65576-45-6,MFCD09838016
Catalog No.:AA00E92A

65576-45-6 | Asenapine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$63.00   $44.00
- +
5mg
≥95%
in stock  
$133.00   $93.00
- +
10mg
≥95%
in stock  
$219.00   $153.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00E92A
Chemical Name:
Asenapine
CAS Number:
65576-45-6
Molecular Formula:
C17H16ClNO
Molecular Weight:
285.7680
MDL Number:
MFCD09838016
SMILES:
Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C
Properties
Properties
 
Storage:
-20 ℃;Inert atmosphere;  

Computed Properties
 
Complexity:
363  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.8  

Literature

Title: Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.

Journal: Journal of medicinal chemistry 20140911

Title: Newer antipsychotics and upcoming molecules for schizophrenia.

Journal: European journal of clinical pharmacology 20130801

Title: Asenapine for the treatment of manic and mixed episodes associated with bipolar I disorder: from clinical research to clinical practice.

Journal: Expert opinion on pharmacotherapy 20130301

Title: Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults.

Journal: Expert review of clinical pharmacology 20130101

Title: Development and validation of automated SPE-HPLC-MS/MS methods for the quantification of asenapine, a new antipsychotic agent, and its two major metabolites in human urine.

Journal: Biomedical chromatography : BMC 20121201

Title: New serotonin/dopamine antagonists for the treatment of schizophrenia: are we making real progress?

Journal: Clinical schizophrenia & related psychoses 20121001

Title: Pharmacological and clinical profile of recently approved second-generation antipsychotics: implications for treatment of schizophrenia in older patients.

Journal: Drugs & aging 20121001

Title: Iloperidone, asenapine and lurasidone: a primer on their current status.

Journal: Expert opinion on pharmacotherapy 20120901

Title: Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis.

Journal: CNS drugs 20120901

Title: Clinically important differences in the pharmacokinetics of the ten newer 'atypical' antipsychotics: Part 2. Metabolism and elimination.

Journal: Journal of psychiatric practice 20120901

Title: A systematic review of meta-analyses of the efficacy of oral atypical antipsychotics for the treatment of adult patients with schizophrenia.

Journal: Expert opinion on pharmacotherapy 20120801

Title: Involvement of 5-HT2A receptor and α2-adrenoceptor blockade in the asenapine-induced elevation of prefrontal cortical monoamine outflow.

Journal: Synapse (New York, N.Y.) 20120701

Title: Long-term efficacy and safety of asenapine or olanzapine in patients with schizophrenia or schizoaffective disorder: an extension study.

Journal: Pharmacopsychiatry 20120701

Title: Weight gain and glucose dysregulation with second-generation antipsychotics and antidepressants: a review for primary care physicians.

Journal: Postgraduate medicine 20120701

Title: ▼Asenapine for bipolar I disorder?

Journal: Drug and therapeutics bulletin 20120601

Title: [Asenapine in bipolar disorder: efficacy, safety and place in clinical practice].

Journal: L'Encephale 20120601

Title: Summary of the comparative effectiveness review on off-label use of atypical antipsychotics.

Journal: Journal of managed care pharmacy : JMCP 20120601

Title: Valproate reduces the glucuronidation of asenapine without affecting asenapine plasma concentrations.

Journal: Journal of clinical pharmacology 20120501

Title: Short-term safety and pharmacokinetic profile of asenapine in older patients with psychosis.

Journal: International journal of geriatric psychiatry 20120501

Title: Asenapine: a clinical review of a second-generation antipsychotic.

Journal: Clinical therapeutics 20120501

Title: Clinically important differences in the pharmacokinetics of the ten newer 'atypical' antipsychotics: part 1.

Journal: Journal of psychiatric practice 20120501

Title: Allergic reactions and sudden death with asenapine.

Journal: The Journal of clinical psychiatry 20120501

Title: Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration.

Journal: Neuropharmacology 20120301

Title: [Antipsychotic medications for bipolar I disorders. New atypical neuroleptic drug asenapine approved].

Journal: Der Nervenarzt 20120301

Title: Interactions between antiepileptics and second-generation antipsychotics.

Journal: Expert opinion on drug metabolism & toxicology 20120301

Title: Quantification of asenapine and three metabolites in human plasma using liquid chromatography-tandem mass spectrometry with automated solid-phase extraction: application to a phase I clinical trial with asenapine in healthy male subjects.

Journal: Biomedical chromatography : BMC 20120201

Title: Asenapine as adjunctive treatment for acute mania associated with bipolar disorder: results of a 12-week core study and 40-week extension.

Journal: Journal of clinical psychopharmacology 20120201

Title: Asenapine versus olanzapine in people with persistent negative symptoms of schizophrenia.

Journal: Journal of clinical psychopharmacology 20120201

Title: The psychopharmacology of agitation: consensus statement of the american association for emergency psychiatry project Beta psychopharmacology workgroup.

Journal: The western journal of emergency medicine 20120201

Title: Asenapine: a synthesis of efficacy data in bipolar mania and schizophrenia.

Journal: Clinical schizophrenia & related psychoses 20120101

Title: The neuroprotective disease-modifying potential of psychotropics in Parkinson's disease.

Journal: Parkinson's disease 20120101

Title: Update on the role of antipsychotics in the treatment of Tourette syndrome.

Journal: Neuropsychiatric disease and treatment 20120101

Title: Critical appraisal of lurasidone in the management of schizophrenia.

Journal: Neuropsychiatric disease and treatment 20120101

Title: Atypical antipsychotic drugs, schizophrenia, and metabolic syndrome in non-Euro-American societies.

Journal: Clinical neuropharmacology 20120101

Title: Safety and tolerability of switching to asenapine from other antipsychotic agents: pooled results from two randomized multicenter trials in stable patients with persistent negative symptoms in schizophrenia.

Journal: Neuropsychiatric disease and treatment 20120101

Title: Stability-indicating liquid chromatographic method for the quantification of the new antipsychotic agent asenapine in bulk and in pharmaceutical formulation.

Journal: Scientia pharmaceutica 20120101

Title: Smoking and metabolism; asenapine; irreversible MAOIs.

Journal: Psychosomatics 20120101

Title: Asenapine: a review of acute and extension phase data in bipolar disorder.

Journal: CNS neuroscience & therapeutics 20111201

Title: System for disclosing hospitality should be transparent.

Journal: BMJ (Clinical research ed.) 20111115

Title: Long-Term Assessment of Asenapine vs. Olanzapine in Patients with Schizophrenia or Schizoaffective Disorder.

Journal: Pharmacopsychiatry 20111101

Title: Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis.

Journal: Lancet (London, England) 20111008

Title: Attenuation of chronic mild stress-induced 'anhedonia' by asenapine is not associated with a 'hedonic' profile in intracranial self-stimulation.

Journal: Journal of psychopharmacology (Oxford, England) 20111001

Title: Biological perspectives: update on newer antipsychotic drugs: are they evidence based?

Journal: Perspectives in psychiatric care 20111001

Title: Asenapine: a new antipsychotic option.

Journal: Journal of pharmacy practice 20111001

Title: Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis.

Journal: JAMA 20110928

Title: Functional potencies of dopamine agonists and antagonists at human dopamine D₂ and D₃ receptors.

Journal: European journal of pharmacology 20110901

Title: Suicidal ideation associated with asenapine use: a report of 2 cases.

Journal: Journal of clinical psychopharmacology 20110801

Title: Asenapine pharmacokinetics in hepatic and renal impairment.

Journal: Clinical pharmacokinetics 20110701

Title: Unmet treatment needs in schizophrenia patients: is asenapine a potential therapeutic option?

Journal: Expert review of neurotherapeutics 20110701

Title: Asenapine for the treatment of stuttering: an analysis of three cases.

Journal: The American journal of psychiatry 20110601

Title: Asenapine improves phencyclidine-induced object recognition deficits in the rat: evidence for engagement of a dopamine D1 receptor mechanism.

Journal: Psychopharmacology 20110401

Title: Metabolism and excretion of asenapine in healthy male subjects.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110401

Title: Dual inhibition: a novel promising pharmacological approach for different disease conditions.

Journal: The Journal of pharmacy and pharmacology 20110401

Title: Update on newer antipsychotic drugs.

Journal: Journal of psychosocial nursing and mental health services 20110401

Title: Newer molecules in the treatment of schizophrenia: A clinical update.

Journal: Indian journal of pharmacology 20110401

Title: Dopamine D2 occupancy as a biomarker for antipsychotics: quantifying the relationship with efficacy and extrapyramidal symptoms.

Journal: The AAPS journal 20110301

Title: Asenapine: a review of its use in the management of mania in adults with bipolar I disorder.

Journal: CNS drugs 20110301

Title: A randomized placebo-controlled trial of asenapine for the prevention of relapse of schizophrenia after long-term treatment.

Journal: The Journal of clinical psychiatry 20110301

Title: Iloperidone, asenapine, and lurasidone: a brief overview of 3 new second-generation antipsychotics.

Journal: Postgraduate medicine 20110301

Title: The role of serotonin receptors in the action of atypical antipsychotic drugs.

Journal: Current opinion in pharmacology 20110201

Title: Efficacy of antimanic treatments: meta-analysis of randomized, controlled trials.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110101

Title: Comparison of QTc data analysis methods recommended by the ICH E14 guidance and exposure-response analysis: case study of a thorough QT study of asenapine.

Journal: Clinical pharmacology and therapeutics 20110101

Title: Atypical antipsychotics: the two new arrivals.

Journal: Issues in mental health nursing 20110101

Title: Paliperidone ER and oral risperidone in patients with schizophrenia: a comparative database analysis.

Journal: BMC psychiatry 20110101

Title: Weight gain, obesity, and psychotropic prescribing.

Journal: Journal of obesity 20110101

Title: Class effect of pharmacotherapy in bipolar disorder: fact or misbelief?

Journal: Annals of general psychiatry 20110101

Title: The role of asenapine in the treatment of manic or mixed states associated with bipolar I disorder.

Journal: Neuropsychiatric disease and treatment 20110101

Title: Role of sublingual asenapine in treatment of schizophrenia.

Journal: Neuropsychiatric disease and treatment 20110101

Title: Effects of asenapine on depressive symptoms in patients with bipolar I disorder experiencing acute manic or mixed episodes: a post hoc analysis of two 3-week clinical trials.

Journal: BMC psychiatry 20110101

Title: Clinical potential of lurasidone in the management of schizophrenia.

Journal: Therapeutics and clinical risk management 20110101

Title: Review of the safety, efficacy, and side effect profile of asenapine in the treatment of bipolar 1 disorder.

Journal: Patient preference and adherence 20110101

Title: Clinical utility of the risperidone formulations in the management of schizophrenia.

Journal: Neuropsychiatric disease and treatment 20110101

Title: Asenapine: a clinical overview.

Journal: The Journal of clinical psychiatry 20110101

Title: Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the rat.

Journal: Behavioural brain research 20101225

Title: A review of new atypical antipsychotic launches in the United States.

Journal: Psychiatry (Edgmont (Pa. : Township)) 20101201

Title: Asenapine for long-term treatment of bipolar disorder: a double-blind 40-week extension study.

Journal: Journal of affective disorders 20101101

Title: Effects of asenapine on prefrontal N-methyl-D-aspartate receptor-mediated transmission: involvement of dopamine D1 receptors.

Journal: Synapse (New York, N.Y.) 20101101

Title: Adjunctive use of atypical antipsychotics for treatment-resistant generalized anxiety disorder.

Journal: Pharmacotherapy 20100901

Title: New antipsychotic drugs: how do their receptor-binding profiles compare?

Journal: The Journal of clinical psychiatry 20100901

Title: Evaluation of the clinical efficacy of asenapine in schizophrenia.

Journal: Expert opinion on pharmacotherapy 20100801

Title: Effect of absorption site on the pharmacokinetics of sublingual asenapine in healthy male subjects.

Journal: Biopharmaceutics & drug disposition 20100701

Title: Long-term assessment of Asenapine vs. Olanzapine in patients with schizophrenia or schizoaffective disorder.

Journal: Pharmacopsychiatry 20100601

Title: Pharmacology and efficacy of asenapine for manic and mixed states in adults with bipolar disorder.

Journal: Expert review of neurotherapeutics 20100501

Title: Repeated effects of asenapine on adrenergic and cholinergic muscarinic receptors.

Journal: The international journal of neuropsychopharmacology 20100401

Title: Asenapine in the treatment of acute mania in bipolar I disorder: a randomized, double-blind, placebo-controlled trial.

Journal: Journal of affective disorders 20100401

Title: Efficacy and safety of asenapine in a placebo- and haloperidol-controlled trial in patients with acute exacerbation of schizophrenia.

Journal: Journal of clinical psychopharmacology 20100401

Title: Asenapine induces differential regional effects on serotonin receptor subtypes.

Journal: Journal of psychopharmacology (Oxford, England) 20100301

Title: New drug information. Saphris.

Journal: JAAPA : official journal of the American Academy of Physician Assistants 20100301

Title: Asenapine (Saphris) sublingual tablets for schizophrenia and bipolar disorder.

Journal: The Medical letter on drugs and therapeutics 20100208

Title: New drugs: asenapine, iloperidone, and bepotastine besilate.

Journal: Journal of the American Pharmacists Association : JAPhA 20100101

Title: A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder.

Journal: BMC systems biology 20100101

Title: [The quest for the pharmacological treatment of schizophrenia: from conventional neuroleptics to atypical antipsychotics and beyond].

Journal: Vertex (Buenos Aires, Argentina) 20100101

Title: Neuroleptic malignant syndrome after exposure to asenapine: a case report.

Journal: Primary care companion to the Journal of clinical psychiatry 20100101

Title: Asenapine, a new sublingual atypical antipsychotic.

Journal: Journal of pharmacology & pharmacotherapeutics 20100101

Title: Asenapine versus olanzapine in acute mania: a double-blind extension study.

Journal: Bipolar disorders 20091201

Title: Asenapine for schizophrenia and bipolar disorder: a review of the efficacy and safety profile for this newly approved sublingually absorbed second-generation antipsychotic.

Journal: International journal of clinical practice 20091201

Title: Asenapine maleate: a new drug for the treatment of schizophrenia and bipolar mania.

Journal: Drugs of today (Barcelona, Spain : 1998) 20091201

Title: Asenapine effects in animal models of psychosis and cognitive function.

Journal: Psychopharmacology 20091101

Title: A 3-week, randomized, placebo-controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states.

Journal: Bipolar disorders 20091101

Title: Exposure-response analysis in patients with schizophrenia to assess the effect of asenapine on QTc prolongation.

Journal: Journal of clinical pharmacology 20091101

Title: Asenapine.

Journal: Nature reviews. Drug discovery 20091101

Title: Asenapine approved for treatment of schizophrenia, bipolar disorder.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090915

Title: Asenapine.

Journal: CNS drugs 20090901

Title: Modeling and simulation of the time course of asenapine exposure response and dropout patterns in acute schizophrenia.

Journal: Clinical pharmacology and therapeutics 20090701

Title: Asenapine elevates cortical dopamine, noradrenaline and serotonin release. Evidence for activation of cortical and subcortical dopamine systems by different mechanisms.

Journal: Psychopharmacology 20090601

Title: Asenapine exerts distinctive regional effects on ionotropic glutamate receptor subtypes in rat brain.

Journal: Synapse (New York, N.Y.) 20090501

Title: Electrophysiological characterization of the effects of asenapine at 5-HT(1A), 5-HT(2A), alpha(2)-adrenergic and D(2) receptors in the rat brain.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090301

Title: Asenapine: a novel psychopharmacologic agent with a unique human receptor signature.

Journal: Journal of psychopharmacology (Oxford, England) 20090101

Title: Asenapine restores cognitive flexibility in rats with medial prefrontal cortex lesions.

Journal: Psychopharmacology 20090101

Title: Asenapine monotherapy in the acute treatment of both schizophrenia and bipolar I disorder.

Journal: Neuropsychiatric disease and treatment 20090101

Title: Asenapine increases dopamine, norepinephrine, and acetylcholine efflux in the rat medial prefrontal cortex and hippocampus.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081101

Title: Actions of novel agonists, antagonists and antipsychotic agents at recombinant rat 5-HT6 receptors: a comparative study of coupling to G alpha s.

Journal: European journal of pharmacology 20080707

Title: Acute and long-term treatment of mania.

Journal: Dialogues in clinical neuroscience 20080601

Title: Bipolar depression: trial-based insights to guide patient care.

Journal: Dialogues in clinical neuroscience 20080601

Title: American psychiatric association.

Journal: P & T : a peer-reviewed journal for formulary management 20080601

Title: Differential regional and dose-related effects of asenapine on dopamine receptor subtypes.

Journal: Psychopharmacology 20080501

Title: Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia.

Journal: Psychopharmacology 20080201

Title: Efficacy and tolerability of asenapine in acute schizophrenia: a placebo- and risperidone-controlled trial.

Journal: The Journal of clinical psychiatry 20071001

Title: Drug-drug interactions associated with second-generation antipsychotics: considerations for clinicians and patients.

Journal: Psychopharmacology bulletin 20070101

Title: Asenapine in the treatment of negative symptoms of schizophrenia: clinical trial design and rationale.

Journal: Psychopharmacology bulletin 20070101

Title: Actions of ORG 5222 as a novel psychotropic agent.

Journal: Pharmacology, biochemistry, and behavior 19900301

Title: M Shahid, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73.

Title: Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl). 2008 Feb;196(3):417-29.

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SDS
Tags:65576-45-6 Molecular Formula|65576-45-6 MDL|65576-45-6 SMILES|65576-45-6 Asenapine
Catalog No.: AA00E92A
65576-45-6,MFCD09838016
65576-45-6 | Asenapine
Pack Size: 1mg
Purity: ≥95%
in stock
$63.00 $44.00
Pack Size: 5mg
Purity: ≥95%
in stock
$133.00 $93.00
Pack Size: 10mg
Purity: ≥95%
in stock
$219.00 $153.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00E92A
Chemical Name: Asenapine
CAS Number: 65576-45-6
Molecular Formula: C17H16ClNO
Molecular Weight: 285.7680
MDL Number: MFCD09838016
SMILES: Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C
Properties
Storage: -20 ℃;Inert atmosphere;  
Complexity: 363  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 2  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 20  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.8  
Literature fold

Title: Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.

Journal: Journal of medicinal chemistry20140911

Title: Newer antipsychotics and upcoming molecules for schizophrenia.

Journal: European journal of clinical pharmacology20130801

Title: Asenapine for the treatment of manic and mixed episodes associated with bipolar I disorder: from clinical research to clinical practice.

Journal: Expert opinion on pharmacotherapy20130301

Title: Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults.

Journal: Expert review of clinical pharmacology20130101

Title: Development and validation of automated SPE-HPLC-MS/MS methods for the quantification of asenapine, a new antipsychotic agent, and its two major metabolites in human urine.

Journal: Biomedical chromatography : BMC20121201

Title: New serotonin/dopamine antagonists for the treatment of schizophrenia: are we making real progress?

Journal: Clinical schizophrenia & related psychoses20121001

Title: Pharmacological and clinical profile of recently approved second-generation antipsychotics: implications for treatment of schizophrenia in older patients.

Journal: Drugs & aging20121001

Title: Iloperidone, asenapine and lurasidone: a primer on their current status.

Journal: Expert opinion on pharmacotherapy20120901

Title: Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis.

Journal: CNS drugs20120901

Title: Clinically important differences in the pharmacokinetics of the ten newer 'atypical' antipsychotics: Part 2. Metabolism and elimination.

Journal: Journal of psychiatric practice20120901

Title: A systematic review of meta-analyses of the efficacy of oral atypical antipsychotics for the treatment of adult patients with schizophrenia.

Journal: Expert opinion on pharmacotherapy20120801

Title: Involvement of 5-HT2A receptor and α2-adrenoceptor blockade in the asenapine-induced elevation of prefrontal cortical monoamine outflow.

Journal: Synapse (New York, N.Y.)20120701

Title: Long-term efficacy and safety of asenapine or olanzapine in patients with schizophrenia or schizoaffective disorder: an extension study.

Journal: Pharmacopsychiatry20120701

Title: Weight gain and glucose dysregulation with second-generation antipsychotics and antidepressants: a review for primary care physicians.

Journal: Postgraduate medicine20120701

Title: ▼Asenapine for bipolar I disorder?

Journal: Drug and therapeutics bulletin20120601

Title: [Asenapine in bipolar disorder: efficacy, safety and place in clinical practice].

Journal: L'Encephale20120601

Title: Summary of the comparative effectiveness review on off-label use of atypical antipsychotics.

Journal: Journal of managed care pharmacy : JMCP20120601

Title: Valproate reduces the glucuronidation of asenapine without affecting asenapine plasma concentrations.

Journal: Journal of clinical pharmacology20120501

Title: Short-term safety and pharmacokinetic profile of asenapine in older patients with psychosis.

Journal: International journal of geriatric psychiatry20120501

Title: Asenapine: a clinical review of a second-generation antipsychotic.

Journal: Clinical therapeutics20120501

Title: Clinically important differences in the pharmacokinetics of the ten newer 'atypical' antipsychotics: part 1.

Journal: Journal of psychiatric practice20120501

Title: Allergic reactions and sudden death with asenapine.

Journal: The Journal of clinical psychiatry20120501

Title: Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration.

Journal: Neuropharmacology20120301

Title: [Antipsychotic medications for bipolar I disorders. New atypical neuroleptic drug asenapine approved].

Journal: Der Nervenarzt20120301

Title: Interactions between antiepileptics and second-generation antipsychotics.

Journal: Expert opinion on drug metabolism & toxicology20120301

Title: Quantification of asenapine and three metabolites in human plasma using liquid chromatography-tandem mass spectrometry with automated solid-phase extraction: application to a phase I clinical trial with asenapine in healthy male subjects.

Journal: Biomedical chromatography : BMC20120201

Title: Asenapine as adjunctive treatment for acute mania associated with bipolar disorder: results of a 12-week core study and 40-week extension.

Journal: Journal of clinical psychopharmacology20120201

Title: Asenapine versus olanzapine in people with persistent negative symptoms of schizophrenia.

Journal: Journal of clinical psychopharmacology20120201

Title: The psychopharmacology of agitation: consensus statement of the american association for emergency psychiatry project Beta psychopharmacology workgroup.

Journal: The western journal of emergency medicine20120201

Title: Asenapine: a synthesis of efficacy data in bipolar mania and schizophrenia.

Journal: Clinical schizophrenia & related psychoses20120101

Title: The neuroprotective disease-modifying potential of psychotropics in Parkinson's disease.

Journal: Parkinson's disease20120101

Title: Update on the role of antipsychotics in the treatment of Tourette syndrome.

Journal: Neuropsychiatric disease and treatment20120101

Title: Critical appraisal of lurasidone in the management of schizophrenia.

Journal: Neuropsychiatric disease and treatment20120101

Title: Atypical antipsychotic drugs, schizophrenia, and metabolic syndrome in non-Euro-American societies.

Journal: Clinical neuropharmacology20120101

Title: Safety and tolerability of switching to asenapine from other antipsychotic agents: pooled results from two randomized multicenter trials in stable patients with persistent negative symptoms in schizophrenia.

Journal: Neuropsychiatric disease and treatment20120101

Title: Stability-indicating liquid chromatographic method for the quantification of the new antipsychotic agent asenapine in bulk and in pharmaceutical formulation.

Journal: Scientia pharmaceutica20120101

Title: Smoking and metabolism; asenapine; irreversible MAOIs.

Journal: Psychosomatics20120101

Title: Asenapine: a review of acute and extension phase data in bipolar disorder.

Journal: CNS neuroscience & therapeutics20111201

Title: System for disclosing hospitality should be transparent.

Journal: BMJ (Clinical research ed.)20111115

Title: Long-Term Assessment of Asenapine vs. Olanzapine in Patients with Schizophrenia or Schizoaffective Disorder.

Journal: Pharmacopsychiatry20111101

Title: Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis.

Journal: Lancet (London, England)20111008

Title: Attenuation of chronic mild stress-induced 'anhedonia' by asenapine is not associated with a 'hedonic' profile in intracranial self-stimulation.

Journal: Journal of psychopharmacology (Oxford, England)20111001

Title: Biological perspectives: update on newer antipsychotic drugs: are they evidence based?

Journal: Perspectives in psychiatric care20111001

Title: Asenapine: a new antipsychotic option.

Journal: Journal of pharmacy practice20111001

Title: Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis.

Journal: JAMA20110928

Title: Functional potencies of dopamine agonists and antagonists at human dopamine D₂ and D₃ receptors.

Journal: European journal of pharmacology20110901

Title: Suicidal ideation associated with asenapine use: a report of 2 cases.

Journal: Journal of clinical psychopharmacology20110801

Title: Asenapine pharmacokinetics in hepatic and renal impairment.

Journal: Clinical pharmacokinetics20110701

Title: Unmet treatment needs in schizophrenia patients: is asenapine a potential therapeutic option?

Journal: Expert review of neurotherapeutics20110701

Title: Asenapine for the treatment of stuttering: an analysis of three cases.

Journal: The American journal of psychiatry20110601

Title: Asenapine improves phencyclidine-induced object recognition deficits in the rat: evidence for engagement of a dopamine D1 receptor mechanism.

Journal: Psychopharmacology20110401

Title: Metabolism and excretion of asenapine in healthy male subjects.

Journal: Drug metabolism and disposition: the biological fate of chemicals20110401

Title: Dual inhibition: a novel promising pharmacological approach for different disease conditions.

Journal: The Journal of pharmacy and pharmacology20110401

Title: Update on newer antipsychotic drugs.

Journal: Journal of psychosocial nursing and mental health services20110401

Title: Newer molecules in the treatment of schizophrenia: A clinical update.

Journal: Indian journal of pharmacology20110401

Title: Dopamine D2 occupancy as a biomarker for antipsychotics: quantifying the relationship with efficacy and extrapyramidal symptoms.

Journal: The AAPS journal20110301

Title: Asenapine: a review of its use in the management of mania in adults with bipolar I disorder.

Journal: CNS drugs20110301

Title: A randomized placebo-controlled trial of asenapine for the prevention of relapse of schizophrenia after long-term treatment.

Journal: The Journal of clinical psychiatry20110301

Title: Iloperidone, asenapine, and lurasidone: a brief overview of 3 new second-generation antipsychotics.

Journal: Postgraduate medicine20110301

Title: The role of serotonin receptors in the action of atypical antipsychotic drugs.

Journal: Current opinion in pharmacology20110201

Title: Efficacy of antimanic treatments: meta-analysis of randomized, controlled trials.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20110101

Title: Comparison of QTc data analysis methods recommended by the ICH E14 guidance and exposure-response analysis: case study of a thorough QT study of asenapine.

Journal: Clinical pharmacology and therapeutics20110101

Title: Atypical antipsychotics: the two new arrivals.

Journal: Issues in mental health nursing20110101

Title: Paliperidone ER and oral risperidone in patients with schizophrenia: a comparative database analysis.

Journal: BMC psychiatry20110101

Title: Weight gain, obesity, and psychotropic prescribing.

Journal: Journal of obesity20110101

Title: Class effect of pharmacotherapy in bipolar disorder: fact or misbelief?

Journal: Annals of general psychiatry20110101

Title: The role of asenapine in the treatment of manic or mixed states associated with bipolar I disorder.

Journal: Neuropsychiatric disease and treatment20110101

Title: Role of sublingual asenapine in treatment of schizophrenia.

Journal: Neuropsychiatric disease and treatment20110101

Title: Effects of asenapine on depressive symptoms in patients with bipolar I disorder experiencing acute manic or mixed episodes: a post hoc analysis of two 3-week clinical trials.

Journal: BMC psychiatry20110101

Title: Clinical potential of lurasidone in the management of schizophrenia.

Journal: Therapeutics and clinical risk management20110101

Title: Review of the safety, efficacy, and side effect profile of asenapine in the treatment of bipolar 1 disorder.

Journal: Patient preference and adherence20110101

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