Name: Name:Episilvestrol
Brand: AABLOCKS
SKU: AA00FF6H
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00FF6H

Chemical Name: Episilvestrol

CAS Number: 697235-39-5

Molecular Formula: C34H38O13

Molecular Weight: 654.6577

MDL Number: MFCD25541744

SMILES: OCC(C1COC(C(O1)Oc1cc2OC3(C(c2c(c1)OC)(O)C(C(C3c1ccccc1)C(=O)OC)O)c1ccc(cc1)OC)OC)O

Properties

Complexity: 1050

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 9

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 47

Hydrogen Bond Acceptor Count: 13

Hydrogen Bond Donor Count: 4

Isotope Atom Count: 0

Rotatable Bond Count: 11

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 1.6

Literature fold

Title: Total synthesis of 2''',5'''-diepisilvestrol and its C1''' epimer: key structure activity relationships at C1''' and C2'''.

Journal: Journal of natural products20120824

Title: Isolation and characterization of minor analogues of silvestrol and other constituents from a large-scale re-collection of Aglaia foveolata.

Journal: Journal of natural products20101129

Title: Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol.

Journal: Journal of the American Chemical Society20090204

Title: Total synthesis of (-)-episilvestrol and (-)-silvestrol.

Journal: Angewandte Chemie (International ed. in English)20070101

Title: Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.

Journal: The Journal of organic chemistry20040514

Title: Chambers JM, et al. Synthesis of biotinylated episilvestrol: highly selective targeting of the translation factors eIF4AI/II. Org Lett. 2013 Mar 15;15(6):1406-9.

Title: Hwang BY, et al. Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. J Org Chem. 2004 May 14;69(10):3350-8.

Title: Daker M, et al. Inhibition of nasopharyngeal carcinoma cell proliferation and synergism of cisplatin with silvestrol and episilvestrol isolated from Aglaia stellatopilosa. Exp Ther Med. 2016 Jun;11(6):2117-2126. Epub 2016 Mar 29.

697235-39-5 | Episilvestrol