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666837-93-0,MFCD17010284
Catalog No.:AA0035JN

666837-93-0 | Su9516

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99+%
in stock  
$25.00   $18.00
- +
5mg
99+%
in stock  
$74.00   $52.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0035JN
Chemical Name:
Su9516
CAS Number:
666837-93-0
Molecular Formula:
C13H11N3O2
Molecular Weight:
241.2453
MDL Number:
MFCD17010284
SMILES:
COc1ccc2c(c1)/C(=C/c1c[nH]cn1)/C(=O)N2
Properties
Properties
 
Form:
Solid  
Solubility:
DMSO: ~17 mg/mL  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
369  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
1  
XLogP3:
1  

Literature

Title: Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations.

Journal: Journal of medicinal chemistry 20060824

Title: The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism.

Journal: Molecular pharmacology 20060801

Title: Novel pyrrolyllactone and pyrrolyllactam indolinones as potent cyclin-dependent kinase 2 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20030602

Title: SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells.

Journal: Biochemical pharmacology 20021001

Title: A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells.

Journal: Cancer research 20010815

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SDS
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Tags:666837-93-0 Molecular Formula|666837-93-0 MDL|666837-93-0 SMILES|666837-93-0 Su9516
Catalog No.: AA0035JN
666837-93-0,MFCD17010284
666837-93-0 | Su9516
Pack Size： 1mg
Purity： 99+%
in stock
$25.00 $18.00
Pack Size： 5mg
Purity： 99+%
in stock
$74.00 $52.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA0035JN
Chemical Name: Su9516
CAS Number: 666837-93-0
Molecular Formula: C13H11N3O2
Molecular Weight: 241.2453
MDL Number: MFCD17010284
SMILES: COc1ccc2c(c1)/C(=C/c1c[nH]cn1)/C(=O)N2
Properties
Form: Solid  
Solubility: DMSO: ~17 mg/mL  
Storage: Keep in dry area;2-8℃;  
Complexity: 369  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 18  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 1  
XLogP3: 1  
Literature fold

Title: Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations.

Journal: Journal of medicinal chemistry20060824

Title: The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism.

Journal: Molecular pharmacology20060801

Title: Novel pyrrolyllactone and pyrrolyllactam indolinones as potent cyclin-dependent kinase 2 inhibitors.

Journal: Bioorganic & medicinal chemistry letters20030602

Title: SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells.

Journal: Biochemical pharmacology20021001

Title: A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells.

Journal: Cancer research20010815

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