626-48-2,MFCD00006028
Catalog No.:AA0032WP

626-48-2 | 2,4-Dihydroxy-6-methylpyrimidine

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Purity
Availability
Price(USD)
Quantity
  
25g
98%
in stock  
$15.00   $11.00
- +
100g
98%
in stock  
$26.00   $19.00
- +
500g
98%
in stock  
$32.00   $23.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0032WP
Chemical Name:
2,4-Dihydroxy-6-methylpyrimidine
CAS Number:
626-48-2
Molecular Formula:
C5H6N2O2
Molecular Weight:
126.1133
MDL Number:
MFCD00006028
SMILES:
Cc1cc(O)nc(n1)O
NSC Number:
9456
Properties
Properties
 
BP:
420.4°C at 760 mmHg  
Form:
Solid  
MP:
318 °C (dec.)(lit.)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
195  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-0.8  

Literature

Title: Effect of tissue-specific acetylcholinesterase inhibitor C-547 on α3β4 and αβεδ acetylcholine receptors in COS cells.

Journal: European journal of pharmacology 20120805

Title: [Stages of bone regeneration and foundation of pharmacоlogical correction of the mandible reparative osteogenesis].

Journal: Stomatologiia 20120101

Title: Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis.

Journal: Nature 20111208

Title: Synthesis of various 5-alkoxymethyluracil analogues and structure-cytotoxic activity relationship study.

Journal: Carbohydrate research 20111018

Title: Different sensitivities of rat skeletal muscles and brain to novel anti-cholinesterase agents, alkylammonium derivatives of 6-methyluracil (ADEMS).

Journal: British journal of pharmacology 20110601

Title: Hydrothermal synthesis, experimental and theoretical characterization of a novel cocrystal compound in the 2:1 stoichiometric ratio containing 6-methyluracil and dipicolinic acid.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110501

Title: Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

Journal: Journal of medicinal chemistry 20110127

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: 1,3-Bis(4-meth-oxy-benz-yl)-6-methyl-pyrimidine-2,4(1H,3H)-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20100701

Title: An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20091201

Title: Mechanisms of cardiac muscle insensitivity to a novel acetylcholinesterase inhibitor C-547.

Journal: Journal of cardiovascular pharmacology 20090201

Title: Different sensitivity of miniature endplate currents in rat external and internal intercostal muscles to the acetylcholinesterase inhibitor C-547 as compared with diaphragm and extensor digitorum longus.

Journal: Physiological research 20090101

Title: Compounds with the dioxopyrimidine cycle inhibit cholinesterases from different groups of animals.

Journal: Chemico-biological interactions 20080925

Title: Tetrakis- and tris(1-Methyluracil) complexes of Pt(II): formation and properties of a carbon-bonded nucleobase species as well as of heternonuclear derivatives.

Journal: Inorganic chemistry 20071224

Title: The design and synthesis of N-1-alkylated-5-aminoarylalkylsubstituted-6-methyluracils as potential non-nucleoside HIV-1 RT inhibitors.

Journal: Bioorganic & medicinal chemistry 20071201

Title: Selective oxidation of key functional groups in cyanotoxins during drinking water ozonation.

Journal: Environmental science & technology 20070615

Title: Effect of a tetraalkylammonium derivative of 6-methyluracil from a new class of acetylcholinesterase inhibitors on the endplate potential amplitude in muscles of different function types under high-frequency nerve stimulation.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20070101

Title: [Studying the nootropic effects of betamecil].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20070101

Title: [Realization of optic activatory mechanism in laser-medication impact].

Journal: Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 20060101

Title: Different sensitivity of miniature endplate currents of the rat extensor digitorum longus, soleus and diaphragm muscles to a novel acetylcholinesterase inhibitor C-547.

Journal: Physiological research 20060101

Title: Reaction of substituted pyrimidines with photochemically generated t-BuO* radicals.

Journal: Indian journal of biochemistry & biophysics 20051201

Title: Atropisomeric property of 1-(2,6-difluorobenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil.

Journal: Chirality 20051101

Title: Electron impact mass spectral study of 1,2-di-o-(m- and p-)nitro-(bromo-)benzyl-2-thio-6-methyluracils and 1,2-di-o-(m- and p-)nitro-(bromo-)benzyl-2-thio-5-bromo-6-methyluracils.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20040503

Title: Effect of tetraalkylammonium derivatives of 6-methyluracil on the endplate potentials of muscles of different functional types.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20040101

Title: Antiparasitic activity of highly conjugated pyrimidine-2,4-dione derivatives.

Journal: Farmaco (Societa chimica italiana : 1989) 20031201

Title: Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20031006

Title: Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor.

Journal: Bioorganic & medicinal chemistry letters 20031006

Title: [Current methods for local drug therapy of infected wounds].

Journal: Khirurgiia 20030101

Title: Pyrrolidino-DNA.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Biological activity of bacterial lectins and their molecular complexes with heterocyclic bis-adducts.

Journal: Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20030101

Title: The acidity of uracil and uracil analogs in the gas phase: four surprisingly acidic sites and biological implications.

Journal: Journal of the American Society for Mass Spectrometry 20020801

Title: Genotoxicity study of a new tetraalkylammonium derivative of 6-methyluracil (agent No. 547).

Journal: Archives of toxicology 20020301

Title: [Photophoresis of methyluracil ointment in the complex treatment of temporomandibular pain syndrome].

Journal: Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 20020101

Title: [Studies of biological activity of mineral oil dialkyl disulfide (an experimental study)].

Journal: Meditsina truda i promyshlennaia ekologiia 20020101

Title: [Morphological aspects of dermatotrophic action of methyluracil applied epicutaneously].

Journal: Morfologiia (Saint Petersburg, Russia) 20020101

Title: [Surgical infected wound treatment in patients with severe gastrointestinal ulcer hemorrhage].

Journal: Klinichna khirurhiia 20020101

Title: Effect of tetraalkylammonium derivative of 6-methyluracil on amplitude and temporal parameters of miniature endplate potentials in frog neuromuscular junction.

Journal: Bulletin of experimental biology and medicine 20010501

Title: Tetraalkylammonium derivatives of 6-methyluracil, a new class of cholinesterase inhibitors: characteristics of interaction with cholinesterases from different groups of animals.

Journal: Doklady. Biochemistry and biophysics 20010101

Title: Structure-activity relationship of ligands of uracil phosphoribosyltransferase from Toxoplasma gondii.

Journal: Biochemical pharmacology 19940817

Title: Cromby CH, et, al. 6-Methyluracil excretion in 2-methylacetoacetyl-CoA thiolase deficiency and in two children with an unexplained recurrent ketoacidaemia. J Inherit Metab Dis. 1994;17(1):81-4.

Title: Taran IP, et, al. [The antiradiation action of 6-methyluracil Radiobiologiia. Mar-Apr 1993;33(2):285-90.

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Historical Records
Tags:626-48-2 Molecular Formula|626-48-2 MDL|626-48-2 SMILES|626-48-2 2,4-Dihydroxy-6-methylpyrimidine
Catalog No.: AA0032WP
626-48-2,MFCD00006028
626-48-2 | 2,4-Dihydroxy-6-methylpyrimidine
Pack Size: 25g
Purity: 98%
in stock
$15.00 $11.00
Pack Size: 100g
Purity: 98%
in stock
$26.00 $19.00
Pack Size: 500g
Purity: 98%
in stock
$32.00 $23.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0032WP
Chemical Name: 2,4-Dihydroxy-6-methylpyrimidine
CAS Number: 626-48-2
Molecular Formula: C5H6N2O2
Molecular Weight: 126.1133
MDL Number: MFCD00006028
SMILES: Cc1cc(O)nc(n1)O
NSC Number: 9456
Properties
BP: 420.4°C at 760 mmHg  
Form: Solid  
MP: 318 °C (dec.)(lit.)  
Storage: Inert atmosphere;Room Temperature;  
Complexity: 195  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 9  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -0.8  
Literature fold

Title: Effect of tissue-specific acetylcholinesterase inhibitor C-547 on α3β4 and αβεδ acetylcholine receptors in COS cells.

Journal: European journal of pharmacology20120805

Title: [Stages of bone regeneration and foundation of pharmacоlogical correction of the mandible reparative osteogenesis].

Journal: Stomatologiia20120101

Title: Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis.

Journal: Nature20111208

Title: Synthesis of various 5-alkoxymethyluracil analogues and structure-cytotoxic activity relationship study.

Journal: Carbohydrate research20111018

Title: Different sensitivities of rat skeletal muscles and brain to novel anti-cholinesterase agents, alkylammonium derivatives of 6-methyluracil (ADEMS).

Journal: British journal of pharmacology20110601

Title: Hydrothermal synthesis, experimental and theoretical characterization of a novel cocrystal compound in the 2:1 stoichiometric ratio containing 6-methyluracil and dipicolinic acid.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20110501

Title: Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

Journal: Journal of medicinal chemistry20110127

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: 1,3-Bis(4-meth-oxy-benz-yl)-6-methyl-pyrimidine-2,4(1H,3H)-dione.

Journal: Acta crystallographica. Section E, Structure reports online20100701

Title: An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial.

Journal: Reproductive toxicology (Elmsford, N.Y.)20091201

Title: Mechanisms of cardiac muscle insensitivity to a novel acetylcholinesterase inhibitor C-547.

Journal: Journal of cardiovascular pharmacology20090201

Title: Different sensitivity of miniature endplate currents in rat external and internal intercostal muscles to the acetylcholinesterase inhibitor C-547 as compared with diaphragm and extensor digitorum longus.

Journal: Physiological research20090101

Title: Compounds with the dioxopyrimidine cycle inhibit cholinesterases from different groups of animals.

Journal: Chemico-biological interactions20080925

Title: Tetrakis- and tris(1-Methyluracil) complexes of Pt(II): formation and properties of a carbon-bonded nucleobase species as well as of heternonuclear derivatives.

Journal: Inorganic chemistry20071224

Title: The design and synthesis of N-1-alkylated-5-aminoarylalkylsubstituted-6-methyluracils as potential non-nucleoside HIV-1 RT inhibitors.

Journal: Bioorganic & medicinal chemistry20071201

Title: Selective oxidation of key functional groups in cyanotoxins during drinking water ozonation.

Journal: Environmental science & technology20070615

Title: Effect of a tetraalkylammonium derivative of 6-methyluracil from a new class of acetylcholinesterase inhibitors on the endplate potential amplitude in muscles of different function types under high-frequency nerve stimulation.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections20070101

Title: [Studying the nootropic effects of betamecil].

Journal: Eksperimental'naia i klinicheskaia farmakologiia20070101

Title: [Realization of optic activatory mechanism in laser-medication impact].

Journal: Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury20060101

Title: Different sensitivity of miniature endplate currents of the rat extensor digitorum longus, soleus and diaphragm muscles to a novel acetylcholinesterase inhibitor C-547.

Journal: Physiological research20060101

Title: Reaction of substituted pyrimidines with photochemically generated t-BuO* radicals.

Journal: Indian journal of biochemistry & biophysics20051201

Title: Atropisomeric property of 1-(2,6-difluorobenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil.

Journal: Chirality20051101

Title: Electron impact mass spectral study of 1,2-di-o-(m- and p-)nitro-(bromo-)benzyl-2-thio-6-methyluracils and 1,2-di-o-(m- and p-)nitro-(bromo-)benzyl-2-thio-5-bromo-6-methyluracils.

Journal: Rapid communications in mass spectrometry : RCM20050101

Title: Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters20040503

Title: Effect of tetraalkylammonium derivatives of 6-methyluracil on the endplate potentials of muscles of different functional types.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections20040101

Title: Antiparasitic activity of highly conjugated pyrimidine-2,4-dione derivatives.

Journal: Farmaco (Societa chimica italiana : 1989)20031201

Title: Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters20031006

Title: Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor.

Journal: Bioorganic & medicinal chemistry letters20031006

Title: [Current methods for local drug therapy of infected wounds].

Journal: Khirurgiia20030101

Title: Pyrrolidino-DNA.

Journal: Nucleosides, nucleotides & nucleic acids20030101

Title: Biological activity of bacterial lectins and their molecular complexes with heterocyclic bis-adducts.

Journal: Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993)20030101

Title: The acidity of uracil and uracil analogs in the gas phase: four surprisingly acidic sites and biological implications.

Journal: Journal of the American Society for Mass Spectrometry20020801

Title: Genotoxicity study of a new tetraalkylammonium derivative of 6-methyluracil (agent No. 547).

Journal: Archives of toxicology20020301

Title: [Photophoresis of methyluracil ointment in the complex treatment of temporomandibular pain syndrome].

Journal: Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury20020101

Title: [Studies of biological activity of mineral oil dialkyl disulfide (an experimental study)].

Journal: Meditsina truda i promyshlennaia ekologiia20020101

Title: [Morphological aspects of dermatotrophic action of methyluracil applied epicutaneously].

Journal: Morfologiia (Saint Petersburg, Russia)20020101

Title: [Surgical infected wound treatment in patients with severe gastrointestinal ulcer hemorrhage].

Journal: Klinichna khirurhiia20020101

Title: Effect of tetraalkylammonium derivative of 6-methyluracil on amplitude and temporal parameters of miniature endplate potentials in frog neuromuscular junction.

Journal: Bulletin of experimental biology and medicine20010501

Title: Tetraalkylammonium derivatives of 6-methyluracil, a new class of cholinesterase inhibitors: characteristics of interaction with cholinesterases from different groups of animals.

Journal: Doklady. Biochemistry and biophysics20010101

Title: Structure-activity relationship of ligands of uracil phosphoribosyltransferase from Toxoplasma gondii.

Journal: Biochemical pharmacology19940817

Title: Cromby CH, et, al. 6-Methyluracil excretion in 2-methylacetoacetyl-CoA thiolase deficiency and in two children with an unexplained recurrent ketoacidaemia. J Inherit Metab Dis. 1994;17(1):81-4.

Title: Taran IP, et, al. [The antiradiation action of 6-methyluracil Radiobiologiia. Mar-Apr 1993;33(2):285-90.

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