695-53-4,MFCD00005379
Catalog No.:AA005WFO

695-53-4 | 5,5-Dimethyloxazolidine-2,4-dione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$7.00   $5.00
- +
5g
95%
in stock  
$8.00   $6.00
- +
10g
95%
in stock  
$12.00   $8.00
- +
25g
95%
in stock  
$14.00   $10.00
- +
100g
95%
in stock  
$49.00   $34.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA005WFO
Chemical Name:
5,5-Dimethyloxazolidine-2,4-dione
CAS Number:
695-53-4
Molecular Formula:
C5H7NO3
Molecular Weight:
129.1140
MDL Number:
MFCD00005379
SMILES:
O=C1NC(=O)C(O1)(C)C
Properties
Properties
 
BP:
137°C at 760 mmHg  
Form:
Solid  
MP:
77-80 °C(lit.)  
Refractive Index:
1.4220 (estimate)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
173  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
0.1  

Literature

Title: In Utero Exposure to a Cardiac Teratogen Causes Reversible Deficits in Postnatal Cardiovascular Function, But Altered Adaptation to the Burden of Pregnancy.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20151101

Title: Maternal rat serum concentrations of dimethadione do not explain intra-litter differences in the incidence of dimethadione-induced birth defects, including novel findings in foetal lung.

Journal: Toxicology 20141204

Title: In utero dimethadione exposure causes postnatal disruption in cardiac structure and function in the rat.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20141201

Title: Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators.

Journal: Journal of medicinal chemistry 20111222

Title: Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione.

Journal: Birth defects research. Part B, Developmental and reproductive toxicology 20110601

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Alterations in mouse embryo intracellular pH by DMO during culture impair implantation and fetal growth.

Journal: Reproductive biomedicine online 20100801

Title: Acidic and basic solutions dissolve protein plugs made of lithostathine complicating choledochal cyst/pancreaticobiliary maljunction.

Journal: Digestive diseases and sciences 20090701

Title: Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures.

Journal: Neuropsychiatric disease and treatment 20090101

Title: Glucose loading precipitates focal lactic acidosis in the vulnerable medial thalamus of thiamine-deficient rats.

Journal: Metabolic brain disease 20080301

Title: Polytherapy with hERG-blocking antiepileptic drugs: increased risk for embryonic cardiac arrhythmia and teratogenicity.

Journal: Birth defects research. Part A, Clinical and molecular teratology 20070801

Title: Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20070701

Title: Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca(2+) and H(+) concentrations in Dictyostelium discoideum.

Journal: Development, growth & differentiation 20070401

Title: Thoracic skeletal defects and cardiac malformations: a common epigenetic link?

Journal: Birth defects research. Part C, Embryo today : reviews 20061201

Title: Interactive effects of cadmium and all-trans-retinoic acid on the induction of forelimb ectrodactyly in C57BL/6 mice.

Journal: Birth defects research. Part A, Clinical and molecular teratology 20060101

Title: Discriminative power of an assay for automated in vitro screening of teratogens.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20040801

Title: Disruption of bovine oocytes and preimplantation embryos by urea and acidic pH.

Journal: Journal of dairy science 20030401

Title: Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?

Journal: Epilepsia 20020501

Title: Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods.

Journal: Alternatives to laboratory animals : ATLA 20020101

Title: The clinical importance of the trimethadione tolerance test as a method for quantitative assessment of hepatic functional reserve in patients with biliary atresia.

Journal: Journal of clinical pharmacy and therapeutics 20011201

Title: Na(+)-dependent pH regulation by the amitochondriate protozoan parasite Giardia intestinalis.

Journal: The Journal of biological chemistry 20010803

Title: Altering intracellular pH disrupts development and cellular organization in preimplantation hamster embryos.

Journal: Biology of reproduction 20010601

Title: Trimethadione N-demethylation by rat liver CYP2E1 in vitro.

Journal: Research communications in molecular pathology and pharmacology 19960701

Title: Effects of the oxazolidinedione anticonvulsants trimethadione and dimethadione and the barbiturate homolog 5,5-dimethylbarbituric acid on N-nitrosodiethylamine-initiated renal and hepatic carcinogenesis in the F344/NCr rat.

Journal: Archives of toxicology 19920101

Title: Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons.

Journal: Annals of neurology 19890601

Title: Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons.

Journal: Neuroscience letters 19890313

Title: Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.

Journal: The Journal of pediatrics 19760801

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SDS
Related Products of 695-53-4
Tags:695-53-4 Molecular Formula|695-53-4 MDL|695-53-4 SMILES|695-53-4 5,5-Dimethyloxazolidine-2,4-dione
Catalog No.: AA005WFO
695-53-4,MFCD00005379
695-53-4 | 5,5-Dimethyloxazolidine-2,4-dione
Pack Size: 1g
Purity: 95%
in stock
$7.00 $5.00
Pack Size: 5g
Purity: 95%
in stock
$8.00 $6.00
Pack Size: 10g
Purity: 95%
in stock
$12.00 $8.00
Pack Size: 25g
Purity: 95%
in stock
$14.00 $10.00
Pack Size: 100g
Purity: 95%
in stock
$49.00 $34.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA005WFO
Chemical Name: 5,5-Dimethyloxazolidine-2,4-dione
CAS Number: 695-53-4
Molecular Formula: C5H7NO3
Molecular Weight: 129.1140
MDL Number: MFCD00005379
SMILES: O=C1NC(=O)C(O1)(C)C
Properties
BP: 137°C at 760 mmHg  
Form: Solid  
MP: 77-80 °C(lit.)  
Refractive Index: 1.4220 (estimate)  
Storage: Keep in dry area;2-8℃;  
Complexity: 173  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 9  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 0.1  
Literature fold

Title: In Utero Exposure to a Cardiac Teratogen Causes Reversible Deficits in Postnatal Cardiovascular Function, But Altered Adaptation to the Burden of Pregnancy.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20151101

Title: Maternal rat serum concentrations of dimethadione do not explain intra-litter differences in the incidence of dimethadione-induced birth defects, including novel findings in foetal lung.

Journal: Toxicology20141204

Title: In utero dimethadione exposure causes postnatal disruption in cardiac structure and function in the rat.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20141201

Title: Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators.

Journal: Journal of medicinal chemistry20111222

Title: Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione.

Journal: Birth defects research. Part B, Developmental and reproductive toxicology20110601

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Alterations in mouse embryo intracellular pH by DMO during culture impair implantation and fetal growth.

Journal: Reproductive biomedicine online20100801

Title: Acidic and basic solutions dissolve protein plugs made of lithostathine complicating choledochal cyst/pancreaticobiliary maljunction.

Journal: Digestive diseases and sciences20090701

Title: Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures.

Journal: Neuropsychiatric disease and treatment20090101

Title: Glucose loading precipitates focal lactic acidosis in the vulnerable medial thalamus of thiamine-deficient rats.

Journal: Metabolic brain disease20080301

Title: Polytherapy with hERG-blocking antiepileptic drugs: increased risk for embryonic cardiac arrhythmia and teratogenicity.

Journal: Birth defects research. Part A, Clinical and molecular teratology20070801

Title: Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs.

Journal: Reproductive toxicology (Elmsford, N.Y.)20070701

Title: Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca(2+) and H(+) concentrations in Dictyostelium discoideum.

Journal: Development, growth & differentiation20070401

Title: Thoracic skeletal defects and cardiac malformations: a common epigenetic link?

Journal: Birth defects research. Part C, Embryo today : reviews20061201

Title: Interactive effects of cadmium and all-trans-retinoic acid on the induction of forelimb ectrodactyly in C57BL/6 mice.

Journal: Birth defects research. Part A, Clinical and molecular teratology20060101

Title: Discriminative power of an assay for automated in vitro screening of teratogens.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20040801

Title: Disruption of bovine oocytes and preimplantation embryos by urea and acidic pH.

Journal: Journal of dairy science20030401

Title: Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?

Journal: Epilepsia20020501

Title: Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods.

Journal: Alternatives to laboratory animals : ATLA20020101

Title: The clinical importance of the trimethadione tolerance test as a method for quantitative assessment of hepatic functional reserve in patients with biliary atresia.

Journal: Journal of clinical pharmacy and therapeutics20011201

Title: Na(+)-dependent pH regulation by the amitochondriate protozoan parasite Giardia intestinalis.

Journal: The Journal of biological chemistry20010803

Title: Altering intracellular pH disrupts development and cellular organization in preimplantation hamster embryos.

Journal: Biology of reproduction20010601

Title: Trimethadione N-demethylation by rat liver CYP2E1 in vitro.

Journal: Research communications in molecular pathology and pharmacology19960701

Title: Effects of the oxazolidinedione anticonvulsants trimethadione and dimethadione and the barbiturate homolog 5,5-dimethylbarbituric acid on N-nitrosodiethylamine-initiated renal and hepatic carcinogenesis in the F344/NCr rat.

Journal: Archives of toxicology19920101

Title: Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons.

Journal: Annals of neurology19890601

Title: Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons.

Journal: Neuroscience letters19890313

Title: Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.

Journal: The Journal of pediatrics19760801

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