67-92-5,MFCD00079158
Catalog No.:AA00FARM

67-92-5 | DICYCLOMINE HYDROCHLORIDE

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Purity
Availability
Price(USD)
Quantity
  
500mg
≥98%
in stock  
$29.00   $20.00
- +
1g
≥98%
in stock  
$48.00   $33.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00FARM
Chemical Name:
DICYCLOMINE HYDROCHLORIDE
CAS Number:
67-92-5
Molecular Formula:
C19H36ClNO2
Molecular Weight:
345.9476
MDL Number:
MFCD00079158
SMILES:
CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC.Cl
NSC Number:
756727
Properties
Computed Properties
 
Complexity:
326  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Task demands dissociate the effects of muscarinic M1 receptor blockade and protein kinase C inhibition on attentional performance in rats.

Journal: Journal of psychopharmacology (Oxford, England) 20120801

Title: Infantile colic: a systematic review of medical and conventional therapies.

Journal: Journal of paediatrics and child health 20120201

Title: Studies on antidiarrheal and antispasmodic activities of Lepidium sativum crude extract in rats.

Journal: Phytotherapy research : PTR 20120101

Title: Dicyclomine: cause of abnormally decreased gall bladder ejection with sincalide-stimulated hepatobiliary scintigraphy.

Journal: Clinical nuclear medicine 20120101

Title: Epidemiological evidence in forensic pharmacovigilance.

Journal: The International journal of risk & safety in medicine 20120101

Title: Modulation of behavioral phenotypes by a muscarinic M1 antagonist in a mouse model of fragile X syndrome.

Journal: Psychopharmacology 20110901

Title: A computer-automated touchscreen paired-associates learning (PAL) task for mice: impairments following administration of scopolamine or dicyclomine and improvements following donepezil.

Journal: Psychopharmacology 20110301

Title: Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin).

Journal: Therapeutic drug monitoring 20110201

Title: Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.

Journal: American journal of obstetrics and gynecology 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Clinical practice. Nausea and vomiting in pregnancy.

Journal: The New England journal of medicine 20101014

Title: Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment.

Journal: Journal of neuroscience research 20091201

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin.

Journal: The Journal of pediatrics 20090701

Title: Dicyclomine, an M1 muscarinic antagonist, reduces biomarker levels, but not neuronal degeneration, in fluid percussion brain injury.

Journal: Journal of neurotrauma 20081101

Title: Interaction between glutamatergic-NMDA and cholinergic-muscarinic systems in classical fear conditioning.

Journal: Brain research bulletin 20080930

Title: Antagonism of muscarinic M1 receptors by dicyclomine inhibits the consolidation of morphine-associated contextual memory.

Journal: Brain research bulletin 20080701

Title: Blockade of M1 muscarinic acetylcholine receptors modulates the methamphetamine-induced psychomotor stimulant effect.

Journal: Neuroscience 20080602

Title: [Drug treatment of irritable bowel syndrome: an unmet need].

Journal: Gastroenterologia y hepatologia 20070301

Title: American Gastroenterological Association institute medical position statement on the use of gastrointestinal medication in pregnancy.

Journal: Gastroenterology 20070201

Title: Preventing recurrence of severe morning sickness.

Journal: Canadian family physician Medecin de famille canadien 20061210

Title: Role of muscarinic M1 receptors in inhibitory avoidance and contextual fear conditioning.

Journal: Neurobiology of learning and memory 20060901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: M1 receptors play a central role in modulating AD-like pathology in transgenic mice.

Journal: Neuron 20060302

Title: The negative impact of litigation on women's health care.

Journal: Gender medicine 20051201

Title: Interaction between M1-muscarinic and glutamatergic NMDA receptors on an inhibitory avoidance task.

Journal: Brain research bulletin 20051130

Title: Pharmacodynamic effects of darifenacin, a muscarinic M selective receptor antagonist for the treatment of overactive bladder, in healthy volunteers.

Journal: BJU international 20051101

Title: Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies.

Journal: Behavioural brain research 20050620

Title: Infantile colic.

Journal: Clinical evidence 20050601

Title: Post-marketing surveillance using pharmacy-based cohorts: results of a pilot study.

Journal: Pharmacoepidemiology and drug safety 20050501

Title: Quantitative determination of pharmaceuticals using nano-electrospray ionization mass spectrometry after reversed phase mini-solid phase extraction.

Journal: Journal of pharmaceutical and biomedical analysis 20050223

Title: Prophylactic Diclectin reduces the incidence of postoperative vomiting.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20050101

Title: Experimental analysis of antimicrobial action of dicyclomine hydrochloride.

Journal: Biological & pharmaceutical bulletin 20041201

Title: Pre-emptive therapy for severe nausea and vomiting of pregnancy and hyperemesis gravidarum.

Journal: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20040801

Title: Infantile colic.

Journal: Clinical evidence 20040601

Title: Dicycloverine for persistent crying in babies: dicycloverine is contraindicated in infants.

Journal: BMJ (Clinical research ed.) 20040417

Title: Dicycloverine for persistent crying in babies: beware recommending dicycloverine treatment in babies.

Journal: BMJ (Clinical research ed.) 20040417

Title: Infantile colic.

Journal: The journal of family health care 20040101

Title: Science v. law. A decade-old rule on scientific evidence comes under fire.

Journal: Scientific American 20031201

Title: Infantile colic.

Journal: Clinical evidence 20031201

Title: Antibacterial potential of an antispasmodic drug dicyclomine hydrochloride.

Journal: The Indian journal of medical research 20031101

Title: Prenatal prescription of macrolide antibiotics and infantile hypertrophic pyloric stenosis.

Journal: Obstetrics and gynecology 20030401

Title: Bendectin and birth defects: hopefully, the final chapter.

Journal: Birth defects research. Part A, Clinical and molecular teratology 20030201

Title: Bendectin and birth defects. II: Ecological analyses.

Journal: Birth defects research. Part A, Clinical and molecular teratology 20030201

Title: Use of pi-acceptors for spectrophotometric determination of dicyclomine hydrochloride.

Journal: Journal of AOAC International 20030101

Title: [Hyperemesis gravidarum--etiology and treatment].

Journal: La Clinica terapeutica 20030101

Title: Infantile colic.

Journal: Clinical evidence 20021201

Title: Infantile colic.

Journal: Clinical evidence 20020601

Title: Medical, social, and legal implications of treating nausea and vomiting of pregnancy.

Journal: American journal of obstetrics and gynecology 20020501

Title: Alternative therapies of morning sickness.

Journal: Clinical obstetrics and gynecology 20011201

Title: Evidence based management of nocturnal enuresis.

Journal: BMJ (Clinical research ed.) 20011117

Title: The expert witness. Neither Frye nor Daubert solved the problem: what can be done?

Journal: Science & justice : journal of the Forensic Science Society 20010101

Title: Bendectin.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20010101

Title: Return of the morning sickness pill. Could Bendectin be coming back to market?

Journal: AWHONN lifelines 20010101

Title: The effect of M1 muscarinic blockade on behavior and physiological responses following traumatic brain injury in the rat.

Journal: Brain research 19900312

Title: Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine.

Journal: British journal of pharmacology 19860901

Title: Evaluation of bendectin embryotoxicity in nonhuman primates: I. Ventricular septal defects in prenatal macaques and baboon.

Journal: Teratology 19851001

Title: Congenital heart disease in relation to maternal use of Bendectin and other drugs in early pregnancy.

Journal: The New England journal of medicine 19850808

Title: Prune belly syndrome and heart defect in one of monozygotic twins, following exposure to Tigan and Bendectin.

Journal: Acta geneticae medicae et gemellologiae 19850101

Title: Dicyclomine: worrying symptoms associated with its use in some small babies.

Journal: British medical journal (Clinical research ed.) 19840324

Title: Bendectin (Debendox) as a risk factor for pyloric stenosis.

Journal: American journal of obstetrics and gynecology 19821215

Title: J Pavía,et al. Pharmacological Characterization and Distribution of Muscarinic Receptors in Human Placental Syncytiotrophoblast Brush-Border and Basal Plasma Membranes. Eur J Pharmacol. . 1997 Feb 12;320(2-3):209-14.

Title: Antonella Caccamo, et al.  M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49(5):671-82.doi: 10.1016/j.neuron.2006.01.020.

Title: Susan J Bartko,et al. A Computer-Automated Touchscreen Paired-Associates Learning (PAL) Task for Mice: Impairments Following Administration of Scopolamine or Dicyclomine and Improvements Following Donepezil.Psychopharmacology (Berl). 2011 Mar;214(2):537-48.

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Additional Info:
SDS
Historical Records
Tags:67-92-5 Molecular Formula|67-92-5 MDL|67-92-5 SMILES|67-92-5 DICYCLOMINE HYDROCHLORIDE
Catalog No.: AA00FARM
67-92-5,MFCD00079158
67-92-5 | DICYCLOMINE HYDROCHLORIDE
Pack Size: 500mg
Purity: ≥98%
in stock
$29.00 $20.00
Pack Size: 1g
Purity: ≥98%
in stock
$48.00 $33.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00FARM
Chemical Name: DICYCLOMINE HYDROCHLORIDE
CAS Number: 67-92-5
Molecular Formula: C19H36ClNO2
Molecular Weight: 345.9476
MDL Number: MFCD00079158
SMILES: CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC.Cl
NSC Number: 756727
Properties
Complexity: 326  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 23  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 8  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Task demands dissociate the effects of muscarinic M1 receptor blockade and protein kinase C inhibition on attentional performance in rats.

Journal: Journal of psychopharmacology (Oxford, England)20120801

Title: Infantile colic: a systematic review of medical and conventional therapies.

Journal: Journal of paediatrics and child health20120201

Title: Studies on antidiarrheal and antispasmodic activities of Lepidium sativum crude extract in rats.

Journal: Phytotherapy research : PTR20120101

Title: Dicyclomine: cause of abnormally decreased gall bladder ejection with sincalide-stimulated hepatobiliary scintigraphy.

Journal: Clinical nuclear medicine20120101

Title: Epidemiological evidence in forensic pharmacovigilance.

Journal: The International journal of risk & safety in medicine20120101

Title: Modulation of behavioral phenotypes by a muscarinic M1 antagonist in a mouse model of fragile X syndrome.

Journal: Psychopharmacology20110901

Title: A computer-automated touchscreen paired-associates learning (PAL) task for mice: impairments following administration of scopolamine or dicyclomine and improvements following donepezil.

Journal: Psychopharmacology20110301

Title: Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin).

Journal: Therapeutic drug monitoring20110201

Title: Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.

Journal: American journal of obstetrics and gynecology20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Clinical practice. Nausea and vomiting in pregnancy.

Journal: The New England journal of medicine20101014

Title: Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment.

Journal: Journal of neuroscience research20091201

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin.

Journal: The Journal of pediatrics20090701

Title: Dicyclomine, an M1 muscarinic antagonist, reduces biomarker levels, but not neuronal degeneration, in fluid percussion brain injury.

Journal: Journal of neurotrauma20081101

Title: Interaction between glutamatergic-NMDA and cholinergic-muscarinic systems in classical fear conditioning.

Journal: Brain research bulletin20080930

Title: Antagonism of muscarinic M1 receptors by dicyclomine inhibits the consolidation of morphine-associated contextual memory.

Journal: Brain research bulletin20080701

Title: Blockade of M1 muscarinic acetylcholine receptors modulates the methamphetamine-induced psychomotor stimulant effect.

Journal: Neuroscience20080602

Title: [Drug treatment of irritable bowel syndrome: an unmet need].

Journal: Gastroenterologia y hepatologia20070301

Title: American Gastroenterological Association institute medical position statement on the use of gastrointestinal medication in pregnancy.

Journal: Gastroenterology20070201

Title: Preventing recurrence of severe morning sickness.

Journal: Canadian family physician Medecin de famille canadien20061210

Title: Role of muscarinic M1 receptors in inhibitory avoidance and contextual fear conditioning.

Journal: Neurobiology of learning and memory20060901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: M1 receptors play a central role in modulating AD-like pathology in transgenic mice.

Journal: Neuron20060302

Title: The negative impact of litigation on women's health care.

Journal: Gender medicine20051201

Title: Interaction between M1-muscarinic and glutamatergic NMDA receptors on an inhibitory avoidance task.

Journal: Brain research bulletin20051130

Title: Pharmacodynamic effects of darifenacin, a muscarinic M selective receptor antagonist for the treatment of overactive bladder, in healthy volunteers.

Journal: BJU international20051101

Title: Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies.

Journal: Behavioural brain research20050620

Title: Infantile colic.

Journal: Clinical evidence20050601

Title: Post-marketing surveillance using pharmacy-based cohorts: results of a pilot study.

Journal: Pharmacoepidemiology and drug safety20050501

Title: Quantitative determination of pharmaceuticals using nano-electrospray ionization mass spectrometry after reversed phase mini-solid phase extraction.

Journal: Journal of pharmaceutical and biomedical analysis20050223

Title: Prophylactic Diclectin reduces the incidence of postoperative vomiting.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie20050101

Title: Experimental analysis of antimicrobial action of dicyclomine hydrochloride.

Journal: Biological & pharmaceutical bulletin20041201

Title: Pre-emptive therapy for severe nausea and vomiting of pregnancy and hyperemesis gravidarum.

Journal: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology20040801

Title: Infantile colic.

Journal: Clinical evidence20040601

Title: Dicycloverine for persistent crying in babies: dicycloverine is contraindicated in infants.

Journal: BMJ (Clinical research ed.)20040417

Title: Dicycloverine for persistent crying in babies: beware recommending dicycloverine treatment in babies.

Journal: BMJ (Clinical research ed.)20040417

Title: Infantile colic.

Journal: The journal of family health care20040101

Title: Science v. law. A decade-old rule on scientific evidence comes under fire.

Journal: Scientific American20031201

Title: Infantile colic.

Journal: Clinical evidence20031201

Title: Antibacterial potential of an antispasmodic drug dicyclomine hydrochloride.

Journal: The Indian journal of medical research20031101

Title: Prenatal prescription of macrolide antibiotics and infantile hypertrophic pyloric stenosis.

Journal: Obstetrics and gynecology20030401

Title: Bendectin and birth defects: hopefully, the final chapter.

Journal: Birth defects research. Part A, Clinical and molecular teratology20030201

Title: Bendectin and birth defects. II: Ecological analyses.

Journal: Birth defects research. Part A, Clinical and molecular teratology20030201

Title: Use of pi-acceptors for spectrophotometric determination of dicyclomine hydrochloride.

Journal: Journal of AOAC International20030101

Title: [Hyperemesis gravidarum--etiology and treatment].

Journal: La Clinica terapeutica20030101

Title: Infantile colic.

Journal: Clinical evidence20021201

Title: Infantile colic.

Journal: Clinical evidence20020601

Title: Medical, social, and legal implications of treating nausea and vomiting of pregnancy.

Journal: American journal of obstetrics and gynecology20020501

Title: Alternative therapies of morning sickness.

Journal: Clinical obstetrics and gynecology20011201

Title: Evidence based management of nocturnal enuresis.

Journal: BMJ (Clinical research ed.)20011117

Title: The expert witness. Neither Frye nor Daubert solved the problem: what can be done?

Journal: Science & justice : journal of the Forensic Science Society20010101

Title: Bendectin.

Journal: Reproductive toxicology (Elmsford, N.Y.)20010101

Title: Return of the morning sickness pill. Could Bendectin be coming back to market?

Journal: AWHONN lifelines20010101

Title: The effect of M1 muscarinic blockade on behavior and physiological responses following traumatic brain injury in the rat.

Journal: Brain research19900312

Title: Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine.

Journal: British journal of pharmacology19860901

Title: Evaluation of bendectin embryotoxicity in nonhuman primates: I. Ventricular septal defects in prenatal macaques and baboon.

Journal: Teratology19851001

Title: Congenital heart disease in relation to maternal use of Bendectin and other drugs in early pregnancy.

Journal: The New England journal of medicine19850808

Title: Prune belly syndrome and heart defect in one of monozygotic twins, following exposure to Tigan and Bendectin.

Journal: Acta geneticae medicae et gemellologiae19850101

Title: Dicyclomine: worrying symptoms associated with its use in some small babies.

Journal: British medical journal (Clinical research ed.)19840324

Title: Bendectin (Debendox) as a risk factor for pyloric stenosis.

Journal: American journal of obstetrics and gynecology19821215

Title: J Pavía,et al. Pharmacological Characterization and Distribution of Muscarinic Receptors in Human Placental Syncytiotrophoblast Brush-Border and Basal Plasma Membranes. Eur J Pharmacol. . 1997 Feb 12;320(2-3):209-14.

Title: Antonella Caccamo, et al.  M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49(5):671-82.doi: 10.1016/j.neuron.2006.01.020.

Title: Susan J Bartko,et al. A Computer-Automated Touchscreen Paired-Associates Learning (PAL) Task for Mice: Impairments Following Administration of Scopolamine or Dicyclomine and Improvements Following Donepezil.Psychopharmacology (Berl). 2011 Mar;214(2):537-48.

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