Name: Name:Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)-,dihydrochloride
Brand: AABLOCKS
SKU: AA00FYPC
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00FYPC

Chemical Name: Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)-,dihydrochloride

CAS Number: 67469-75-4

Molecular Formula: C28H32N2O

Molecular Weight: 412.5665

MDL Number: MFCD00209830

SMILES: c1ccc(cc1)/C=C/CN1CCN(CC1)CCOC(c1ccccc1)c1ccccc1

Properties

Complexity: 477

Covalently-Bonded Unit Count: 3

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 1

Formal Charge: 0

Heavy Atom Count: 33

Hydrogen Bond Acceptor Count: 3

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 9

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

Literature fold

Title: A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20120701

Title: Pharmacological manipulation of the dopaminergic system affects wheel-running activity in differentially active mice.

Journal: Journal of biological regulators and homeostatic agents20120101

Title: Synergistic activation of dopamine D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala.

Journal: PloS one20110101

Title: A new model of the disrupted latent inhibition in C57BL/6J mice after bupropion treatment.

Journal: Psychopharmacology20100201

Title: Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20080501

Title: Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20070401

Title: Comparisons between bupropion and dexamphetamine in a range of in vivo tests exploring dopaminergic transmission.

Journal: British journal of pharmacology20070301

Title: Methylphenidate and MK-801, an N-methyl-d-aspartate receptor antagonist: shared biological properties.

Journal: Neuroscience20040101

Title: Stimulation of postsynaptic alpha1b- and alpha2-adrenergic receptors amplifies dopamine-mediated locomotor activity in both rats and mice.

Journal: Synapse (New York, N.Y.)20031215

Title: Critical role of alpha1-adrenergic receptors in acute and sensitized locomotor effects of D-amphetamine, cocaine, and GBR 12783: influence of preexposure conditions and pharmacological characteristics.

Journal: Synapse (New York, N.Y.)20020101

Title: Nail-Boucherie K, et al. The specific dopamine uptake inhibitor GBR 12783 improves learning of inhibitory avoidance and increases hippocampal acetylcholine release. Brain Res Cogn Brain Res. 1998 Oct;7(2):203-5.

Title: Bonnet JJ, et al. GBR 12783, a potent and selective inhibitor of dopamine uptake: biochemical studies in vivo and ex vivo. Eur J Pharmacol. 1986 Feb 18;121(2):199-209.

67469-75-4 | Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)-,dihydrochloride