Name: Name:(2E,4E,6E,8E)-9-(3-hydroxy-2,6,6-trimethyl-1-cyclohexenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid
Brand: AABLOCKS
SKU: AA00FDNH
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00FDNH

Chemical Name: (2E,4E,6E,8E)-9-(3-hydroxy-2,6,6-trimethyl-1-cyclohexenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid

CAS Number: 66592-72-1

Molecular Formula: C20H28O3

Molecular Weight: 316.4345

MDL Number: MFCD00872034

SMILES: C/C(=C\C=C\C(=C\C(=O)O)\C)/C=C/C1=C(C)C(O)CCC1(C)C

Properties

Complexity: 598

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 4

Formal Charge: 0

Heavy Atom Count: 23

Hydrogen Bond Acceptor Count: 3

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 5

Undefined Atom Stereocenter Count: 1

Undefined Bond Stereocenter Count: 0

XLogP3: 4.5

Literature fold

Title: Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids.

Journal: Molecular pharmacology20150301

Title: The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system.

Journal: Pharmacogenetics and genomics20070301

Title: A novel cytochrome P450, zebrafish Cyp26D1, is involved in metabolism of all-trans retinoic acid.

Journal: Molecular endocrinology (Baltimore, Md.)20060701

Title: The control of morphogen signalling: regulation of the synthesis and catabolism of retinoic acid in the developing embryo.

Journal: Developmental biology20050901

Title: HPLC-MS/MS analysis of the products generated from all-trans-retinoic acid using recombinant human CYP26A.

Journal: Journal of lipid research20020701

Title: Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites.

Journal: Cancer research20010115

Title: Induction of the cytochrome P450 gene CYP26 during mucous cell differentiation of normal human tracheobronchial epithelial cells.

Journal: Molecular pharmacology20000901

Title: Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation.

Journal: Biochemical pharmacology20000815

66592-72-1 | (2E,4E,6E,8E)-9-(3-hydroxy-2,6,6-trimethyl-1-cyclohexenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid