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61350-00-3,MFCD00548412
Catalog No.:AA00ECGO

61350-00-3 | VU 0364770

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99+%
in stock  
$10.00   $7.00
- +
5mg
99+%
in stock  
$22.00   $16.00
- +
10mg
99+%
in stock  
$32.00   $23.00
- +
25mg
99+%
in stock  
$59.00   $42.00
- +
50mg
99+%
in stock  
$87.00   $61.00
- +
100mg
99+%
in stock  
$134.00   $94.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00ECGO
Chemical Name:
VU 0364770
CAS Number:
61350-00-3
Molecular Formula:
C12H9ClN2O
Molecular Weight:
232.6657
MDL Number:
MFCD00548412
SMILES:
Clc1cccc(c1)NC(=O)c1ccccn1
Properties
Computed Properties
 
Complexity:
247  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.6  

Literature

Title: Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist.

Journal: Neuropharmacology 20150801

Title: The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

Journal: The Journal of pharmacology and experimental therapeutics 20120201

Title: Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).

Journal: Journal of medicinal chemistry 20090723

Title: Jones CK, et al. The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J Pharmacol Exp Ther. 2012 Feb;340(2):404-21.

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SDS
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Tags:61350-00-3 Molecular Formula|61350-00-3 MDL|61350-00-3 SMILES|61350-00-3 VU 0364770
Catalog No.: AA00ECGO
61350-00-3,MFCD00548412
61350-00-3 | VU 0364770
Pack Size： 1mg
Purity： 99+%
in stock
$10.00 $7.00
Pack Size： 5mg
Purity： 99+%
in stock
$22.00 $16.00
Pack Size： 10mg
Purity： 99+%
in stock
$32.00 $23.00
Pack Size： 25mg
Purity： 99+%
in stock
$59.00 $42.00
Pack Size： 50mg
Purity： 99+%
in stock
$87.00 $61.00
Pack Size： 100mg
Purity： 99+%
in stock
$134.00 $94.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00ECGO
Chemical Name: VU 0364770
CAS Number: 61350-00-3
Molecular Formula: C12H9ClN2O
Molecular Weight: 232.6657
MDL Number: MFCD00548412
SMILES: Clc1cccc(c1)NC(=O)c1ccccn1
Properties
Complexity: 247  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 16  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.6  
Literature fold

Title: Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist.

Journal: Neuropharmacology20150801

Title: The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

Journal: The Journal of pharmacology and experimental therapeutics20120201

Title: Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).

Journal: Journal of medicinal chemistry20090723

Title: Jones CK, et al. The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J Pharmacol Exp Ther. 2012 Feb;340(2):404-21.

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