Name: Name:daurisoline
Brand: AABLOCKS
SKU: AA00FBD6
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00FBD6

Chemical Name: daurisoline

CAS Number: 70553-76-3

Molecular Formula: C37H42N2O6

Molecular Weight: 610.7392

MDL Number: MFCD00221740

SMILES: COc1cc2c(cc1OC)CCN([C@@H]2Cc1ccc(cc1)Oc1cc(ccc1O)C[C@H]1N(C)CCc2c1cc(O)c(c2)OC)C

Properties

Complexity: 917

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 2

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 45

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 9

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 6.4

Literature fold

Title: Effect of daurisoline on HERG channel electrophysiological function and protein expression.

Journal: Journal of natural products20120928

Title: Daurisoline suppressed early afterdepolarizations and inhibited L-type calcium current.

Journal: The American journal of Chinese medicine20100101

Title: [Effect of phenolic alkaloids of Menispermum dauricum on thrombosis and platelet aggregation].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20051001

Title: [Protective effects of phenolic alkaloids from Menispermum dauricum on inflammatory injury following focal cerebral ischemia-reperfusion in rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20040801

Title: [Determination of daurisoline in rabbit plasma and study on its pharmacokinetics].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20031201

Title: Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs.

Journal: Acta pharmacologica Sinica20031001

Title: Interaction of multidrug resistance reversal agents with P-glycoprotein ATPase activity on blood-brain barrier.

Journal: Acta pharmacologica Sinica20020501

Title: Liu Q, et al. Effect of daurisoline on HERG channel electrophysiological function and protein expression. J Nat Prod. 2012 Sep 28;75(9):1539-45.

Title: Wu MY, et al. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells tocamptothecin-induced toxicity. Oncotarget. 2017 Sep 8;8(44):77673-77684.

Title: Shi SJ, et al. Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs. Acta Pharmacol Sin. 2003 Oct;24(10):1011-5.

70553-76-3 | daurisoline