Name: Name:Pradefovir mesylate
Brand: AABLOCKS
SKU: AA01EOE2
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA01EOE2

Chemical Name: Pradefovir mesylate

CAS Number: 625095-61-6

Molecular Formula: C18H23ClN5O7PS

Molecular Weight: 519.8963

MDL Number: MFCD08435984

SMILES: CS(=O)(=O)O.Clc1cccc(c1)[C@@H]1CCO[P@@](=O)(O1)COCCn1cnc2c1ncnc2N

Properties

Complexity: 668

Covalently-Bonded Unit Count: 2

Defined Atom Stereocenter Count: 2

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 33

Hydrogen Bond Acceptor Count: 11

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 6

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

Literature fold

Title: Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B.

Journal: Journal of medicinal chemistry20080214

Title: Pradefovir, a liver-targeted prodrug of adefovir against HBV infection.

Journal: Current opinion in investigational drugs (London, England : 2000)20070801

Title: Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer.

Journal: Antimicrobial agents and chemotherapy20060901

Title: HepDirect prodrugs for targeting nucleotide-based antiviral drugs to the liver.

Journal: Current opinion in investigational drugs (London, England : 2000)20060201

Title: Pharmacokinetics of pradefovir and PMEA in healthy volunteers after oral dosing of pradefovir.

Journal: Journal of clinical pharmacology20051101

Title: Liver-targeted drug delivery using HepDirect prodrugs.

Journal: The Journal of pharmacology and experimental therapeutics20050201

Title: Remofovir mesylate: a prodrug of PMEA with improved liver-targeting and safety in rats and monkeys.

Journal: Antiviral chemistry & chemotherapy20041101

Title: Lin CC, et al. Metabolic activation of Pradefovir by CYP3A4 and its potential as an inhibitor or inducer. Antimicrob Agents Chemother. 2006 Sep;50(9):2926-31.

625095-61-6 | Pradefovir mesylate