Name: Name:JNJ-1661010
Brand: AABLOCKS
SKU: AA003T8A
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA003T8A

Chemical Name: JNJ-1661010

CAS Number: 681136-29-8

Molecular Formula: C19H19N5OS

Molecular Weight: 365.4521

MDL Number: MFCD00209157

SMILES: O=C(N1CCN(CC1)c1snc(n1)c1ccccc1)Nc1ccccc1

Properties

Form: Solid

Solubility: DMSO: ≥28mg/mL

Storage: Keep in dry area;2-8℃;

Complexity: 459

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 26

Hydrogen Bond Acceptor Count: 5

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 3

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.5

Literature fold

Title: The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).

Journal: Bioorganic & medicinal chemistry letters20110815

Title: Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.

Journal: Bioorganic & medicinal chemistry letters20110415

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.

Journal: Bioorganic & medicinal chemistry letters20090801

Title: Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.

Journal: Anesthesia and analgesia20090101

Title: Dynamic regulation of the endocannabinoid system: implications for analgesia.

Journal: Molecular pain20090101

Title: Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.

Journal: Bioorganic & medicinal chemistry letters20080901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Keith JM, et al. Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4838-43.

Title: Karbarz MJ, et al. Biochemical and biological properties of 4-(3-phenyl-,2,4 thiadiazol-5-yl)-piperazine-1-carboxylicacid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. Anesth Analg. 2009 Jan;108(1):316-29.

681136-29-8 | JNJ-1661010