journal of medicinal chemistry20140911
Title: Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands.
Journal: Journal of medicinal chemistry20140710
Title: Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457.
Journal: Neuropharmacology20121001
Title: Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT₆ receptor antagonist showing activity in rat social recognition test.
Journal: Bioorganic & medicinal chemistry letters20120201
Title: Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.
Journal: Journal of medicinal chemistry20111208
Title: Central nervous system effects of the interaction between risperidone (single dose) and the 5-HT6 antagonist SB742457 (repeated doses) in healthy men.
Journal: British journal of clinical pharmacology20110601
Title: SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study.
Journal: International journal of geriatric psychiatry20110501
Title: Double-blind, controlled phase II study of a 5-HT6 receptor antagonist, SB-742457, in Alzheimer's disease.
Journal: Current Alzheimer research20100801
Title: (3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: potent and selective antagonists of the serotonin 5-HT6 receptor.
Journal: Journal of medicinal chemistry20100722
Title: Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms.
Journal: Psychopharmacology20100101
Title: 5-HT6 receptor antagonists as potential therapeutics for cognitive impairment.
Journal: Current topics in medicinal chemistry20100101
Title: Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands.
Journal: Bioorganic & medicinal chemistry letters20090615
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Title: SB-742457
