Name: Name:4-Methylpiperidine
Brand: AABLOCKS
SKU: AA0035WE
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA0035WE

Chemical Name: 4-Methylpiperidine

CAS Number: 626-58-4

Molecular Formula: C6H13N

Molecular Weight: 99.1741

MDL Number: MFCD00006005

SMILES: CC1CCNCC1

NSC Number: 66495

Properties

BP: 130.0°C

Form: Liquid

MP: 4-5 °C

Refractive Index: n20/D 1.446(lit.)

Complexity: 46.1

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 7

Hydrogen Bond Acceptor Count: 1

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 0

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 1.1

Literature fold

Title: 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: structure-activity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region.

Journal: Journal of medicinal chemistry20121011

Title: 4-Methyl-N-p-tolyl-piperidine-1-carbox-amide.

Journal: Acta crystallographica. Section E, Structure reports online20120501

Title: (2,6-Difluoro-phen-yl)(4-methyl-piperidin-1-yl)methanone.

Journal: Acta crystallographica. Section E, Structure reports online20110901

Title: Biosynthetic chlorination of the piperazate residue in kutzneride biosynthesis by KthP.

Journal: Biochemistry20110712

Title: N-(4-Chloro-phen-yl)-4-methyl-piperidine-1-carboxamide.

Journal: Acta crystallographica. Section E, Structure reports online20110701

Title: 3-Bromo-5-meth-oxy-4-(4-methyl-piperidin-1-yl)furan-2(5H)-one.

Journal: Acta crystallographica. Section E, Structure reports online20110401

Title: (5S)-3-Chloro-5-[(1R,2S,5R)-2-isopropyl-5-methyl-cyclo-hex-yloxy]-4-(4-methyl-piperidin-1-yl)furan-2(5H)-one.

Journal: Acta crystallographica. Section E, Structure reports online20110301

Title: Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines.

Journal: European journal of medicinal chemistry20100301

Title: Density functional analysis of the trigonal uranyl equatorial coordination in hexahomotrioxacalix[3]arene-based macrocyclic complexes.

Journal: Inorganic chemistry20100215

Title: Cyr61/CCN1 displays high-affinity binding to the somatomedin B(1-44) domain of vitronectin.

Journal: PloS one20100101

Title: 2,2'-[(Biphenyl-4,4'-di-yl)di(ethene-1,2-di-yl)]dibenzene-sulfonic acid-4-methyl-piperidine-water (1/2/2).

Journal: Acta crystallographica. Section E, Structure reports online20090801

Title: Bis(4-methyl-piperidinium) hexa-chlorido-stannate(IV).

Journal: Acta crystallographica. Section E, Structure reports online20080401

Title: Solution structure of the Legionella pneumophila Mip-rapamycin complex.

Journal: BMC structural biology20080101

Title: DFT and ab initio calculations of the vibrational frequencies and visible spectra of triazenes derived from cyclic amines.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20070601

Title: Combined experimental and computational study of the thermochemistry of methylpiperidines.

Journal: The Journal of organic chemistry20060512

Title: Letter: electron ionization-induced fragmentation of new thiochalcone derivatives.

Journal: European journal of mass spectrometry (Chichester, England)20060101

Title: Mechanism of hydrodenitrogenation on phosphides and sulfides.

Journal: The journal of physical chemistry. B20050217

Title: Exocellular peptides from Antarctic psychrophile Pseudoalteromonas Haloplanktis.

Journal: Marine biotechnology (New York, N.Y.)20050101

Title: Five- to six-coordination in (nitrosyl)iron(II) porphyrinates: effects of binding the sixth ligand.

Journal: Inorganic chemistry20030908

Title: [Fe(TPP)(4-MePip)(2)]: an axially compressed bis(secondary amine) complex of an iron(II) porphyrin.

Journal: Acta crystallographica. Section C, Crystal structure communications20030601

Title: Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects.

Journal: Journal of medicinal chemistry20020801

Title: Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides.

Journal: Bioorganic & medicinal chemistry letters20020520

Title: A short synthesis of argatroban. a potent selective thrombin inhibitor.

Journal: Bioorganic & medicinal chemistry letters20010806

Application fold

4-Methylpiperidine serves as a versatile building block in organic synthesis, particularly in the creation of bioactive compounds with diverse applications. Through its incorporation into chemical reactions, it facilitates the synthesis of various biologically significant molecules. Among its synthetic uses, 4-Methylpiperidine is instrumental in the preparation of dimethyl bis(4-methylpiperidine-dithiocarbamato-S,S′)-tin(IV), which may exhibit potential pharmacological properties. Additionally, it is employed in the synthesis of (E)-4-(4′-methylpiperidino-N-alkoxy) stilbenes and 4-methylpiperidinoalkylthio and 4-methylpiperidinoalkoxy derivatives of (E)-chalcone, compounds that could possess biological activity relevant to medicinal chemistry. Furthermore, 4-Methylpiperidine serves as a valuable deprotecting reagent in solid-phase peptide synthesis, enabling the removal of Fmoc (fluorenylmethyloxycarbonyl) protecting groups from amino acids. Its versatility and utility make it a valuable asset in synthetic organic chemistry, contributing to the development of bioactive molecules with potential therapeutic applications.

626-58-4 | 4-Methylpiperidine