644-62-2,MFCD00072053
Catalog No.:AA00E8SG

644-62-2 | Meclofenamic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
1 week  
$209.00   $147.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00E8SG
Chemical Name:
Meclofenamic acid
CAS Number:
644-62-2
Molecular Formula:
C14H11Cl2NO2
Molecular Weight:
296.1486
MDL Number:
MFCD00072053
SMILES:
OC(=O)c1ccccc1Nc1c(Cl)ccc(c1Cl)C
NSC Number:
95309
Properties
Computed Properties
 
Complexity:
327  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
5.2  

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Tags:644-62-2 Molecular Formula|644-62-2 MDL|644-62-2 SMILES|644-62-2 Meclofenamic acid
Catalog No.: AA00E8SG
644-62-2,MFCD00072053
644-62-2 | Meclofenamic acid
Pack Size: 1mg
Purity: 98%
1 week
$209.00 $147.00
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Technical Information
Catalog Number: AA00E8SG
Chemical Name: Meclofenamic acid
CAS Number: 644-62-2
Molecular Formula: C14H11Cl2NO2
Molecular Weight: 296.1486
MDL Number: MFCD00072053
SMILES: OC(=O)c1ccccc1Nc1c(Cl)ccc(c1Cl)C
NSC Number: 95309
Properties
Complexity: 327  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 19  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 5.2  
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Journal: The Journal of urology20090701

Title: The effects of propofol on vascular function in mesenteric arteries of the aging rat.

Journal: American journal of physiology. Heart and circulatory physiology20090701

Title: Resveratrol protects against ultraviolet A-mediated inhibition of the phagocytic function of human retinal pigment epithelial cells via large-conductance calcium-activated potassium channels.

Journal: The Kaohsiung journal of medical sciences20090701

Title: Synthesis, pharmacological evaluation and docking studies of new sulindac analogues.

Journal: European journal of medicinal chemistry20090501

Title: Organotin meclofenamic complexes: Synthesis, crystal structures and antiproliferative activity of the first complexes of meclofenamic acid - novel anti-tuberculosis agents.

Journal: Journal of inorganic biochemistry20090501

Title: Meclofenamic acid blocks electrical synapses of retinal AII amacrine and on-cone bipolar cells.

Journal: Journal of neurophysiology20090501

Title: Predicting sorption of pharmaceuticals and personal care products onto soil and digested sludge using artificial neural networks.

Journal: The Analyst20090401

Title: Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs.

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Title: Response to endothelin-1 in arteries from human colorectal tumours: role of endothelin receptors.

Journal: Experimental biology and medicine (Maywood, N.J.)20081201

Title: Resveratrol and large-conductance calcium-activated potassium channels in the protection of human retinal pigment epithelial cells.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20081201

Title: Embryo transfer induces a subclinical endometritis in recipient mares which can be prevented by treatment with non-steroid anti-inflammatory drugs.

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Title: Intermedin/adrenomedullin-2 (IMD/AM2) relaxes rat main pulmonary arterial rings via cGMP-dependent pathway: role of nitric oxide and large conductance calcium-activated potassium channels (BK(Ca)).

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Title: Confirmatory identification of sixteen non-steroidal anti-inflammatory drug residues in raw milk by liquid chromatography coupled with ion trap mass spectrometry.

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Title: Virtual screening for novel COX-2 inhibitors using the ZINC database.

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Title: Endothelium-dependent relaxation of isolated splanchnic arteries from cirrhotic patients: Role of reactive oxygen species.

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Title: Simultaneous determination of various pharmaceutical compounds in water by solid-phase extraction-liquid chromatography-tandem mass spectrometry.

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Title: Non-steroidal anti-inflammatory drugs increase insulin release from beta cells by inhibiting ATP-sensitive potassium channels.

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Title: Alpha2-adrenoreceptor mediated sympathoinhibition of heart rate during acute hypoxia is diminished in conscious prostacyclin synthase deficient mice.

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Title: Spurious urine excretion drug profile in the horse due to bedding contamination and drug recycling: the case of meclofenamic acid.

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Title: Differential effects of losartan and candesartan on vasoconstrictor responses in the rat.

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Title: A novel role for connexin hemichannel in oxidative stress and smoking-induced cell injury.

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Title: Clinical management of adult patients with a history of nonsteroidal anti-inflammatory drug-induced urticaria/angioedema: update.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology20070101

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Title: Role for prostaglandins in the regulation of type 1 11beta-hydroxysteroid dehydrogenase in human granulosa-lutein cells.

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Title: Angiotensin-(1-7) potentiates responses to bradykinin but does not change responses to angiotensin I.

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Title: Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents.

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Title: Hemopressin, a hemoglobin fragment, dilates the rat systemic vascular bed through release of nitric oxide.

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Title: Meclofenamic acid extends donor-recipient asynchrony in equine embryo transfer.

Journal: Equine veterinary journal20060901

Title: Early aging and anatomic heterogeneity determine cyclooxygenase-mediated vasoconstriction to angiotensin II in mice.

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Title: Antiepileptic effect of gap-junction blockers in a rat model of refractory focal cortical epilepsy.

Journal: Epilepsia20060701

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Title: Use of accelerating solvent extraction for detecting non-steroidal anti-inflammatory drugs in horse feces.

Journal: Journal of analytical toxicology20060601

Title: Starch-based microspheres produced by emulsion crosslinking with a potential media dependent responsive behavior to be used as drug delivery carriers.

Journal: Journal of materials science. Materials in medicine20060401

Title: Second-order calibration of excitation-emission matrix fluorescence spectra for the determination of N-phenylanthranilic acid derivatives.

Journal: Applied spectroscopy20060301

Title: Partial renal ischemia elicits heterogeneous control of renal sympathetic nerve activity to ischemic and nonischemic regions of the kidney.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20060201

Title: Vasoconstrictor prostanoids may be involved in reduced coronary reactive hyperemia after ischemia-reperfusion in anesthetized goats.

Journal: European journal of pharmacology20060120

Title: QSAR analysis of meclofenamic acid analogues as selective COX-2 inhibitors.

Journal: Bioorganic & medicinal chemistry letters20060115

Title: Analysis of responses to kava kava in the feline pulmonary vascular bed.

Journal: Journal of medicinal food20060101

Title: Determination of fourteen non-steroidal anti-inflammatory drugs in animal serum and plasma by liquid chromatography/mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM20060101

Title: Enhanced response of pig coronary arteries to endothelin-1 after ischemia-reperfusion. Role of endothelin receptors, nitric oxide and prostanoids.

Journal: European journal of pharmacology20051107

Title: Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors.

Journal: Nature neuroscience20050901

Title: Increased myogenic tone in 7-month-old adult male but not female offspring from rat dams exposed to hypoxia during pregnancy.

Journal: American journal of physiology. Heart and circulatory physiology20050801

Title: Coronary effects of endothelin-1 and vasopressin during acute hypotension in anesthetized goats.

Journal: Life sciences20050610

Title: Mechanisms of the protective effects of urocortin on coronary endothelial function during ischemia-reperfusion in rat isolated hearts.

Journal: British journal of pharmacology20050601

Title: Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties.

Journal: Molecular pharmacology20050401

Title: Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning.

Journal: Free radical biology & medicine20050315

Title: Tracking acidic pharmaceuticals, caffeine, and triclosan through the wastewater treatment process.

Journal: Environmental toxicology and chemistry20050101

Title: Embryo transfer in the dromedary camel (Camelus dromedarius) using asynchronous, meclofenamic acid-treated recipients.

Journal: Reproduction, fertility, and development20050101

Title: Responses to bradykinin are mediated by NO-independent mechanisms in the rat hindlimb vascular bed.

Journal: Pharmacological research20041201

Title: Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid A receptors.

Journal: The Journal of pharmacology and experimental therapeutics20041101

Title: Analysis of gamma-aminobutyric acid-mediated responses in the pulmonary vascular bed of the cat.

Journal: Anesthesia and analgesia20040901

Title: Roles for prostaglandins in the steroidogenic response of human granulosa cells to high-density lipoproteins.

Journal: Molecular and cellular endocrinology20040730

Title: Vasopressin effects on the coronary circulation after a short ischemia in anesthetized goats: role of nitric oxide and prostanoids.

Journal: European journal of pharmacology20040714

Title: Myogenic reactivity is enhanced in rat radial uterine arteries in a model of maternal undernutrition.

Journal: American journal of obstetrics and gynecology20040701

Title: Race-specific differences in endothelial function: predisposition of African Americans to vascular diseases.

Journal: Circulation20040601

Title: Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs.

Journal: American journal of veterinary research20040601

Title: Role of potassium channels in the nitric oxide-independent vasodilator response to acetylcholine.

Journal: Pharmacological research20040301

Title: Effects of chronic PGHS-2 inhibition on PGHS-dependent vasoconstriction in the aged female rat.

Journal: Cardiovascular research20040201

Title: Topical NSAIDs for acute pain: a meta-analysis.

Journal: BMC family practice20040101

Title: Effects of lornoxicam on the physiology of severe sepsis.

Journal: Critical care (London, England)20040101

Title: Coronary action of endothelin-1 and vasopressin during acute hypertension in anesthetized goats. Role of nitric oxide and prostanoids.

Journal: Vascular pharmacology20040101

Title: Analysis of responses to St. John's Wort in the feline pulmonary vascular bed.

Journal: Journal of herbal pharmacotherapy20040101

Title: Endothelium-dependent, vasopressin-induced contractions in rabbit renal arteries.

Journal: Journal of cardiovascular pharmacology20031201

Title: Endothelial-dependent vasodilation is reduced in mesenteric arteries from superoxide dismutase knockout mice.

Journal: Cardiovascular research20031201

Title: Variable effects of nonsteroidal antiinflammatory agents on thyroid test results.

Journal: The Journal of clinical endocrinology and metabolism20031201

Title: Analysis of responses to valerian root extract in the feline pulmonary vascular bed.

Journal: Journal of alternative and complementary medicine (New York, N.Y.)20031201

Title: Comparison of the in vivo coronary action of endothelin-1 and vasopressin role of nitric oxide and prostanoids.

Journal: Vascular pharmacology20031201

Title: In vivo coronary effects of endothelin-1 after ischemia-reperfusion. Role of nitric oxide and prostanoids.

Journal: European journal of pharmacology20031114

Title: Effects of exogenous heme on renal function: role of heme oxygenase and cyclooxygenase.

Journal: Hypertension (Dallas, Tex. : 1979)20031001

Title: Interactions between vasoconstrictors and vasodilators in regulating hemodynamics of distinct vascular beds.

Journal: Hypertension (Dallas, Tex. : 1979)20031001

Title: Identification of gap junction blockers using automated fluorescence microscopy imaging.

Journal: Journal of biomolecular screening20031001

Title: Meta-analysis of dyspepsia and nonsteroidal antiinflammatory drugs.

Journal: Arthritis and rheumatism20030815

Title: Reduced perivascular PO2 increases nitric oxide release from endothelial cells.

Journal: American journal of physiology. Heart and circulatory physiology20030801

Title: NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.

Journal: The Journal of clinical investigation20030801

Title: Coronary effects of vasopressin during partial ischemia and reperfusion in anesthetized goats. Role of nitric oxide and prostanoids.

Journal: European journal of pharmacology20030718

Title: Relaxation by urocortin of rat renal arteries: effects of diabetes in males and females.

Journal: Cardiovascular research20030601

Title: Relaxation of rat arteries by urocortin: effects of gender and diabetes.

Journal: The Journal of pharmacy and pharmacology20030601

Title: Chronic hypoxia opposes pregnancy-induced increase in uterine artery vasodilator response to flow.

Journal: American journal of physiology. Heart and circulatory physiology20030301

Title: Mechanism of inhibitory actions of oxidizing agents on calcium-activated potassium current in cultured pigment epithelial cells of the human retina.

Journal: Investigative ophthalmology & visual science20030301

Title: Pregnancy-induced alterations of vascular function in mouse mesenteric and uterine arteries.

Journal: Biology of reproduction20030301

Title: Angiotensin-(1-7) reduces renal angiotensin II receptors through a cyclooxygenase-dependent mechanism.

Journal: Journal of cardiovascular pharmacology20030201

Title: Vascular reactivity to vasopressin during diabetes: gender and regional differences.

Journal: European journal of pharmacology20030117

Title: Regulation of intraluteal production of prostaglandins.

Journal: Reproductive biology and endocrinology : RB&E20030101

Title: Coronary reactivity to endothelin-1 during partial ischemia and reperfusion in anesthetized goats. Role of nitric oxide and prostanoids.

Journal: European journal of pharmacology20021220

Title: Vascular adaptations to pregnancy in mice: effects on myogenic tone.

Journal: American journal of physiology. Heart and circulatory physiology20021201

Title: Idiosyncratic NSAID drug induced oxidative stress.

Journal: Chemico-biological interactions20021110

Title: Obesity increases prostanoid-mediated vasoconstriction and vascular thromboxane receptor gene expression.

Journal: Journal of hypertension20021101

Title: Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs.

Journal: The Journal of biological chemistry20021011

Title: Postnatal maturation in nitric oxide-induced pulmonary artery relaxation involving cyclooxygenase-1 activity.

Journal: American journal of physiology. Lung cellular and molecular physiology20021001

Title: Endothelin-induced modulation of neuropeptide Y and norepinephrine release from the rat mesenteric bed.

Journal: American journal of physiology. Heart and circulatory physiology20021001

Title: Estrogen replacement reduces PGHS-2-dependent vasoconstriction in the aged rat.

Journal: American journal of physiology. Heart and circulatory physiology20020901

Title: Enhanced endothelin activity prevents vasodilation to insulin in insulin resistance.

Journal: Hypertension (Dallas, Tex. : 1979)20020701

Title: Relaxation by urocortin of human saphenous veins.

Journal: British journal of pharmacology20020501

Title: Differential binding mode of diverse cyclooxygenase inhibitors.

Journal: Journal of molecular graphics & modelling20020301

Title: Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.

Journal: Bioorganic & medicinal chemistry letters20020225

Title: Native LDL induces proliferation of human vascular smooth muscle cells via redox-mediated activation of ERK 1/2 mitogen-activated protein kinases.

Journal: Hypertension (Dallas, Tex. : 1979)20020201

Title: Cyclic adenosine monophosphate-dependent vascular responses to purinergic agonists adenosine triphosphate and uridine triphosphate in the anesthetized mouse.

Journal: Journal of cardiovascular pharmacology20020101

Title: Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).

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Title: Meclofenamic acid for inhibition of human vascular smooth muscle cell proliferation and migration: an in vitro study.

Journal: Cardiovascular and interventional radiology20020101

Title: Relationship between the production of prostaglandins and progesterone by luteinizing human granulosa cells.

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Title: Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine.

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Title: NO and prostaglandin interactions during hemodynamic stress in the fetal ovine pulmonary circulation.

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Title: Fenamates stimulate BKCa channel osteoblast-like MG-63 cells activity in the human.

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Title: Nitric oxide buffers renal medullary vasoconstriction induced by prostaglandins synthesis blockade.

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Title: [HPLC analysis of nonsteroidal antirheumatic substances in biological material. V. Fenamates].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti20011101

Title: Differential responses to ATPgammaS in the mesenteric and hindlimb vascular bed of the cat.

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Title: Diabetes abolishes the gender difference in vasopressin-mediated potentiation of sympathetic vasoconstriction.

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Title: Fenamates: a novel class of reversible gap junction blockers.

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Title: Contribution of nitric oxide and prostanoids to the cardiac electrophysiological and coronary vasomotor effects of diadenosine polyphosphates.

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Title: Vasodilator responses to ATP and UTP are cAMP dependent in the mesenteric vascular bed of the cat.

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Title: Pregnancy enhances G protein activation and nitric oxide release from uterine arteries.

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Title: Cerebral vasoconstriction produced by vasopressin in conscious goats: role of vasopressin V(1) and V(2) receptors and nitric oxide.

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Title: EDHF contributes to strain-related differences in pulmonary arterial relaxation in rats.

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Title: Screening procedure for detection of non-steroidal anti-inflammatory drugs and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry after extractive methylation.

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Title: Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes.

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Title: Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig.

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Title: The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis.

Journal: Pulmonary pharmacology19940401

Title: Thyroid hormone uptake by hepatocytes: structure-activity relationships of phenylanthranilic acids with inhibitory activity.

Journal: Journal of medicinal chemistry19930430

Title: Anti-inflammatory properties of the protein kinase C inhibitor, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H- pyrrole-2,5-dione monohydrochloride (GF109203X) in the PMA-mouse ear edema model.

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Title: Bradykinin-induced vasoconstriction of rat mesenteric arteries precontracted with noradrenaline.

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Title: Prostaglandin I2 and glucocorticoid-induced rise in arterial pressure in the rat.

Journal: Journal of hypertension19890801

Title: Meclofenamate sodium is an inhibitor of both the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade in vitro.

Journal: Prostaglandins, leukotrienes, and medicine19860801

Title: Yohimbine induces sympathetically mediated renin release in the conscious rat.

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Title: Effect of prostaglandin synthetase inhibitors on experimentally induced convulsions in rats.

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Title: Effect of prostaglandin synthetase inhibitors on non-analgesic actions of morphine.

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Title: Central cardiovascular and thermal effects of prostaglandin E2 in rats.

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Title: Influence of analgesic antipyretics on the central cardiovascular effects of clonidine in rats.

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