7085-55-4,MFCD00893813
Catalog No.:AA00IC16

7085-55-4 | Troxerutin

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Purity
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100mg
97+%
in stock  
$6.00   $4.00
- +
1g
97+%
in stock  
$11.00   $8.00
- +
5g
≥90%
in stock  
$46.00   $32.00
- +
10g
≥90%
in stock  
$79.00   $55.00
- +
25g
≥90%
in stock  
$123.00   $86.00
- +
100g
95 - 105% (UV, on dry basis)
in stock  
$328.00   $230.00
- +
250g
95 - 105% (UV, on dry basis)
in stock  
$742.00   $520.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00IC16
Chemical Name:
Troxerutin
CAS Number:
7085-55-4
Molecular Formula:
C33H42O19
Molecular Weight:
742.6752
MDL Number:
MFCD00893813
SMILES:
OCCOc1cc(OCCO)c2c(c1)oc(c(c2=O)O[C@@H]1O[C@H](CO[C@@H]2O[C@@H](C)[C@@H]([C@H]([C@H]2O)O)O)[C@H]([C@@H]([C@H]1O)O)O)c1ccc(c(c1)O)OCCO
Properties
Computed Properties
 
Complexity:
1170  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
52  
Hydrogen Bond Acceptor Count:
19  
Hydrogen Bond Donor Count:
10  
Isotope Atom Count:
0  
Rotatable Bond Count:
15  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-2.4  

Literature

Title: Troxerutin abrogates mitochondrial oxidative stress and myocardial apoptosis in mice fed calorie-rich diet.

Journal: Chemico-biological interactions 20171225

Title: Troxerutin inhibits 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)-induced hepatocyte apoptosis by restoring proteasome function.

Journal: Toxicology letters 20150318

Title: Ameliorating effects of troxerutin on nickel-induced oxidative stress in rats.

Journal: Redox report : communications in free radical research 20130101

Title: Phlebotonics for haemorrhoids.

Journal: The Cochrane database of systematic reviews 20120815

Title: Radioprotective effects of troxerutin against gamma irradiation in mice liver.

Journal: International journal of radiation biology 20120801

Title: Battling brain diabetes: antioxidants may reduce cognitive deficits induced by cholesterol.

Journal: Neurosurgery 20110601

Title: Troxerutin protects against high cholesterol-induced cognitive deficits in mice.

Journal: Brain : a journal of neurology 20110301

Title: Ultrasound-promoted enzymatic synthesis of troxerutin esters in nonaqueous solvents.

Journal: Ultrasonics sonochemistry 20110101

Title: Pharmacological treatment of primary chronic venous disease: rationale, results and unanswered questions.

Journal: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20110101

Title: Chronic administration of troxerutin protects mouse kidney against D-galactose-induced oxidative DNA damage.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20101001

Title: Pharmacological treatment in patients with C4, C5 and C6 venous disease.

Journal: Phlebology 20101001

Title: NGF-Dependent activation of TrkA pathway: A mechanism for the neuroprotective effect of troxerutin in D-galactose-treated mice.

Journal: Brain pathology (Zurich, Switzerland) 20100901

Title: Chronic administration of troxerutin protects mouse brain against D-galactose-induced impairment of cholinergic system.

Journal: Neurobiology of learning and memory 20100201

Title: Troxerutin protects the mouse liver against oxidative stress-mediated injury induced by D-galactose.

Journal: Journal of agricultural and food chemistry 20090909

Title: Pharmacological agents in the treatment of venous disease: an update of the available evidence.

Journal: Current vascular pharmacology 20090701

Title: Troxerutin protects the mouse kidney from d-galactose-caused injury through anti-inflammation and anti-oxidation.

Journal: International immunopharmacology 20090101

Title: Conversion from nonischemic to ischemic retinal vein occlusion: prediction by venous velocity on color Doppler imaging.

Journal: European journal of ophthalmology 20090101

Title: Aescin and troxerutin as a successful combination for the treatment of inner ear perfusion disturbances.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20080301

Title: The simultaneous separation and determination of six flavonoids and troxerutin in rat urine and chicken plasma by reversed-phase high-performance liquid chromatography with ultraviolet-visible detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070901

Title: Effect on capillary permeability in rabbits of iridoids from Buddleia scordioides.

Journal: Phytotherapy research : PTR 20060701

Title: Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency.

Journal: Angiology 20060101

Title: Troxerutin protects the isolated perfused rat liver from a possible lipid peroxidation by coumarin.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20050101

Title: Efficacy of troxerutin on streptozotocin-induced rat model in the early stage of diabetic retinopathy.

Journal: Arzneimittel-Forschung 20050101

Title: HNE-dependent molecular damage in diabetic nephropathy and its possible prevention by N-acetyl-cysteine and oxerutin.

Journal: BioFactors (Oxford, England) 20050101

Title: Comparative study on the inclusion behaviour of cyclodextrin derivatives with venoruton and rutin by thin layer chromatography.

Journal: Biomedical chromatography : BMC 20041001

Title: Epidemiology of restless legs syndrome as diagnosed in UK primary care.

Journal: Sleep medicine 20040901

Title: Treatment of the common cold with troxerutin.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20040901

Title: Clinical study of the Ginko biloba--Troxerutin-Heptaminol Hce in the treatment of acute hemorrhoidal attacks.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20040201

Title: Benzo-pyrones for reducing and controlling lymphoedema of the limbs.

Journal: The Cochrane database of systematic reviews 20040101

Title: Treatment of the leg ulcers by skin grafting.

Journal: Medicina (Kaunas, Lithuania) 20040101

Title: Safety aspects of a coumarin-troxerutin combination regarding liver function in a double-blind placebo-controlled study.

Journal: International journal of clinical pharmacology and therapeutics 20030501

Title: Vascular permeabilization by intravenous arachidonate in the rat peritoneal cavity: antagonism by antioxidants.

Journal: European journal of pharmacology 20030411

Title: Vascular permeabilization by intravenous arachidonate in the rat peritoneal cavity: antagonism by ethamsylate.

Journal: European journal of pharmacology 20030411

Title: Single copy of variant CYP2A6 alleles does not confer susceptibility to liver dysfunction in patients treated with coumarin.

Journal: International journal of clinical pharmacology and therapeutics 20030401

Title: Comparative trial of N-acetyl-cysteine, taurine, and oxerutin on skin and kidney damage in long-term experimental diabetes.

Journal: Diabetes 20030201

Title: Free radical scavenging and skin penetration of troxerutin and vitamin derivatives.

Journal: The Journal of dermatological treatment 20020901

Title: Pharmacokinetics of mono-3'- and mono-4'-0-(beta-hydroxyethyl)-rutoside derivatives, after single doses of Venoruton powder in healthy volunteers.

Journal: European journal of clinical pharmacology 20020901

Title: HR (Venoruton1000, Paroven, 0-[beta-hydroxyethyl]-rutosides) vs. Daflon 500 in chronic venous disease and microangiopathy: an independent prospective, controlled, randomized trial.

Journal: Journal of cardiovascular pharmacology and therapeutics 20020701

Title: [High-altitude retinopathy].

Journal: Oftalmologia (Bucharest, Romania : 1990) 20010101

Title: Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study.

Journal: Current medical research and opinion 20010101

Title: Double-blind, randomized clinical trial of troxerutin-carbazochrome in patients with hemorrhoids.

Journal: European review for medical and pharmacological sciences 20000101

Title: Lim KM, et al. Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells. Mol Med Rep. 2015 Aug;12(2):2650-60.

Title: Zhang Z, et al. Troxerutin Attenuates Enhancement of Hepatic Gluconeogenesis by Inhibiting NOD Activation-Mediated Inflammation in High-Fat Diet-Treated Mice. Int J Mol Sci. 2016 Dec 25;18(1). pii: E31.

Title: Badalzadeh R, et al. Beneficial effect of troxerutin on diabetes-induced vascular damages in rat aorta: histopathological alterations and antioxidation mechanism. Int J Endocrinol Metab. 2015 Apr 30;13(2):e25969.

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SDS
Historical Records
Tags:7085-55-4 Molecular Formula|7085-55-4 MDL|7085-55-4 SMILES|7085-55-4 Troxerutin
Catalog No.: AA00IC16
7085-55-4,MFCD00893813
7085-55-4 | Troxerutin
Pack Size: 100mg
Purity: 97+%
in stock
$6.00 $4.00
Pack Size: 1g
Purity: 97+%
in stock
$11.00 $8.00
Pack Size: 5g
Purity: ≥90%
in stock
$46.00 $32.00
Pack Size: 10g
Purity: ≥90%
in stock
$79.00 $55.00
Pack Size: 25g
Purity: ≥90%
in stock
$123.00 $86.00
Pack Size: 100g
Purity: 95 - 105% (UV, on dry basis)
in stock
$328.00 $230.00
Pack Size: 250g
Purity: 95 - 105% (UV, on dry basis)
in stock
$742.00 $520.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00IC16
Chemical Name: Troxerutin
CAS Number: 7085-55-4
Molecular Formula: C33H42O19
Molecular Weight: 742.6752
MDL Number: MFCD00893813
SMILES: OCCOc1cc(OCCO)c2c(c1)oc(c(c2=O)O[C@@H]1O[C@H](CO[C@@H]2O[C@@H](C)[C@@H]([C@H]([C@H]2O)O)O)[C@H]([C@@H]([C@H]1O)O)O)c1ccc(c(c1)O)OCCO
Properties
Complexity: 1170  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 10  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 52  
Hydrogen Bond Acceptor Count: 19  
Hydrogen Bond Donor Count: 10  
Isotope Atom Count: 0  
Rotatable Bond Count: 15  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -2.4  
Literature fold

Title: Troxerutin abrogates mitochondrial oxidative stress and myocardial apoptosis in mice fed calorie-rich diet.

Journal: Chemico-biological interactions20171225

Title: Troxerutin inhibits 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)-induced hepatocyte apoptosis by restoring proteasome function.

Journal: Toxicology letters20150318

Title: Ameliorating effects of troxerutin on nickel-induced oxidative stress in rats.

Journal: Redox report : communications in free radical research20130101

Title: Phlebotonics for haemorrhoids.

Journal: The Cochrane database of systematic reviews20120815

Title: Radioprotective effects of troxerutin against gamma irradiation in mice liver.

Journal: International journal of radiation biology20120801

Title: Battling brain diabetes: antioxidants may reduce cognitive deficits induced by cholesterol.

Journal: Neurosurgery20110601

Title: Troxerutin protects against high cholesterol-induced cognitive deficits in mice.

Journal: Brain : a journal of neurology20110301

Title: Ultrasound-promoted enzymatic synthesis of troxerutin esters in nonaqueous solvents.

Journal: Ultrasonics sonochemistry20110101

Title: Pharmacological treatment of primary chronic venous disease: rationale, results and unanswered questions.

Journal: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery20110101

Title: Chronic administration of troxerutin protects mouse kidney against D-galactose-induced oxidative DNA damage.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20101001

Title: Pharmacological treatment in patients with C4, C5 and C6 venous disease.

Journal: Phlebology20101001

Title: NGF-Dependent activation of TrkA pathway: A mechanism for the neuroprotective effect of troxerutin in D-galactose-treated mice.

Journal: Brain pathology (Zurich, Switzerland)20100901

Title: Chronic administration of troxerutin protects mouse brain against D-galactose-induced impairment of cholinergic system.

Journal: Neurobiology of learning and memory20100201

Title: Troxerutin protects the mouse liver against oxidative stress-mediated injury induced by D-galactose.

Journal: Journal of agricultural and food chemistry20090909

Title: Pharmacological agents in the treatment of venous disease: an update of the available evidence.

Journal: Current vascular pharmacology20090701

Title: Troxerutin protects the mouse kidney from d-galactose-caused injury through anti-inflammation and anti-oxidation.

Journal: International immunopharmacology20090101

Title: Conversion from nonischemic to ischemic retinal vein occlusion: prediction by venous velocity on color Doppler imaging.

Journal: European journal of ophthalmology20090101

Title: Aescin and troxerutin as a successful combination for the treatment of inner ear perfusion disturbances.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20080301

Title: The simultaneous separation and determination of six flavonoids and troxerutin in rat urine and chicken plasma by reversed-phase high-performance liquid chromatography with ultraviolet-visible detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20070901

Title: Effect on capillary permeability in rabbits of iridoids from Buddleia scordioides.

Journal: Phytotherapy research : PTR20060701

Title: Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency.

Journal: Angiology20060101

Title: Troxerutin protects the isolated perfused rat liver from a possible lipid peroxidation by coumarin.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20050101

Title: Efficacy of troxerutin on streptozotocin-induced rat model in the early stage of diabetic retinopathy.

Journal: Arzneimittel-Forschung20050101

Title: HNE-dependent molecular damage in diabetic nephropathy and its possible prevention by N-acetyl-cysteine and oxerutin.

Journal: BioFactors (Oxford, England)20050101

Title: Comparative study on the inclusion behaviour of cyclodextrin derivatives with venoruton and rutin by thin layer chromatography.

Journal: Biomedical chromatography : BMC20041001

Title: Epidemiology of restless legs syndrome as diagnosed in UK primary care.

Journal: Sleep medicine20040901

Title: Treatment of the common cold with troxerutin.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica20040901

Title: Clinical study of the Ginko biloba--Troxerutin-Heptaminol Hce in the treatment of acute hemorrhoidal attacks.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet20040201

Title: Benzo-pyrones for reducing and controlling lymphoedema of the limbs.

Journal: The Cochrane database of systematic reviews20040101

Title: Treatment of the leg ulcers by skin grafting.

Journal: Medicina (Kaunas, Lithuania)20040101

Title: Safety aspects of a coumarin-troxerutin combination regarding liver function in a double-blind placebo-controlled study.

Journal: International journal of clinical pharmacology and therapeutics20030501

Title: Vascular permeabilization by intravenous arachidonate in the rat peritoneal cavity: antagonism by antioxidants.

Journal: European journal of pharmacology20030411

Title: Vascular permeabilization by intravenous arachidonate in the rat peritoneal cavity: antagonism by ethamsylate.

Journal: European journal of pharmacology20030411

Title: Single copy of variant CYP2A6 alleles does not confer susceptibility to liver dysfunction in patients treated with coumarin.

Journal: International journal of clinical pharmacology and therapeutics20030401

Title: Comparative trial of N-acetyl-cysteine, taurine, and oxerutin on skin and kidney damage in long-term experimental diabetes.

Journal: Diabetes20030201

Title: Free radical scavenging and skin penetration of troxerutin and vitamin derivatives.

Journal: The Journal of dermatological treatment20020901

Title: Pharmacokinetics of mono-3'- and mono-4'-0-(beta-hydroxyethyl)-rutoside derivatives, after single doses of Venoruton powder in healthy volunteers.

Journal: European journal of clinical pharmacology20020901

Title: HR (Venoruton1000, Paroven, 0-[beta-hydroxyethyl]-rutosides) vs. Daflon 500 in chronic venous disease and microangiopathy: an independent prospective, controlled, randomized trial.

Journal: Journal of cardiovascular pharmacology and therapeutics20020701

Title: [High-altitude retinopathy].

Journal: Oftalmologia (Bucharest, Romania : 1990)20010101

Title: Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study.

Journal: Current medical research and opinion20010101

Title: Double-blind, randomized clinical trial of troxerutin-carbazochrome in patients with hemorrhoids.

Journal: European review for medical and pharmacological sciences20000101

Title: Lim KM, et al. Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells. Mol Med Rep. 2015 Aug;12(2):2650-60.

Title: Zhang Z, et al. Troxerutin Attenuates Enhancement of Hepatic Gluconeogenesis by Inhibiting NOD Activation-Mediated Inflammation in High-Fat Diet-Treated Mice. Int J Mol Sci. 2016 Dec 25;18(1). pii: E31.

Title: Badalzadeh R, et al. Beneficial effect of troxerutin on diabetes-induced vascular damages in rat aorta: histopathological alterations and antioxidation mechanism. Int J Endocrinol Metab. 2015 Apr 30;13(2):e25969.

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